Azedi, F., Mehrpour, M., Talebi, S., Zendedel, A., Kazemnejad, S., Mousavizadeh, K., . . . Joghataei, M. T. (2019). Melatonin regulates neuroinflammation ischemic stroke damage through interactions with microglia in reperfusion phase. Brain Res, 1723, 146401. https://doi.org/10.1016/j.brainres.2019.146401
Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H (1986) Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17(3):472–476. https://doi.org/10.1161/01.str.17.3.472
Article PubMed CAS Google Scholar
Belayev, L., Alonso, O. F., Busto, R., Zhao, W., & Ginsberg, M. D. (1996). Middle cerebral artery occlusion in the rat by intraluminal suture. Neurological and pathological evaluation of an improved model. Stroke, 27(9), 1616–1622; discussion 1623. https://doi.org/10.1161/01.str.27.9.1616
Calvo JR, González-Yanes C, Maldonado MD (2013) The role of melatonin in the cells of the innate immunity: a review. J Pineal Res 55(2):103–120. https://doi.org/10.1111/jpi.12075
Article PubMed CAS Google Scholar
Campanella M, Sciorati C, Tarozzo G, Beltramo M (2002) Flow cytometric analysis of inflammatory cells in ischemic rat brain. Stroke 33(2):586–592. https://doi.org/10.1161/hs0202.103399
Cardona AE, Huang D, Sasse ME, Ransohoff RM (2006) Isolation of murine microglial cells for RNA analysis or flow cytometry. Nat Protoc 1(4):1947–1951
Article PubMed CAS Google Scholar
Carrillo-Vico A, Lardone PJ, Álvarez-Sánchez N, Rodríguez-Rodríguez A, Guerrero JM (2013) Melatonin: Buffering the Immune System. Int J Mol Sci 14(4):8638–8683
Article PubMed PubMed Central Google Scholar
Chang, C. C., Tien, C. H., Lee, E. J., Juan, W. S., Chen, Y. H., Hung, Y. C., . . . Wu, T. S. (2012). Melatonin inhibits matrix metalloproteinase-9 (MMP-9) activation in the lipopolysaccharide (LPS)-stimulated RAW 264.7 and BV2 cells and a mouse model of meningitis. J Pineal Res, 53(2), 188–197. https://doi.org/10.1111/j.1600-079X.2012.00986.x
Chen TY, Tai SH, Lee EJ, Huang CC, Lee AC, Huang SY, Wu TS (2011) Cinnamophilin offers prolonged neuroprotection against gray and white matter damage and improves functional and electrophysiological outcomes after transient focal cerebral ischemia. Crit Care Med 39(5):1130–1137. https://doi.org/10.1097/CCM.0b013e31820a9442
Article PubMed CAS Google Scholar
Chen, H. Y., Chen, T. Y., Lee, M. Y., Chen, S. T., Hsu, Y. S., Kuo, Y. L., . . . Lee, E. J. (2006). Melatonin decreases neurovascular oxidative/nitrosative damage and protects against early increases in the blood-brain barrier permeability after transient focal cerebral ischemia in mice. J Pineal Res, 41(2), 175–182. https://doi.org/10.1111/j.1600-079X.2006.00351.x
Chen, H. Y., Hung, Y. C., Chen, T. Y., Huang, S. Y., Wang, Y. H., Lee, W. T., . . . Lee, E. J. (2009). Melatonin improves presynaptic protein, SNAP-25, expression and dendritic spine density and enhances functional and electrophysiological recovery following transient focal cerebral ischemia in rats. J Pineal Res, 47(3), 260–270. https://doi.org/10.1111/j.1600-079X.2009.00709.x
Chern CM, Liao JF, Wang YH, Shen YC (2012) Melatonin ameliorates neural function by promoting endogenous neurogenesis through the MT2 melatonin receptor in ischemic-stroke mice. Free Radic Biol Med 52(9):1634–1647. https://doi.org/10.1016/j.freeradbiomed.2012.01.030
Article PubMed CAS Google Scholar
Clark WM, Rinker LG, Lessov NS, Hazel K, Hill JK, Stenzel-Poore M, Eckenstein F (2000) Lack of interleukin-6 expression is not protective against focal central nervous system ischemia. Stroke 31(7):1715–1720. https://doi.org/10.1161/01.str.31.7.1715
Article PubMed CAS Google Scholar
Hardeland R (2018) Melatonin and inflammation-Story of a double-edged blade. J Pineal Res 65(4):e12525. https://doi.org/10.1111/jpi.12525
Article PubMed CAS Google Scholar
Huang SY, Chang CH, Hung HY, Lin YW, Lee EJ (2018a) Neuroanatomical and electrophysiological recovery in the contralateral intact cortex following transient focal cerebral ischemia in rats. Neurol Res 40(2):130–138. https://doi.org/10.1080/01616412.2017.1411454
Huang SY, Tai SH, Chang CC, Tu YF, Chang CH, Lee EJ (2018b) Magnolol protects against ischemic-reperfusion brain damage following oxygen-glucose deprivation and transient focal cerebral ischemia. Int J Mol Med 41(4):2252–2262. https://doi.org/10.3892/ijmm.2018.3387
Article PubMed CAS Google Scholar
Iadecola C, Buckwalter MS, Anrather J (2020) Immune responses to stroke: mechanisms, modulation, and therapeutic potential. J Clin Invest 130(6):2777–2788. https://doi.org/10.1172/jci135530
Article PubMed PubMed Central CAS Google Scholar
Juan, W. S., Huang, S. Y., Chang, C. C., Hung, Y. C., Lin, Y. W., Chen, T. Y., . . . Lee, E. J. (2014). Melatonin improves neuroplasticity by upregulating the growth-associated protein-43 (GAP-43) and NMDAR postsynaptic density-95 (PSD-95) proteins in cultured neurons exposed to glutamate excitotoxicity and in rats subjected to transient focal cerebral ischemia even during a long-term recovery period. Journal of Pineal Research, 56(2), 213–223. https://doi.org/10.1111/jpi.12114
Kamel H, Iadecola C (2012) Brain-immune interactions and ischemic stroke: clinical implications. Arch Neurol 69(5):576–581. https://doi.org/10.1001/archneurol.2011.3590
Article PubMed PubMed Central Google Scholar
Lee EJ, Wu TS, Lee MY, Chen TY, Tsai YY, Chuang JI, Chang GL (2004) Delayed treatment with melatonin enhances electrophysiological recovery following transient focal cerebral ischemia in rats. J Pineal Res 36(1):33–42. https://doi.org/10.1046/j.1600-079x.2003.00093.x
Article PubMed CAS Google Scholar
Lee EJ, Lee MY, Chang GL, Chen LH, Hu YL, Chen TY, Wu TS (2005a) Delayed treatment with magnesium: reduction of brain infarction and improvement of electrophysiological recovery following transient focal cerebral ischemia in rats. J Neurosurg 102(6):1085–1093. https://doi.org/10.3171/jns.2005.102.6.1085
Article PubMed CAS Google Scholar
Lee EJ, Lee MY, Chen HY, Hsu YS, Wu TS, Chen ST, Chang GL (2005b) Melatonin attenuates gray and white matter damage in a mouse model of transient focal cerebral ischemia. J Pineal Res 38(1):42–52. https://doi.org/10.1111/j.1600-079X.2004.00173.x
Article PubMed CAS Google Scholar
Lee, M. Y., Kuan, Y. H., Chen, H. Y., Chen, T. Y., Chen, S. T., Huang, C. C., . . . Lee, E. J. (2007). Intravenous administration of melatonin reduces the intracerebral cellular inflammatory response following transient focal cerebral ischemia in rats. J Pineal Res, 42(3), 297–309. https://doi.org/10.1111/j.1600-079X.2007.00420.x
Liu ZJ, Ran YY, Qie SY, Gong WJ, Gao FH, Ding ZT, Xi JN (2019) Melatonin protects against ischemic stroke by modulating microglia/macrophage polarization toward anti-inflammatory phenotype through STAT3 pathway. CNS Neurosci Ther 25(12):1353–1362. https://doi.org/10.1111/cns.13261
Article PubMed PubMed Central CAS Google Scholar
Mauriz JL, Collado PS, Veneroso C, Reiter RJ, González-Gallego J (2013) A review of the molecular aspects of melatonin's anti-inflammatory actions: recent insights and new perspectives. J Pineal Res 54(1):1–14. https://doi.org/10.1111/j.1600-079X.2012.01014.x
Moller, K., Posel, C., Kranz, A., Schulz, I., Scheibe, J., Didwischus, N., . . . Wagner, D. C. (2015). Arterial Hypertension Aggravates Innate Immune Responses after Experimental Stroke. Front Cell Neurosci, 9, 461. https://doi.org/10.3389/fncel.2015.00461
Pei Z, Cheung RT (2004) Pretreatment with melatonin exerts anti-inflammatory effects against ischemia/reperfusion injury in a rat middle cerebral artery occlusion stroke model. J Pineal Res 37(2):85–91. https://doi.org/10.1111/j.1600-079X.2004.00138.x
Article PubMed CAS Google Scholar
Planas AM (2018) Role of Immune Cells Migrating to the Ischemic Brain. Stroke 49(9):2261–2267. https://doi.org/10.1161/STROKEAHA.118.021474
Reiter RJ, Mayo JC, Tan DX, Sainz RM, Alatorre-Jimenez M, Qin L (2016) Melatonin as an antioxidant: under promises but over delivers. J Pineal Res 61(3):253–278. https://doi.org/10.1111/jpi.12360
Article PubMed CAS Google Scholar
Sadanandan, N., Cozene, B., Cho, J., Park, Y. J., Saft, M., Gonzales-Portillo, B., & Borlongan, C. V. (2020). Melatonin-A Potent Therapeutic for Stroke and Stroke-Related Dementia. Antioxidants (Basel), 9(8). https://doi.org/10.3390/antiox9080672
Schulze J, Gellrich J, Kirsch M, Dressel A, Vogelgesang A (2021) Central Nervous System-Infiltrating T Lymphocytes in Stroke Are Activated via Their TCR (T-Cell Receptor) but Lack CD25 Expression. Stroke 52(9):2939–2947. https://doi.org/10.1161/STROKEAHA.120.032763
Article PubMed CAS Google Scholar
Shinozuka K, Staples M, Borlongan CV (2013) Melatonin-based therapeutics for neuroprotection in stroke. Int J Mol Sci 14(5):8924–8947. https://doi.org/10.3390/ijms14058924
Article PubMed PubMed Central CAS Google Scholar
Swanson RA, Morton MT, Tsaowu G, Savalos RA, Davidson C, Sharp FR (1990) A Semiautomated Method for Measuring Brain Infarct Volume. J Cereb Blood Flow Metab 10(2):290–293. https://doi.org/10.1038/jcbfm.1990.47
Article PubMed CAS Google Scholar
Tan DX, Manchester LC, Liu X, Rosales-Corral SA, Acuna-Castroviejo D, Reiter RJ (2013) Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin’s primary function and evolution in eukaryotes. J Pineal Res 54(2):127–138. https://doi.org/10.1111/jpi.12026
Article PubMed CAS Google Scholar
Tarocco A, Caroccia N, Morciano G, Wieckowski MR, Ancora G, Garani G, Pinton P (2019) Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care. Cell Death Dis 10(4):317. https://doi.org/10.1038/s41419-019-1556-7
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