Baigent C, Keech A, Kearney PM, Blackwell L, Buck G, Pollicino C, et al. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of Statins. Lancet. 2005;366(9493):1267–78. https://doi.org/10.1016/s0140-6736(05)67394-1.

Article  CAS  PubMed  Google Scholar 

Stone NJ, Robinson JG, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel RH, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American college of Cardiology/American heart association task force on practice guidelines. J Am Coll Cardiol. 2014;63(25 Pt B):2889–934. https://doi.org/10.1016/j.jacc.2013.11.002.

Article  PubMed  Google Scholar 

Bay B, Tanner R, Gao M, Oliva A, Sartori S, Vogel B, et al. Residual cholesterol and inflammatory risk in statin-treated patients undergoing percutaneous coronary intervention†. Eur Heart J. 2025. https://doi.org/10.1093/eurheartj/ehaf196.

Article  PubMed  Google Scholar 

Gallone G, Bellettini M, Gatti M, Tore D, Bruno F, Scudeler L, et al. Coronary plaque characteristics associated with major adverse cardiovascular events in atherosclerotic patients and lesions: a systematic review and meta-analysis. JACC: Cardiovasc Imaging. 2023;16(12):1584–604. https://doi.org/10.1016/j.jcmg.2023.08.006.

Article  PubMed  Google Scholar 

Arad Y, Spadaro LA, Roth M, Newstein D. Treatment of asymptomatic adults with elevated coronary calcium scores with atorvastatin, vitamin C, and vitamin E: the st. Francis heart study randomized clinical trial. J Am Coll Cardiol. 2005;46(1):166–72. https://doi.org/10.1016/j.jacc.2005.02.089.

Article  CAS  PubMed  Google Scholar 

Serruys PW, Hara H, Garg S, Kawashima H, Nørgaard BL, Dweck MR, et al. Coronary computed tomographic angiography for complete assessment of coronary artery disease: JACC State-of-the-Art review. J Am Coll Cardiol. 2021;78(7):713–36. https://doi.org/10.1016/j.jacc.2021.06.019.

Article  PubMed  Google Scholar 

Motoyama S, Ito H, Sarai M, Kondo T, Kawai H, Nagahara Y, et al. Plaque characterization by coronary computed tomography angiography and the likelihood of acute coronary events in mid-term follow-up. J Am Coll Cardiol. 2015;66(4):337–46. https://doi.org/10.1016/j.jacc.2015.05.069.

Article  PubMed  Google Scholar 

Abdelrahman KM, Chen MY, Dey AK, Virmani R, Finn AV, Khamis RY, et al. Coronary computed tomography angiography from clinical uses to emerging technologies: JACC State-of-the-Art review. J Am Coll Cardiol. 2020;76(10):1226–43. https://doi.org/10.1016/j.jacc.2020.06.076.

Article  PubMed  PubMed Central  Google Scholar 

Al Rifai M, Ahmed AI, Alahdab F, Al-Mallah MH. Clinical utility of coronary artery computed tomography angiography- what we know and what’s new? Prog Cardiovasc Dis. 2022;75:12–20. https://doi.org/10.1016/j.pcad.2022.10.013.

Article  PubMed  Google Scholar 

Williams MC, Kwiecinski J, Doris M, McElhinney P, D’Souza MS, Cadet S, et al. Low-attenuation noncalcified plaque on coronary computed tomography angiography predicts myocardial infarction: results from the multicenter SCOT-HEART trial (Scottish computed tomography of the HEART). Circulation. 2020;141(18):1452–62. https://doi.org/10.1161/circulationaha.119.044720.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Williams MC, Moss AJ, Dweck M, Adamson PD, Alam S, Hunter A, et al. Coronary artery plaque characteristics associated with adverse outcomes in the SCOT-HEART study. J Am Coll Cardiol. 2019;73(3):291–301. https://doi.org/10.1016/j.jacc.2018.10.066.

Article  PubMed  PubMed Central  Google Scholar 

Lee JM, Choi KH, Koo BK, Park J, Kim J, Hwang D, et al. Prognostic implications of plaque characteristics and stenosis severity in patients with coronary artery disease. J Am Coll Cardiol. 2019;73(19):2413–24. https://doi.org/10.1016/j.jacc.2019.02.060.

Article  PubMed  Google Scholar 

Sagris M, Antonopoulos AS, Simantiris S, Oikonomou E, Siasos G, Tsioufis K, et al. Pericoronary fat Attenuation index—a new imaging biomarker and its diagnostic and prognostic utility: a systematic review and meta-analysis. Eur Heart J - Cardiovasc Imaging. 2022;23(12):e526–36. https://doi.org/10.1093/ehjci/jeac174.

Article  PubMed  PubMed Central  Google Scholar 

Satny M, Hubacek JA, Vrablik M. Statins and inflammation. Curr Atheroscler Rep. 2021;23(12):80. https://doi.org/10.1007/s11883-021-00977-6.

Article  CAS  PubMed  Google Scholar 

Vogiatzi G, Oikonomou E, Siasos G, Tsalamandris S, Briasoulis A, Androulakis E, et al. Statins and inflammation in cardiovascular disease. Curr Pharm Des. 2017. https://doi.org/10.2174/1381612823666171009141201.

Article  PubMed  Google Scholar 

Liberale L, Carbone F, Montecucco F, Sahebkar A. Statins reduce vascular inflammation in atherogenesis: a review of underlying molecular mechanisms. Int J Biochem Cell Biol. 2020;122:105735. https://doi.org/10.1016/j.biocel.2020.105735.

Article  CAS  PubMed  Google Scholar 

Libby P. Inflammation during the life cycle of the atherosclerotic plaque. Cardiovasc Res. 2021;117(13):2525–36. https://doi.org/10.1093/cvr/cvab303.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Andelius L, Mortensen MB, Nørgaard BL, Abdulla J. Impact of statin therapy on coronary plaque burden and composition assessed by coronary computed tomographic angiography: a systematic review and meta-analysis. Eur Heart J Cardiovasc Imaging. 2018;19(8):850–8. https://doi.org/10.1093/ehjci/jey012.

Article  PubMed  Google Scholar 

Lee SE, Chang HJ, Sung JM, Park HB, Heo R, Rizvi A, et al. Effects of Statins on coronary atherosclerotic plaques: the PARADIGM study. JACC Cardiovasc Imaging. 2018;11(10):1475–84. https://doi.org/10.1016/j.jcmg.2018.04.015.

Article  PubMed  Google Scholar 

Weichsel L, André F, Renker M, Breitbart P, Overhoff D, Beer M, et al. Effects of high- versus low-intensity lipid-lowering treatment in patients undergoing serial coronary computed tomography angiography: results of the multi-center LOCATE study. Clin Res Cardiol. 2024. https://doi.org/10.1007/s00392-024-02502-6.

Article  PubMed  Google Scholar 

Inoue K, Motoyama S, Sarai M, Sato T, Harigaya H, Hara T, et al. Serial coronary CT Angiography–Verified changes in plaque characteristics as an end point: evaluation of effect of Statin intervention. JACC: Cardiovasc Imaging. 2010;3(7):691–8. https://doi.org/10.1016/j.jcmg.2010.04.011.

Article  PubMed  Google Scholar 

Zeb I, Li D, Nasir K, Malpeso J, Batool A, Flores F, et al. Effect of statin treatment on coronary plaque progression - a serial coronary CT angiography study. Atherosclerosis. 2013;231(2):198–204. https://doi.org/10.1016/j.atherosclerosis.2013.08.019.

Article  CAS  PubMed  Google Scholar 

Wen D, Zhao H, Zhong S, Li C, Liu B, An R, et al. Diagnostic performance of corrected FFR(CT) metrics to predict hemodynamically significant coronary artery stenosis. Eur Radiol. 2021;31(12):9232–9. https://doi.org/10.1007/s00330-021-08064-9.

Article  PubMed  Google Scholar 

Lan Z, Ding X, Yu Y, Yu L, Yang W, Dai X, et al. CT-derived fractional flow reserve for prediction of major adverse cardiovascular events in diabetic patients. Cardiovasc Diabetol. 2023;22(1):65. https://doi.org/10.1186/s12933-023-01801-y.

Article  PubMed  PubMed Central  Google Scholar 

Li Z, Xu T, Wang Z, Ding Y, Zhang Y, Lin L, et al. Prognostic significance of computed tomography-derived fractional flow reserve for long-term outcomes in individuals with coronary artery disease. J Am Heart Assoc. 2025;14(2):e037988. https://doi.org/10.1161/jaha.124.037988.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu M, Dai X, Yu L, Lu Z, Shen C, Tao X, et al. Hemodynamic change of coronary atherosclerotic plaque after statin treatment: a serial follow-up study by computed tomography-derived fractional flow reserve. J Am Heart Assoc. 2020;9(10):e015772. https://doi.org/10.1161/jaha.120.015772.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mortensen MB, Sand NP, Busk M, Jensen JM, Grove EL, Dey D, et al. Influence of intensive lipid-lowering on CT derived fractional flow reserve in patients with stable chest pain: rationale and design of the FLOWPROMOTE study. Clin Cardiol. 2022;45(10):986–94. https://doi.org/10.1002/clc.23895.

Article  PubMed  PubMed Central  Google Scholar 

Dai X, Yu L, Lu Z, Shen C, Tao X, Zhang J. Serial change of perivascular fat attenuati