Falcone T, Flyckt R. Clinical management of endometriosis. Obstet Gynecol. 2018;131(3):557–71.

Article  PubMed  Google Scholar 

Lebovic DI, Mueller MD, Taylor RN. Immunobiology of endometriosis. Fertil Steril. 2001;75(1):1–10.

Article  CAS  PubMed  Google Scholar 

Jiang L, Yan Y, Liu Z, Wang Y. Inflammation and endometriosis. Front Biosci (Landmark Ed). 2016;21(5):941–8.

Article  CAS  PubMed  Google Scholar 

Scutiero G, Iannone P, Bernardi G, Bonaccorsi G, Spadaro S, Volta CA, et al. Oxidative stress and endometriosis: a systematic review of the literature. Oxid Med Cell Longev. 2017;2017:7265238.

Article  PubMed  PubMed Central  Google Scholar 

Wyatt J, Fernando SM, Powell SG, Hill CJ, Arshad I, Probert C, et al. The role of iron in the pathogenesis of endometriosis: a systematic review. Hum Reprod Open. 2023;2023(3):hoad033.

Article  PubMed  PubMed Central  Google Scholar 

Huang L, Shi L, Li M, Yin X, Ji X. Oxidative stress in endometriosis: Sources, mechanisms and therapeutic potential of antioxidants (Review). Int J Mol Med. 2025;55(5).

Garcia Garcia JM, Vannuzzi V, Donati C, Bernacchioni C, Bruni P, Petraglia F. Endometriosis: cellular and molecular mechanisms leading to fibrosis. Reprod Sci. 2023;30(5):1453–61.

Article  PubMed  Google Scholar 

Zhang M, Xu T, Tong D, Li S, Yu X, Liu B, et al. Research advances in endometriosis-related signaling pathways: a review. Biomed Pharmacother. 2023;164:114909.

Article  CAS  PubMed  Google Scholar 

Bo C, Wang Y. Angiogenesis signaling in endometriosis: Molecules, diagnosis and treatment (review). Mol Med Rep. 2024;29(3).

Nakamura A, Tanaka Y, Amano T, Takebayashi A, Takahashi A, Hanada T et al. mTOR inhibitors as potential therapeutics for endometriosis: a narrative review. Mol Hum Reprod. 2024;30(12).

Mariadas H, Chen JH, Chen KH. The molecular and cellular mechanisms of endometriosis: from basic pathophysiology to clinical implications. Int J Mol Sci. 2025;26(6).

França PRC, Lontra ACP, Fernandes PD. Endometriosis: A disease with few direct treatment options. Molecules. 2022;27(13).

Mao Y, Pierce J, Singh-Varma A, Boyer M, Kohn J, Reems JA. Processed human amniotic fluid retains its antibacterial activity. J Transl Med. 2019;17(1):68.

Article  PubMed  PubMed Central  Google Scholar 

Carr LE, Virmani MD, Rosa F, Munblit D, Matazel KS, Elolimy AA, et al. Role of human milk bioactives on infants’ gut and immune health. Front Immunol. 2021;12:604080.

Agostoni CV, Bresson JL, Fairweather-Tait S, Flynn A, Golly I, Korhonen H, et al. Scientific opinion on bovine lactoferrin. EFSA J. 2012;10(7):2811.

Google Scholar 

Kitaya K, Ishikawa T. Genital tract dysbiosis in infertile women with a history of repeated implantation failure and pilot study for reproductive outcomes following oral enteric coating lactoferrin supplementation. Arch Gynecol Obstet. 2022;306(5):1761–9.

Article  CAS  PubMed  Google Scholar 

Giunta G, Giuffrida L, Mangano K, Fagone P, Cianci A. Influence of lactoferrin in preventing preterm delivery: a pilot study. Mol Med Rep. 2012;5(1):162–6.

CAS  PubMed  Google Scholar 

D’Amico A, Buca D, Tinari S, Oronzii L, Lucidi A, F DIS, et al. Role of lactoferrin in preventing preterm birth and pregnancy complications: a systematic review and meta-analysis. Minerva Obstet Gynecol. 2023;75(3):273–8.

Article  PubMed  Google Scholar 

Manzoni P, Meyer M, Stolfi I, Rinaldi M, Cattani S, Pugni L, et al. Bovine lactoferrin supplementation for prevention of necrotizing Enterocolitis in very-low-birth-weight neonates: a randomized clinical trial. Early Hum Dev. 2014;90(Suppl 1):S60–5.

Article  CAS  PubMed  Google Scholar 

Li W, Fu K, Lv X, Wang Y, Wang J, Li H, et al. Lactoferrin suppresses lipopolysaccharide-induced endometritis in mice via down-regulation of the NF-κB pathway. Int Immunopharmacol. 2015;28(1):695–9.

Article  CAS  PubMed  Google Scholar 

Otsuki K, Imai N. Effects of lactoferrin in 6 patients with refractory bacterial vaginosis. Biochem Cell Biol. 2017;95(1):31–3.

Article  CAS  PubMed  Google Scholar 

Pino A, Giunta G, Randazzo CL, Caruso S, Caggia C, Cianci A. Bacterial biota of women with bacterial vaginosis treated with lactoferrin: an open prospective randomized trial. Microb Ecol Health Dis. 2017;28(1):1357417.

PubMed  PubMed Central  Google Scholar 

Otsuki K, Nishi T, Kondo T, Okubo K. Review, role of lactoferrin in preventing preterm delivery. Biometals. 2023;36(3):521–30.

Article  CAS  PubMed  Google Scholar 

Trentini A, Maritati M, Rosta V, Cervellati C, Manfrinato MC, Hanau S, et al. Vaginal lactoferrin administration decreases oxidative stress in the amniotic fluid of pregnant women: an open-label randomized pilot study. Front Med (Lausanne). 2020;7:555.

Article  PubMed  PubMed Central  Google Scholar 

Li HY, Li M, Luo CC, Wang JQ, Zheng N. Lactoferrin exerts antitumor effects by inhibiting angiogenesis in a HT29 human colon tumor model. J Agric Food Chem. 2017;65(48):10464–72.

Article  CAS  PubMed  Google Scholar 

Ayuningtyas NF, Chea C, Ando T, Saninggar KE, Tanimoto K, Inubushi T et al. Bovine lactoferrin suppresses tumor angiogenesis through NF-κB pathway Inhibition by binding to TRAF6. Pharmaceutics. 2023;15(1).

Ye T, Yan Z, Chen C, Wang D, Wang A, Li T, et al. Lactoferrin attenuates cardiac fibrosis and cardiac remodeling after myocardial infarction via inhibiting mTORC1/S6K signaling pathway. Theranostics. 2023;13(10):3419–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu Y, Fang J, Li Y, Wang X, Zhang J, Wang J et al. The novel effect and potential mechanism of lactoferrin on organ fibrosis prevention. Nutrients. 2025;17(1).

Nakamura A, Tanaka Y, Tsuji S, Amano T, Takebayashi A, Takahashi A, et al. Bovine lactoferrin suppresses the proliferation of endometriotic stromal cells via the PI3K/Akt/mTOR pathway. Biochem Cell Biol. 2025;103:1–8.

Article  PubMed  Google Scholar 

Wang Y, Nicholes K, Shih IM. The origin and pathogenesis of endometriosis. Annu Rev Pathol. 2020;15:71–95.

Article  CAS  PubMed  Google Scholar 

Taylor HS, Kotlyar AM, Flores VA. Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. Lancet. 2021;397(10276):839–52.

Article  CAS  PubMed  Google Scholar 

Christ JP, Yu O, Schulze-Rath R, Grafton J, Hansen K, Reed SD. Incidence, prevalence, and trends in endometriosis diagnosis: a united States population-based study from 2006 to 2015. Am J Obstet Gynecol. 2021;225(5):500. .e1-.e9.

Article  Google Scholar 

Shen DY, Li J, Hu P, Qi C, Yang H. Global, regional, and National prevalence and disability-adjusted life-years for endometriosis in 204 countries and territories, 1990–2019: findings from a global burden of disease study. Eur J Obstet Gynecol Reprod Biol X. 2025;25:100363.

PubMed  Google Scholar 

Riccio L, Santulli P, Marcellin L, Abrão MS, Batteux F, Chapron C. Immunology of endometriosis. Best Pract Res Clin Obstet Gynaecol. 2018;50:39–49.

Article  PubMed  Google Scholar 

Koninckx PR, Ussia A, Adamyan L, Wattiez A, Gomel V, Martin DC. Pathogenesis of endometriosis: the genetic/epigenetic theory. Fertil Steril. 2019;111(2):327–40.

Article  CAS  PubMed  Google Scholar 

Abramiuk M, Grywalska E, Małkowska P, Sierawska O, Hrynkiewicz R, Niedźwiedzka-Rystwej P. The role of the immune system in the development of endometriosis. Cells. 2022;11:13.

Article  Google Scholar 

Reis JL, Rosa NN, Martins C, Ângelo-Dias M, Borrego LM, Lima J. The role of NK and T cells in endometriosis. Int J Mol Sci. 2024;25(18).

Bedaiwy MA, Falcone T. Peritoneal fluid environment in endometriosis. Clinicopathological implications. Minerva Ginecol. 2003;55(4):333–45.

CAS  PubMed  Google Scholar 

Zhang J, Mei S, Wang X. Role of neutrophils in the immune microenvironment of endometriosis. Afr J Reprod Health. 2025;29(5s):13–9.

Article  PubMed  Google Scholar 

Bukulmez O, Hardy DB, Carr BR, Word RA, Mendelson CR. Inflammatory status influences aromatase and steroid receptor expression in endometriosis. Endocrinology. 2008;149(3):1190–204.

Article  CAS  PubMed  Google Scholar 

Wu MH, Lu CW, Chuang PC, Tsai SJ. Prostaglandin E2: the master of endometriosis? Exp Biol Med (Maywood). 2010;235(6):668–77.

Article  CAS  PubMed