Al-Olama M, Lange S, Lönnroth I, Gatzinsky K, Jennische E (2015) Uptake of the antisecretory factor peptide AF-16 in rat blood and cerebrospinal fluid and effects on elevated intracranial pressure. Acta Neurochir 157(1):129–137. https://doi.org/10.1007/s00701-014-2221-7

Article  PubMed  Google Scholar 

Al-Olama M, Wallgren A, Andersson B, Gatzinsky K, Hultborn R, Karlsson-Parra A, Lange S, Hansson H-A, Jennische E (2011a) The peptide AF-16 decreases high interstitial fluid pressure in solid tumors. Acta Oncol 50(7):1098–1104. https://doi.org/10.3109/0284186X.2011.562240

Article  CAS  PubMed  Google Scholar 

Al-Olama M, Wallgren A, Andersson B et al (2011b) The peptide AF-16 decreases high interstitial fluid pressure in solid tumors. 50(7):1098–1104. https://doi.org/10.3109/0284186X.2011.562240

Asemota AO, George BP, Bowman SM, Haider AH, Schneider EB (2013) Causes and trends in traumatic brain injury for United States adolescents. J Neurotrauma 30(2):67–75. https://doi.org/10.1089/neu.2012.2605

Article  PubMed  Google Scholar 

Bao HJ, Zhang L, Han WC et al (2015) Apelin-13 attenuates traumatic brain injury-induced damage by suppressing autophagy. Neurochem Res 40:89–97. https://doi.org/10.1007/s11064-014-1469-x

Article  CAS  PubMed  Google Scholar 

Barrueta Tenhunen A, Massaro F, Hansson HA, Feinstein R, Larsson A, Larsson A, Perchiazzi G (2019) Does the antisecretory peptide AF-16 reduce lung oedema in experimental ARDS? Upsala J Med Sci 124(4):246–253. https://doi.org/10.1080/03009734.2019.1685029

Article  PubMed  PubMed Central  Google Scholar 

Batulu H, Du G, Li D, Sailike D, Fan Y, Geng D (2019) Effect of poly-arginine R18 on neurocyte cell growth via autophagy in traumatic brain injury. Exp Ther Med 17(5):4109–4115. https://doi.org/10.3892/etm.2019.7423

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bazzurro V, Gatta E, Cupello A, Lange S, Robello M (2018) Antisecretory factor modulates GABAA Receptor activity in neurons. J Mol Neurosci 64(2):312–320. https://doi.org/10.1007/s12031-017-1024-8

Article  CAS  PubMed  Google Scholar 

Beauchamp K, Mutlak H, Smith WR, Shohami E, Stahel PF (2008) Pharmacology of traumatic brain injury: where is the “golden bullet”? Mol Med 114(11–12):731–740. https://doi.org/10.2119/2008-00050.Beauchamp

Article  CAS  Google Scholar 

Bieri G, Lucin KM, O’Brien CE, Zhang H, Villeda SA, Wyss-Coray T (2018) Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration. Mol Neurodegener 13(1):68. https://doi.org/10.1186/s13024-018-0302-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Borlongan C, Acosta S, de la Pena I, Tajiri N, Kaneko Y, Lozano D, Gonzales-Portillo G (2015) Neuroinflammatory responses to traumatic brain injury: etiology, clinical consequences, and therapeutic opportunities. Neuropsychiatr Dis Treat 11:97. https://doi.org/10.2147/NDT.S65815

Article  PubMed  PubMed Central  Google Scholar 

Bornschlögl T (2013) How filopodia pull: what we know about the mechanics and dynamics of filopodia. Cytoskeleton 70(10):590–603. https://doi.org/10.1002/cm.21130

Article  CAS  PubMed  Google Scholar 

Buitendag JJP, Ras A, Kong VY et al (2018). Validation of the simplified motor score in patients with traumatic brain injury at a major trauma centre in South Africa. In South African Medical Journal South African Medical Association 108(2):90–93. https://doi.org/10.7196/SAMJ.2018.v108i2.12757

Carloni S, Buonocore G, Balduini W (2008) Protective role of autophagy in neonatal hypoxia–ischemia induced brain injury. Neurobiol Dis 32(3):329–339. https://doi.org/10.1016/j.nbd.2008.07.022

Article  PubMed  Google Scholar 

Cederberg D, Hansson H-A, Visse E, Siesjö P (2020) Antisecretory factor may reduce ICP in severe TBI—a case series. Front Neurol 11:95. https://doi.org/10.3389/fneur.2020.00095

Article  PubMed  PubMed Central  Google Scholar 

Clausen F, Hansson H-A, Raud J, Marklund N (2017) Intranasal administration of the antisecretory peptide AF-16 reduces edema and improves cognitive function following diffuse traumatic brain injury in the rat. Front Neurol 8(FEB):39. https://doi.org/10.3389/fneur.2017.00039

Article  PubMed  PubMed Central  Google Scholar 

Conrady CD, Zheng M, van Rooijen N, Drevets DA, Royer D, Alleman A, Carr DJJ (2013) Microglia and a functional type I IFN pathway are required to counter HSV-1–driven brain lateral ventricle enlargement and encephalitis. J Immunol 190(6):2807–2817. https://doi.org/10.4049/jimmunol.1203265

Article  CAS  PubMed  Google Scholar 

Cooper GM (2000) The cell: a molecular approach. Sinauer Associates. https://www.ncbi.nlm.nih.gov/books/NBK9953/. Accessed 2 Oct 2024

Coronado VG, McGuire LC, Sarmiento K, Bell J, Lionbarger MR, Jones CD, Geller AI, Khoury N, Xu L (2012) Trends in traumatic brain injury in the U.S. and the public health response: 1995–2009. J Safe Rese 43(4):299–307. https://doi.org/10.1016/j.jsr.2012.08.011

Article  Google Scholar 

Davidson TS, Hickey WF (2004) Distribution and immunoregulatory properties of antisecretory factor. Lab Invest 84(3):307–319. https://doi.org/10.1038/LABINVEST.3700036

Article  CAS  PubMed  Google Scholar 

Dewan MC, Rattani A, Gupta S, Baticulon RE, Hung YC, Punchak M, Agrawal A, Adeleye AO, Shrime MG, Rubiano AM, Rosenfeld JV, Park KB (2019) Estimating the global incidence of traumatic brain injury. J Neurosurg 130(4):1080–1097. https://doi.org/10.3171/2017.10.JNS17352

Article  PubMed  Google Scholar 

Di Pietro V, Lazzarino G, Amorini AM, Signoretti S, Hill LJ, Porto E, Tavazzi B, Lazzarino G, Belli A (2017) Fusion or fission: the destiny of mitochondria in traumatic brain injury of different severities. Sci Rep 7(1):1–13. https://doi.org/10.1038/s41598-017-09587-2

Article  CAS  Google Scholar 

Ding W-X, Yin X-M (2012) Mitophagy: mechanisms, pathophysiological roles, and analysis. Bchm 393(7):547–564. https://doi.org/10.1515/hsz-2012-0119

Article  CAS  Google Scholar 

Dolman NJ, Chambers KM, Mandavilli B, Batchelor RH, Janes MS (2013) Tools and techniques to measure mitophagy using fluorescence microscopy. Autophagy 9(11):1653–1662. https://doi.org/10.4161/auto.24001

Article  CAS  PubMed  Google Scholar 

Eskelinen E-L (2008) Fine structure of the autophagosome. In Methods in molecular biology (Clifton, N.J.). Methods Mol Biol 445:11–28. https://doi.org/10.1007/978-1-59745-157-4_2

Evans CS, Holzbaur ELF (2020) Quality control in neurons: mitophagy and other selective autophagy mechanisms. J Mol Biol 432(1):240–260. https://doi.org/10.1016/j.jmb.2019.06.031

Article  CAS  PubMed  Google Scholar 

Feng Y, Gao J, Cui Y, Li M, Li R, Cui C, Cui J (2017) Neuroprotective effects of resatorvid against traumatic brain injury in rat: involvement of neuronal autophagy and TLR4 signaling pathway. Cell Mol Neurobiol 37(1):155–168. https://doi.org/10.1007/s10571-016-0356-1

Article  CAS  PubMed  Google Scholar 

Fischer TD, Hylin MJ, Zhao J, Moore AN, Waxham MN, Dash PK (2016) Altered mitochondrial dynamics and tbi pathophysiology. Front Syst Neurosci 10(MAR):29. https://doi.org/10.3389/fnsys.2016.00029

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao Y, Li J, Wu L, Zhou C, Wang Q, Li X, Zhou M, Wang H (2016) Tetrahydrocurcumin provides neuroprotection in rats after traumatic brain injury: autophagy and the PI3K/AKT pathways as a potential mechanism. J Surg Res 206(1):67–76. https://doi.org/10.1016/J.JSS.2016.07.014

Article  CAS  PubMed  Google Scholar 

Gatzinsky K, Johansson E, Jennische E, Oshalim M, Lange S (2020) Elevated intracranial pressure after head trauma can be suppressed by antisecretory factor—a pilot study. Acta Neurochir 162(7):1629–1637. https://doi.org/10.1007/s00701-020-04407-5

Article  PubMed  Google Scholar 

Giannone G, Dubin-Thaler BJ, Rossier O, Cai Y, Chaga O, Jiang G, Beaver W, Döbereiner H-G, Freund Y, Borisy G, Sheetz MP (2007) Lamellipodial actin mechanically links myosin activity with adhesion-site formation. Cell 128(3):561–575. https://doi.org/10.1016/j.cell.2006.12.039

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gomez TA, Clarke SG (2007) Autophagy and in