Daycare mastectomy is a safe and feasible option for selected breast cancer patients, even in low- and middle-income countries such as India, where it is not yet a standard practice.

In our retrospective analysis of 302 mastectomies, 82% of patients were successfully discharged on the same day, with minimal complication and readmission rates.

Lower ASA grade, absence of comorbidities, and no recent neoadjuvant chemotherapy were significantly associated with same-day discharge, indicating key selection criteria for implementing daycare protocols.

Implementation of a structured perioperative care pathway—including total IV anaesthesia, pectoral nerve blocks, early mobilization, and standardized discharge education—enabled safe outpatient recovery.

Deferred discharges were primarily due to psychological concerns, logistical issues, or minor clinical factors such as bleeding from drains, highlighting the importance of robust preoperative counselling and logistical planning.

Our findings support the broader application of Enhanced Recovery After Surgery (ERAS) principles to breast surgery, especially in resource-limited settings, with potential to improve patient satisfaction, reduce hospital stays, and optimize healthcare resources.