A Review on Mitochondrial Derived Peptide Humanin and Small Humanin-Like Peptides and Their Therapeutic Strategies

Alfadhli EM (2015) Gestational diabetes Mellitus. Saudi Med J 36(4):399–406

Article  PubMed  PubMed Central  Google Scholar 

Basrai MA, Hieter P, Boeke JD (1997) Small open reading frames: beautiful needles in the haystack. Genome Res 7(8):768–771

Article  CAS  PubMed  Google Scholar 

Bellance N, Lestienne P, Rossignol R (2009) Mitochondria: from bioenergetics to the metabolic regulation of carcinogenesis. Front Biosci-Landmark 14(11):4015–4034

Google Scholar 

Blake R, Trounce IA (2014) Mitochondrial dysfunction and complications associated with diabetes. Biochim Biophys Acta 1840(4):1404–1412

Article  CAS  PubMed  Google Scholar 

Bodzioch M et al (2009) Evidence for potential functionality of nuclearly-encoded humanin isoforms. Genomics 94(4):247–256

Article  CAS  PubMed  Google Scholar 

Boutari C et al (2022) Humanin and diabetes mellitus: a review of and studies. World J Diabetes 13(3):213–223

Article  PubMed  PubMed Central  Google Scholar 

Caricasole A et al (2002) A novel rat gene encoding a humanin-like peptide endowed with broad neuroprotective activity. FASEB J 16(10):1331–1333

Article  CAS  PubMed  Google Scholar 

Chiba T et al (2005) Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer’s disease-relevant insults in vitro and in vivo. J Neurosci 25(44):10252–10261

Article  CAS  PubMed  PubMed Central  Google Scholar 

Clayton DA (1992) Structure and function of the mitochondrial genome. J Inherit Metab Di. https://doi.org/10.1007/bf01799602

Article  Google Scholar 

Cobb LJ et al (2016) Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers. Aging 8(4):796–809

Article  CAS  PubMed  PubMed Central  Google Scholar 

Colovos C, Yeates TO (1993) Verification of protein structures: patterns of nonbonded atomic interactions. Protein Sci 2(9):1511–1519

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cui H, Kong Y, Zhang H (2012) Oxidative stress, mitochondrial dysfunction, and aging. J Signal Transduct 2012:646354

Article  PubMed  Google Scholar 

Dabravolski SA et al (2021) The role of mitochondria-derived peptides in cardiovascular diseases and their potential as therapeutic targets. Int J Mol Sci. https://doi.org/10.3390/ijms22168770

Article  PubMed  PubMed Central  Google Scholar 

Diaz-Vegas A et al (2020) Is mitochondrial dysfunction a common root of noncommunicable chronic diseases ? Endocr Rev. https://doi.org/10.1210/endrev/bnaa005

Article  PubMed  PubMed Central  Google Scholar 

Gissi C, Iannelli F, Pesole G (2008) Evolution of the mitochondrial genome of Metazoa as exemplified by comparison of congeneric species. Heredity 101(4):301–320

Article  CAS  PubMed  Google Scholar 

Gong Z, Tas E, Muzumdar R (2014) Humanin and age-related diseases: a new link? Front Endocrinol 5:210

Article  Google Scholar 

Hashemi ZS et al (2021) Approaches for the design and optimization of interfering peptides against protein-protein interactions. Front Mol Biosci 8:669431

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hashimoto Y, Niikura T, Tajima H et al (2001a) A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer’s disease genes and Abeta. Proc Natl Acad Sci USA 98(11):6336–6341

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hashimoto Y, Niikura T, Ito Y et al (2001b) Detailed characterization of neuroprotection by a rescue factor humanin against various Alzheimer’s disease-relevant insults. J Neurosci 21(23):9235–9245

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hawley JA et al (2014) Integrative biology of exercise. Cell 159(4):738–749

Article  CAS  PubMed  Google Scholar 

Hombach S, Kretz M (2016) Non-coding RNAs: classification, Biology and Functioning. Adv Exp Med Biol 937:3–17

Article  CAS  PubMed  Google Scholar 

Jiang H, Xu Y, Cao L (2022) The protective effects of S14G-humanin on gestational diabetes mellitus symptoms. Gynecol Endocrinol 38(6):503–507

Article  CAS  PubMed  Google Scholar 

Khaksar M et al (2018) High glucose condition limited the angiogenic/cardiogenic capacity of murine cardiac progenitor cells in in vitro and in vivo milieu. Cell Biochem Funct 36(7):346–356

Article  CAS  PubMed  Google Scholar 

Khan MAB et al (2020) Epidemiology of type 2 diabetes - global burden of disease and forecasted trends. J Epidemiol Global Health 10(1):107–111

Article  Google Scholar 

Kim S-J et al (2017) Mitochondrially derived peptides as novel regulators of metabolism. J Physiol 595(21):6613–6621

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim S-J et al (2018) Mitochondrial peptides modulate mitochondrial function during cellular senescence. Aging 10(6):1239–1256

Article  CAS  PubMed  PubMed Central  Google Scholar 

Klein LE et al (2013) A humanin analog decreases oxidative stress and preserves mitochondrial integrity in cardiac myoblasts. Biochem Biophys Res Commun 440(2):197–203

Article  CAS  PubMed  Google Scholar 

Kumagai H et al (2023) Novel insights into mitochondrial DNA: mitochondrial microproteins and mtDNA variants modulate athletic performance and age-related diseases. Genes 14(2):286

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee C et al (2014) IGF-I regulates the age-dependent signaling peptide humanin. Aging Cell 13(5):958–961

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee C et al (2015) The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabol 21(3):443–454

Article  CAS  Google Scholar 

Li W et al (2020) Humanin ameliorates free fatty acid-Induced endothelial inflammation by suppressing the NLRP3 inflammasome. ACS Omega 5(35):22039–22045

Article  CAS  PubMed  PubMed Central  Google Scholar 

Logan IS (2017) Pseudogenization of the gene is common in the mitochondrial DNA of many vertebrates. Zoological Res 38(4):198–202

CAS  Google Scholar 

Lue Y et al (2018) Humanin analog enhances the protective effect of dexrazoxane against doxorubicin-induced cardiotoxicity. Am J Physiol Heart Circ Physiol 315(3):H634–H643

Article  PubMed  PubMed Central  Google Scholar 

Maftei M, Tian X, Manea M, Exner TE, Schwanzar D, von Arnim CA, Przybylski M (2012) Interaction structure of the complex between neuroprotective factor humanin and Alzheimer’s β-amyloid peptide revealed by affinity mass spectrometry and molecular modeling. J Pept Sci 18(6):373–382

Article  CAS  PubMed  Google Scholar 

Matsuoka M (2015) Protective effects of humanin and calmodulin-like skin protein in Alzheimer’s disease and broad range of abnormalities. Mol Neurobiol 51(3):1232–1239

Article  CAS  PubMed  Google Scholar 

Mehta HH et al (2019) Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment. Metabolomics 15(6):88

Article  PubMed  PubMed Central  Google Scholar 

Mendelsohn AR, Larrick JW (2018) Mitochondrial-derived peptides exacerbate senescence. Rejuven Res 21(4):369–373

Article  CAS  Google Scholar 

Mercer TR et al (2011) The human mitochondrial transcriptome. Cell 146(4):645–658

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meridor D, Cohen A, Khalfin B, Uppalapati L, Kasher R, Nathan I, Parola AH (2019) The protective effect of humanin derivative AGA (C8R)-HNG17 against acetaminophen-induced liver injury in mice. Int J Pept Res Ther 25:565–571

Article  CAS 

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