Ulbricht CE, Natural Standard Research Collaboration. An evidence-based systematic review of Yin Yang Huo (Epimedium spp.) by the Natural Standard Research Collaboration. J Diet Suppl. 2016;13:136–64. https://doi.org/10.3109/19390211.2015.1008817
Xu Y, Liu L, Liu S, He Y, Li R, Ge F. The taxonomic relevance of flower colour for Epimedium (Berberidaceae), with morphological and nomenclatural notes for five species from China. PhytoKeys. 2019;118:33–64. https://doi.org/10.3897/phytokeys.118.30268
Zhang H, Wang H, Wei J, Chen X, Sun M, Ouyang H, et al. Comparison of the active compositions between raw and processed Epimedium from different species. Molecules. 2018;23:1656. https://doi.org/10.3390/molecules23071656
Article PubMed PubMed Central CAS Google Scholar
Ma H, He X, Yang Y, Li M, Hao D, Jia Z. The genus Epimedium: an ethnopharmacological and phytochemical review. J Ethnopharmacol. 2011;134:519–41. https://doi.org/10.1016/j.jep.2011.01.001
Article PubMed CAS Google Scholar
Sun S, Liu L, Tian X, Guo Y, Cao Y, Mei Y, et al. Icariin attenuates high glucose-induced apoptosis, oxidative stress, and inflammation in human umbilical venous endothelial cells. Planta Med. 2019;85:473–82. https://doi.org/10.1055/a-0837-0975
Article PubMed CAS Google Scholar
Liu FY, Ding DN, Wang YR, Liu SX, Peng C, Shen F, et al. Icariin as a potential anticancer agent: a review of its biological effects on various cancers. Front Pharmacol. 2023;14:1216363. https://doi.org/10.3389/fphar.2023.1216363
Article PubMed PubMed Central CAS Google Scholar
Gao Y, Shi W, Tu C, Li P, Zhao G, Xiao X, et al. Immunostimulatory activity and structure-activity relationship of epimedin B from Epimedium brevicornu Maxim. Front Pharmacol. 2022;13:1015846. https://doi.org/10.3389/fphar.2022.1015846
Article PubMed PubMed Central CAS Google Scholar
Li C, Li Q, Mei Q, Lu T. Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii. Life Sci. 2015;126:57–68. https://doi.org/10.1016/j.lfs.2015.01.006
Article PubMed CAS Google Scholar
Seyedi Z, Amiri MS, Mohammadzadeh V, Hashemzadeh A, Haddad-Mashadrizeh A, Mashreghi M, et al. Icariin: a promising natural product in biomedicine and tissue engineering. J Funct Biomater. 2023;14:44. https://doi.org/10.3390/jfb14010044
Article PubMed PubMed Central CAS Google Scholar
Liu Y, Yang H, Xiong J, Zhao J, Guo M, Chen J, et al. Icariin as an emerging candidate drug for anticancer treatment: current status and perspective. Biomed Pharmacother. 2023;157:113991. https://doi.org/10.1016/j.biopha.2022.113991
Article PubMed CAS Google Scholar
Mou Z, Chen Y, Hu J, Hu Y, Zou L, Chen X, et al. Icaritin inhibits the progression of urothelial cancer by suppressing PADI2-mediated neutrophil infiltration and neutrophil extracellular trap formation. Acta Pharm Sin B. 2024;14:3916–30. https://doi.org/10.1016/j.apsb.2024.06.029
Article PubMed PubMed Central CAS Google Scholar
Jin J, Wang H, Hua X, Chen D, Huang C, Chen Z. An outline for the pharmacological effect of icariin in the nervous system. Eur J Pharmacol. 2019;842:20–32. https://doi.org/10.1016/j.ejphar.2018.10.006
Article PubMed CAS Google Scholar
Szabó R, Rácz CP, Dulf FV. Bioavailability improvement strategies for icariin and its derivates: a review. Int J Mol Sci. 2022;23:7519. https://doi.org/10.3390/ijms23147519
Article PubMed PubMed Central CAS Google Scholar
Kim DH, Jung HA, Sohn HS, Kim JW, Choi JS. Potential of icariin metabolites from Epimedium koreanum nakai as antidiabetic therapeutic agents. Molecules. 2017;22:986. https://doi.org/10.3390/molecules22060986
Article PubMed PubMed Central CAS Google Scholar
Zhang H, Wu X, Wang J, Wang M, Wang X, Shen T, et al. Flavonoids from the leaves of Epimedium Koreanum Nakai and their potential cytotoxic activities. Nat Prod Res. 2020;34:1256–63. https://doi.org/10.1080/14786419.2018.1560283
Article PubMed CAS Google Scholar
Zhang S, Luo J, Dong Y, Wang Z, Xiao W, Zhao L. Biotransformation of the total flavonoid extract of epimedium into icaritin by two thermostable glycosidases from Dictyoglomus thermophilum DSM3960. Process Biochem. 2021;105:8–18. https://doi.org/10.1016/j.procbio.2021.03.002
Han F, Kim JH, Lee IS. Microbial transformation of icariin and its derivatives. Nat Prod Res. 2022;36:4103–13. https://doi.org/10.1080/14786419.2021.1975702
Article PubMed CAS Google Scholar
Huong NT, Son NT. Icaritin: a phytomolecule with enormous pharmacological values. Phytochemistry. 2023;213:113772. https://doi.org/10.1016/j.phytochem.2023.113772
Article PubMed CAS Google Scholar
Gani I, Jameel S, Bhat SA, Amin H, Bhat KA. Prenylated flavonoids of genus Epimedium: phytochemistry, estimation and synthesis. ChemistrySelect. 2023;8:e202204263. https://doi.org/10.1002/slct.202204263
Luo P, An Y, He J, Xing X, Zhang Q, Liu X, et al. Icaritin with autophagy/mitophagy inhibitors synergistically enhances anticancer efficacy and apoptotic effects through PINK1/Parkin-mediated mitophagy in hepatocellular carcinoma. Cancer Lett. 2024;587:216621. https://doi.org/10.1016/j.canlet.2024.216621
Article PubMed CAS Google Scholar
Zhou X, Wu D, Mi T, Li R, Guo T, Li W. Icaritin activates p53 and inhibits aerobic glycolysis in liver cancer cells. Chem Biol Interact. 2024;392:110926. https://doi.org/10.1016/j.cbi.2024.110926
Article PubMed CAS Google Scholar
Sun Q, Yang R, Chen T, Li S, Wang H, Kong D, et al. Icaritin attenuates ischemia-reperfusion injury by anti-inflammation, anti-oxidative stress, and anti-autophagy in mouse liver. Int Immunopharmacol. 2024;138:112533. https://doi.org/10.1016/j.intimp.2024.112533
Article PubMed CAS Google Scholar
Xu W, Li Y, Liu L, Xie J, Hu Z, Kuang S, et al. Icaritin-curcumol activates CD8+ T cells through regulation of gut microbiota and the DNMT1/IGFBP2 axis to suppress the development of prostate cancer. J Exp Clin Cancer Res. 2024;43:149. https://doi.org/10.1186/s13046-024-03063-2
Article PubMed PubMed Central CAS Google Scholar
Zhang D, Liang J, Qu S, Xu C, Kan H, Dong K, et al. Metabolomics and pharmacodynamic analysis unveil the therapeutic role of icaritin on osteoporosis rats. J Pharm Biomed Anal. 2024;241:115979. https://doi.org/10.1016/j.jpba.2024.115979
Article PubMed CAS Google Scholar
Zhang C, Wang X, Zhang C. Icaritin inhibits CDK2 expression and activity to interfere with tumor progression. iScience. 2022;25:104991. https://doi.org/10.1016/j.isci.2022.104991
Article PubMed PubMed Central CAS Google Scholar
Wei CY, Wang YP, Wang J, Zhang L. Advance in chemical synthesis and structural modification of icaritin. Chem Reagent. 2023;45:1–8. https://doi.org/10.13822/j.cnki.hxsj.2023.0478
Cui HQ, Wang XH, He YQ, Wang YH, Lan Q, Pu Y, et al. Advance on the structural modification and activities of icaritin derivatives. Chem Res Appl. 2020;32:2113–23.
Ding H, Li J, Meng K. Polyhydroxy benzopyran ketone compounds as estrogen receptor ER-α36 regulators and their preparation, pharmaceutical compositions and use in the treatment of cancer. 2013;WO2013104263
Meng K, Zhang Y, Fang F, Shang X. Improved synthesis method of SNG-1153. 2017;CN107216302
Ye HY, Liu J, Lou YJ. Preparation of two derivatives from icariin and investigation of their estrogen-like effects. J Zhejiang Univ Med Sci. 2005;34:131–6.
Comments (0)