Awale G, Kan HM, Laurencin CT, Lo K. Molecular mechanisms underlying the short-term intervention of forskolin-mediated bone regeneration. Regen Eng Transl Med. 2022. https://doi.org/10.1007/s40883-022-00285-8.
Ifegwu, O.C., Awale, G., Kan, H.M., Rajpura K, O'Neil E, Kuo, C.-L., Lo, K.W.-H., Laurencin, C.T. one Regenerative Engineering Using a Protein Kinase A-Specific Cyclic AMP Analogue Administered for Short Term. Regen. Eng. Transl. Med. 2018. https://doi.org/10.1007/s40883-018-0063-1.
Lo KW, Ashe KM, Kan HM, Laurencin CT. The role of small molecules in musculoskeletal regeneration. Regen Med. 2012;7(4):535–49. https://doi.org/10.2217/rme.12.33.
Article CAS PubMed PubMed Central Google Scholar
Ifegwu OC, Awale G, Rajpura K, Lo KW, Laurencin CT. Harnessing cAMP signaling in musculoskeletal regenerative engineering. Drug Discov Today. 2017;22(7):1027–44.
Article CAS PubMed PubMed Central Google Scholar
Lo KW, Ulery BD, Ashe KM, Laurencin CT. Studies of bone morphogenetic protein-based surgical repair. Adv Drug Deliv Rev. 2012;64(12):1277–91. https://doi.org/10.1016/j.addr.2012.03.014.
Article CAS PubMed PubMed Central Google Scholar
Duan P, Bonewald LF. The role of the wnt/β-catenin signaling pathway in formation and maintenance of bone and teeth. Int J Biochem Cell Biol. 2016;77:23–9. https://doi.org/10.1016/j.biocel.2016.05.015.
Article CAS PubMed PubMed Central Google Scholar
Abeynayake N, Arthur A, Gronthos S. Crosstalk between skeletal and neural tissues is critical for skeletal health. Bone. 2021;142:115645. https://doi.org/10.1016/j.bone.2020.115645.
Article CAS PubMed Google Scholar
Turney SG, Ahmed M, Chandrasekar I, et al. Nerve growth factor stimulates axon outgrowth through negative regulation of growth cone actomyosin restraint of microtubule advance. Mol Biol Cell. 2016;27(3):500–17. https://doi.org/10.1091/mbc.E15-09-0636.
Article CAS PubMed Google Scholar
Mitchell DJ, Blasier KR, Jeffery ED, et al. Trk activation of the ERK1/2 kinase pathway stimulates intermediate chain phosphorylation and recruits cytoplasmic dynein to signaling endosomes for retrograde axonal transport. J Neurosci. 2012;32(44):15495–510. https://doi.org/10.1523/JNEUROSCI.5599-11.2012.
Article CAS PubMed PubMed Central Google Scholar
Yang X, Mou D, Yu Q, et al. Nerve growth factor promotes osteogenic differentiation of MC3T3-E1 cells via BMP-2/Smads pathway. Annals of Anatomy - Anatomischer Anzeiger. 2022;239:151819. https://doi.org/10.1016/j.aanat.2021.151819.
Yada M, Yamaguchi K, Tsuji T. NGF stimulates differentiation of osteoblastic MC3T3-E1 cells. Biochem Biophys Res Commun. 1994;205(2):1187–93. https://doi.org/10.1006/bbrc.1994.2791.
Article CAS PubMed Google Scholar
Zhang L, Xie J, Dai W, Lu B, Yi S. Schwann cells in regeneration and cancer. Front Pharmacol. 2025. https://doi.org/10.3389/fphar.2025.1506552.
Article PubMed PubMed Central Google Scholar
Su Q, Nasser MI, He J, et al. Engineered Schwann Cell-Based Therapies for Injury Peripheral Nerve Reconstruction. Front Cell Neurosci. 2022;16:865266. https://doi.org/10.3389/fncel.2022.865266.
Article CAS PubMed PubMed Central Google Scholar
Abeynayake N, Arthur A, Gronthos S. Crosstalk between skeletal and neural tissues is critical for skeletal health. Bone. 2021;142:115645. https://doi.org/10.1016/j.bone.2020.115645.
Article CAS PubMed Google Scholar
Aloe L, Rocco ML, Balzamino BO, Micera A. Nerve growth factor: a focus on neuroscience and therapy. Curr Neuropharmacol. 2015;13(3):294–303. https://doi.org/10.2174/1570159x13666150403231920.
Article CAS PubMed PubMed Central Google Scholar
Taylor JSH, Bampton ETW. Factors secreted by Schwann cells stimulate the regeneration of neonatal retinal ganglion cells. J Anat. 2004;204(1):25–31. https://doi.org/10.1111/j.1469-7580.2004.00262.x.
Article CAS PubMed PubMed Central Google Scholar
Shima WN, Ali AM, Subramani T, et al. Rapid growth and osteogenic differentiation of mesenchymal stem cells isolated from human bone marrow. Exp Ther Med. 2015;9(6):2202–6. https://doi.org/10.3892/etm.2015.2381.
Article CAS PubMed PubMed Central Google Scholar
Choi JY, Lee BH, Song KB, et al. Expression patterns of bone-related proteins during osteoblastic differentiation in MC3T3-E1 cells. J Cell Biochem. 1996;61(4):609–18.
Article CAS PubMed Google Scholar
Liu Z, Suh JS, Deng P, et al. Epigenetic regulation of NGF-mediated osteogenic differentiation in human dental mesenchymal stem cells. Stem Cells. 2022;40(9):818–30. https://doi.org/10.1093/stmcls/sxac042.
Article PubMed PubMed Central Google Scholar
Chen K, Chen L, Ma Y, et al. From neuromodulation to bone homeostasis: therapeutic targets of nerve growth factor in skeletal diseases. Front Pharmacol. 2025;16:1614542. https://doi.org/10.3389/fphar.2025.1614542.
Article CAS PubMed PubMed Central Google Scholar
Park EJ, Truong V, Jeong W, Min W. Brain-derived neurotrophic factor (BDNF) enhances osteogenesis and may improve bone microarchitecture in an ovariectomized rat model. Cells. 2024;13(6):518. https://doi.org/10.3390/cells13060518.
Article CAS PubMed PubMed Central Google Scholar
Li X, Wang X, Wang X, et al. 3D bioprinted rat Schwann cell-laden structures with shape flexibility and enhanced nerve growth factor expression. 3 Biotech. 2018;8(8):342–9. https://doi.org/10.1007/s13205-018-1341-9.
Article PubMed PubMed Central Google Scholar
Rad A, Weigl L, Steinecker-Frohnwieser B, et al. Nuclear magnetic resonance treatment induces ßNGF release from Schwann cells and enhances the neurite growth of dorsal root ganglion neurons in vitro. Cells. 2024;13(18):1544. https://doi.org/10.3390/cells13181544.
Article CAS PubMed PubMed Central Google Scholar
Barker PA, Mantyh P, Arendt-Nielsen L, Viktrup L, Tive L. Nerve growth factor signaling and its contribution to pain. J Pain Res. 2020;13:1223–41. https://doi.org/10.2147/JPR.S247472.
Article CAS PubMed PubMed Central Google Scholar
Lang UE, Gallinat J, Danker-Hopfe H, Bajbouj M, Hellweg R. Nerve growth factor serum concentrations in healthy human volunteers: physiological variance and stability. Neurosci Lett. 2003;344(1):13–6. https://doi.org/10.1016/s0304-3940(03)00403-8.
Article CAS PubMed Google Scholar
Piovesana R, Faroni A, Taggi M, et al. Muscarinic receptors modulate Nerve Growth Factor production in rat Schwann-like adipose-derived stem cells and in Schwann cells. Sci Rep. 2020;10(1):7159. https://doi.org/10.1038/s41598-020-63645-w.
Article CAS PubMed PubMed Central Google Scholar
Alhamdi AA, Mackie S, Trueman RP, Rayner MLD. Pharmacologically targeting Schwann cells to improve regeneration following nerve damage. Front Cell Dev Biol. 2025;13:1603752. https://doi.org/10.3389/fcell.2025.1603752.
Article PubMed PubMed Central Google Scholar
Rao Z, Lin Z, Song P, Quan D, Bai Y. Biomaterial-based Schwann cell transplantation and Schwann cell-derived biomaterials for nerve regeneratio
Comments (0)