Simons M, Nave KA. Oligodendrocytes: myelination and axonal support. Cold Spring Harb Perspect Biol. 2015;8:a020479.
Popescu BF, Lucchinetti CF. Pathology of demyelinating diseases. Annu Rev Pathol. 2012;7:185–217.
Article CAS PubMed Google Scholar
Cayre M, Falque M, Mercier O, Magalon K, Durbec P. Myelin repair: from animal models to humans. Front Cell Neurosci. 2021;15:604865.
Article CAS PubMed PubMed Central Google Scholar
Fancy SPJ, Chan JR, Baranzini SE, Franklin RJM, Rowitch DH. Myelin regeneration: a recapitulation of development? Annu Rev Neurosci. 2011;34:21–43.
Article CAS PubMed Google Scholar
Kuhlmann T, Miron V, Cui Q, Wegner C, Antel J, Bruck W. Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis. Brain. 2008;131:1749–58.
Article CAS PubMed Google Scholar
Koutsoudaki PN, Papadopoulos D, Passias PG, Koutsoudaki P, Gorgoulis VG. Cellular senescence and failure of myelin repair in multiple sclerosis. Mech Ageing Dev. 2020;192:111366.
Article CAS PubMed Google Scholar
van Tilborg E, de Theije CGM, van Hal M, Wagenaar N, de Vries LS, Benders MJ, et al. Origin and dynamics of oligodendrocytes in the developing brain: Implications for perinatal white matter injury. Glia. 2018;66:221–38.
Bergles DE, Richardson WD. Oligodendrocyte development and plasticity. Cold Spring Harb Perspect Biol. 2015;8:a020453.
Bedner P, Jabs R, Steinhauser C. Properties of human astrocytes and NG2 glia. Glia. 2020;68:756–67.
Fang M, Yu Q, Ou B, Huang H, Yi M, Xie B, et al. Genetic evidence that dorsal spinal oligodendrocyte progenitor cells are capable of myelinating ventral axons effectively in mice. Neurosci Bull. 2020;36:1474–83.
Article CAS PubMed PubMed Central Google Scholar
Zhang SC. Defining glial cells during CNS development. Nat Rev Neurosci. 2001;2:840–3.
Article CAS PubMed Google Scholar
Santos AK, Vieira MS, Vasconcellos R, Goulart VAM, Kihara AH, Resende RR. Decoding cell signalling and regulation of oligodendrocyte differentiation. Semin Cell Dev Biol. 2019;95:54–73.
Article CAS PubMed Google Scholar
Takebayashi H, Ikenaka K. Oligodendrocyte generation during mouse development. Glia. 2015;63:1350–6.
Tyler WA, Gangoli N, Gokina P, Kim HA, Covey M, Levison SW, et al. Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation. J Neurosci. 2009;29:6367–78.
Article CAS PubMed PubMed Central Google Scholar
Wang S, Sdrulla AD, diSibio G, Bush G, Nofziger D, Hicks C, et al. Notch receptor activation inhibits oligodendrocyte differentiation. Neuron. 1998;21:63–75.
Fancy SPJ, Baranzini SE, Zhao C, Yuk DI, Irvine KA, Kaing S, et al. Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. Gene Dev. 2009;23:1571–85.
Article CAS PubMed PubMed Central Google Scholar
Mogha A, D’Rozario M, Monk KR. G protein-coupled receptors in myelinating glia. Trends Pharmacol Sci. 2016;37:977–87.
Article CAS PubMed PubMed Central Google Scholar
Deshmukh VA, Tardif V, Lyssiotis CA, Green CC, Kerman B, Kim HJ, et al. A regenerative approach to the treatment of multiple sclerosis. Nature. 2013;502:327–32.
Article CAS PubMed PubMed Central Google Scholar
Mei F, Fancy SPJ, Shen YA, Niu J, Zhao C, Presley B, et al. Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis. Nat Med. 2014;20:954–60.
Article CAS PubMed PubMed Central Google Scholar
Du C, Duan Y, Wei W, Cai Y, Chai H, Lv J, et al. Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination. Nat Commun. 2016;7:11120.
Article CAS PubMed PubMed Central Google Scholar
Mei F, Mayoral SR, Nobuta H, Wang F, Desponts C, Lorrain DS, et al. Identification of the kappa-opioid receptor as a therapeutic target for oligodendrocyte remyelination. J Neurosci. 2016;36:7925–35.
Article CAS PubMed PubMed Central Google Scholar
Chen Y, Wu H, Wang S, Koito H, Li J, Ye F, et al. The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination. Nat Neurosci. 2009;12:1398–406.
Article CAS PubMed PubMed Central Google Scholar
Lu C, Dong L, Zhou H, Li Q, Huang G, Bai SJ, et al. G-protein-coupled receptor Gpr17 regulates oligodendrocyte differentiation in response to lysolecithin-induced demyelination. Sci Rep. 2018;8:4502.
Article PubMed PubMed Central Google Scholar
Ou Z, Sun Y, Lin L, You N, Liu X, Li H, et al. Olig2-targeted G-protein-coupled receptor Gpr17 regulates oligodendrocyte survival in response to lysolecithin-induced demyelination. J Neurosci. 2016;36:10560–73.
Article CAS PubMed PubMed Central Google Scholar
Simon K, Hennen S, Merten N, Blattermann S, Gillard M, Kostenis E, et al. The orphan G protein-coupled receptor GPR17 negatively regulates oligodendrocyte differentiation via Galphai/o and its downstream effector molecules. J Biol Chem. 2016;291:705–18.
Article CAS PubMed Google Scholar
Yang HJ, Vainshtein A, Maik-Rachline G, Peles E. G protein-coupled receptor 37 is a negative regulator of oligodendrocyte differentiation and myelination. Nat Commun. 2016;7:10884–94.
Smith BM, Giddens MM, Neil J, Owino S, Nguyen TT, Duong D, et al. Mice lacking Gpr37 exhibit decreased expression of the myelin-associated glycoprotein MAG and increased susceptibility to demyelination. Neuroscience. 2017;358:49–57.
Article CAS PubMed Google Scholar
Meyer RC, Giddens MM, Schaefer SA, Hall RA. GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. Proc Natl Acad Sci USA. 2013;110:9529–34.
Article CAS PubMed PubMed Central Google Scholar
Raible DW, Mcmorris FA. Induction of oligodendrocyte differentiation by activators of adenylate-cyclase. J Neurosci Res. 1990;27:43–6.
Article CAS PubMed Google Scholar
Shin D, Lin ST, Fu YH, Ptacek LJ. Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via Galphas/Galphaq-mediated protein kinases A/C. Proc Natl Acad Sci USA. 2013;110:19101–6.
Article CAS PubMed PubMed Central Google Scholar
Giera S, Deng YY, Luo R, Ackerman SD, Mogha A, Monk KR, et al. The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development. Nat Commun 2015;6:6121–32.
Ackerman SD, Garcia C, Piao X, Gutmann DH, Monk KR. The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Galpha12/13 and RhoA. Nat Commun. 2015;6:6122.
Article CAS PubMed Google Scholar
Suo N, He B, Cui S, Yang Y, Wang M, Yuan Q, et al. The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination. Glia. 2022;70:1992–2008.
Article CAS PubMed Google Scholar
Marinissen MJ, Gutkind JS. G-protein-coupled receptors and signaling networks: emerging paradigms. Trends Pharmacol Sci. 2001;22:368–76.
Article CAS PubMed Google Scholar
Dikic I, Blaukat A. Protein tyrosine kinase-mediated pathways in G protein-coupled receptor signaling. Cell Biochem Biophys. 1999;30:369–87.
Article CAS PubMed Google Scholar
Chen Y, Balasubramaniyan V, Peng J, Hurlock EC, Tallquist M, Li J, et al. Isolation and culture of rat and mouse oligodendrocyte precursor cells. Nat Protoc. 2007;2:1044–51.
Article CAS PubMed Google Scholar
Guo YE, Suo N, Cui X, Yuan Q, Xie X. Vitamin C promotes oligodendrocytes generation and remyelination. Glia. 2018;66:1302–16.
Article PubMed PubMed Central Google Scholar
Suo N, Guo YE, He B, Gu H, Xie X. Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseases. Glia. 2019;67:1320–32.
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