Huang WJ, Liu WJ, Xiao YH, Zheng HJ, Xiao Y, Jia Q, et al. Tripterygium and its extracts for diabetic nephropathy: efficacy and pharmacological mechanisms. Biomed Pharmacother. 2020;121: 109599. https://doi.org/10.1016/j.biopha.2019.109599.
Article CAS PubMed Google Scholar
Lv H, Jiang L, Zhu M, Li Y, Luo M, Jiang P, et al. The genus Tripterygium: a phytochemistry and pharmacological review. Fitoterapia. 2019;137: 104190. https://doi.org/10.1016/j.fitote.2019.104190.
Article CAS PubMed Google Scholar
Song J, He GN, Dai L. A comprehensive review on celastrol, triptolide and triptonide: insights on their pharmacological activity, toxicity, combination therapy, new dosage form and novel drug delivery routes. Biomed Pharmacother. 2023;162: 114705. https://doi.org/10.1016/j.biopha.2023.114705.
Article CAS PubMed Google Scholar
Tong L, Zhao Q, Datan E, Lin GQ, Minn I, Pomper MG, et al. Triptolide: reflections on two decades of research and prospects for the future. Nat Prod Rep. 2021;38:843–60. https://doi.org/10.1039/d0np00054j.
Article CAS PubMed Google Scholar
Lu Y, Liu Y, Zhou J, Li D, Gao W. Biosynthesis, total synthesis, structural modifications, bioactivity, and mechanism of action of the quinone-methide triterpenoid celastrol. Med Res Rev. 2021;41:1022–60. https://doi.org/10.1002/med.21751.
Article CAS PubMed Google Scholar
Corson TW, Crews CM. Molecular understanding and modern application of traditional medicines: triumphs and trials. Cell. 2007;130:769–74. https://doi.org/10.1016/j.cell.2007.08.021.
Article CAS PubMed PubMed Central Google Scholar
Annesley SJ, Fisher PR. Mitochondria in health and disease. Cells. 2019;8(7):680. https://doi.org/10.3390/cells8070680.
Article CAS PubMed PubMed Central Google Scholar
Bock FJ, Tait SWG. Mitochondria as multifaceted regulators of cell death. Nat Rev Mol Cell Biol. 2020;21:85–100. https://doi.org/10.1038/s41580-019-0173-8.
Article CAS PubMed Google Scholar
Benador IY, Veliova M, Liesa M, Shirihai OS. Mitochondria bound to lipid droplets: where mitochondrial dynamics regulate lipid storage and utilization. Cell Metab. 2019;29:827–35. https://doi.org/10.1016/j.cmet.2019.02.011.
Article CAS PubMed PubMed Central Google Scholar
Rocca C, Soda T, De Francesco EM, Fiorillo M, Moccia F, Viglietto G, et al. Mitochondrial dysfunction at the crossroad of cardiovascular diseases and cancer. J Transl Med. 2023;21:635. https://doi.org/10.1186/s12967-023-04498-5.
Article PubMed PubMed Central Google Scholar
Chan DC. Mitochondrial dynamics and its involvement in disease. Annu Rev Pathol. 2020;15:235–59. https://doi.org/10.1146/annurev-pathmechdis-012419-032711.
Article CAS PubMed Google Scholar
Tadokoro T, Ikeda M, Ide T, Deguchi H, Ikeda S, Okabe K, et al. Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity. JCI Insight. 2023;8(6):e169756. https://doi.org/10.1172/jci.insight.169756.
Article PubMed PubMed Central Google Scholar
Peng SZ, Chen XH, Chen SJ, Zhang J, Wang CY, Liu WR, et al. Phase separation of Nur77 mediates celastrol-induced mitophagy by promoting the liquidity of p62/SQSTM1 condensates. Nat Commun. 2021;12:5989. https://doi.org/10.1038/s41467-021-26295-8.
Article CAS PubMed PubMed Central Google Scholar
Chen X, Zhao Y, Luo W, Chen S, Lin F, Zhang X, et al. Celastrol induces ROS-mediated apoptosis via directly targeting peroxiredoxin-2 in gastric cancer cells. Theranostics. 2020;10:10290–308. https://doi.org/10.7150/thno.46728.
Article CAS PubMed PubMed Central Google Scholar
Xi C, Peng S, Wu Z, Zhou Q, Zhou J. Toxicity of triptolide and the molecular mechanisms involved. Biomed Pharmacother. 2017;90:531–41. https://doi.org/10.1016/j.biopha.2017.04.003.
Article CAS PubMed Google Scholar
Zhang Y, Mao X, Li W, Chen W, Wang X, Ma Z, et al. Tripterygium wilfordii: an inspiring resource for rheumatoid arthritis treatment. Med Res Rev. 2021;41:1337–74. https://doi.org/10.1002/med.21762.
Tong X, Qiao Y, Yang Y, Liu H, Cao Z, Yang B, et al. Applications and mechanisms of Tripterygium Wilfordii Hook F and its preparations in kidney diseases. Front Pharmacol. 2022;13:846746. https://doi.org/10.3389/fphar.2022.846746.
Article CAS PubMed PubMed Central Google Scholar
Lou D, Xu W. [Immunoregulatory effects of monomer T4 from Tripterygium wilfordii hook. I. Immunoregulatory effects of T4 on NK activity of mouse splenocytes]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 1990;12:115–20.
Wang C, Dai S, Zhao X, Zhang Y, Gong L, Fu K, et al. Celastrol as an emerging anticancer agent: current status, challenges and therapeutic strategies. Biomed Pharmacother. 2023;163: 114882. https://doi.org/10.1016/j.biopha.2023.114882.
Article CAS PubMed Google Scholar
Wu J, Zhou Y, Wang L, Zuo J, Zhao W. Terpenoids from root bark of Celastrus orbiculatus. Phytochemistry. 2012;75:159–68. https://doi.org/10.1016/j.phytochem.2011.11.023.
Article CAS PubMed Google Scholar
Hou W, Liu B, Xu H. Celastrol: Progresses in structure-modifications, structure-activity relationships, pharmacology and toxicology. Eur J Med Chem. 2020;189: 112081. https://doi.org/10.1016/j.ejmech.2020.112081.
Article CAS PubMed Google Scholar
Yang J, He B, Dang L, Liu J, Liu G, Zhao Y, et al. Celastrol regulates the Hsp90-NLRP3 interaction to alleviate rheumatoid arthritis. Inflammation. 2025;48:346–60. https://doi.org/10.1007/s10753-024-02060-z.
Article CAS PubMed Google Scholar
Yu X, Meng X, Xu M, Zhang X, Zhang Y, Ding G, et al. Celastrol ameliorates cisplatin nephrotoxicity by inhibiting NF-kappaB and improving mitochondrial function. EBioMedicine. 2018;36:266–80. https://doi.org/10.1016/j.ebiom.2018.09.031.
Article PubMed PubMed Central Google Scholar
Kupchan SM, Court WA, Dailey RG Jr, Gilmore CJ, Bryan RF. Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii. J Am Chem Soc. 1972;94:7194–5. https://doi.org/10.1021/ja00775a078.
Article CAS PubMed Google Scholar
Noel P, Von Hoff DD, Saluja AK, Velagapudi M, Borazanci E, Han H. Triptolide and its derivatives as cancer therapies. Trends Pharmacol Sci. 2019;40:327–41. https://doi.org/10.1016/j.tips.2019.03.002.
Article CAS PubMed Google Scholar
Yuan K, Li X, Lu Q, Zhu Q, Jiang H, Wang T, et al. Application and mechanisms of triptolide in the treatment of inflammatory diseases-a review. Front Pharmacol. 2019;10:1469. https://doi.org/10.3389/fphar.2019.01469.
Article CAS PubMed PubMed Central Google Scholar
Wang X, Ni T, Miao J, Huang X, Feng Z. The role and mechanism of triptolide, a potential new DMARD, in the treatment of rheumatoid arthritis. Ageing Res Rev. 2025;104: 102643. https://doi.org/10.1016/j.arr.2024.102643.
Article CAS PubMed Google Scholar
Patil S, Lis LG, Schumacher RJ, Norris BJ, Morgan ML, Cuellar RA, et al. Phosphonooxymethyl prodrug of triptolide: synthesis, physicochemical characterization, and efficacy in human colon adenocarcinoma and ovarian cancer xenografts. J Med Chem. 2015;58:9334–44. https://doi.org/10.1021/acs.jmedchem.5b01329.
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