Oral melatonin vs nitrous oxide inhalation for paediatric dental sedation: a randomised controlled ELISA-based study

Alzahrani AM, Wyne AH. Use of oral midazolam sedation in pediatric dentistry: a review. Pak Oral Dent J. 2012;32(3):444–55

Attri JP, Sharan R, Makkar V, Gupta KK, Khetarpal R, Kataria AP. Conscious sedation: emerging trends in pediatric dentistry. Anesth Essays Res. 2017;11(2):277–81.

Article  PubMed  PubMed Central  Google Scholar 

Buckinghamshire Healthcare NHS Trust. Melatonin prescribing guidance for children [Internet]. 2023 [cited 2025 Jul 1]. Available from: https://www.bucksformulary.nhs.uk/docs/Guideline_509FM.pdf

Clark MS, Brunick A. Handbook of nitrous oxide and oxygen sedation. 4th ed. St Louis (MO): Elsevier; 2015.

Google Scholar 

Coté CJ, Wilson S. Guidelines for monitoring and management of pediatric patients before, during, and after sedation for diagnostic and therapeutic procedures: update 2016. Pediatr Dent. 2016;38(4):E13-39.

Google Scholar 

Curcio WB, Abreu LG, Carrada CF, Ribeiro Scalioni FA, Ribeiro RA. Relationship between salivary cortisol levels and children’s behavior during a dental examination. J Dent Child (Chic). 2017May 15;84(2):80–5.

PubMed  Google Scholar 

Elicherla NR, Saikiran KV, Anchala K, Elicherla SR, Nuvvula S. Evaluation of the effectiveness of tell-show-do and ask-tell-ask in the management of dental fear and anxiety: a double-blinded randomized control trial. J Dent Anesth Pain Med. 2024;24(1):57–65.

Article  PubMed  PubMed Central  Google Scholar 

Golombek DA, Pévet P, Cardinali DP. Melatonin effects on behavior: possible mediation by the central GABAergic system. Neurosci Biobehav Rev. 1996;20(3):403–12.

Article  CAS  PubMed  Google Scholar 

Gupta N, Gupta A, Narayanan MRV. Current status of nitrous oxide use in pediatric patients. World J Clin Pediatr. 2022;11(2):93–104.

Article  PubMed  PubMed Central  Google Scholar 

Hellhammer DH, Wüst S, Kudielka BM. Salivary cortisol as a biomarker in stress research. Psychoneuroendocrinology. 2009;34(2):163–71.

Article  CAS  PubMed  Google Scholar 

Janjua I, Goldman RD. Sleep-related melatonin use in healthy children. Can Fam Physician. 2016;62(4):315–7.

PubMed  PubMed Central  Google Scholar 

Khinda V, Rao D, Sodhi SPS. Nitrous oxide inhalation sedation rapid analgesia in dentistry: an overview of technique, objectives, indications, advantages, monitoring, and safety profile. Int J Clin Pediatr Dent. 2023;16(1):131–8.

Article  PubMed  PubMed Central  Google Scholar 

Lane KJ, Nelson TM, Thikkurissy S, Scott JM. Assessing temperament as a predictor of oral sedation success using the Children’s Behavior Questionnaire Short Form. Pediatr Dent. 2015;37(5):429–35.

PubMed  Google Scholar 

Lapere C, Roelofse J, Omar Y, Du Plessis A, Von Backstrom A, Botha W, et al. Patient satisfaction during and following procedural sedation for ambulatory surgery. S Afr J Anaesth Analg. 2015;21(4):113–8.

Article  Google Scholar 

Logani M, Vaid P, Ravisankar K, Singh M, Singh MM, Kumar K. Comparative evaluation of anxiolytic and analgesic effects of melatonin in paediatric subjects. South Asian Res J Oral Dent Sci. 2021;3(1):1–5.

Article  Google Scholar 

Malamed SF. Handbook of local anesthesia. 7th ed. St Louis (MO): Elsevier; 2019.

Google Scholar 

Marseglia L, D’Angelo G, Manti S, et al. Analgesic, anxiolytic and anaesthetic effects of melatonin: new potential uses in pediatrics. Int J Mol Sci. 2015;16(1):1209–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Merkel SI, Voepel-Lewis T, Shayevitz JR, Malviya S. The FLACC: a behavioral scale for scoring postoperative pain in young children. Pediatr Nurs. 1997;23(3):293–7.

CAS  PubMed  Google Scholar 

Sack RL, Auckley D, Auger RR, et al. Circadian rhythm sleep disorders: Part I, basic principles, shift work and jet lag disorders. Sleep. 2007;30(11):1460–83.

Samarkandi A, Naguib M, Riad W, et al. Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study. Eur J Anaesthesiol. 2005;22(3):189–96.

Article  CAS  PubMed  Google Scholar 

Shenoy P, Etcheverry A, Ia J, Witmans M, Tablizo MA. Melatonin use in pediatrics: a clinical review on indications, multisystem effects, and toxicity. Children (Basel). 2024;11(3):323.

PubMed  Google Scholar 

Venham LL, Gaulin-Kremer E, Munster E, Bengston-Audia D, Cohan J. Interval rating scales for children’s dental anxiety and uncooperative behavior. Pediatr Dent. 1980;2(3):195–202.

CAS  PubMed  Google Scholar 

Wright GZ, Kupietzky A. Behavior management in dentistry for children. 2nd ed. Ames (IA): Wiley-Blackwell; 2014.

Book  Google Scholar 

Zisapel N. New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation. Br J Pharmacol. 2018;175(16):3190–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

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