Depression, Anxiety, and Bipolar Disorder and Atherosclerosis

Bueno H, Deaton C, Farrero M, et al. 2025 ESC clinical consensus statement on mental health and cardiovascular disease: developed under the auspices of the ESC clinical practice guidelines committee. Eur Heart J. 2025;46:4156–225. https://doi.org/10.1093/eurheartj/ehaf191.

Article  PubMed  Google Scholar 

Apostolos A, Konstantinou K, Ktenopoulos N, et al. Depression and coronary artery disease—where we stand? J Clin Med. 2025;14:4281. https://doi.org/10.3390/jcm14124281.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goldstein BI, Schaffer A, Wang S, Blanco C. Excessive and premature new-onset cardiovascular disease among adults with bipolar disorder in the US NESARC cohort. J Clin Psychiatry. 2015;76:163–9. https://doi.org/10.4088/JCP.14m09300.

Article  PubMed  Google Scholar 

Gupta A, Tejpal T, Seo C, et al. Mental disorders as a risk factor of acute coronary syndrome. JAMA Psychiatry. 2026. https://doi.org/10.1001/jamapsychiatry.2025.4253.

Article  PubMed  PubMed Central  Google Scholar 

Li X, Zhou J, Wang M, et al. Cardiovascular disease and depression: a narrative review. Front Cardiovasc Med. 2023;10:1274595. https://doi.org/10.3389/fcvm.2023.1274595.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rozanski A, Blumenthal JA, Kaplan J. Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy. Circulation. 1999;99:2192–217. https://doi.org/10.1161/01.CIR.99.16.2192.

Article  CAS  PubMed  Google Scholar 

Kumar M, Nayak PK. Psychological sequelae of myocardial infarction. Biomed Pharmacother. 2017;95:487–96. https://doi.org/10.1016/j.biopha.2017.08.109.

Article  PubMed  Google Scholar 

Ong LT, Sia C-H. Pathophysiological links between myocardial infarction and anxiety disorder, major depressive disorder, bipolar disorder and schizophrenia. Biology (Basel). 2025;14:336. https://doi.org/10.3390/biology14040336.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nagel M, Jansen PR, Stringer S, et al. Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways. Nat Genet. 2018;50:920–7. https://doi.org/10.1038/s41588-018-0151-7.

Article  CAS  PubMed  Google Scholar 

Torgersen K, Bahrami S, Frei O, et al. Shared genetic architecture between neuroticism, coronary artery disease and cardiovascular risk factors. Transl Psychiatry. 2021;11:368. https://doi.org/10.1038/s41398-021-01466-9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rødevand L, Bahrami S, Frei O, et al. Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms. Transl Psychiatry. 2021;11:3. https://doi.org/10.1038/s41398-020-01142-4.

Article  PubMed  PubMed Central  Google Scholar 

Amare AT, Schubert KO, Klingler-Hoffmann M, et al. The genetic overlap between mood disorders and cardiometabolic diseases: a systematic review of genome wide and candidate gene studies. Transl Psychiatry. 2017;7:e1007. https://doi.org/10.1038/tp.2016.261.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goldfarb M, De Hert M, Detraux J, et al. Severe Mental Illness and Cardiovascular Disease: JACC State-of-the-Art Review. J Am Coll Cardiol. 2022;80:918–33. https://doi.org/10.1016/j.jacc.2022.06.017.

Article  PubMed  Google Scholar 

Xu L, Zhai X, Shi D, Zhang Y. Depression and coronary heart disease: mechanisms, interventions, and treatments. Front Psychiatry. 2024;15:1328048. https://doi.org/10.3389/fpsyt.2024.1328048.

Article  PubMed  PubMed Central  Google Scholar 

Belialov FI. Depression, anxiety, and stress in patients with coronary heart disease. Ter Arkh. 2017;89:104–9. https://doi.org/10.17116/terarkh2017898104-109.

Article  CAS  PubMed  Google Scholar 

Wu J-Y, Chang H-Y, Kao C-L, et al. Association between SSRI use and cardiovascular outcomes in patients with coronary artery disease and generalized anxiety disorder: a real-world cohort study. Atherosclerosis. 2025;407:120390. https://doi.org/10.1016/j.atherosclerosis.2025.120390.

Article  CAS  PubMed  Google Scholar 

Kim J-M, Stewart R, Lee Y-S, et al. Effect of Escitalopram vs placebo treatment for depression on long-term cardiac outcomes in patients with acute coronary syndrome: a randomized clinical trial. JAMA. 2018;320:350–8. https://doi.org/10.1001/jama.2018.9422.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Blatch Armon D, Buhayer A, Miteva K, et al. Depression and cardiovascular disease: mind the gap in the guidelines. Eur Heart J. 2025;46:4226–69. https://doi.org/10.1093/eurheartj/ehaf479.

Article  PubMed  PubMed Central  Google Scholar 

Lee Y-B, Kim H, Lee J, et al. Bipolar disorder and the risk of cardiometabolic diseases, heart failure, and all-cause mortality: a population-based matched cohort study in South Korea. Sci Rep. 2024;14:1932. https://doi.org/10.1038/s41598-024-51757-6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zeng J, Qiu Y, Yang C, et al. Cardiovascular diseases and depression: A meta-analysis and Mendelian randomization analysis. Mol Psychiatry. 2025;30:4234–46. https://doi.org/10.1038/s41380-025-03003-2.

Article  PubMed  PubMed Central  Google Scholar 

Serber ER, Todaro JF, Tilkemeier PL, Niaura R. Prevalence and characteristics of multiple psychiatric disorders in cardiac rehabilitation patients. J Cardiopulm Rehabil Prev. 2009;29:161–70. https://doi.org/10.1097/HCR.0b013e3181a33365.

Article  PubMed  PubMed Central  Google Scholar 

Lane D, Carroll D, Ring C, et al. The prevalence and persistence of depression and anxiety following myocardial infarction. Br J Health Psychol. 2002;7:11–21. https://doi.org/10.1348/135910702169321.

Article  PubMed  Google Scholar 

Vaccarino V, Badimon L, Bremner JD, et al. Depression and coronary heart disease: 2018 position paper of the ESC working group on coronary pathophysiology and microcirculation. Eur Heart J. 2020;41:1687–96. https://doi.org/10.1093/eurheartj/ehy913.

Article  PubMed  PubMed Central  Google Scholar 

Carney RM, Freedland KE, Steinmeyer B, et al. History of depression and survival after acute myocardial infarction. Psychosom Med. 2009;71:253–9. https://doi.org/10.1097/PSY.0b013e31819b69e3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sims M, Redmond N, Khodneva Y, et al. Depressive symptoms are associated with incident coronary heart disease or revascularization among blacks but not among whites in the Reasons for Geographical and Racial Differences in Stroke study. Ann Epidemiol. 2015;25:426–32. https://doi.org/10.1016/j.annepidem.2015.03.014.

Article  PubMed  PubMed Central  Google Scholar 

Das DR, Nayak MR, Mohapatra D, Mahanta D. Association of anxiety and depression in patients undergoing cardiac catheterization with number of major coronary artery stenosis: a cross-sectional study. Cureus. 2022;14:e21630. https://doi.org/10.7759/cureus.21630.

Article  PubMed  PubMed Central  Google Scholar 

Pająk A, Jankowski P, Kotseva K, et al. Depression, anxiety, and risk factor control in patients after hospitalization for coronary heart disease: the EUROASPIRE III Study. Eur J Prev Cardiol. 2013;20:331–40. https://doi.org/10.1177/2047487312441724.

Article  PubMed  Google Scholar 

Mallik S, Spertus JA, Reid KJ. Depressive symptoms after acute myocardial infarction: evidence for highest rates in younger women. Arch Intern Med. 2006;166:876–83.

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