Ephrin-A5 or EphA7 stimulation is anti-proliferative for human rhabdomyosarcoma in vitro

Ognjanovic S, Linabery AM, Charbonneau B, Ross JA. Trends in childhood rhabdomyosarcoma incidence and survival in the united States, 1975–2005. Cancer. 2009;115:4218–26.

Article  PubMed  Google Scholar 

Moore O, Grossi C. Embryonal rhabdomyosarcoma of the head and neck. Cancer. 1959;12:69–73.

Article  CAS  PubMed  Google Scholar 

Enterline HT, Horn RC. Alveolar rhabdomyosarcoma; a distinctive tumor type. Am J Clin Pathol. 1958;29:356–66.

Article  CAS  PubMed  Google Scholar 

Loh WE, Scrable HJ, Livanos E, et al. Human chromosome 11 contains two different growth suppressor genes for embryonal rhabdomyosarcoma. Proc Natl Acad Sci U S A. 1992;89:1755–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parham DM, Barr FG. Classification of rhabdomyosarcoma and its molecular basis. Adv Anat Pathol. 2013;20:387–97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xia SJ, Pressey JG, Barr FG. Molecular pathogenesis of rhabdomyosarcoma. Cancer Biol Ther. 2002;1:97–104.

Article  CAS  PubMed  Google Scholar 

Gurney JG, Davis S, Severson RK, Fang JY, Ross JA, Robison LL. Trends in cancer incidence among children in the U.S. Cancer. 1996;78:532–41.

Article  CAS  PubMed  Google Scholar 

Galili N, Davis RJ, Fredericks WJ, et al. Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma. Nat Genet. 1993;5:230–5.

Article  CAS  PubMed  Google Scholar 

Shapiro DN, Sublett JE, Li B, Downing JR, Naeve CW. Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma. Cancer Res. 1993;53:5108–12.

CAS  PubMed  Google Scholar 

Barr FG. Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma. Oncogene. 2001;20:5736–46.

Article  CAS  PubMed  Google Scholar 

Stout AP. Rhabdomyosarcoma of the skeletal muscles. Ann Surg. 1946;123:447–72.

Article  PubMed  PubMed Central  Google Scholar 

Abraham J, Nunez-Alvarez Y, Hettmer S, et al. Lineage of origin in rhabdomyosarcoma informs Pharmacological response. Genes Dev. 2014;28:1578–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hatley ME, Tang W, Garcia MR, et al. A mouse model of rhabdomyosarcoma originating from the adipocyte lineage. Cancer Cell. 2012;22:536–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mansouri A. The role of Pax3 and Pax7 in development and cancer. Crit Rev Oncog. 1998;9:141–9.

Article  CAS  PubMed  Google Scholar 

Sebire NJ, Malone M. Myogenin and MyoD1 expression in paediatric rhabdomyosarcomas. J Clin Pathol. 2003;56:412–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Strickland S, Mahdavi V. The induction of differentiation in teratocarcinoma stem cells by retinoic acid. Cell. 1978;15:393–403.

Article  CAS  PubMed  Google Scholar 

Madan V, Koeffler HP. Differentiation therapy of myeloid leukemia: four decades of development. Haematologica. 2021;106:26–38.

CAS  PubMed  Google Scholar 

Nagai Y, Ambinder AJ. The promise of retinoids in the treatment of cancer: neither burnt out nor fading away. Cancers (Basel). 2023;15:3535.

Article  CAS  PubMed  Google Scholar 

Makimoto A, Fujisaki H, Matsumoto K, et al. Retinoid therapy for neuroblastoma: historical overview, regulatory challenges, and prospects. Cancers (Basel). 2024;16:544.

Article  CAS  PubMed  Google Scholar 

Cruz FD, Matushansky I. Solid tumor differentiation therapy - is it possible? Oncotarget. 2012;3:559–67.

Article  PubMed  Google Scholar 

Chen Y, Cao J, Zhang N, et al. Advances in differentiation therapy for osteosarcoma. Drug Discov Today. 2020;25:497–504.

Article  CAS  PubMed  Google Scholar 

Bar-Hai N, Ishay-Ronen D. Engaging plasticity: differentiation therapy in solid tumors. Front Pharmacol. 2022;13:944773.

Article  PubMed  PubMed Central  Google Scholar 

Frisen J, Holmberg J, Barbacid M. Ephrins and their Eph receptors: multitalented directors of embryonic development. EMBO J. 1999;18:5159–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Davis S, Gale NW, Aldrich TH, et al. Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. Science. 1994;266:816–9.

Article  CAS  PubMed  Google Scholar 

Pandey A, Lindberg RA, Dixit VM. Cell signalling. Receptor orphans find a family. Curr Biol. 1995;5:986–9.

Article  CAS  PubMed  Google Scholar 

Egea J, Klein R. Bidirectional Eph-ephrin signaling during axon guidance. Trends Cell Biol. 2007;17:230–8.

Article  CAS  PubMed  Google Scholar 

Wu Z, Ashlin TG, Xu Q, Wilkinson DG. Role of forward and reverse signaling in Eph receptor and Ephrin mediated cell segregation. Exp Cell Res. 2019;381:57–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dai D, Huang Q, Nussinov R, Ma B. Promiscuous and specific recognition among Ephrins and Eph receptors. Biochim Biophys Acta. 2014;1844:1729–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Himanen JP, Saha N, Nikolov DB. Cell-cell signaling via Eph receptors and Ephrins. Curr Opin Cell Biol. 2007;19:534–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pasquale EB. Eph receptors and Ephrins in cancer progression. Nat Rev Cancer. 2024;24:5–27.

Article  CAS  PubMed  Google Scholar 

Kandouz M. The Eph/Ephrin family in cancer metastasis: communication at the service of invasion. Cancer Metastasis Rev. 2012;31:353–73.

Article  CAS  PubMed  Google Scholar 

Chen J. Regulation of tumor initiation and metastatic progression by Eph receptor tyrosine kinases. Adv Cancer Res. 2012;114:1–20.

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