Akashi K, Traver D, Miyamoto T, Weissman IL (2000) A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404(6774):193–7

Article  CAS  PubMed  Google Scholar 

Arranz L, Sánchez-Aguilera A, Martín-Pérez D, Isern J, Langa X, Tzankov A, Lundberg P, Muntion S, Tzeng YS, Lai DM, Schwaller Jskoda RC, Mendez-Ferrer S (2014) Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms. Nature 512(7512):78–81. https://doi.org/10.1038/nature13383

Article  CAS  PubMed  Google Scholar 

Bianchi ME, Mezzapelle R (2020) The chemokine receptor CXCR4 in cell proliferation and tissue regeneration. Front Immunol 11:2109. https://doi.org/10.3389/fimmu202002109

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bozdağ SC, Yüksel MK, Demirer T (2018) Adult Stem Cells and Medicine. Adv Exp Med Biol 1079:17–36. https://doi.org/10.1007/5584_2018_184

Article  CAS  PubMed  Google Scholar 

Buijs RM, Scheer FA, Kreier F, Yi C, Bos N, Goncharuk VD, Kalsbeek A (2006) Organization of circadian functions: interaction with the body. Prog Brain Res 153:341–360. https://doi.org/10.1016/S0079-6123(06)53020-

Article  CAS  PubMed  Google Scholar 

Calvo W (1968) The innervation of the bone marrow in laboratory animals. Am J Anat 123(2):315–328. https://doi.org/10.1002/aja1001230206

Article  CAS  PubMed  Google Scholar 

Chan KL, Poller WC, Swirski FK, Russo SJ (2023) Central regulation of stress-evoked peripheral immune responses. Nat Rev Neurosci 24(10):591–604. https://doi.org/10.1038/s41583-023-00729-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheshier SH, Morrison SJ, Liao X, Weissman IL (1999) In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells. Proc Natl Acad Sci U S A 96(6):3120–3125. https://doi.org/10.1073/pnas9663120

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cora MC Latimer K, Travlos GC (2018) Bone Marrow In: Suttie AW editor Boorman’s pathology of the rat, 2nd edn. Elsevier Inc Academic Press Boston

Cossío I, Lucas D, Hidalgo A (2019) Neutrophils as regulators of the hematopoietic niche. Blood 133(20):2140–2148. https://doi.org/10.1182/blood-2018-10-844571

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong J, Mrabet O, Moze E, Li K, Neveu PJ (2002) Lateralization and catecholaminergic neuroimmunomodulation: prazosin an alpha1/alpha2-adrenergic receptor antagonist suppresses interleukin-1 and increases interleukin-10 production induced bylipopolysaccharides. Neuroimmunomodulation 10(3):163–168. https://doi.org/10.1159/000067178

Article  CAS  PubMed  Google Scholar 

Drinker CK, Drinker KR (1916) A method for maintaining an artificial circulation through the tibia of the dog with a demonstration of the vasomotor control of the marrow vessels. Am J Physiol 40:514–521

Article  Google Scholar 

Fielding C, García-García A, Korn C, Gadomski S, Fang Z, Reguera JL, Pérez-Simón JA, Göttgens B, Méndez-Ferrer S (2022) Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis. Nat Commun 13(1):543. https://doi.org/10.1038/s41467-022-28175-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fielding C, Méndez-Ferrer S (2020) Neuronal regulation of bone marrow stem cell niches. F1000Res 9 F1000 Faculty Rev 614. https://doi.org/10.12688/f1000research225541

Freire BM, de Melo FM, Basso AS (2022) Adrenergic signaling regulation of macrophage function: do we understand it yet? Immunother Adv 2(1):ltac010. https://doi.org/10.1093/immadv/ltac010

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao X, Murphy MM, Peyer JG, Ni Y, Yang MZ, HangY Guo J, Kara N, Embree C, Tasdogan A, Ubellacker JM, Crane GM, Fang S, Zhao Z, Shen B, Morrison SJ (2023) Leptin receptor+ cells promote bone marrow innervation and regeneration by synthesizing nerve growth factor. Nat Cell Biol 25(12):1746–1757. https://doi.org/10.1038/s41556-023-01284-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

García-García A, Korn C, García-Fernández M, Domingues O, Villadiego J, Martin-Perrz D, Iser J, Bejarano-Garcia JA, Zimmer J, Perez-Simon JA, Toledo-Aral JJ, Michel T, Airaksinen MS, Mendez-Ferrer S (2020) Dual cholinergic signals regulate daily migration of hematopoietic stem cells and leukocytes [published correction appears in Blood Dec 17 136(25):2965 101182/blood2020009650]. Blood 2019133(3):224–236. https://doi.org/10.1182/blood-2018-08-867648

Article  CAS  Google Scholar 

Graham RM (1990) Adrenergic receptors: structure and function. Cleve Clin J Med 57(5):481–491. https://doi.org/10.3949/ccjm575481

Article  CAS  PubMed  Google Scholar 

Groarke EM, Young NS (2019) Aging and Hematopoiesis. Clin Geriatr Med 35(3):285–293. https://doi.org/10.1016/j.cger.2019.03.001

Article  PubMed  PubMed Central  Google Scholar 

Guidi N, Geiger H (2017) Rejuvenation of aged hematopoietic stem cells. Semin Hematol 54(1):51–55. https://doi.org/10.1053/jseminhematol201610005

Article  PubMed  Google Scholar 

Hanoun M, Zhang D, Mizoguchi T, Pinho S, Pierce H, Kunisaki Y, Lacombe J, Armsrong SA, Dürsen U, Frenette PS (2014) Acute myelogenous leukemia-induced sympathetic neuropathy promotes malignancy in an altered hematopoietic stem cell niche. Cell Stem Cell 15(3):365–375. https://doi.org/10.1016/jstem201406020

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heidt T, Sager HB, Courties G, Dutta P, Iwamoto Y, Zaltsman A, vor zur Muheln C, Bode C, Fricchione GL, Denninger J, Lin CP, Vinegoni C, Libby P, Swirski FK, Weissleder R, Nahrendorf M (2014) Chronic variable stress activates hematopoietic stem cells. Nat Med 20(7):754–758. https://doi.org/10.1038/nm3589

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ho YH, Del Toro R, Rivera-Torres J, Rak J, Korn C, Garcia-Garcia A, Macia D, Gonzales-Gomez C, Del Monte A, Wittner M, Waller AK, Foster HR, Lopez-Otin C, Johnson RS, Nerlov C, Ghevaert C, Vainchenker W, Louache F, Andres V, Mendez-Ferrer S (2019) Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging. Cell Stem Cell 25(3):407-418e6. https://doi.org/10.1016/jstem2019060076

Article  CAS  PubMed  PubMed Central  Google Scholar 

Höfer T, Rodewald HR (2018) Differentiation-based model of hematopoietic stem cell functions and lineage pathways. Blood 132(11):1106–1113. https://doi.org/10.1182/blood-2018-03-791517

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kandarakov O, Belyavsky A, Semenova E (2022) Bone Marrow Niches of Hematopoietic Stem and Progenitor Cells. Int J Mol Sci 23(8):4462. https://doi.org/10.3390/ijms23084462

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karsunky H, Inlay MA, Serwold T, Bhattacharya D, Weissman IL (2008) Flk2+ common lymphoid progenitors possess equivalent differentiation potential for the B and T lineages. Blood 111(12):5562–70. https://doi.org/10.1182/blood-2007-11-126219

Article  CAS  PubMed  PubMed Central  Google Scholar 

Katayama Y, Battista M, Kao WM, Hidalgo A, Peired AJ, Thomas SA, Frenette PS (2006) Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell 124(2):407–421. https://doi.org/10.1016/jcell200510041

Article  CAS  PubMed  Google Scholar 

Kaushansky K (2018) Hunting for hematopoietic transcriptional networks. Proc Natl Acad Sci U S A 115(40):9818–9820. https://doi.org/10.1073/pnas.1813863115

Article  CAS  PubMed