Altman R, Bosch B, Brune K et al (2015) Advances in NSAID development: evolution of diclofenac products using pharmaceutical technology. Drugs 75:859–877. https://doi.org/10.1007/s40265-015-0392-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baliyan S, Mukherjee R, Priyadarshini A et al (2022) Determination of antioxidants by DPPH radical scavenging activity and quantitative phytochemical analysis of Ficus religiosa. Molecules 27:1326. https://doi.org/10.3390/molecules27041326

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ben-Ari Y (2002) Excitatory actions of Gaba during development: the nature of the nurture. Nat Rev Neurosci 3:728–739. https://doi.org/10.1038/nrn920

Article  CAS  PubMed  Google Scholar 

Bhardwaj M, Kumar A (2016) Neuroprotective effect of lycopene against PTZ-induced kindling seizures in mice: possible behavioural, biochemical and mitochondrial dysfunction. Phyther Res 30:306–313. https://doi.org/10.1002/ptr.5533

Article  CAS  Google Scholar 

Bhattacharya S, Haertel C, Maelicke A, Montag D (2014) Galantamine slows down plaque formation and behavioral decline in the 5XFAD mouse model of Alzheimer’s disease. PLoS ONE 9:e89454. https://doi.org/10.1371/journal.pone.0089454

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bröer S, Pauletti A (2024) Microglia and infiltrating macrophages in ictogenesis and epileptogenesis. Front Mol Neurosci 17. https://doi.org/10.3389/fnmol.2024.1404022

Calabrese G, Petralia S, Fabbi C et al (2020) Au, Pd and maghemite nanofunctionalized hydroxyapatite scaffolds for bone regeneration. Regen Biomater 7:461–469. https://doi.org/10.1093/rb/rbaa033

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cerón-Carrasco JP, Roy HM, Cerezo J et al (2014) Theoretical insights on the antioxidant activity of Edaravone free radical scavengers derivatives. Chem Phys Lett 599:73–79. https://doi.org/10.1016/j.cplett.2014.03.010

Article  CAS  Google Scholar 

Cho S-J, Byun D, Nam T-S et al (2017) Zebrafish as an animal model in epilepsy studies with multichannel EEG recordings. Sci Rep 7:3099. https://doi.org/10.1038/s41598-017-03482-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Costagliola G, Depietri G, Michev A et al (2022) Targeting inflammatory mediators in epilepsy: A systematic review of its molecular basis and clinical applications. Front Neurol 13. https://doi.org/10.3389/fneur.2022.741244

Dhall M, Kadian R, Sharma P et al (2023) Unravelling the neurochemical maze: neurotransmitters, neuropeptides and novel drug modes of action based on epilepsy pathophysiology. Epilepsy Paroxysmal Cond 15:282–293. https://doi.org/10.17749/2077-8333/epi.par.con.2023.152

Article  Google Scholar 

Diamantino TC, Almeida E, Soares AMVM, Guilhermino L (2001) Lactate dehydrogenase activity as an effect criterion in toxicity tests with Daphnia magna Straus. Chemosphere 45:553–560. https://doi.org/10.1016/S0045-6535(01)00029-7

Article  CAS  PubMed  Google Scholar 

Dyomina AV, Zubareva OE, Smolensky IV et al (2020) Anakinra reduces epileptogenesis, provides neuroprotection, and attenuates behavioral impairments in rats in the Lithium–Pilocarpine model of epilepsy. Pharmaceuticals 13:340. https://doi.org/10.3390/ph13110340

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elkamhawy A, Oh NK, Gouda NA et al (2023) Novel hybrid Indole-Based caffeic acid amide derivatives as potent free radical scavenging agents: rational design, synthesis, spectroscopic characterization. In Silico and In Vitro Investigations Metabolites 13:141. https://doi.org/10.3390/metabo13020141

Article  CAS  PubMed  Google Scholar 

Fabisiak T, Patel M (2022) Crosstalk between neuroinflammation and oxidative stress in epilepsy. Front Cell Dev Biol 10. https://doi.org/10.3389/fcell.2022.976953

Fan J, Xiao Z, Zhang H et al (2010) Linear ordered collagen scaffolds loaded with collagen-Binding Neurotrophin-3 promote axonal regeneration and partial functional recovery after complete spinal cord transection. J Neurotrauma 27:1671–1683. https://doi.org/10.1089/neu.2010.1281

Article  PubMed  Google Scholar 

Fan R, Chen J, Gao X, Zhang Q (2021) Neurodevelopmental toxicity of alumina nanoparticles to zebrafish larvae: toxic effects of particle sizes and ions. Food Chem Toxicol 157:112587. https://doi.org/10.1016/j.fct.2021.112587

Article  CAS  PubMed  Google Scholar 

Ganie SA, Haq E, Hamid A et al (2011) Carbon tetrachloride induced kidney and lung tissue damages and antioxidant activities of the aqueous rhizome extract of Podophyllum hexandrum. BMC Complement Altern Med 11:17. https://doi.org/10.1186/1472-6882-11-17

Article  PubMed  PubMed Central  Google Scholar 

Gourmaud S, Shou H, Irwin DJ et al (2020) Alzheimer-like amyloid and Tau alterations associated with cognitive deficit in Temporal lobe epilepsy. Brain 143:191–209. https://doi.org/10.1093/brain/awz381

Article  PubMed  Google Scholar 

Guo Q, Wang C, Xue X et al (2021) SOCS1 mediates Berberine-Induced amelioration of microglial activated States in N9 microglia exposed to Β amyloid. Biomed Res Int 2021. https://doi.org/10.1155/2021/9311855

Guru A, Issac PK, Saraswathi NT et al (2021) Deteriorating insulin resistance due to WL15 peptide from cysteine and glycine-rich protein 2 in high glucose‐induced rat skeletal muscle L6 cells. Cell Biol Int 45:1698–1709. https://doi.org/10.1002/cbin.11608

Article  CAS  PubMed  Google Scholar 

Guru A, Velayutham M, Arockiaraj J (2022) Lipid-Lowering and antioxidant activity of RF13 peptide from vacuolar protein Sorting-Associated protein 26B (VPS26B) by modulating lipid metabolism and oxidative stress in HFD induced obesity in zebrafish larvae. Int J Pept Res Ther 28:74. https://doi.org/10.1007/s10989-022-10376-3

Article  CAS  Google Scholar 

Gururaj G, Satishchandra P, Amudhan S (2015) Epilepsy in India II: impact, burden, and need for a multisectoral public health response. Ann Indian Acad Neurol. https://doi.org/10.4103/0972-2327.165483

Article  PubMed  PubMed Central  Google Scholar 

Haridevamuthu B, Murugan R, Seenivasan B et al (2024) Synthetic azo-dye, tartrazine induces neurodevelopmental toxicity via mitochondria-mediated apoptosis in zebrafish embryos. J Hazard Mater 461:132524. https://doi.org/10.1016/j.jhazmat.2023.132524

Article  CAS  PubMed  Google Scholar 

Hasan MM, Islam ME, Hossain MS et al (2024) Unveiling the therapeutic potential: evaluation of anti-inflammatory and antineoplastic activity of Magnolia champaca Linn’s stem bark isolate through molecular Docking insights. Heliyon 10:e22972. https://doi.org/10.1016/j.heliyon.2023.e22972

Article  CAS  PubMed  Google Scholar 

Hong J-M, Kim JE, Min SK et al (2021) Anti-Inflammatory effects of Antarctic lichen Umbilicaria Antarctica methanol extract in Lipopolysaccharide-Stimulated RAW 264.7 macrophage cells and zebrafish model. Biomed Res Int 2021:1–12. https://doi.org/10.1155/2021/8812090

Article  CAS  Google Scholar 

Huang H, Liao Y, Yu Y et al (2024) Adult-onset neuronal ceroid lipofuscinosis misdiagnosed as autoimmune encephalitis and normal-pressure hydrocephalus: A 10-year case report and case-based review. Med (Baltim) 103:e40248. https://doi.org/10.1097/MD.0000000000040248

Article  Google Scholar 

Issac PK, Lite C, Guru A et al (2021) Tryptophan-tagged peptide from Serine threonine-protein kinase of Channa striatus improves antioxidant defence in L6 myotubes and attenuates caspase 3–dependent apoptotic response in zebrafish larvae. Fish Physiol Biochem 47:293–311. https://doi.org/10.1007/s10695-020-00912-7

Article  CAS  PubMed  Google Scholar 

Klawonn AM, Fritz M, Castany S et al (2021) Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons. Immunity 54:225–234e6. https://doi.org/10.1016/j.immuni.2020.12.016

Article  CAS  PubMed  Google Scholar 

Lach P, Klus W, Zajdel K et al (2022) Neuroinflammation in Epilepsy—Diagnostics and therapeutic perspectives. Curr Pharmacol Rep 8:31–35. https://doi.org/10.1007/s40495-021-00270-9

Article  CAS  Google Scholar 

Li H, Tan Y, Cheng X et al (2022) Untargeted metabolomics analysis of the hippocampus and cerebral cortex identified the neuroprotective mechanisms of Bushen Tiansui formula in an aβ25-35-induced rat model of Alzheimer’s disease. Front Pharmacol 13. https://doi.org/10.3389/fphar.2022.990307

Li Y, He X, Sun B et al (2024) Combined exposure of beta-cypermethrin and Emamectin benzoate interferes with the HPO axis through oxidative stress, causing an imbalance of hormone homeostasis in female rats. Reprod Toxicol 123:108502. https://doi.org/10.1016/j.reprotox.2023.108502

Article  CAS  PubMed