Shamovsky I, Nudler E. New insights into the mechanism of heat shock response activation. Cell Mol Life Sci. 2008;65:855–61. https://doi.org/10.1007/s00018-008-7458-y.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gomez-Pastor R, Burchfiel ET, Thiele DJ. Regulation of heat shock transcription factors and their roles in physiology and disease. Nat Rev Mol Cell Biol. 2018;19:4–19. https://doi.org/10.1038/nrm.2017.73.

Article  CAS  PubMed  Google Scholar 

Whitesell L, Lindquist SL. HSP90 and the chaperoning of cancer. Nat Rev Cancer. 2005;5:761–72. https://doi.org/10.1038/nrc1716.

Article  CAS  PubMed  Google Scholar 

Dong B, Jaeger AM, Thiele DJ. Inhibiting Heat Shock Factor 1 in Cancer: A Unique Therapeutic Opportunity. Trends Pharmacol Sci. 2019;40:986–1005. https://doi.org/10.1016/j.tips.2019.10.008.

Article  CAS  PubMed  Google Scholar 

Akerfelt M, Morimoto RI, Sistonen L. Heat shock factors: integrators of cell stress, development and lifespan. Nat Rev Mol Cell Biol. 2010;11:545–55. https://doi.org/10.1038/nrm2938.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang CQ, Williams H, Prince TL, Ho ES. Overexpressed HSF1 cancer signature genes cluster in human chromosome 8q. Hum Genomics. 2017;11:35. https://doi.org/10.1186/s40246-017-0131-5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mendillo ML, Santagata S, Koeva M, Bell GW, Hu R, Tamimi RM, et al. HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers. Cell. 2012;150:549–62. https://doi.org/10.1016/j.cell.2012.06.031.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dai C, Whitesell L, Rogers AB, Lindquist S. Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell. 2007;130:1005–18. https://doi.org/10.1016/j.cell.2007.07.020.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Santagata S, Hu R, Lin NU, Mendillo ML, Collins LC, Hankinson SE, et al. High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer. PNAS. 2011;108:18378–83. https://doi.org/10.1073/pnas.1115031108.

Article  PubMed  PubMed Central  Google Scholar 

Neudegger T, Verghese J, Hayer-Hartl M, Hartl FU, Bracher A. Structure of human heat-shock transcription factor 1 in complex with DNA. Nat Struct Mol Biol. 2016;23:140–6. https://doi.org/10.1038/nsmb.3149.

Article  CAS  PubMed  Google Scholar 

Darnell JE Jr. Transcription factors as targets for cancer therapy. Nat Rev Cancer. 2002;2:740–9. https://doi.org/10.1038/nrc906.

Article  CAS  PubMed  Google Scholar 

Kijima T, Prince T, Neckers L, Koga F, Fujii Y. Heat shock factor 1 (HSF1)-targeted anticancer therapeutics: overview of current preclinical progress. Expert Opin Ther Targets. 2019;23:369–77. https://doi.org/10.1080/14728222.2019.1602119.

Article  CAS  PubMed  Google Scholar 

Gumilar KE, Chin Y, Ibrahim IH, Tjokroprawiro BA, Yang JY, Zhou M, et al. Heat shock factor 1 inhibition: a novel anti-cancer strategy with promise for precision oncology. Cancers. 2023;15:5167 https://doi.org/10.3390/cancers15215167.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sharma C, Seo YH. Small molecule inhibitors of HSF1-activated pathways as potential next-generation anticancer therapeutics. Molecules. 2018;23:2757 https://doi.org/10.3390/molecules23112757.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yoon YJ, Kim JA, Shin KD, Shin DS, Han YM, Lee YJ, et al. KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter. J Biol Chem. 2011;286:1737–47. https://doi.org/10.1074/jbc.M110.179440.

Article  CAS  PubMed  Google Scholar 

Vilaboa N, Bore A, Martin-Saavedra F, Bayford M, Winfield N, Firth-Clark S, et al. New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival. Nucleic Acids Res. 2017;45:5797–817. https://doi.org/10.1093/nar/gkx194.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Takii R, Fujimoto M, Tan K, Takaki E, Hayashida N, Nakato R, et al. ATF1 modulates the heat shock response by regulating the stress-inducible heat shock factor 1 transcription complex. Mol Cell Biol. 2015;35:11–25. https://doi.org/10.1128/MCB.00754-14.

Article  CAS  PubMed  Google Scholar 

Dong B, Jaeger AM, Hughes PF, Loiselle DR, Hauck JS, Fu Y, et al. Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1. Sci Transl Med. 2020;12:eabb5647 https://doi.org/10.1126/scitranslmed.abb5647.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moerke NJ. Fluorescence polarization (FP) assays for monitoring peptide-protein or nucleic acid-protein binding. Curr Protoc Chem Biol. 2009;1:1–15. https://doi.org/10.1002/9780470559277.ch090102.

Article  PubMed  Google Scholar 

Lundblad JR, Laurance M, Goodman RH. Fluorescence polarization analysis of protein-DNA and protein-protein interactions. Mol Endocrinol. 1996;10:607–12. https://doi.org/10.1210/mend.10.6.8776720.

Article  CAS  PubMed  Google Scholar 

Roehrl MH, Wang JY, Wagner G. A general framework for development and data analysis of competitive high-throughput screens for small-molecule inhibitors of protein-protein interactions by fluorescence polarization. Biochemistry. 2004;43:16056–66. https://doi.org/10.1021/bi048233g.

Article  CAS  PubMed  Google Scholar 

Shih PC, Yang Y, Parkinson GN, Wilderspin A, Wells G. A high-throughput fluorescence polarization assay for discovering inhibitors targeting the DNA-binding domain of signal transducer and activator of transcription 3 (STAT3). Oncotarget. 2018;9:32690–701. https://doi.org/10.18632/oncotarget.26013.

Article  PubMed  PubMed Central  Google Scholar 

Fontaine F, Overman J, Moustaqil M, Mamidyala S, Salim A, Narasimhan K, et al. Small-molecule inhibitors of the SOX18 transcription factor. Cell Chem Biol. 2017;24:346–59. https://doi.org/10.1016/j.chembiol.2017.01.003.

Article  CAS  PubMed  Google Scholar 

Rishi V, Potter T, Laudeman J, Reinhart R, Silvers T, Selby M, et al. A high-throughput fluorescence-anisotropy screen that identifies small molecule inhibitors of the DNA binding of B-ZIP transcription factors. Anal Biochem. 2005;340:259–71. https://doi.org/10.1016/j.ab.2005.02.012.

Article  CAS  PubMed  Google Scholar 

Wang Z, Bhattacharya A, Ivanov DN. Identification of small-molecule inhibitors of the HuR/RNA interaction using a fluorescence polarization screening assay followed by NMR validation. PLoS One. 2015;10:e0138780 https://doi.org/10.1371/journal.pone.0138780.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu X, Chen Y, Fierke CA. A real-time fluorescence polarization activity assay to screen for inhibitors of bacterial ribonuclease P. Nucleic Acids Res. 2014;42:e159 https://doi.org/10.1093/nar/gku850.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cho EJ, Xia S, Ma LC, Robertus J, Krug RM, Anslyn EV, et al. Identification of influenza virus inhibitors targeting NS1A utilizing fluorescence polarization-based high-throughput assay. J Biomol Screen. 2012;17:448–59. https://doi.org/10.1177/1087057111431488.