Humbert M, Kovacs G, Hoeper MM, Badagliacca R, Berger RMF, Brida M, et al. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J. 2022;43:3618–731. https://doi.org/10.1093/eurheartj/ehac237.

Article  PubMed  CAS  Google Scholar 

Fukuda K, Date H, Doi S, Fukumoto Y, Fukushima N, Hatano M, et al. Guidelines for the treatment of pulmonary hypertension (JCS 2017/JPCPHS 2017). Circ J. 2019;83:842–945. https://doi.org/10.1253/circj.CJ-66-0158.

Article  PubMed  Google Scholar 

Yang J, Madani MM, Mahmud E, Kim NH. Evaluation and management of chronic thromboembolic pulmonary hypertension. Chest. 2023;164:490–502. https://doi.org/10.1016/j.chest.2023.03.029.

Article  PubMed  PubMed Central  Google Scholar 

Tunariu N, Gibbs SJR, Win Z, Gin-Sing W, Graham A, Gishen P, et al. Ventilation-perfusion scintigraphy is more sensitive than multidetector CTPA in detecting chronic thromboembolic pulmonary disease as a treatable cause of pulmonary hypertension. J Nucl Med. 2007;48:680–4. https://doi.org/10.2967/jnumed.106.039438.

Article  PubMed  Google Scholar 

Gutte H, Mortensen J, Jensen CV, von der Recke P, Petersen CL, Kristoffersen US, et al. Comparison of V/Q SPECT and planar V/Q lung scintigraphy in diagnosing acute pulmonary embolism. Nucl Med Commun. 2010;31:82–6. https://doi.org/10.1097/MNM.0b013e3283336747.

Article  PubMed  Google Scholar 

Stubbs M, Chan K, McMeekin H, Navalkissoor S, Wagner T. Incidence of a single subsegmental mismatched perfusion defect in single-photon emission computed tomography and planar ventilation/perfusion scans. Nucl Med Commun. 2017;38:135–40. https://doi.org/10.1097/MNM.0000000000000632.

Article  PubMed  Google Scholar 

Wang L, Wang M, Yang T, Wu D, Xiong C, Fang W. A prospective, comparative study of ventilation-perfusion planar imaging and ventilation-perfusion SPECT for chronic thromboembolic pulmonary hypertension. J Nucl Med. 2020;61:1832–8. https://doi.org/10.2967/jnumed.120.243188.

Article  PubMed  CAS  Google Scholar 

Chan K, Ioannidis S, Coghlan JG, Hall M, Schreiber BE. Pulmonary arterial hypertension with abnormal V/Q single-photon emission computed tomography. JACC Cardiovasc Imaging. 2018;11:1487–93. https://doi.org/10.1016/j.jcmg.2017.07.026.

Article  PubMed  Google Scholar 

Bajc M, Schümichen C, Grüning T, Lindqvist A, Le Roux PY, Alatri A, et al. EANM guideline for ventilation/perfusion single-photon emission computed tomography (SPECT) for diagnosis of pulmonary embolism and beyond. Eur J Nucl Med Mol Imaging. 2019;46:2429–51. https://doi.org/10.1007/s00259-019-04450-0.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hoeper MM, Madani MM, Nakanishi N, Meyer B, Cebotari S, Rubin LJ. Chronic thromboembolic pulmonary hypertension. Lancet Respir Med. 2014;2:573–82. https://doi.org/10.1016/S2213-2600(14)70089-X.

Article  PubMed  Google Scholar 

Gopalan D, Delcroix M, Held M. Diagnosis of chronic thromboembolic pulmonary hypertension. Eur Respir Rev. 2017;26:160108. https://doi.org/10.1183/16000617.0108-2016.

Article  PubMed  PubMed Central  Google Scholar 

Guérin L, Couturaud F, Parent F, Revel MP, Gillaizeau F, Planquette B, et al. Prevalence of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism. prevalence of CTEPH after pulmonary embolism. Thromb Haemost. 2014;112:598–605. https://doi.org/10.1160/TH13-07-0538.

Article  PubMed  CAS  Google Scholar 

Kayaalp I, Varol Y, Çimen P, Demirci Üçsular F, Katgı N, Ünlü M, et al. The incidence of chronic thromboembolic pulmonary hypertension secondary to acute pulmonary thromboembolism. Tuberk Toraks. 2014;62:199–206. https://doi.org/10.5578/tt.7717.

Article  PubMed  Google Scholar 

Lang IM, Pesavento R, Bonderman D, Yuan JXJ. Risk factors and basic mechanisms of chronic thromboembolic pulmonary hypertension: a current understanding. Eur Respir J. 2013;41:462–8. https://doi.org/10.1183/09031936.00049312.

Article  PubMed  Google Scholar 

Sugimura K, Fukumoto Y, Satoh K, Nochioka K, Miura Y, Aoki T, et al. Percutaneous transluminal pulmonary angioplasty markedly improves pulmonary hemodynamics and longterm prognosis in patients with chronic thromboembolic pulmonary hypertension. Circ J. 2012;76:485–8. https://doi.org/10.1253/circj.cj-11-1217.

Article  PubMed  Google Scholar 

Mizoguchi H, Ogawa A, Munemasa M, Mikouchi H, Ito H, Matsubara H. Refined balloon pulmonary angioplasty for inoperable patients with chronic thromboembolic pulmonary hypertension. Circ Cardiovasc Interv. 2012;5:748–55. https://doi.org/10.1161/CIRCINTERVENTIONS.112.971077.

Article  PubMed  Google Scholar 

Kataoka M, Inami T, Hayashida K, Shimura N, Ishiguro H, Abe T, et al. Percutaneous transluminal pulmonary angioplasty for the treatment of chronic thromboembolic pulmonary hypertension. Circ Cardiovasc Interv. 2012;5:756–62. https://doi.org/10.1161/CIRCINTERVENTIONS.112.971390.

Article  PubMed  Google Scholar 

Jögi J, Jonson B, Ekberg M, Bajc M. Ventilation-perfusion SPECT with 99mTc-DTPA versus technegas: a head-to-head study in obstructive and nonobstructive disease. J Nucl Med. 2010;51:735–41. https://doi.org/10.2967/jnumed.109.073957.

Article  PubMed  Google Scholar 

Burch WM, Tetley IJ, Gras JL. Technetium-99m “pseudogas” for diagnostic studies in the lung. Clin Phys Physiol Meas. 1984;5:79–85. https://doi.org/10.1088/0143-0815/5/2/003.

Article  PubMed  CAS  Google Scholar 

Lemb M, Oei TH, Eifert H, Günther B. Technegas: a study of particle structure, size and distribution. Eur J Nucl Med. 1993;20:576–9. https://doi.org/10.1007/BF00176550.

Article  PubMed  CAS  Google Scholar 

Heck LL, Duley JW Jr. Statistical considerations in lung imaging with 99mTc albumin particles. Radiology. 1974;113:675–9. https://doi.org/10.1148/113.3.675.

Article  PubMed  CAS  Google Scholar 

Bhuyan U, Peters AM, Gordon I, Davies H, Helms P. Effects of posture on the distribution of pulmonary ventilation and perfusion in children and adults. Thorax. 1989;44:480–4. https://doi.org/10.1136/thx.44.6.480.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Rich JD, Rich S. Clinical diagnosis of pulmonary hypertension. Circulation. 2014;130:1820–30. https://doi.org/10.1161/CIRCULATIONAHA.114.006971.

Article  PubMed  Google Scholar 

Konstantinides SV, Meyer G, Becattini C, Bueno H, Geersing GJ, Harjola VP, et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). Eur Heart J. 2020;41:543–603. https://doi.org/10.1093/eurheartj/ehz405.

Article  PubMed  Google Scholar 

Le Pennec R, Tromeur C, Orione C, Robin P, Le Mao R, De Moreuil C, et al. Lung ventilation/perfusion scintigraphy for the screening of chronic thromboembolic pulmonary hypertension (CTEPH): which criteria to use? Front Med (Lausanne). 2022;9:851935. https://doi.org/10.3389/fmed.2022.851935.

Article  PubMed  Google Scholar 

Ogawa Y, Nishimura T, Hayashida K, Uehara T, Shimonagata T. Perfusion lung scintigraphy in primary pulmonary hypertension. Br J Radiol. 1993;66:677–80. https://doi.org/10.1259/0007-1285-66-788-677.

Article  PubMed  CAS  Google Scholar 

Lisbona R, Kreisman H, Novales-Diaz J, Derbekyan V. Perfusion lung scanning: differentiation of primary from thromboembolic pulmonary hypertension. AJR Am J Roentgenol. 1985;144:27–30. https://doi.org/10.2214/ajr.144.1.27.

Article  PubMed  CAS  Google Scholar 

Powe JE, Palevsky HI, McCarthy KE, Alavi A. Pulmonary arterial hypertension: value of perfusion scintigraphy. Radiology. 1987;164:727–30. https://doi.org/10.1148/radiology.164.3.3615869.

Article  PubMed  CAS  Google Scholar 

Worsley DF, Palevsky HI, Alavi A. Ventilation-perfusion lung scanning in the evaluation of pulmonary hypertension. J Nucl Med. 1994;35:793–6.

PubMed  CAS