The aminosteroid U73122 promotes oligodendrocytes generation and myelin formation

Simons M, Nave KA. Oligodendrocytes: myelination and axonal support. Cold Spring Harb Perspect Biol. 2015;8:a020479.

Article  PubMed  Google Scholar 

Popescu BF, Lucchinetti CF. Pathology of demyelinating diseases. Annu Rev Pathol. 2012;7:185–217.

Article  CAS  PubMed  Google Scholar 

Cayre M, Falque M, Mercier O, Magalon K, Durbec P. Myelin repair: from animal models to humans. Front Cell Neurosci. 2021;15:604865.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fancy SPJ, Chan JR, Baranzini SE, Franklin RJM, Rowitch DH. Myelin regeneration: a recapitulation of development? Annu Rev Neurosci. 2011;34:21–43.

Article  CAS  PubMed  Google Scholar 

Kuhlmann T, Miron V, Cui Q, Wegner C, Antel J, Bruck W. Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis. Brain. 2008;131:1749–58.

Article  CAS  PubMed  Google Scholar 

Koutsoudaki PN, Papadopoulos D, Passias PG, Koutsoudaki P, Gorgoulis VG. Cellular senescence and failure of myelin repair in multiple sclerosis. Mech Ageing Dev. 2020;192:111366.

Article  CAS  PubMed  Google Scholar 

van Tilborg E, de Theije CGM, van Hal M, Wagenaar N, de Vries LS, Benders MJ, et al. Origin and dynamics of oligodendrocytes in the developing brain: Implications for perinatal white matter injury. Glia. 2018;66:221–38.

Article  PubMed  Google Scholar 

Bergles DE, Richardson WD. Oligodendrocyte development and plasticity. Cold Spring Harb Perspect Biol. 2015;8:a020453.

Article  PubMed  Google Scholar 

Bedner P, Jabs R, Steinhauser C. Properties of human astrocytes and NG2 glia. Glia. 2020;68:756–67.

Article  PubMed  Google Scholar 

Fang M, Yu Q, Ou B, Huang H, Yi M, Xie B, et al. Genetic evidence that dorsal spinal oligodendrocyte progenitor cells are capable of myelinating ventral axons effectively in mice. Neurosci Bull. 2020;36:1474–83.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang SC. Defining glial cells during CNS development. Nat Rev Neurosci. 2001;2:840–3.

Article  CAS  PubMed  Google Scholar 

Santos AK, Vieira MS, Vasconcellos R, Goulart VAM, Kihara AH, Resende RR. Decoding cell signalling and regulation of oligodendrocyte differentiation. Semin Cell Dev Biol. 2019;95:54–73.

Article  CAS  PubMed  Google Scholar 

Takebayashi H, Ikenaka K. Oligodendrocyte generation during mouse development. Glia. 2015;63:1350–6.

Article  PubMed  Google Scholar 

Tyler WA, Gangoli N, Gokina P, Kim HA, Covey M, Levison SW, et al. Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation. J Neurosci. 2009;29:6367–78.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang S, Sdrulla AD, diSibio G, Bush G, Nofziger D, Hicks C, et al. Notch receptor activation inhibits oligodendrocyte differentiation. Neuron. 1998;21:63–75.

Article  PubMed  Google Scholar 

Fancy SPJ, Baranzini SE, Zhao C, Yuk DI, Irvine KA, Kaing S, et al. Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. Gene Dev. 2009;23:1571–85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mogha A, D’Rozario M, Monk KR. G protein-coupled receptors in myelinating glia. Trends Pharmacol Sci. 2016;37:977–87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deshmukh VA, Tardif V, Lyssiotis CA, Green CC, Kerman B, Kim HJ, et al. A regenerative approach to the treatment of multiple sclerosis. Nature. 2013;502:327–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mei F, Fancy SPJ, Shen YA, Niu J, Zhao C, Presley B, et al. Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis. Nat Med. 2014;20:954–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Du C, Duan Y, Wei W, Cai Y, Chai H, Lv J, et al. Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination. Nat Commun. 2016;7:11120.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mei F, Mayoral SR, Nobuta H, Wang F, Desponts C, Lorrain DS, et al. Identification of the kappa-opioid receptor as a therapeutic target for oligodendrocyte remyelination. J Neurosci. 2016;36:7925–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Y, Wu H, Wang S, Koito H, Li J, Ye F, et al. The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination. Nat Neurosci. 2009;12:1398–406.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu C, Dong L, Zhou H, Li Q, Huang G, Bai SJ, et al. G-protein-coupled receptor Gpr17 regulates oligodendrocyte differentiation in response to lysolecithin-induced demyelination. Sci Rep. 2018;8:4502.

Article  PubMed  PubMed Central  Google Scholar 

Ou Z, Sun Y, Lin L, You N, Liu X, Li H, et al. Olig2-targeted G-protein-coupled receptor Gpr17 regulates oligodendrocyte survival in response to lysolecithin-induced demyelination. J Neurosci. 2016;36:10560–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Simon K, Hennen S, Merten N, Blattermann S, Gillard M, Kostenis E, et al. The orphan G protein-coupled receptor GPR17 negatively regulates oligodendrocyte differentiation via Galphai/o and its downstream effector molecules. J Biol Chem. 2016;291:705–18.

Article  CAS  PubMed  Google Scholar 

Yang HJ, Vainshtein A, Maik-Rachline G, Peles E. G protein-coupled receptor 37 is a negative regulator of oligodendrocyte differentiation and myelination. Nat Commun. 2016;7:10884–94.

Smith BM, Giddens MM, Neil J, Owino S, Nguyen TT, Duong D, et al. Mice lacking Gpr37 exhibit decreased expression of the myelin-associated glycoprotein MAG and increased susceptibility to demyelination. Neuroscience. 2017;358:49–57.

Article  CAS  PubMed  Google Scholar 

Meyer RC, Giddens MM, Schaefer SA, Hall RA. GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. Proc Natl Acad Sci USA. 2013;110:9529–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Raible DW, Mcmorris FA. Induction of oligodendrocyte differentiation by activators of adenylate-cyclase. J Neurosci Res. 1990;27:43–6.

Article  CAS  PubMed  Google Scholar 

Shin D, Lin ST, Fu YH, Ptacek LJ. Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via Galphas/Galphaq-mediated protein kinases A/C. Proc Natl Acad Sci USA. 2013;110:19101–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Giera S, Deng YY, Luo R, Ackerman SD, Mogha A, Monk KR, et al. The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development. Nat Commun 2015;6:6121–32.

Ackerman SD, Garcia C, Piao X, Gutmann DH, Monk KR. The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Galpha12/13 and RhoA. Nat Commun. 2015;6:6122.

Article  CAS  PubMed  Google Scholar 

Suo N, He B, Cui S, Yang Y, Wang M, Yuan Q, et al. The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination. Glia. 2022;70:1992–2008.

Article  CAS  PubMed  Google Scholar 

Marinissen MJ, Gutkind JS. G-protein-coupled receptors and signaling networks: emerging paradigms. Trends Pharmacol Sci. 2001;22:368–76.

Article  CAS  PubMed  Google Scholar 

Dikic I, Blaukat A. Protein tyrosine kinase-mediated pathways in G protein-coupled receptor signaling. Cell Biochem Biophys. 1999;30:369–87.

Article  CAS  PubMed  Google Scholar 

Chen Y, Balasubramaniyan V, Peng J, Hurlock EC, Tallquist M, Li J, et al. Isolation and culture of rat and mouse oligodendrocyte precursor cells. Nat Protoc. 2007;2:1044–51.

Article  CAS  PubMed  Google Scholar 

Guo YE, Suo N, Cui X, Yuan Q, Xie X. Vitamin C promotes oligodendrocytes generation and remyelination. Glia. 2018;66:1302–16.

Article  PubMed  PubMed Central  Google Scholar 

Suo N, Guo YE, He B, Gu H, Xie X. Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseases. Glia. 2019;67:1320–32.

Article 

Comments (0)

No login
gif