Al-Ward H, Liu N, Omorou M, Huang Y, Chen W, Liu C-Y, Lv S, Murshed A, Shaher F, Li Y (2023) The relationship between miRNA-210 and SCN1B in fetal rats with hypoxic-ischemic brain injury. Biosci Rep 43:BSR20222016

Article  CAS  PubMed  PubMed Central  Google Scholar 

Banerjee R, Evande R, Kabil Ö, Ojha S, Taoka S (2003) Reaction mechanism and regulation of cystathionine β-synthase. Biochim Biophys Acta (BBA)-Proteins Proteom 1647:30–35

Article  CAS  Google Scholar 

Cho KHT, Xu B, Blenkiron C, Fraser M (2019) Emerging roles of miRNAs in brain development and perinatal brain injury. Front Physiol 10:227

Article  PubMed  PubMed Central  Google Scholar 

Chu X, Liu D, Li T, Ke H, Xin D, Wang S, Cao Y, Xue H, Wang Z (2020) Hydrogen sulfide-modified extracellular vesicles from mesenchymal stem cells for treatment of hypoxic-ischemic brain injury. J Control Release 328:13–27

Article  CAS  PubMed  Google Scholar 

Cuevasanta E, Möller MN, Alvarez B (2017) Biological chemistry of hydrogen sulfide and persulfides. Arch Biochem Biophys 617:9–25

Article  CAS  PubMed  Google Scholar 

Dong X, Cong S (2019) The emerging role of microRNAs in polyglutamine diseases. Front Mol Neurosci 12:156

Article  CAS  PubMed  PubMed Central  Google Scholar 

Evande R, Ojha S, Banerjee R (2004) Visualization of PLP-bound intermediates in hemeless variants of human cystathionine β-synthase: evidence that lysine 119 is a general base. Arch Biochem Biophys 427:188–196

Article  CAS  PubMed  Google Scholar 

Fan Y, Ding S, Sun Y, Zhao B, Pan Y, Wan J (2018) MiR-377 regulates inflammation and angiogenesis in rats after cerebral ischemic injury. J Cell Biochem 119:327–337

Article  CAS  PubMed  Google Scholar 

Greco P, Nencini G, Piva I, Scioscia M, Volta C, Spadaro S, Neri M, Bonaccorsi G, Greco F, Cocco I (2020) Pathophysiology of hypoxic–ischemic encephalopathy: a review of the past and a view on the future. Acta Neurol Belg 120:277–288

Article  CAS  PubMed  Google Scholar 

Hellmich MR, Coletta C, Chao C, Szabo C (2015) The therapeutic potential of cystathionine β-synthetase/hydrogen sulfide inhibition in cancer. Antioxid Redox Signal 22:424–448

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ignoul S, Eggermont J (2005) CBS domains: structure, function, and pathology in human proteins. Am J Physiol Cell Physiol 289:C1369–C1378

Article  CAS  PubMed  Google Scholar 

Johnston MV (2005) Excitotoxicity in perinatal brain injury. Brain Pathol 15:234–240

Article  CAS  PubMed  Google Scholar 

Kabil O, Banerjee R (2014) Enzymology of H2S biogenesis, decay and signaling. Antioxid Redox Signal 20:770–782

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karnati HK, Panigrahi MK, Gutti RK, Greig NH, Tamargo IA (2015) miRNAs: key players in neurodegenerative disorders and epilepsy. J Alzheimers Dis 48:563–580

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kimura H (2013) Physiological role of hydrogen sulfide and polysulfide in the central nervous system. Neurochem Int 63:492–497

Article  CAS  PubMed  Google Scholar 

Liu F, Zhang Z, Chen W, Gu H, Yan Q (2018) Regulatory mechanism of microRNA-377 on CDH13 expression in the cell model of Alzheimer’s disease. Eur Rev Med Pharmacol Sci 22:2801–2808

PubMed  Google Scholar 

Liu S, Xin D, Wang L, Zhang T, Bai X, Li T, Xie Y, Xue H, Bo S, Liu D (2017) Therapeutic effects of L-Cysteine in newborn mice subjected to hypoxia-ischemia brain injury via the CBS/H2S system: role of oxidative stress and endoplasmic reticulum stress. Redox Biol 13:528–540

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu M, Jiang X, Tong L, Zhang F, Ma L, Dong X, Sun X (2018) MicroRNA-21-regulated activation of the Akt pathway participates in the protective effects of H2S against liver ischemia-reperfusion injury. Biol Pharm Bull b17–00769

Majtan T, Pey AL, Ereño-Orbea J, Alfonso Martinez-Cruz L, Kraus JP (2016) Targeting cystathionine beta-synthase misfolding in homocystinuria by small ligands: state of the art and future directions. Curr Drug Targets 17:1455–1470

Article  CAS  PubMed  Google Scholar 

Northington FJ, Chavez-Valdez R, Martin LJ (2011) Neuronal cell death in neonatal hypoxia-ischemia. Ann Neurol 69:743–758

Article  CAS  PubMed  PubMed Central  Google Scholar 

Paul BD, Snyder SH (2015) H2S: a novel gasotransmitter that signals by sulfhydration. Trends Biochem Sci 40:687–700

Article  CAS  PubMed  PubMed Central  Google Scholar 

Robert K, Vialard F, Thiery E, Toyama K, Sinet P-M, Janel N, London J (2003) Expression of the cystathionine β synthase (CBS) gene during mouse development and immunolocalization in adult brain. J Histochem Cytochem 51:363–371

Article  CAS  PubMed  Google Scholar 

Shaposhnikov MV, Zakluta AS, Zemskaya NV, Guvatova ZG, Shilova VY, Yakovleva DV, Gorbunova AA, Koval LA, Ulyasheva NS, Evgen’ev MB (2022) Deletions of the cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) genes, involved in the control of hydrogen sulfide biosynthesis, significantly affect lifespan and fitness components of Drosophila melanogaster. Mech Ageing Dev 111656

Shefa U, Yeo SG, Kim M-S, Song IO, Jung J, Jeong NY, Huh Y (2017) Role of gasotransmitters in oxidative stresses, neuroinflammation, and neuronal repair. BioMed Res Int 2017

Stipanuk MH (2004) Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine. Annu Rev Nutr 24:539–577

Article  CAS  PubMed  Google Scholar 

Thorson MK, Majtan T, Kraus JP, Barrios AM (2013) Identification of cystathionine β-synthase inhibitors using a hydrogen sulfide selective probe. Angew Chem 125:4739–4742

Article  Google Scholar 

Treiber T, Treiber N, Meister G (2019) Regulation of microRNA biogenesis and its crosstalk with other cellular pathways. Nat Rev Mol Cell Biol 20:5–20

Article  CAS  PubMed  Google Scholar 

Wallace JL, Wang R (2015) Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter. Nat Rev Drug Discovery 14:329–345

Article  CAS  PubMed  Google Scholar 

Xie M, Steitz JA (2014) Versatile microRNA biogenesis in animals and their viruses. RNA Biol 11:673–681

Article  PubMed  PubMed Central  Google Scholar 

Zhang M, Wu X, Xu Y, He M, Yang J, Li J, Li Y, Ao G, Cheng J, Jia J (2017) The cystathionine β-synthase/hydrogen sulfide pathway contributes to microglia-mediated neuroinflammation following cerebral ischemia. Brain Behav Immun 66:332–346

Article  CAS  PubMed  Google Scholar 

Zhang R, Luo H, Wang S, Chen W, Chen Z, Wang H-W, Chen Y, Yang J, Zhang X, Wu W (2014) MicroRNA-377 inhibited proliferation and invasion of human glioblastoma cells by directly targeting specificity protein 1. Neuro Oncol 16:1510–1522

Article  CAS  PubMed  PubMed Central  Google Scholar