Free Radical Scavenging-Related Antioxidant Properties and Inhibitory Activities of Telfairia occidentalis Seed Protein Hydrolysates and Peptide Fractions Against Two key Enzymes Implicated in Diabetes Mellitus

Acho MA, Olasehinde RO, Arise RO (2023) Antioxidant and antihypertensive properties of neem seed protein hydrolysates: the effects of hydrolytic enzyme type and peptide size. Int J Pept Res Ther 29(3):1–4

Article  Google Scholar 

Ademiluyi AO, Oboh G (2013) Soybean phenolic-rich extracts inhibit key-enzymes linked to type 2 diabetes (α-amylase and α-glucosidase) and hypertension (angiotensin I converting enzyme) in vitro. Exp Toxicol Pathol 65(3):305–309

Article  CAS  PubMed  Google Scholar 

Afolabi OB, Oloyede OI, Ojo AA, Onasanya AA, Agunbiade SO, Ajiboye BO, Jonathan J, Peters OA (2018a) In vitro antioxidant potential and inhibitory effect of hydroethanolic extract from African black velvet tamarind (Dialium indium) pulp on type 2 diabetes linked enzymes. Potravinarstvo 12(1)

Afolabi OB, Oloyede OI, Agunbiade SO (2018b) Inhibitory potentials of phenolic-rich extracts from Bridelia ferruginea on two key carbohydrate-metabolizing enzymes and Fe2+-induced pancreatic oxidative stress. J Integr Med 16(3):192–198

Article  PubMed  Google Scholar 

Afolabi OB, Olasehinde OR, Olanipon DG, Mabayoje SO, Familua OM, Jaiyesimi KF, Agboola EK, Idowu TO, Obafemi OT, Olaoye OA, Oloyede OI (2023) Antioxidant evaluation and computational prediction of prospective drug-like compounds from polyphenolic-rich extract of Hibiscus cannabinus L. seed as antidiabetic and neuroprotective targets: assessment through in vitro and in silico studies. BMC Complement Med Ther 23(1):203

Article  CAS  PubMed  PubMed Central  Google Scholar 

Agbede JO, Adegbenro M, Onibi GE, Oboh C, Aletor VA (2008) Nutritive evaluation of Telfairia occidentalis leaf protein concentrate in infant foods. Afr J Biotechnol 7(15)

Ahmad JB, Ajani EO, Sabiu S (2021) Chemical group profiling, in vitro and in silico evaluation of Aristolochia ringens on α-amylase and α-glucosidase activity. Evid -based Complement Altern Med 2021:1–2

Article  CAS  Google Scholar 

Ajibola CF, Fashakin JB, Fagbemi TN, Aluko RE (2011) Effect of peptide size on antioxidant properties of african yam bean seed (Sphenostylis stenocarpa) protein hydrolysate fractions. Int J Mol Sci 12(10):6685–6702

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alashi AM, Blanchard CL, Mailer RJ, Agboola SO, Mawson AJ, He R, Malomo SA, Girgih AT, Aluko RE (2014) Blood pressure lowering effects of australian canola protein hydrolysates in spontaneously hypertensive rats. Food Res Int 55:281–287

Article  CAS  Google Scholar 

Alnuaimi A, Ajayi FF, Hamdi M, Mudgil P, Kamal H, Gan CY, Maqsood SA (2022) Comparative analysis of anti-lipidemic potential of soybean (Glycine max) protein hydrolysates obtained from different ripening stages: identification, and molecular interaction mechanisms of novel bioactive peptides. Food Chem 12:134192

Google Scholar 

Annih MG, Tatiana NC, Kinge TR, Mariette A, Kebei AK (2020) Effect of animal manure on the incidence and severity of leaf spot disease of fluted pumpkin (Telfairia occidentalis) in Dschang, West Region of Cameroon. Am J Plant Sci 11(07):1057

Article  CAS  Google Scholar 

Arise AK, Amonsou EO, Ijabadeniyi OA (2015) Influence of extraction methods on functional properties of protein concentrates prepared from south african bambara groundnut landraces. Int J Food Sci Technol 50(5):1095–1101

Article  CAS  Google Scholar 

Arise RO, Yekeen AA, Ekun OE (2016) In vitro antioxidant and α-amylase inhibitory properties of watermelon seed protein hydrolysates. Environ Exp Bot 14(4):163–172

Google Scholar 

Arise RO, Taofeek OO, Babaita K, Adeoye RI, Osemwegie O (2021) Blood pressure and sugar regulating potentials of Anarcadium occidentale nut globulin and albumin hydrolysates. Heliyon 7(3):e06384

Article  CAS  PubMed  PubMed Central  Google Scholar 

Babashpour-Asl M, Piryaei M (2021) Free radical scavengering and phenolic compounds of peel and pulp of quince. Int J Hortic Sci Technol 8(1):91–101

CAS  Google Scholar 

Bao ZJ, Zhao Y, Wang XY, Chi YJ (2017) Effects of degree of hydrolysis (DH) on the functional properties of egg yolk hydrolysate with alcalase. J Food Sci Technol 54:669–678

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barber E, Houghton MJ, Visvanathan R, Williamson G (2022) Measuring key human carbohydrate digestive enzyme activities using high-performance anion-exchange chromatography with pulsed amperometric detection. Nat Protoc 17(12):2882–2919

Article  CAS  PubMed  Google Scholar 

Eze BC, Ogbodo EC, Ezejindu DN, Ezeugwunne IP, Analike RA, Onuora IJ, Amah KA, Odumodu IO, Obi-Ezeani CN (2020) Hepatoprotective potential of the aqueous leaf extract of Telfairia occidentalis on the liver function parameters in adult Wistar rats. Ann Geriatic Educ Med Sci 7(1):39–42

Google Scholar 

Famuwagun AA, Alashi AM, Gbadamosi SO, Taiwo KA, Oyedele D, Adebooye OC, Aluko RE (2021) Effect of protease type and peptide size on the in vitro antioxidant, antihypertensive and anti-diabetic activities of eggplant leaf protein hydrolysates. Foods 10(5):1112

Article  CAS  PubMed  PubMed Central  Google Scholar 

Festa M, Sansone C, Brunet C, Crocetta F, Di Paola L, Lombardo M, Bruno A, Noonan DM, Albini A (2020) Cardiovascular active peptides of marine origin with ACE inhibitory activities: potential role as anti-hypertensive drugs and in prevention of SARS-CoV-2 infection. Int J Mol Sci 21:8364

Article  CAS  PubMed  PubMed Central  Google Scholar 

Garza C, Scrimshaw NS, Young VR (1978) Human protein requirements: interrelationships between energy intake and nitrogen balance in young men consuming the 1973 FAO/WHO safe level of egg protein, with added non-essential amino acids. J Nutr 108(1):90–96

Article  CAS  PubMed  Google Scholar 

Girgih AT, Udenigwe CC, Aluko RE (2011) In vitro antioxidant properties of hemp seed (Cannabis sativa L.) protein hydrolysate fractions. J Am Oil Chem Soc 88(3):381–389

Article  CAS  Google Scholar 

González GNG, Chuc KJA, Torres CJA, García ZEA, Betancur AD, Chel GL, Sinagawa GSR (2017) Biofunctional properties of bioactive peptide fractions from protein isolates of moringa seed (Moringa oleifera). J Food Sci Technol 54(13):4268–4276

Article  Google Scholar 

Hwang SJ, Yoon WB, Lee OH, Cha SJ, Dai Kim J (2014) Radical-scavenging-linked antioxidant activities of extracts from black chokeberry and blueberry cultivated in Korea. Food Chem 146:71–77

Article  CAS  PubMed  Google Scholar 

Jao CL, Hung CC, Tung YS, Lin PY, Chen MC, Hsu KC (2015) The development of bioactive peptides from dietary proteins as a dipeptidyl peptidase IV inhibitor for the management of type 2 diabetes. BioMed 5:1–7

Google Scholar 

Jimoh TO (2018) Enzymes inhibitory and radical scavenging potentials of two selected tropical vegetable (Moringa oleifera and Telfairia occidentalis) leaves relevant to type 2 diabetes mellitus. Rev Bras Farmacogn 28:73–79

Article  CAS  Google Scholar 

Karami Z, Akbari-Adergani B (2019) Bioactive food derived peptides: a review on correlation between structure of bioactive peptides and their functional properties. J Food Sci Technol 56(2):535–547

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lammi C, Aiello G, Boschin G, Arnoldi A (2019) Multifunctional peptides for the prevention of cardiovascular disease: a new concept in the area of bioactive food-derived peptides. J Funct Foods 55:135–145

Article  CAS  Google Scholar 

Lin AH, Lee BH, Chang WJ (2016) Small intestine mucosal α-glucosidase: a missing feature of in vitro starch digestibility. Food Hydrocol 53:163–171

Article  CAS  Google Scholar 

Liu Q, Yang M, Zhao B, Yang F (2020) Isolation of antioxidant peptides from yak casein hydrolysate. RSC Adv 10(34):19844–19851

Article  CAS  PubMed  PubMed Central  Google Scholar 

Malomo SA, Aluko RE (2015) Conversion of a low protein hemp seed meal into a functional protein concentrate through enzymatic digestion of fibre coupled with membrane ultrafiltration. Innov Food Sci Emerg Technol 31:151–159

Article  CAS  Google Scholar 

Mazloomi SN, Mahoonak AS, Mora L, Ghorbani M, Houshmand G, Toldrá F (2021) Pepsin hydrolysis of orange by-products for the production of bioactive peptides with gastrointestinal resistant properties. Foods 10(3):679

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mazloomi-Kiyapey SN, Sadeghi-Mahoonak A, Ranjbar-Nedamani E, Nourmohammadi E (2019) Production of antioxidant peptides through hydrolysis of medicinal pumpkin seed protein using pepsin enzyme and the evaluation of their functional and nutritional properties. ARYA atheroscler 15(5):218

PubMed  PubMed Central  Google Scholar 

Mechchate H, Es-Safi I, Louba A, Alqahtani AS, Nasr FA, Noman OM, Farooq M, Alharbi MS, Alqahtani A, Bari A, Bekkari H (2021) In vitro alpha-amylase and alpha-glucosidase inhibitory activity and in vivo antidiabetic activity of Withania frutescens L. Foliar extract. Molecules 26(2):293

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miteu G, Ezeh B (2022) Effects of roasting periods on the nutritive value of Telfaira occidentalis (fluted pumpkin) seeds. IPS J Nutr Food Sci 1(1):6–10

Article  Google Scholar 

Naqash SY, Nazeer RA (2013) Antioxidant and functional properties of protein hydrolysates from pink perch (Nemipterus japonicus) muscle. J Food Sci Technol 50(5):972–978

Article  CAS  PubMed  Google Scholar 

Nwachukwu ID, Aluko RE (2019) Structural and functional properties of food protein-derived antioxidant peptides. J Food Biochem 43(1):e12761

Article  PubMed  Google Scholar 

Okagu IU, Ndefo JC, Aham EC, Obeme-Nmom JI, Agboinghale PE, Aguchem RN, Nechi RN, Lammi C (2021) Lupin-derived bioactive peptides: Intestinal transport, bioavailability and health benefits. Nutrients 13(9): 3266 (2021)

Okaiyeto K, Adeoye RI, Oguntibeju OO (2021) Some common west african spices with antidiabetic potential: a review. J King Saud Uni Sci 33(6):101548

Article  Google Scholar 

Olajide PA, Omowumi OS, Odine GO (2022) Pathogenesis of reactive oxygen species: a review. World News Nat Sci 44:150–164

CAS  Google Scholar 

Olasehinde OR, Acho MA, Afolabi OB, Arise RO (2023) Peptide Hydrolysate of Telfairia occidentalis Hook f. Seed Protein Promotes Effective Glucose Homeostasis by Improving β-cell Dysfunction and Abating Carbohydrate Metabolic Disturbance in Diabetic Rats. J Food Biochem 2023, https://doi.org/10.1155/2023/6652466

Pal S, Mitra RK (2022) Investigation on the effect of nonpolar amino acids as macromolecular crowders on the stability of globular proteins. Chem Thermodyn Thermal Anal 6:100044

Article  Google Scholar 

Comments (0)

No login
gif