Titanium Dioxide Nanotubes for Regenerative and Translational Applications: Advances in Synthesis, Functionalization, and Biomedical Integration

Abdelrhman Y, Kobayashi S, Okano S, Okamoto T, Gepreel MA. Biocompatibility of anodized Low-Cost Ti-4.7Mo-4.5Fe alloy. Mater Sci Forum. 2021;1016:458–64. https://doi.org/10.4028/www.scientific.net/msf.1016.458.

Article  Google Scholar 

Poliwoda S, Noor N, Downs E, Schaaf AL, Cantwell A, Ganti L, Kaye AD, Mosel L, Carroll CB, Viswanath O, Urits I. Stem cells: A comprehensive review of origins and emerging clinical roles in medical practice. Orthop Rev (Pavia). 2022;14. https://doi.org/10.52965/001c.37498.

Amengual-Peñafiel L, Córdova LA, Jara-Sepúlveda MC, Brañes-Aroca M, Marchesani-Carrasco F, Cartes‐Velásquez R. Osteoimmunology drives dental implant osseointegration: A new paradigm for implant dentistry. Japanese Dent Sci Rev. 2021;57:12–9. https://doi.org/10.1016/j.jdsr.2021.01.001.

Article  Google Scholar 

Ocampo RA, Echeverry-Rendón M, DeAlba-Montero I, Robledo SM, Ruíz F, Echeverría F. Effect of surface characteristics on the antibacterial properties of titanium dioxide nanotubes produced in aqueous electrolytes with carboxymethyl cellulose. J Biomed Mater Res A. 2020;109:104–21. https://doi.org/10.1002/jbm.a.37010.

Article  CAS  Google Scholar 

Dong H, Liu H, Zhou N, Li Q, Yang G, Chen L, Mou Y. Surface modified techniques and emerging functional coating of dental implants. Coatings. 2020;10:1012. https://doi.org/10.3390/coatings10111012.

Article  CAS  Google Scholar 

Haryati T, Metiardo DF, Diana AN, Suwardiyanto S, Sulistiyo YA, Andarini N. Two-stage hydrothermal synthesis of TiO2 nanotubes with variations of TiO2/NaOH molar ratio. J Metastable Nanocryst Mater. 2024;40:15–24. https://doi.org/10.4028/p-012ppz.

Article  Google Scholar 

Mubarak S, Dhamodharan D, Kale MB, Divakaran N, Senthil T, Ponnan S, et al. A novel approach to enhance mechanical and thermal properties of SLA 3D printed structure by incorporation of metal–metal oxide nanoparticles. Nanomaterials. 2020;10:217. https://doi.org/10.3390/nano10020217.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yuwendi Y, Ibadurrohman M, Setiadi S, Slamet S. Photocatalytic degradation of polyethylene microplastics and disinfection of E. Coli in water over Fe- and Ag-Modified TiO2 nanotubes. Bull Chem Reaction Eng Catal. 2022;17:263–77. https://doi.org/10.9767/bcrec.17.2.13400.263-277.

Article  CAS  Google Scholar 

Zhang J, Shen Y, Li H. Electrolysis of glycerol by Non-Noble metal hydroxides and oxides. ACS Appl Energy Mater. 2023;6:5508–18. https://doi.org/10.1021/acsaem.3c00590.

Article  CAS  Google Scholar 

Nowak AP, Zarach Z, Łapiński M, Trzciński K, Roda D, Szkoda M. Scaling up the process of titanium dioxide nanotube synthesis and its effect on photoelectrochemical properties. Materials. 2021. https://doi.org/10.3390/ma14195686.

Article  PubMed  PubMed Central  Google Scholar 

Stassi S, Bianco S, Falqui A, Casu A, Ricciardi C, Lamberti A, et al. Evolution of nanomechanical properties and crystallinity of individual titanium dioxide nanotube resonators. Nanotechnology. 2018. https://doi.org/10.1088/1361-6528/aaa46c.

Article  PubMed  Google Scholar 

Kam Hepdeniz O, Karaca MK, Esencan Turkaslan B, Gurdal O. The effect of functionalized titanium dioxide nanotube reinforcement on the water sorption and water solubility properties of flowable bulk-fill composite resins. Odontology. 2021. https://doi.org/10.1007/s10266-021-00664-7.

Article  PubMed  Google Scholar 

Chen Y, Bellini M, Berretti E, Miller HA, Lavacchi A, Marchionni A, et al. Titanium dioxide nanomaterials in electrocatalysis for energy. Curr Opin Electrochem. 2021. https://doi.org/10.1016/j.coelec.2021.100720.

Article  Google Scholar 

Lo YS, Koh PW, Leong CY, Lee SL. Hydrothermal synthesis of titanium dioxide nanotube with methylamine for photodegradation of congo red. IOP Conf Ser Mater Sci Eng. 2020;833. https://doi.org/10.1088/1757-899x/833/1/012075.

Richter C, Pedu S, Taboada-Serrano P, Pustulka S, Close T, Xue Y, et al. Titanium dioxide nanotubes as model systems for electrosorption studies. Nanomaterials. 2018. https://doi.org/10.3390/nano8060404.

Article  PubMed  PubMed Central  Google Scholar 

Alotaibi M. Investigating the electronic properties and stability of Rh3 clusters on rutile TiO2 for potential photocatalytic applications. Nanomaterials. 2024;14:1051. https://doi.org/10.3390/nano14121051.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong Z, Ma J, Qin D, Han S. Reduced Ti–Nb–O nanotube photoanode with Bulk-Phase Nb doping and surface oxygen vacancy engineering for enhanced photoelectrochemical water splitting. Energy Fuels. 2022;37:592–603. https://doi.org/10.1021/acs.energyfuels.2c03283.

Article  CAS  Google Scholar 

Li Z, Jiang N, Zhang F, Wang K, Fu Y, Ye Z, Jiang J, Zhu L. A High-Performance Sb < sub > 2 S < sub > 3–Based photocathode with rGO and TiO2/Pt for photoelectrochemical water splitting. ACS Appl Energy Mater. 2025;8:9175–87. https://doi.org/10.1021/acsaem.5c00811.

Article  CAS  Google Scholar 

Wood ST, Crawford GA, Meyerink JG, Kota D. Transparent titanium dioxide nanotubes: processing, characterization, and application in establishing cellular response mechanisms. Acta Biomater. 2018. https://doi.org/10.1016/j.actbio.2018.08.039.

Article  PubMed  Google Scholar 

Zheng E, Jiang F, Feng G, Hu Z, Wu C, Wei T, Wu Q, Jiang W. Research progress of Fe/C doped titanium dioxide visible light photocatalytic materials. J Phys Conf Ser. 2023;2510:012004. https://doi.org/10.1088/1742-6596/2510/1/012004.

Article  CAS  Google Scholar 

Nair RV, Gummaluri VS, Matham MV, Vijayan C. A Review on Optical Bandgap Engineering in TiO2 Nanostructures via Doping and Intrinsic Vacancy Modulation Towards Visible Light Applications. J Phys D Appl Phys. 2022;55:313003. https://doi.org/10.1088/1361-6463/ac6135.

Article  CAS  Google Scholar 

Kumar A, Krishnan V. Vacancy engineering in semiconductor photocatalysts: implications in hydrogen evolution and nitrogen fixation applications. Adv Funct Mater. 2021. https://doi.org/10.1002/adfm.202009807.

Article  PubMed  PubMed Central  Google Scholar 

Liu Z, Lin J, Xu Z, Li F, Wang S, Gao P, Xiong G, Peng H. Highly effective Fe-Doped nano titanium oxide for removal of Acetamiprid and atrazine under simulated sunlight irradiation. Agronomy. 2024;14:461. https://doi.org/10.3390/agronomy14030461.

Article  CAS  Google Scholar 

Babyszko A, Wanag A, Sadłowski M, Kusiak-Nejman E, Morawski AW. Synthesis and Characterization of SiO2/TiO2 as Photocatalyst on Methylene Blue Degradation. Catalysts. 2022;12:1372. https://doi.org/10.3390/catal12111372.

Article  CAS  Google Scholar 

Zaporotskova IV, Elbakyan LS, Vilkeeva DE. Sensor activity of titanium dioxide nanotubes in relation to acetone molecules, J Phys Conf Ser 1967 (2021). https://doi.org/10.1088/1742-6596/1967/1/012048

Razali MH, Ismail NA, Mat KA, Amin. Titanium dioxide nanotubes incorporated Gellan gum bio-nanocomposite film for wound healing: effect of TiO2 nanotubes concentration. Int J Biol Macromol. 2019;153. https://doi.org/10.1016/j.ijbiomac.2019.10.242.

Garg A. Synthesis, Characterization, and biological activities of Fe- and V‐Doped and Co‐Doped TiO2. Chem Eng Technol. 2022;45:1538–44. https://doi.org/10.1002/ceat.202200116.

Article  CAS  Google Scholar 

Uzal H, Döner A. Corrosion behavior of titanium dioxide nanotubes in alkaline solution. Prot Met Phys Chem Surf. 2020. https://doi.org/10.1134/s207020512002029x.

Article  Google Scholar 

Hoşgün HL, Aydın MTA. Synthesis, characterization and photocatalytic activity of boron-doped titanium dioxide nanotubes. J Mol Struct. 2018;1180. https://doi.org/10.1016/j.molstruc.2018.12.056.

Jiang L, Yao H, Luo X, Zou D, Shen D, Liu L, Yang P, Zhao A, Huang N. Polydopamine-Modified Copper-Doped titanium dioxide nanotube arrays for Copper-Catalyzed controlled endogenous nitric oxide release and improved Re-Endothelialization. ACS Appl Bio Mater. 2020;3:3123–36. https://doi.org/10.1021/acsabm.0c00157.

Article  CAS  PubMed  Google Scholar 

Rezaei M, Khoshgard K, Mohammadi S. Recent applications of titanium dioxide nanoparticles as cancer theranostic agents. Int J Basic Sci Med. 2022;7:147–56. https://doi.org/10.34172/ijbsm.2022.26.

Article  Google Scholar 

Nguyen A, Le PT, Ho TH, Ngo HT, Vu SV, Lo TNH, Park I, Chen H, Pham NNT, Võ KQ. Synthesis of Urchin-Like Au@TiO2 Nano-Carriers in the Drug-Loading system toward cancer treatment, (2023). https://doi.org/10.21203/rs.3.rs-3730658/v1

Nguyen TA, Le PT, Ho TH, Vu SV, Lo TNH, Park I, Pham NNT, Võ KQ. Synthesis of Urchin-Like Au@TiO < sub > 2 Nano‐Carriers as a Drug‐Loading system toward cancer treatment. ChemPlusChem. 2024;90. https://doi.org/10.1002/cplu.202400420.

Gao S, Xu B, Sun J, Zhang Z. Nanotechnological advances in cancer: therapy a comprehensive review of carbon nanotube applications. Front Bioeng Biotechnol. 2024. https://doi.org/10.3389/fbioe.2024.1351787.

Article  PubMed  PubMed Central  Google Scholar 

Andhari SS, Wavhale R, Dhobale KD, Tawade BV, Chate GP, Patil Y, et al. Self-propelling targeted magneto-nanobots for deep tumor penetration and pH-responsive intracellular drug delivery. Sci Rep. 2020. https://doi.org/10.1038/s41598-020-61586-y.

Article  PubMed  PubMed Central  Google Scholar 

Ijäs H, Shen B, Heuer-Jungemann A, Keller A, Kostiainen MA, Liedl T, et al. Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release. Nucleic Acids Res. 2021;49:3048–62. https://doi.org/10.1093/nar/gkab097.

Article 

Comments (0)

No login
gif