Cummings MD, Sekharan S. Structure-based macrocycle design in small-molecule drug discovery and simple metrics to identify opportunities for macrocyclization of small-molecule ligands. J Med Chem. 2019;62:6843–53.
Article CAS PubMed Google Scholar
Diao Y, Liu D, Ge H, Zhang R, Jiang K, Bao R, et al. Macrocyclization of linear molecules by deep learning to facilitate macrocyclic drug candidates discovery. Nat Commun. 2023;14:4552.
Article CAS PubMed PubMed Central Google Scholar
Darlami O, Pun R, Ahn S-H, Kim S-H, Shin D. Macrocyclization strategy for improving candidate profiles in medicinal chemistry. Eur J Med Chem. 2024;272:116501.
Article CAS PubMed Google Scholar
Jimenez DGarcia, Poongavanam V, Kihlberg J. Macrocycles in drug discovery─ learning from the past for the future. J Med Chem. 2023;66:5377–96.
Zhang C, Liu F, Zhang Y, Song C. Macrocycles and macrocyclization in anticancer drug discovery: important pieces of the puzzle. Eur J Med Chem. 2024;268:116234.
Article CAS PubMed Google Scholar
Li Y-H, Lin Y-K, Cai J-F, Zou Z-K, Zhao P-L. A perspective on the application of macrocyclic design strategies in antitumor drugs. Bioorg Chem. 2025;156:108190.
Article CAS PubMed Google Scholar
Kopp F, Stratton CF, Akella LB, Tan DS. A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion. Nat Chem Biol. 2012;8:358–65.
Article CAS PubMed PubMed Central Google Scholar
Mortensen KT, Osberger TJ, King TA, Sore HF, Spring DR. Strategies for the diversity-oriented synthesis of macrocycles. Chem Rev. 2019;119:10288–317.
Article CAS PubMed Google Scholar
Gao Y, Kodadek T. Direct comparison of linear and macrocyclic compound libraries as a source of protein ligands. ACS Combinatorial Sci. 2015;17:190–5.
Ermert P. Design, properties and recent application of macrocycles in medicinal chemistry. Chimia (Aarau). 2017;71:678–678.
Article CAS PubMed Google Scholar
Amrhein JA, Knapp S, Hanke T. Synthetic opportunities and challenges for macrocyclic kinase inhibitors. J Med Chem. 2021;64:7991–8009.
Article CAS PubMed Google Scholar
Filippakopoulos P, Knapp S. The bromodomain interaction module. FEBS Lett. 2012;586:2692–704.
Article CAS PubMed Google Scholar
Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert J-P, Barsyte-Lovejoy D, et al. Histone recognition and large-scale structural analysis of the human bromodomain family. Cell. 2012;149:214–31.
Article CAS PubMed PubMed Central Google Scholar
Trojer P. Targeting BET bromodomains in cancer. Annual Rev cancer Biol. 2022;6:313–36.
Wang N, Wu R, Tang D, Kang R. The BET family in immunity and disease. Signal Transduct Target Ther. 2021;6:23.
Article PubMed PubMed Central Google Scholar
Matzuk MM, McKeown MR, Filippakopoulos P, Li Q, Ma L, Agno JE, et al. Small-molecule inhibition of BRDT for male contraception. Cell. 2012;150:673–84.
Article CAS PubMed PubMed Central Google Scholar
Miller TC, Simon B, Rybin V, Grötsch H, Curtet S, Khochbin S, et al. A bromodomain–DNA interaction facilitates acetylation-dependent bivalent nucleosome recognition by the BET protein BRDT. Nat Commun. 2016;7:13855.
Article CAS PubMed PubMed Central Google Scholar
Philpott M, Rogers CM, Yapp C, Wells C, Lambert J-P, Strain-Damerell C, et al. Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching. Epigenetics Chromatin. 2014;7:14.
Article PubMed PubMed Central Google Scholar
Tyler DS, Vappiani J, Cañeque T, Lam EY, Ward A, Gilan O, et al. Click chemistry enables preclinical evaluation of targeted epigenetic therapies. Science. 2017;356:1397–401.
Article CAS PubMed PubMed Central Google Scholar
Andrieu G, Belkina AC, Denis GV. Clinical trials for BET inhibitors run ahead of the science. Drug Discov Today: Technol. 2016;19:45–50.
Piha-Paul SA, Hann CL, French CA, Cousin S, Braña I, Cassier PA, et al. Phase 1 study of molibresib (GSK525762), a bromodomain and extra-terminal domain protein inhibitor, in NUT carcinoma and other solid tumors. JNCI Cancer Spectr. 2020;4:pkz093.
Moreno V, Sepulveda J, Vieito M, Hernández-Guerrero T, Doger B, Saavedra O, et al. Phase I study of CC-90010, a reversible, oral BET inhibitor in patients with advanced solid tumors and relapsed/refractory non-Hodgkin’s lymphoma. Ann Oncol. 2020;31:780–8.
Article CAS PubMed Google Scholar
Jiang J, Zhao PL, Sigua LH, Chan A, Schönbrunn E, Qi J, et al. 1, 4-Dihydropyridinebutyrolactone-derived ring-opened ester and amide analogs targeting BET bromodomains. Arch Pharm (Weinh). 2022;355:2200288.
Jiang J, Liang T, Solberg J, Chan A, Kalra P, Shi R, et al. Macrocyclic dihydropyridine analogs as pan-BET BD2-preferred inhibitors. Eur J Med Chem. 2025;290:117504.
Article CAS PubMed Google Scholar
Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, et al. Selective inhibition of BET bromodomains. Nature. 2010;468:1067–73.
Article CAS PubMed PubMed Central Google Scholar
Larochelle S, Pandur J, Fisher RP, Salz HK, Suter B. Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity. Genes Dev. 1998;12:370–81.
Article CAS PubMed PubMed Central Google Scholar
Ganuza M, Sáiz-Ladera C, Canamero M, Gomez G, Schneider R, Blasco MA, et al. Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion. EMBO J. 2012;31:2498–510.
Article CAS PubMed PubMed Central Google Scholar
Diab S, Yu M, Wang S. CDK7 inhibitors in cancer therapy: the sweet smell of success?. J Med Chem. 2020;63:7458–74.
Article CAS PubMed Google Scholar
Schachter MM, Fisher RP. The CDK-activating kinase Cdk7: taking yes for an answer. Cell Cycle. 2013;12:3239–40.
Article CAS PubMed PubMed Central Google Scholar
Wang M, Wang T, Zhang X, Wu X, Jiang S. Cyclin-dependent kinase 7 inhibitors in cancer therapy. Future Med Chem. 2020;12:813–33.
Liang H, Du J, Elhassan RM, Hou X, Fang H. Recent progress in development of cyclin-dependent kinase 7 inhibitors for cancer therapy. Expert Opin Investig Drugs. 2021;30:61–76.
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