Rheumatoid arthritis exacerbates apical periodontitis in Wistar rats, increasing IL-17, TNF-α, TRAP, and RANKL levels

Helmick CG, Felson DT, Lawrence RC, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I. Arthritis Rheum. 2008;58(1):15–25.

PubMed  Google Scholar 

Myasoedova E, Crowson CS, Kremers HM, et al. Is the incidence of rheumatoid arthritis rising?: results from Olmsted County, Minnesota, 1955–2007. Arthritis Rheum. 2010;62(6):1576–82.

PubMed  PubMed Central  Google Scholar 

Huang J, Fu X, Chen X, et al. Promising therapeutic targets for treatment of rheumatoid arthritis. Front Immunol. 2021;12: 686155.

PubMed  PubMed Central  CAS  Google Scholar 

Culshaw S, Mcinnes IB, Liew FY. What can the periodontal community learn from the pathophysiology of rheumatoid arthritis? J Clin Periodontol. 2011;38:106–13.

PubMed  Google Scholar 

Firestein GS. Evolving concepts of rheumatoid arthritis. Nature. 2003;423(6937):356–61.

PubMed  CAS  Google Scholar 

Scott DL, Wolfe F, Huizinga TWJ. Rheumatoid arthritis. Lancet. 2010;376:1094–108.

PubMed  Google Scholar 

Van Delft MA, Huizinga TW. An overview of autoantibodies in rheumatoid arthritis. J Autoimmun. 2020;110:102392.

PubMed  Google Scholar 

Gierut A, Perlman H, Pope RM. Innate immunity and rheumatoid arthritis. Rheum Dis Clin North Am. 2010;36(2):271–96.

PubMed  PubMed Central  Google Scholar 

Billings F. Chronic focal infections and their etiologic relations to arthritis and nephritis. Arch Intern Med. 1912;9:484–98.

Google Scholar 

Goadby KW. The association of disease of the mouth with rheumatoid arthritis and certain other forms of rheumatism. Lancet. 1911;1:639–49.

Google Scholar 

Shandalow SL. Oral focal sepsis in relation to systemic disease. Dent Cosmos. 1928;70:609–18.

Google Scholar 

Cecil RL, Nicholls EE, Stainsby WJ. The bacteriology of the blood and joints in chronic infectious arthritis. Arch Intern Med. 1929;43:571–605.

Google Scholar 

Cintra LTA, Gomes MS, da Silva CC, et al. Evolution of endodontic medicine: a critical narrative review of the interrelationship between endodontics and systemic pathological conditions. Odontology. 2021;109(4):741–69.

PubMed  Google Scholar 

González DA, Bianchi ML, Salgado PA, et al. Disease activity and subcutaneous nodules are associated with severe periodontitis in patients with rheumatoid arthritis. Rheumatol Int. 2022;42(8):1331–9.

PubMed  Google Scholar 

Renvert S, Berglund JS, Persson GR, et al. The association between rheumatoid arthritis and periodontal disease in a population-based cross-sectional case-control study. BMC Rheumatol. 2020;20(4):31.

Google Scholar 

Martinez-Martinez RE, Abud-Mendoza C, Patino-Marin N, et al. Detection of periodontal bacterial DNA in serum and synovial fluid in refractory rheumatoid arthritis patients. J Clin Periodontol. 2009;36(12):1004–10.

PubMed  CAS  Google Scholar 

Hirano T. Interleukin 6 in autoimmune and inflammatory diseases: a personal memoir. Proc Jpn Acad Ser B Phys Biol Sci. 2010;86(7):717–30.

PubMed  PubMed Central  CAS  Google Scholar 

Noh M, Jung M, Kim S, et al. Assessment of IL-6, IL-8, and TNF-α levels in the gingival tissue of patients with periodontitis. Exp Ther Med. 2013;6(3):847–51.

PubMed  PubMed Central  CAS  Google Scholar 

Sakaguchi W, To M, Yamamoto Y, et al. Detection of anti-citrullinated protein antibody (ACPA) in saliva for rheumatoid arthritis using DBA mice infected with Porphyromonas gingivalis. Arch Oral Biol. 2019;108: 104510.

PubMed  CAS  Google Scholar 

Samborska-Mazur J, Sikorska D, Wyganowska-Świątkowska M. The relationship between periodontal status and rheumatoid arthritis - systematic review. Reumatologia. 2020;58(4):236–42.

PubMed  PubMed Central  Google Scholar 

Segura-Egea JJ, Martín-González J, Castellanos-Cosano L. Endodontic medicine: connections between apical periodontitis and systemic diseases. Int Endod J. 2015;48(10):933–51.

PubMed  CAS  Google Scholar 

Cintra LTA, Estrela C, Azuma MM, Queiroz ÍOA, et al. Endodontic medicine: interrelationships among apical periodontitis, systemic disorders, and tissue responses of dental materials. Braz Oral Res. 2018;32(suppl 1): e68.

PubMed  Google Scholar 

Yamasaki M, Kumazawa M, Kohsaka T, et al. Reações do tecido pulpar e periapical após exposição pulpar experimental em ratos. J Endod. 1994;20:13–7.

PubMed  CAS  Google Scholar 

Kakehashi S, Stanley HR, Fitzgerald RJ. Os efeitos das exposições cirúrgicas de polpas dentárias em ratos de laboratório convencionais e livres de germes. Oral Surg Oral Med Oral Pathol. 1965;20:340–9.

PubMed  CAS  Google Scholar 

Jakovljevic A, Knezevic A, Karalic D, et al. Pro-inflammatory cytokine levels in human apical periodontitis: correlation with clinical and histological findings. Aust Endod J. 2015;41(2):72–7.

PubMed  Google Scholar 

Korn T, Bettelli E, Gao W, et al. IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells. Nature. 2007;448(7152):484–7.

PubMed  PubMed Central  CAS  Google Scholar 

Ajuz NC, Antunes H, Mendonça TA, et al. Immunoexpression of interleukin 17 in apical periodontitis lesions. J Endod. 2014;40(9):1400–3.

PubMed  Google Scholar 

Marçal JR, Samuel RO, Fernandes D, et al. T-helper cell type 17/regulatory T-cell immunoregulatory balance in human radicular cysts and periapical granulomas. J Endod. 2010;36(6):995–9.

PubMed  Google Scholar 

Henriques LC, de Brito LC, Tavares WL, et al. Cytokine analysis in lesions refractory to endodontic treatment. J Endod. 2011;37(12):1659–62.

PubMed  Google Scholar 

Ferreira LG, Rosin FC, Corrêa L. Analysis of interleukin 17A in periapical abscess and granuloma lesions. Braz Oral Res. 2016;30:1–9.

Google Scholar 

Karataş E, Kul A, Tepecik E. Association between rheumatoid arthritis and apical periodontitis: a cross-sectional study. Eur Endod J. 2020;5(2):155–8.

PubMed  PubMed Central  Google Scholar 

de Araujo BMM, de Miranda BM, Kowaltschuk TC, et al. Impact of chronic diseases on the periapical health of endodontically treated teeth: A systematic review and meta-analysis. PLoS ONE. 2024;19(2): e0297020.

PubMed  PubMed Central  Google Scholar 

Damiani BAM, Pinto KP, Ferreira CMA, et al. Apical periodontitis as an aggravating factor for the severity of rheumatoid arthritis: an animal study. Int Endod J. 2024;57(11):1669–81.

PubMed  Google Scholar 

Ebersole JL, Cappelli D. Acute-phase reactants in infections and inflammatory diseases. Periodontol 2000. 2000;23:19–49.

PubMed  CAS  Google Scholar 

Percie du Sert N, Hurst V, Ahluwalia A, et al. The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. PLoS Biol. 2020;18(7):e3000410.

PubMed  PubMed Central  CAS  Google Scholar 

Azuma MM, Gomes-Filho JE, Prieto AKC, et al. Diabetes increases interleukin-17 levels in periapical, hepatic, and renal tissues in rats. Arch Oral Biol. 2017;83:230–5.

PubMed  CAS  Google Scholar 

Conti LC, Segura-Egea JJ, Cardoso CBM, et al. Relationship between apical periodontitis and atherosclerosis in rats: lipid profile and histological study. Int Endod J. 2020;53(10):1387–97.

PubMed  CAS  Google Scholar 

Cantiga-Silva C, de Oliveira PHC, Faria FD, et al. Increase in Toll-like receptors 2 and 4 in apical periodontitis of rats with chronic liver disease. Odontology. 2025;113:296–304.

PubMed  CAS  Google Scholar 

Oliveira AA, Martins FM, Furlanetto Júnior R, et al. Rheumatoid arthritis-increased gene expressions in muscle atrophy are restored back to control as a response to acute resistance exercise. Rev Bras Cienc e Mov. 2018;26(2):24–33.

Google Scholar 

Cintra LT, da Silva Facundo AC, Prieto AK, et al. Blood profile and histology in oral infections associated with diabetes. J Endod. 2014;40(8):1139–44.

PubMed  Google Scholar 

Cintra LT, Samuel RO, Azuma MM, et al. Multiple apical periodontitis influences serum levels of cytokines and nitric oxide. J Endod. 2016;42(5):747–51.

PubMed  Google Scholar 

Cintra LT, da Silva Facundo AC, Azuma MM, et al. Pulpal and periodontal diseases increase triglyceride levels in diabetic rats. Clin Oral Investig. 2013;17(6):1595–9.

PubMed  Google Scholar 

Azuma MM, Gomes-Filho JE, Ervolino E, et al. Omega-3 fatty acids reduce bone resorption while promoting bone generation in rat apical periodontitis. J Endod. 2017;43(6):970–6.

PubMed  Google Scholar 

Gomes-Filho JE, Wayama MT, Dornelles RC, et al. Effect of raloxifene on periapical lesions in ovariectomized rats. J Endod. 2015;41:671–5.

Comments (0)

No login
gif