Alfadhli EM (2015) Gestational diabetes Mellitus. Saudi Med J 36(4):399–406
Article PubMed PubMed Central Google Scholar
Basrai MA, Hieter P, Boeke JD (1997) Small open reading frames: beautiful needles in the haystack. Genome Res 7(8):768–771
Article CAS PubMed Google Scholar
Bellance N, Lestienne P, Rossignol R (2009) Mitochondria: from bioenergetics to the metabolic regulation of carcinogenesis. Front Biosci-Landmark 14(11):4015–4034
Blake R, Trounce IA (2014) Mitochondrial dysfunction and complications associated with diabetes. Biochim Biophys Acta 1840(4):1404–1412
Article CAS PubMed Google Scholar
Bodzioch M et al (2009) Evidence for potential functionality of nuclearly-encoded humanin isoforms. Genomics 94(4):247–256
Article CAS PubMed Google Scholar
Boutari C et al (2022) Humanin and diabetes mellitus: a review of and studies. World J Diabetes 13(3):213–223
Article PubMed PubMed Central Google Scholar
Caricasole A et al (2002) A novel rat gene encoding a humanin-like peptide endowed with broad neuroprotective activity. FASEB J 16(10):1331–1333
Article CAS PubMed Google Scholar
Chiba T et al (2005) Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer’s disease-relevant insults in vitro and in vivo. J Neurosci 25(44):10252–10261
Article CAS PubMed PubMed Central Google Scholar
Clayton DA (1992) Structure and function of the mitochondrial genome. J Inherit Metab Di. https://doi.org/10.1007/bf01799602
Cobb LJ et al (2016) Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers. Aging 8(4):796–809
Article CAS PubMed PubMed Central Google Scholar
Colovos C, Yeates TO (1993) Verification of protein structures: patterns of nonbonded atomic interactions. Protein Sci 2(9):1511–1519
Article CAS PubMed PubMed Central Google Scholar
Cui H, Kong Y, Zhang H (2012) Oxidative stress, mitochondrial dysfunction, and aging. J Signal Transduct 2012:646354
Dabravolski SA et al (2021) The role of mitochondria-derived peptides in cardiovascular diseases and their potential as therapeutic targets. Int J Mol Sci. https://doi.org/10.3390/ijms22168770
Article PubMed PubMed Central Google Scholar
Diaz-Vegas A et al (2020) Is mitochondrial dysfunction a common root of noncommunicable chronic diseases ? Endocr Rev. https://doi.org/10.1210/endrev/bnaa005
Article PubMed PubMed Central Google Scholar
Gissi C, Iannelli F, Pesole G (2008) Evolution of the mitochondrial genome of Metazoa as exemplified by comparison of congeneric species. Heredity 101(4):301–320
Article CAS PubMed Google Scholar
Gong Z, Tas E, Muzumdar R (2014) Humanin and age-related diseases: a new link? Front Endocrinol 5:210
Hashemi ZS et al (2021) Approaches for the design and optimization of interfering peptides against protein-protein interactions. Front Mol Biosci 8:669431
Article CAS PubMed PubMed Central Google Scholar
Hashimoto Y, Niikura T, Tajima H et al (2001a) A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer’s disease genes and Abeta. Proc Natl Acad Sci USA 98(11):6336–6341
Article CAS PubMed PubMed Central Google Scholar
Hashimoto Y, Niikura T, Ito Y et al (2001b) Detailed characterization of neuroprotection by a rescue factor humanin against various Alzheimer’s disease-relevant insults. J Neurosci 21(23):9235–9245
Article CAS PubMed PubMed Central Google Scholar
Hawley JA et al (2014) Integrative biology of exercise. Cell 159(4):738–749
Article CAS PubMed Google Scholar
Hombach S, Kretz M (2016) Non-coding RNAs: classification, Biology and Functioning. Adv Exp Med Biol 937:3–17
Article CAS PubMed Google Scholar
Jiang H, Xu Y, Cao L (2022) The protective effects of S14G-humanin on gestational diabetes mellitus symptoms. Gynecol Endocrinol 38(6):503–507
Article CAS PubMed Google Scholar
Khaksar M et al (2018) High glucose condition limited the angiogenic/cardiogenic capacity of murine cardiac progenitor cells in in vitro and in vivo milieu. Cell Biochem Funct 36(7):346–356
Article CAS PubMed Google Scholar
Khan MAB et al (2020) Epidemiology of type 2 diabetes - global burden of disease and forecasted trends. J Epidemiol Global Health 10(1):107–111
Kim S-J et al (2017) Mitochondrially derived peptides as novel regulators of metabolism. J Physiol 595(21):6613–6621
Article CAS PubMed PubMed Central Google Scholar
Kim S-J et al (2018) Mitochondrial peptides modulate mitochondrial function during cellular senescence. Aging 10(6):1239–1256
Article CAS PubMed PubMed Central Google Scholar
Klein LE et al (2013) A humanin analog decreases oxidative stress and preserves mitochondrial integrity in cardiac myoblasts. Biochem Biophys Res Commun 440(2):197–203
Article CAS PubMed Google Scholar
Kumagai H et al (2023) Novel insights into mitochondrial DNA: mitochondrial microproteins and mtDNA variants modulate athletic performance and age-related diseases. Genes 14(2):286
Article CAS PubMed PubMed Central Google Scholar
Lee C et al (2014) IGF-I regulates the age-dependent signaling peptide humanin. Aging Cell 13(5):958–961
Article CAS PubMed PubMed Central Google Scholar
Lee C et al (2015) The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabol 21(3):443–454
Li W et al (2020) Humanin ameliorates free fatty acid-Induced endothelial inflammation by suppressing the NLRP3 inflammasome. ACS Omega 5(35):22039–22045
Article CAS PubMed PubMed Central Google Scholar
Logan IS (2017) Pseudogenization of the gene is common in the mitochondrial DNA of many vertebrates. Zoological Res 38(4):198–202
Lue Y et al (2018) Humanin analog enhances the protective effect of dexrazoxane against doxorubicin-induced cardiotoxicity. Am J Physiol Heart Circ Physiol 315(3):H634–H643
Article PubMed PubMed Central Google Scholar
Maftei M, Tian X, Manea M, Exner TE, Schwanzar D, von Arnim CA, Przybylski M (2012) Interaction structure of the complex between neuroprotective factor humanin and Alzheimer’s β-amyloid peptide revealed by affinity mass spectrometry and molecular modeling. J Pept Sci 18(6):373–382
Article CAS PubMed Google Scholar
Matsuoka M (2015) Protective effects of humanin and calmodulin-like skin protein in Alzheimer’s disease and broad range of abnormalities. Mol Neurobiol 51(3):1232–1239
Article CAS PubMed Google Scholar
Mehta HH et al (2019) Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment. Metabolomics 15(6):88
Article PubMed PubMed Central Google Scholar
Mendelsohn AR, Larrick JW (2018) Mitochondrial-derived peptides exacerbate senescence. Rejuven Res 21(4):369–373
Mercer TR et al (2011) The human mitochondrial transcriptome. Cell 146(4):645–658
Article CAS PubMed PubMed Central Google Scholar
Meridor D, Cohen A, Khalfin B, Uppalapati L, Kasher R, Nathan I, Parola AH (2019) The protective effect of humanin derivative AGA (C8R)-HNG17 against acetaminophen-induced liver injury in mice. Int J Pept Res Ther 25:565–571
Comments (0)