Lieutaud P et al (2016) How disordered is my protein and what is its disorder for? A guide through the dark side of the protein universe. Intrinsically Disord Proteins 4(1):e1259708
Article PubMed PubMed Central Google Scholar
Oldfield CJ (2019) Introduction to intrinsically disordered proteins and regions. Intrinsically Disordered Proteins: Dynamics, Binding, and Function. pp 1–34
Habchi J et al (2014) Introducing protein intrinsic disorder. Chem Rev 114(13):6561–6588
Article PubMed CAS Google Scholar
Dunker AK et al (2013) What’s in a name? Why these proteins are intrinsically disordered. Intrinsically Disord Proteins 1(1):e24157
Article PubMed PubMed Central Google Scholar
Ward JJ et al (2004) Prediction and functional analysis of native disorder in proteins from the three kingdoms of life. J Mol Biol 337(3):635–645
Article PubMed CAS Google Scholar
Xue B, Dunker AK, Uversky VN (2012) Orderly order in protein intrinsic disorder distribution: disorder in 3500 proteomes from viruses and the three domains of life. J Biomol Struct Dyn 30(2):137–149
Article PubMed CAS Google Scholar
Peng Z et al (2015) Exceptionally abundant exceptions: comprehensive characterization of intrinsic disorder in all domains of life. Cell Mol Life Sci 72(1):137–151
Article PubMed CAS Google Scholar
Yan J et al (2016) Molecular recognition features (MoRFs) in three domains of life. Mol Biosyst 12(3):697–710
Article PubMed CAS Google Scholar
Zhao B et al (2020) Idpology of the living cell: intrinsic disorder in the subcellular compartments of the human cell. Cell Mol Life Sci. https://doi.org/10.1007/s00018-020-03654-0
Article PubMed PubMed Central Google Scholar
Oldfield CJ, Dunker AK (2014) Intrinsically disordered proteins and intrinsically disordered protein regions. Annu Rev Biochem 83:553–584
Article PubMed CAS Google Scholar
Uversky VN (2013) Unusual biophysics of intrinsically disordered proteins. Biochim Biophys Acta 1834(5):932–951
Article PubMed CAS Google Scholar
Peng Z et al (2014) A creature with a hundred waggly tails: intrinsically disordered proteins in the ribosome. Cell Mol Life Sci 71(8):1477–1504
Article PubMed CAS Google Scholar
Peng ZL et al (2012) More than just tails: intrinsic disorder in histone proteins. Mol Biosyst 8(7):1886–1901
Article PubMed CAS Google Scholar
Staby L et al (2017) Eukaryotic transcription factors: paradigms of protein intrinsic disorder. Biochem J 474(15):2509–2532
Article PubMed CAS Google Scholar
Zhou JH, Zhao SW, Dunker AK (2018) Intrinsically disordered proteins link alternative splicing and post-translational modifications to complex cell signaling and regulation. J Mol Biol 430(16):2342–2359
Article PubMed CAS Google Scholar
Tantos A, Han KH, Tompa P (2012) Intrinsic disorder in cell signaling and gene transcription. Mol Cell Endocrinol 348(2):457–465
Article PubMed CAS Google Scholar
Zhao B et al (2021) Intrinsic disorder in human RNA-Binding proteins. J Mol Biol 433(21):167229
Article PubMed CAS Google Scholar
Wu Z et al (2015) In various protein complexes, disordered protomers have large per-residue surface areas and area of protein-, DNA- and RNA-binding interfaces. FEBS Lett 589(19 Pt A):2561–9
Article PubMed CAS Google Scholar
Fuxreiter M et al (2014) Disordered proteinaceous machines. Chem Rev 114(13):6806–6843
Article PubMed PubMed Central CAS Google Scholar
Uversky VN (2024) Functional unfoldomics: roles of intrinsic disorder in protein (multi)functionality. Adv Protein Chem Struct Biol 138:179–210
Article PubMed CAS Google Scholar
Ibrahim AY et al (2023) Intrinsically disordered regions that drive phase separation form a robustly distinct protein class. J Biol Chem 299(1):102801
Article PubMed CAS Google Scholar
Fonin AV et al (2022) Biological soft matter: intrinsically disordered proteins in liquid-liquid phase separation and biomolecular condensates. Essays Biochem 66(7):831–847
Article PubMed CAS Google Scholar
Darling AL et al (2018) Intrinsically disordered proteome of human Membrane-Less organelles. Proteomics 18(5–6):e1700193
Qin C et al (2025) Current perspectives in drug targeting intrinsically disordered proteins and biomolecular condensates. BMC Biol 23(1):118
Article PubMed PubMed Central Google Scholar
Dhar A, Sisk TR, Robustelli P (2025) Ensemble docking for intrinsically disordered proteins. bioRxiv
Uversky VN (2024) How to drug a cloud? Targeting intrinsically disordered proteins. Pharmacol Rev
Hosoya Y, Ohkanda J (2021) Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets. Molecules. https://doi.org/10.3390/molecules26082118
Article PubMed PubMed Central Google Scholar
Hu G et al (2016) Untapped potential of disordered proteins in current druggable human proteome. Curr Drug Targets 17(10):1198–1205
Article PubMed CAS Google Scholar
Aspromonte MC et al (2024) DisProt in 2024: improving function annotation of intrinsically disordered proteins. Nucleic Acids Res 52(D1):D434–D441
Article PubMed PubMed Central CAS Google Scholar
Le Gall T et al (2007) Intrinsic disorder in the protein data bank. J Biomol Struct Dyn 24(4):325–342
Schad E et al (2018) DIBS: a repository of disordered binding sites mediating interactions with ordered proteins. Bioinformatics 34(3):535–537
Article PubMed PubMed Central CAS Google Scholar
Hatos A et al (2022) FuzDB: a new phase in Understanding fuzzy interactions. Nucleic Acids Res 50(D1):D509–D517
Article PubMed PubMed Central CAS Google Scholar
Ficho E et al (2017) MFIB: a repository of protein complexes with mutual folding induced by binding. Bioinformatics 33(22):3682–3684
Article PubMed PubMed Central CAS Google Scholar
Goldfarb T et al (2025) NCBI refseq: reference sequence standards through 25 years of curation and annotation. Nucleic Acids Res 53(D1):D243–D257
Article PubMed PubMed Central CAS Google Scholar
Walsh I et al (2015) Comprehensive large-scale
Comments (0)