Prevalence, trends, and molecular insights into colistin resistance among gram-negative bacteria in Egypt: a systematic review and meta-analysis

Balasubramanian R, Van Boeckel TP, Carmeli Y, Cosgrove S, Laxminarayan R. Global incidence in hospital-associated infections resistant to antibiotics: an analysis of point prevalence surveys from 99 countries. PLOS Med. 2023;20:e1004178.

Article  PubMed  PubMed Central  Google Scholar 

Schinas G, Skintzi K, De Lastic AL, Rodi M, Gogos C, Mouzaki A, et al. Patterns, cost, and immunological response of MDR vs. Non MDR-Bacteremia: A prospective cohort study. Pathogens. 2023;12:1044.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Siwakoti S, Subedi A, Sharma A, Baral R, Bhattarai NR, Khanal B. Incidence and outcomes of multidrug-resistant gram-negative bacteria infections in intensive care unit from Nepal- a prospective cohort study. Antimicrob Resist Infect Control. 2018;7:1–8.

Article  Google Scholar 

Mondal AH, Khare K, Saxena P, Debnath P, Mukhopadhyay K, Yadav D. A review on colistin resistance: an antibiotic of last resort. Microorganisms. 2024;12:772.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bostanghadiri N, Narimisa N, Mirshekar M, Dadgar-Zankbar L, Taki E, Navidifar T, et al. Prevalence of colistin resistance in clinical isolates of Acinetobacter baumannii: a systematic review and meta-analysis. Antimicrob Resist Infect Control. 2024;13:1–17.

Article  Google Scholar 

Uzairue LI, Rabaan AA, Adewumi FA, Okolie OJ, Folorunso JB, Bakhrebah MA et al. Global prevalence of colistin resistance in Klebsiella pneumoniae from bloodstream infection: A systematic review and Meta-Analysis. Pathogens. 2022;11.

Poirel L, Jayol A, Nordmanna P, Polymyxins. Antibacterial activity, susceptibility testing, and resistance mechanisms encoded by plasmids or chromosomes. Clin Microbiol Rev. 2017;30:557–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kaye KS, Pogue JM, Tran TB, Nation RL, Li J. Agents of last resort: polymyxin resistance. Infect Dis Clin. 2016;30:391–414.

Google Scholar 

Rhouma M, Beaudry F, Letellier A. Resistance to colistin: what is the fate for this antibiotic in pig production? Int J Antimicrob Agents. 2016;48:119–26.

Article  CAS  PubMed  Google Scholar 

Liu YY, Wang Y, Walsh TR, Yi LX, Zhang R, Spencer J, et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: A Microbiological and molecular biological study. Lancet Infect Dis. 2016;16:161–8.

Article  PubMed  Google Scholar 

Aghapour Z, Gholizadeh P, Ganbarov K, Bialvaei AZ, Mahmood SS, Tanomand A, et al. Molecular mechanisms related to colistin resistance in enterobacteriaceae. Infect Drug Resist. 2019;12:965–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Azzam A, Khaled H, Mosa M, Refaey N, AlSaifi M, Elsisi S, et al. Epidemiology of clinically isolated methicillin-resistant Staphylococcus aureus (MRSA) and its susceptibility to linezolid and Vancomycin in Egypt: a systematic review with meta-analysis. BMC Infect Dis. 2023;23:1–15.

Article  Google Scholar 

Azzam A, Elkafas H, Khaled H, Ashraf A, Yousef M, Elkashef AA. Prevalence of Vancomycin-resistant enterococci (VRE) in Egypt (2010–2022): a systematic review and meta-analysis. J Egypt Public Health Assoc. 2023;98:1–13.

Article  Google Scholar 

Azzam A, Khaled H, Samer D, Nageeb WM. Prevalence and molecular characterization of ESBL-producing Enterobacteriaceae in Egypt: a systematic review and meta-analysis of hospital and community-acquired infections. Antimicrob Resist Infect Control. 2024;13:1–14.

Article  Google Scholar 

ElSayed N, Amine A, El-Attar L, Amin MEK. Antimicrobial use in animal farms in Egypt: rates, patterns, and determinants. J Egypt Public Health Assoc. 2025;100:1–12.

Article  PubMed  PubMed Central  Google Scholar 

Prisma. PRISMA 2020 checklist — PRISMA statement. 2020. https://www.prisma-statement.org/prisma-2020-checklist. Accessed 19 Feb 2025.

EUCAST, eucast. Colistin susceptibility testing. https://www.eucast.org/eucast_news/news_singleview?tx_ttnews%5Btt_news%5D=569%26cHash=1e85cf87ccc25aeb7a80122dd1d1b551. Accessed 19 Feb 2025.

CLSI. Antimicrobial and Antifungal Susceptibility Testing Resources. 2017. https://clsi.org/about/about-clsi/about-clsi-antimicrobial-and-antifungal-susceptibility-testing-resources/. Accessed 19 Feb 2025.

JBI. JBI Critical Appraisal Tools| JBI. 2020;:1–5. https://jbi.global/critical-appraisal-tools. Accessed 19 Feb 2025.

Osama R, Bakeer W, Fadel S, Amin M. Association of carbapenem and colistin resistance in pathogenic gram negative bacteria. J Pure Appl Microbiol. 2019;13:733–9.

Article  Google Scholar 

Elnahriry SS, Khalifa HO, Soliman AM, Ahmed AM, Hussein AM, Shimamoto T, et al. Emergence of Plasmid-Mediated colistin resistance gene mcr-1 in a clinical Escherichia coli isolate from Egypt. Antimicrob Agents Chemother. 2016;60:3249–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Edward EA, El Shehawy MR, Abouelfetouh A, Aboulmagd E. Phenotypic and molecular characterization of extended spectrum- and metallo- beta lactamase producing Pseudomonas aeruginosa clinical isolates from Egypt. Infection. 2024;52:2399–414.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alshaikh SA, El-banna T, Sonbol F, Farghali MH. Correlation between antimicrobial resistance, biofilm formation, and virulence determinants in uropathogenic Escherichia coli from Egyptian hospital. Ann Clin Microbiol Antimicrob. 2024;23.

Ali SESI, Mahmoud NAS, Elamin MM, Amr GES, Mahrous HKA. Assessment of carbapenem resistant Klebsiella pneumoniae in intensive care unit of Zagazig university hospitals. Microbes Infect Dis. 2024;5:282–94.

CAS  Google Scholar 

Afify FA, Shata AH, Aboelnaga N, Osama D, Elsayed SW, Saif NA, et al. Emergence of carbapenem resistant gram-negative pathogens with high rate of colistin resistance in Egypt: A cross sectional study to assess resistance trends during the COVID-19 pandemic. J Genet Eng Biotechnol. 2024;22:100351.

Article  PubMed  PubMed Central  Google Scholar 

Abdel-Aty HF, El-Batal HM, Gohar NM. Assessment of colistin resistance among nosocomial multidrug-resistant Gram-negative bacilli isolated from different clinical samples. Microbes Infect Dis. 2024;5:1494–505.

CAS  Google Scholar 

Mahmoud FM, Moustafa NM, Gaber SA, Elsaid RG, Mohamed RA. Molecular mechanisms of colistin resistance among multi-drug resistant (MDR) Klebsiella pneumoniae and Escherichia coli isolated from ICU patients and their susceptibility towards Eravacycline. Microbes Infect Dis. 2023;4:127–37.

CAS  Google Scholar 

Mohamed El-Khatib A, Farouk Basyony A, Ali El-Gharib K. Detection of mcr-1 to mcr-5 Genes-Mediated Colistin-Resistance in Gram-Negative clinical isolates. Al-Azhar Med J. 2023;52:943–56.

Google Scholar 

Elshamy AA, Saleh SE, Aboshanab KM, Aboulwafa MM, Hassouna NA. In vitro meropenem/antibiotic and Meropenem/Bacteriophage combinations against Carbapenem-Resistant Gram-Negative uropathogens. Arch Pharm Sci Ain Shams Univ. 2023;7:19–30.

Abozahra R, Gaballah A, Abdelhamid SM. Prevalence of the colistin resistance gene MCR-1 in colistin-resistant Klebsiella pneumoniae in Egypt. AIMS Microbiol. 2023;9:177–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abdelbary ER, Elsaghier AM, El-Baky RMA, Waly NGFM, Ramadan M, Abd-Elsamea FS, et al. First emergence of NDM-5 and OqxAB efflux pumps among Multidrug-Resistant Klebsiella pneumoniae isolated from pediatric patients in Assiut, Egypt. Infect Drug Resist. 2023;16:5965–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mashaly GES, Mashaly MES. Colistin-heteroresistance in carbapenemase-producing Enterobacter species causing hospital-acquired infections among Egyptian patients. J Glob Antimicrob Resist. 2021;24:108–13.

Article  CAS  PubMed  Google Scholar 

Sorour AE, Ibrahim KAA, Hegab AS. Prevalence of acquired colistin resistance among gram negative Bacilli isolated from patients admitted at Cairo university hospitals. Egypt J Med Microbiol. 2022;31:97–104.

Article  Google Scholar 

Shrief R, El-Ashry AH, Mahmoud R, El-Mahdy R. Effect of colistin, fosfomycin and Meropenem/Vaborbactam on Carbapenem-Resistant enterobacterales in Egypt: A Cross-Sectional study. Infect Drug Resist. 2022;15:6203.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ramadan RA, Bedawy AM, Negm EM, Hassan TH, Ibrahim DA, Elsheikh SM, et al. Carbapenem-Resistant Klebsiella pneumoniae among patients with Ventilator-Associated pneumonia: evaluation of antibiotic combinations and susceptibility to new antibiotics. Infect Drug Resist. 2022;15:3537–48.

Article  PubMed  PubMed Central  Google Scholar 

Mohamed NMK, El-Baghdady KZ, El-Kholy E, Fahmy GM. Prevalence of carbapenemase genes in extreme drug resistant Pseudomonas aeruginosa isolated from ICU in Egypt. Afr J Biol Sci. 2022;18:39–51.

Google Scholar 

Mohamed N, Ghazal A, Ahmed AAH, Zaki A. Prevalence and determinants of antimicrobial resistance of pathogens isolated from cancer patients in an intensive care unit in Alexandria, Egypt. J Egypt Public Health Assoc. 2023;98:9.

Article  PubMed  PubMed Central  Google Scholar 

Mohamed TA, Afifi S, Hassaneen A, Radwan M, Ateya RM. Carbapenem-resistant Klebsiella pneumoniae in COVID-19 patients admitted to intensive care units of Zagazig university hospitals. Microbes Infect Dis. 2024;0:0–0.

Google Scholar 

Gaballah AH, Shawky S, Amer AN. Microbiological profiles of neonatal sepsis in Northern Egypt. Microbes Infect Dis. 2022;3:645–56.

CAS 

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