Zhang J, Guo YY, Zhao XK, Pang JJ, Pan C, Wang JL, et al. The role of aldehyde dehydrogenase 2 in cardiovascular disease. Nat Rev Cardiol. 2023;20:495–509.

Article  PubMed  Google Scholar 

Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, Mochly-Rosen D. Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science. 2008;321:1493–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim J, Chen C-H, Yang J, Mochly-Rosen D. Aldehyde dehydrogenase 2*2 knock-in mice show increased reactive oxygen species production in response to cisplatin treatment. J Biomed Sci. 2017;24:33.

Article  PubMed  PubMed Central  Google Scholar 

Chen CH, Sun LH, Mochly-Rosen D. Mitochondrial aldehyde dehydrogenase and cardiac diseases. Cardiovasc Res. 2010;88:51–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Takeuchi F, Yokota M, Yamamoto K, Nakashima E, Katsuya T, Asano H, et al. Genome-wide association study of coronary artery disease in the Japanese. Europ J Hum Genet. 2012;20:333–40.

Article  CAS  PubMed  Google Scholar 

Bartoli-Leonard F, Saddic L, Aikawa E. Double-edged sword of ALDH2 mutations: one polymorphism can both benefit and harm the cardiovascular system. Eur Heart J. 2020;41:2453–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kiyuna LA, Candido DS, Bechara LRG, Jesus ICG, Ramalho LS, Krum B, et al. 4-Hydroxynonenal impairs miRNA maturation in heart failure via Dicer post-translational modification. Eur Heart J. 2023;44:4696–712.

Article  CAS  PubMed  Google Scholar 

Yang KH, Ren J, Li X, Wang Z, Xue L, Cui SM, et al. Prevention of aortic dissection and aneurysm via an ALDH2-mediated switch in vascular smooth muscle cell phenotype. Eur Heart J. 2020;41:2442–53.

Article  CAS  PubMed  Google Scholar 

Chang YC, Lee HL, Yang WJ, Hsieh ML, Liu CC, Lee TY, et al. A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators. Nat Commun. 2023;14:5971.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee H, Hee S, Hsuan C. A novel ALDH2 activator AD-9308 improves diastolic and systolic myocardial functions in streptozotocin-induced diabetic mice. Antioxidants. 2021;10:450.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hosoi T, Yamaguchi R, Noji K, Matsuo S, Baba S, Toyoda K, et al. Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress. EMBO Mol Med. 2014;6:335–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tian W, Guo JP, Zhang QS, Fang SY, Zhou RL, Hu J, et al. The discovery of novel small molecule allosteric activators of aldehyde dehydrogenase 2. Eur J Med Chem. 2021;212:113119.

Article  CAS  PubMed  Google Scholar 

He L, Liu B, Dai Z, Zhang H-F, Zhang Y-S, Luo X-J, et al. Alpha lipoic acid protects heart against myocardial ischemia–reperfusion injury through a mechanism involving aldehyde dehydrogenase 2 activation. Eur J Pharmacol. 2012;678:32–8.

Article  CAS  PubMed  Google Scholar 

Li WJ, Yin L, Sun XL, Wu J, Dong Z, Hu K, et al. Alpha-lipoic acid protects against pressure overload-induced heart failure via ALDH2-dependent Nrf1-FUNDC1 signaling. Cell Death Dis. 2020;11:599.

Article  PubMed  PubMed Central  Google Scholar 

Jiang WB, Zhao W, Chen H, Wu YY, Wang Y, Fu GS, et al. Baicalin protects H9c2 cardiomyocytes against hypoxia/reoxygenation‐induced apoptosis and oxidative stress through activation of mitochondrial aldehyde dehydrogenase 2. Clin Exp Pharmacol Physiol. 2018;45:303–11.

Article  CAS  PubMed  Google Scholar 

Chen L, Wu YT, Gu XY, Xie LP, Fan HJ, Tan ZB, et al. Magnolol, a natural aldehyde dehydrogenase-2 agonist, inhibits the proliferation and collagen synthesis of cardiac fibroblasts. Bioorg Med Chem Lett. 2021;43:128045.

Article  CAS  PubMed  Google Scholar 

Zhang W, Yang LX, Li LY, Feng W. Dihydromyricetin attenuates neuropathic pain via enhancing the transition from M1 to M2 phenotype polarization by potentially elevating ALDH2 activity in vitro and vivo. Ann Transl Med. 2020;8:1151.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chiu CC, Yeh TH, Lai SC, Wu-Chou YH, Chen CH, Mochly-Rosen D, et al. Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism. Exp Neurol. 2015;263:244–53.

Article  CAS  PubMed  Google Scholar 

Guo JM, Liu AJ, Zang P, Dong WZ, Ying L, Wang W, et al. ALDH2 protects against stroke by clearing 4-HNE. Cell Res. 2013;23:915–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fu SH, Zhang HF, Yang ZB, Li TB, Liu B, Lou Z, et al. Alda-1 reduces cerebral ischemia/reperfusion injury in rat through clearance of reactive aldehydes. Naunyn-Schmiedeberg’s Arch Pharmacol. 2014;387:87–94.

Article  CAS  Google Scholar 

Ning SC, Budas GR, Churchill EN, Chen CH, Knox SJ, Mochly-Rosen D. Mitigation of radiation-induced dermatitis by activation of aldehyde dehydrogenase 2 using topical alda-1 in mice. Radiat Res. 2012;178:69–74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun LH, Cesar J, Ferreira B, Mochly-Rosen D. ALDH2 activator inhibits increased myocardial infarction injury by nitroglycerin tolerance. Sci Transl Med. 2011;3:107–11.

Article  Google Scholar 

Taneja I, Raju KSR, Mittal M, Dev K, Khan MF, Maurya R, et al. Bioavailability, plasma protein binding and metabolic stability studies of a ALDH2 activator, alda-1, using a validated LC-ESI-MS/MS method in rat plasma. Rsc Adv. 2015;5:54395–402.

Article  CAS  Google Scholar 

Belmont‐Díaz JA, Yoval‐Sánchez B, Calleja‐Castañeda LF, Pardo Vázquez JP, Rodríguez‐Zavala JS. Alda‐1 modulates the kinetic properties of mitochondrial aldehyde dehydrogenase (ALDH 2). FEBS J. 2016;283:3637–50.

Article  PubMed  Google Scholar 

Papadatos G, Brown N. In silico applications of bioisosterism in contemporary medicinal chemistry practice. Wires Comput Mol Sci. 2013;3:339–54.

Article  CAS  Google Scholar 

Herr RJ. 5-Substituted-1H-tetrazoles as carboxylic acid isosteres: medicinal chemistry and synthetic methods. Bioorgan Med Chem. 2002;10:3379–93.

Article  CAS  Google Scholar 

Kumari S, Carmona AV, Tiwari AK, Trippier PC. Amide bond bioisosteres: strategies, synthesis, and successes. J Med Chem. 2020;63:12290–358.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Verster JC, Volkerts ER. Clinical pharmacology, clinical efficacy, and behavioral toxicity of alprazolam: a review of the literature. CNS Drug Rev. 2004;10:45–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morán-Serradilla C, Plano D, Sanmartín C, Sharma AK. Selenization of small molecule drugs: a new player on the board. J Med Chem. 2024;67:7759–87.

Article  PubMed  Google Scholar 

Xu H, Su X, Guo M-b, An R, Mou Y-h, Hou Z, et al. Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. Eur J Med Chem. 2020;198:112360.

Article  CAS  PubMed  Google Scholar