Experimental modulation of physiological force application on leg joint neurons in intact Drosophila melanogaster

Hoffman, B. D., Grashoff, C. & Schwartz, M. A. Dynamic molecular processes mediate cellular mechanotransduction. Nature 475, 316–323 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hudspeth, A. J. Integrating the active process of hair cells with cochlear function. Nat. Rev. Neurosci. 15, 600–614 (2014).

Article  CAS  PubMed  Google Scholar 

Ranade, S. S., Syeda, R. & Patapoutian, A. Mechanically activated ion channels. Neuron 87, 1162–1179 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Langenhan, T., Piao, X. & Monk, K. R. Adhesion G protein-coupled receptors in nervous system development and disease. Nat. Rev. Neurosci. 17, 550–561 (2016).

Article  CAS  PubMed  Google Scholar 

Scholz, N., Monk, K. R., Kittel, R. J. & Langenhan, T. Adhesion GPCRs as a putative class of metabotropic mechanosensors. Handb. Exp. Pharmacol. 234, 221–247 (2016).

Article  CAS  PubMed  Google Scholar 

Wolfenson, H., Yang, B. & Sheetz, M. P. Steps in mechanotransduction pathways that control cell morphology. Annu. Rev. Physiol. 81, 1–21 (2017).

Google Scholar 

Mammoto, A., Mammoto, T. & Ingber, D. E. Mechanosensitive mechanisms in transcriptional regulation. J. Cell Sci. 125, 3061–3073 (2012).

CAS  PubMed  PubMed Central  Google Scholar 

Scholz, N. et al. Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation. Nature 615, 945–953 (2023).

Article  CAS  PubMed  Google Scholar 

Scholz, N. et al. The adhesion GPCR Latrophilin/CIRL shapes mechanosensation. Cell Rep. 11, 866–874 (2015).

Article  CAS  PubMed  Google Scholar 

Dannhäuser, S. et al. Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination. Elife 9, e56738 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Scholz, N. et al. Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons. Elife 6, e28360 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Desai, B. S., Chadha, A. & Cook, B. The stum gene is essential for mechanical sensing in proprioceptive neurons. Science 343, 1256–1259 (2014).

Article  PubMed  Google Scholar 

He, L., Binari, R., Huang, J., Falo-Sanjuan, J. & Perrimon, N. In vivo study of gene expression with an enhanced dual-color fluorescent transcriptional timer. Elife 8, e46181 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Simpson, J. H. & Looger, L. L. Functional imaging and optogenetics in Drosophila. Genetics 208, 1291–1309 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luo, L., Callaway, E. M. & Svoboda, K. Genetic dissection of neural circuits: a decade of progress. Neuron 98, 256–281 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bos, J. L. Epac: a new cAMP target and new avenues in cAMP research. Nat. Rev. Mol. Cell Biol. 4, 733–738 (2003).

Article  CAS  PubMed  Google Scholar 

Robichaux, W. G. & Cheng, X. Intracellular cAMP sensor EPAC: physiology, pathophysiology, and therapeutics development. Physiol. Rev. 98, 919–1053 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang, H. H. & St-Pierre, F. Genetically encoded voltage indicators: opportunities and challenges. J. Neurosci. 36, 9977–9989 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bando, Y., Sakamoto, M., Kim, S., Ayzenshtat, I. & Yuste, R. Comparative evaluation of genetically encoded voltage indicators. Cell Rep. 26, 802–813.e4 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fosque, B. F. et al. Labeling of active neural circuits in vivo with designed calcium integrators. Science 347, 755–760 (2015).

Article  CAS  PubMed  Google Scholar 

Grashoff, C. et al. Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics. Nature 466, 263–266 (2010).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Krieg, M., Dunn, A. R. & Goodman, M. B. Mechanical control of the sense of touch by β-spectrin. Nat. Cell Biol. 16, 224–233 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schmied, C. & Tomancak, P. Sample reparation and mounting of Drosophila embryos for multiview light sheet microscopy. Methods Mol. Biol. 1478, 189–202 (2016).

Article  CAS  PubMed  Google Scholar 

Buhlan, M., Ljaschenko, D., Scholz, N. & Langenhan, T. Figshare Raw Image Data. Available at https://doi.org/10.6084/m9.figshare.24024480

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