Chalmers JD, Polverino E, Crichton ML, Ringshausen FC, De Soyza A, Vendrell M, Burgel PR, Haworth CS, Loebinger MR, Dimakou K, et al. Bronchiectasis in Europe: data on disease characteristics from the European Bronchiectasis registry (EMBARC). Lancet Respir Med. 2023;11(7):637–49.

Article  PubMed  Google Scholar 

Quint JK, Millett ER, Joshi M, Navaratnam V, Thomas SL, Hurst JR, Smeeth L, Brown JS. Changes in the incidence, prevalence and mortality of bronchiectasis in the UK from 2004 to 2013: a population-based cohort study. Eur Respir J. 2016;47(1):186–93.

Article  PubMed  Google Scholar 

Lin JL, Xu JF, Qu JM. Bronchiectasis in China. Ann Am Thorac Soc. 2016;13(5):609–16.

Article  PubMed  Google Scholar 

Feng J, Sun L, Sun X, Xu L, Liu L, Liu G, Wang J, Gao P, Zhan S, Chen Y, et al. Increasing prevalence and burden of bronchiectasis in urban Chinese adults, 2013–2017: a nationwide population-based cohort study. Respir Res. 2022;23(1):111.

Article  PubMed  PubMed Central  Google Scholar 

Roberts JM, Goyal V, Kularatna S, Chang AB, Kapur N, Chalmers JD, Goeminne PC, Hernandez F, Marchant JM, McPhail SM. The economic burden of bronchiectasis: a systematic review. Chest. 2023;164(6):1396–421.

Article  PubMed  Google Scholar 

Gao YH, Guan WJ, Liu SX, Wang L, Cui JJ, Chen RC, Zhang GJ. Aetiology of bronchiectasis in adults: a systematic literature review. Respirology (Carlton, Vic). 2016;21(8):1376–83.

Article  PubMed  Google Scholar 

Hill AT, Sullivan AL, Chalmers JD, De Soyza A, Elborn SJ, Floto AR, Grillo L, Gruffydd-Jones K, Harvey A, Haworth CS, et al. British thoracic society guideline for bronchiectasis in adults. Thorax. 2019;74(Suppl 1):1–69.

Article  PubMed  Google Scholar 

Guan WJ, Gao YH, Xu G, Lin ZY, Tang Y, Li HM, Lin ZM, Zheng JP, Chen RC, Zhong NS. Aetiology of bronchiectasis in Guangzhou, southern China. Respirology. 2015;20(5):739–48.

Article  PubMed  Google Scholar 

Qi Q, Wang W, Li T, Zhang Y, Li Y. Aetiology and clinical characteristics of patients with bronchiectasis in a Chinese Han population: a prospective study. Respirology (Carlton, Vic). 2015;20(6):917–24.

Article  PubMed  Google Scholar 

Chalmers JD, Aliberti S, Filonenko A, Shteinberg M, Goeminne PC, Hill AT, Fardon TC, Obradovic D, Gerlinger C, Sotgiu G, et al. Characterization of the “Frequent Exacerbator Phenotype” in bronchiectasis. Am J Respir Crit Care Med. 2018;197(11):1410–20.

Article  PubMed  Google Scholar 

De Angelis A, Johnson ED, Sutharsan S, Aliberti S. Exacerbations of bronchiectasis. Eur Respir Rev. 2024;33(173): 240085.

Article  PubMed  PubMed Central  Google Scholar 

Chalmers JD, Mall MA, McShane PJ, Nielsen KG, Shteinberg M, Sullivan SD, Chotirmall SH. A systematic literature review of the clinical and socioeconomic burden of bronchiectasis. Eur Respir Rev. 2024;33(173): 240049.

Article  PubMed  PubMed Central  Google Scholar 

Dicker AJ, Lonergan M, Keir HR, Smith AH, Pollock J, Finch S, Cassidy AJ, Huang JTJ, Chalmers JD. The sputum microbiome and clinical outcomes in patients with bronchiectasis: a prospective observational study. Lancet Respir Med. 2021;9(8):885–96.

Article  CAS  PubMed  Google Scholar 

Araújo D, Shteinberg M, Aliberti S, Goeminne PC, Hill AT, Fardon TC, Obradovic D, Stone G, Trautmann M, Davis A, et al. The independent contribution of Pseudomonas aeruginosa infection to long-term clinical outcomes in bronchiectasis. Eur Respir J. 2018;51(2):1701953.

Article  PubMed  Google Scholar 

Wang R, Ding S, Lei C, Yang D, Luo H. The contribution of Pseudomonas aeruginosa infection to clinical outcomes in bronchiectasis: a prospective cohort study. Ann Med. 2021;53(1):459–69.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pieters A, Bakker M, Hoek RAS, Altenburg J, van Westreenen M, Aerts J, van der Eerden MM. Predicting factors for chronic colonization of Pseudomonas aeruginosa in bronchiectasis. Eur J Clin Microbiol Infect Dis. 2019;38(12):2299–304.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Finch S, McDonnell MJ, Abo-Leyah H, Aliberti S, Chalmers JD. A Comprehensive analysis of the impact of Pseudomonas aeruginosa colonization on prognosis in adult bronchiectasis. Ann Am Thorac Soc. 2015;12(11):1602–11.

PubMed  Google Scholar 

Polverino E, Goeminne PC, McDonnell MJ, Aliberti S, Marshall SE, Loebinger MR, Murris M, Cantón R, Torres A, Dimakou K, et al. European Respiratory Society guidelines for the management of adult bronchiectasis. Eur Respir J. 2017;50(3):1700629.

Article  PubMed  Google Scholar 

Conceicao M, Shteinberg M, Goeminne P, Altenburg J, Chalmers JD. Eradication treatment for Pseudomonas aeruginosa infection in adults with bronchiectasis: a systematic review and meta-analysis. Eur Respir Rev. 2024;33(171): 230178.

Article  PubMed  PubMed Central  Google Scholar 

Reyes J, Komarow L, Chen L, Ge L, Hanson BM, Cober E, Herc E, Alenazi T, Kaye KS, Garcia-Diaz J, et al. Global epidemiology and clinical outcomes of carbapenem-resistant Pseudomonas aeruginosa and associated carbapenemases (POP): a prospective cohort study. The Lancet Microbe. 2023;4(3):e159–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma Y, Aung TT, Lakshminarayanan R, Chua SL. Biofilm formation and virulence potential of carbapenem-resistant Pseudomonas aeruginosa. Lancet Microbe. 2023;4(7): e489.

Article  PubMed  Google Scholar 

Hassoun-Kheir N, Guedes M, Ngo Nsoga MT, Argante L, Arieti F, Gladstone BP, Kingston R, Naylor NR, Pezzani MD, Pouwels KB, et al. A systematic review on the excess health risk of antibiotic-resistant bloodstream infections for six key pathogens in Europe. Clin Microbiol Infect. 2023. https://doi.org/10.1016/j.cmi.2023.09.001.

Article  PubMed  Google Scholar 

WHO. Media Center. WHO publishes list of bacteria for which new antibiotics are urgently needed. World Health Organization: Feb 27, 2017. https://www.who.int/news/item/27-02-2017who-publishes-list-of-bacteria-for-which-new-antibiotics-are-urgently-needed. Accessed 24 Aug 2024.

Wolff BJ, Bramley AM, Thurman KA, Whitney CG, Whitaker B, Self WH, Arnold SR, Trabue C, Wunderink RG, McCullers J, et al. Improved detection of respiratory pathogens by use of high-quality sputum with TaqMan array card technology. J Clin Microbiol. 2017;55(1):110–21.

Article  PubMed  Google Scholar 

Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing. 35th ed. Wayne: CLSI; 2025.

Google Scholar 

Gao YH, Guan WJ, Zhu YN, Chen RC, Zhang GJ. Antibiotic-resistant Pseudomonas aeruginosa infection in patients with bronchiectasis: prevalence, risk factors and prognostic implications. Int J Chron Obstruct Pulmon Dis. 2018;13:237–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Magiorakos AP, Srinivasan A, Carey RB, Carmeli Y, Falagas ME, Giske CG, Harbarth S, Hindler JF, Kahlmeter G, Olsson-Liljequist B, et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect. 2012;18(3):268–81.

Article  CAS  PubMed  Google Scholar 

Hill AT, Haworth CS, Aliberti S, Barker A, Blasi F, Boersma W, Chalmers JD, De Soyza A, Dimakou K, Elborn JS, et al. Pulmonary exacerbation in adults with bronchiectasis: a consensus definition for clinical research. Eur Respir J. 2017;49(6):1700051.

Article  PubMed  Google Scholar 

Agustí A, Celli BR, Criner GJ, Halpin D, Anzueto A, Barnes P, Bourbeau J, Han MK, Martinez FJ, Montes de Oca M, et al. Global initiative for chronic obstructive lung disease 2023 report: GOLD executive summary. Eur Respir J. 2023;61(4):2300239.

Article  PubMed  PubMed Central  Google Scholar 

Reddel HK, Bateman ED, Becker A, Boulet LP, Cruz AA, Drazen JM, Haahtela T, Hurd SS, Inoue H, de Jongste JC, et al. A summary of the new GINA strategy: a roadmap to asthma control. Eur Respir J. 2015;46(3):622–39.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choi H, Ryu S, Keir HR, Giam YH, Dicker AJ, Perea L, Richardson H, Huang JTJ, Cant E, Blasi F, et al. Inflammatory molecular endotypes in bronchiectasis: a european multicenter cohort study. Am J Respir Crit Care Med. 2023;208(11):1166–76.

Article  CAS  PubMed  Google Scholar 

Cole PJ. Inflammation: a two-edged sword–the model of bronchiectasis. Eur J Respir Dis. 1986;147:6–15.