Hoffman, B. D., Grashoff, C. & Schwartz, M. A. Dynamic molecular processes mediate cellular mechanotransduction. Nature 475, 316–323 (2011).
Article CAS PubMed PubMed Central Google Scholar
Hudspeth, A. J. Integrating the active process of hair cells with cochlear function. Nat. Rev. Neurosci. 15, 600–614 (2014).
Article CAS PubMed Google Scholar
Ranade, S. S., Syeda, R. & Patapoutian, A. Mechanically activated ion channels. Neuron 87, 1162–1179 (2015).
Article CAS PubMed PubMed Central Google Scholar
Langenhan, T., Piao, X. & Monk, K. R. Adhesion G protein-coupled receptors in nervous system development and disease. Nat. Rev. Neurosci. 17, 550–561 (2016).
Article CAS PubMed Google Scholar
Scholz, N., Monk, K. R., Kittel, R. J. & Langenhan, T. Adhesion GPCRs as a putative class of metabotropic mechanosensors. Handb. Exp. Pharmacol. 234, 221–247 (2016).
Article CAS PubMed Google Scholar
Wolfenson, H., Yang, B. & Sheetz, M. P. Steps in mechanotransduction pathways that control cell morphology. Annu. Rev. Physiol. 81, 1–21 (2017).
Mammoto, A., Mammoto, T. & Ingber, D. E. Mechanosensitive mechanisms in transcriptional regulation. J. Cell Sci. 125, 3061–3073 (2012).
CAS PubMed PubMed Central Google Scholar
Scholz, N. et al. Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation. Nature 615, 945–953 (2023).
Article CAS PubMed Google Scholar
Scholz, N. et al. The adhesion GPCR Latrophilin/CIRL shapes mechanosensation. Cell Rep. 11, 866–874 (2015).
Article CAS PubMed Google Scholar
Dannhäuser, S. et al. Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination. Elife 9, e56738 (2020).
Article PubMed PubMed Central Google Scholar
Scholz, N. et al. Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons. Elife 6, e28360 (2017).
Article PubMed PubMed Central Google Scholar
Desai, B. S., Chadha, A. & Cook, B. The stum gene is essential for mechanical sensing in proprioceptive neurons. Science 343, 1256–1259 (2014).
He, L., Binari, R., Huang, J., Falo-Sanjuan, J. & Perrimon, N. In vivo study of gene expression with an enhanced dual-color fluorescent transcriptional timer. Elife 8, e46181 (2019).
Article PubMed PubMed Central Google Scholar
Simpson, J. H. & Looger, L. L. Functional imaging and optogenetics in Drosophila. Genetics 208, 1291–1309 (2018).
Article CAS PubMed PubMed Central Google Scholar
Luo, L., Callaway, E. M. & Svoboda, K. Genetic dissection of neural circuits: a decade of progress. Neuron 98, 256–281 (2018).
Article CAS PubMed PubMed Central Google Scholar
Bos, J. L. Epac: a new cAMP target and new avenues in cAMP research. Nat. Rev. Mol. Cell Biol. 4, 733–738 (2003).
Article CAS PubMed Google Scholar
Robichaux, W. G. & Cheng, X. Intracellular cAMP sensor EPAC: physiology, pathophysiology, and therapeutics development. Physiol. Rev. 98, 919–1053 (2018).
Article CAS PubMed PubMed Central Google Scholar
Yang, H. H. & St-Pierre, F. Genetically encoded voltage indicators: opportunities and challenges. J. Neurosci. 36, 9977–9989 (2016).
Article CAS PubMed PubMed Central Google Scholar
Bando, Y., Sakamoto, M., Kim, S., Ayzenshtat, I. & Yuste, R. Comparative evaluation of genetically encoded voltage indicators. Cell Rep. 26, 802–813.e4 (2019).
Article CAS PubMed PubMed Central Google Scholar
Fosque, B. F. et al. Labeling of active neural circuits in vivo with designed calcium integrators. Science 347, 755–760 (2015).
Article CAS PubMed Google Scholar
Grashoff, C. et al. Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics. Nature 466, 263–266 (2010).
Article CAS PubMed PubMed Central Google Scholar
Krieg, M., Dunn, A. R. & Goodman, M. B. Mechanical control of the sense of touch by β-spectrin. Nat. Cell Biol. 16, 224–233 (2014).
Article CAS PubMed PubMed Central Google Scholar
Schmied, C. & Tomancak, P. Sample reparation and mounting of Drosophila embryos for multiview light sheet microscopy. Methods Mol. Biol. 1478, 189–202 (2016).
Article CAS PubMed Google Scholar
Buhlan, M., Ljaschenko, D., Scholz, N. & Langenhan, T. Figshare Raw Image Data. Available at https://doi.org/10.6084/m9.figshare.24024480
Comments (0)