NSAID-encapsulated nanoparticles as a targeted therapeutic platform for modulating chronic inflammation and inhibiting cancer progression: a review

Abou Shousha SA, Hussein B, Shahine Y, Fadali G, Zohir M, Hamed Y, Hemedah M, Baheeg SA, Ibrahim A, El Shannawy M, Osman EM (2022) Angiogenic activities of interleukin-8, vascular endothelial growth factor and matrix metalloproteinase-9 in breast cancer. Egypt J Immunol 29:54–63

Article  PubMed  Google Scholar 

Agarwal R, Kaye SB (2003) Ovarian cancer: strategies for overcoming resistance to chemotherapy. Nat Rev Cancer 3:502–516. https://doi.org/10.1038/nrc1123

Article  CAS  PubMed  Google Scholar 

Akrami H, Moradi B, Borzabadi Farahani D, Mehdizadeh K (2018) Ibuprofen reduces cell proliferation through inhibiting Wnt/β catenin signaling pathway in gastric cancer stem cells. Cell Biol Int 42:949–958. https://doi.org/10.1002/cbin.10959

Article  CAS  PubMed  Google Scholar 

Albanese A, Lam AK, Sykes EA, Rocheleau JV, Chan WCW (2013) Tumour-on-a-chip provides an optical window into nanoparticle tissue transport. Nat Commun 4:2718. https://doi.org/10.1038/ncomms3718

Article  CAS  PubMed  Google Scholar 

Alexis F, Basto P, Levy-Nissenbaum E, Radovic-Moreno AF, Zhang L, Pridgen E, Wang AZ, Marein SL, Westerhof K, Molnar LK, Farokhzad OC (2008a) HER-2-targeted nanoparticle-affibody bioconjugates for cancer therapy. ChemMedChem 3:1839–1843. https://doi.org/10.1002/cmdc.200800122

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alexis F, Pridgen E, Molnar LK, Farokhzad OC (2008b) Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol Pharm 5:505–515. https://doi.org/10.1021/mp800051m

Article  CAS  PubMed  PubMed Central  Google Scholar 

Allen JD, Brinkhuis RF, van Deemter L, Wijnholds J, Schinkel AH (2000) Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance. Cancer Res 60:5761–5766

CAS  PubMed  Google Scholar 

Alves Rico SR, Abbasi AZ, Ribeiro G, Ahmed T, Wu XY, de Oliveira Silva D (2017) Diruthenium(ii, iii) metallodrugs of ibuprofen and naproxen encapsulated in intravenously injectable polymer-lipid nanoparticles exhibit enhanced activity against breast and prostate cancer cells. Nanoscale 9:10701–10714. https://doi.org/10.1039/c7nr01582h

Article  CAS  PubMed  Google Scholar 

Amreddy N, Muralidharan R, Babu A, Mehta M, Johnson EV, Zhao YD, Munshi A, Ramesh R (2015) Tumor-targeted and pH-controlled delivery of doxorubicin using gold nanorods for lung cancer therapy. Int J Nanomedicine 10:6773–6788. https://doi.org/10.2147/IJN.S93237

Article  CAS  PubMed  PubMed Central  Google Scholar 

Annunziata CM, Stavnes HT, Kleinberg L, Berner A, Hernandez LF, Birrer MJ, Steinberg SM, Davidson B, Kohn EC (2010) Nuclear factor kappaB transcription factors are coexpressed and convey a poor outcome in ovarian cancer. Cancer 116:3276–3284. https://doi.org/10.1002/cncr.25190

Article  CAS  PubMed  Google Scholar 

Apte RS, Chen DS, Ferrara N (2019) VEGF in signaling and disease: beyond discovery and development. Cell 176:1248–1264. https://doi.org/10.1016/j.cell.2019.01.021

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arico S, Pattingre S, Bauvy C, Gane P, Barbat A, Codogno P, Ogier-Denis E (2002) Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell line. J Biol Chem 277:27613–27621. https://doi.org/10.1074/jbc.M201119200

Article  CAS  PubMed  Google Scholar 

Arruebo M, Vilaboa N, Sáez-Gutierrez B, Lambea J, Tres A, Valladares M, González-Fernández A (2011) Assessment of the evolution of cancer treatment therapies. Cancers (Basel) 3:3279–3330. https://doi.org/10.3390/cancers3033279

Article  CAS  PubMed  Google Scholar 

Ashok V, Dash C, Rohan TE, Sprafka JM, Terry PD (2011) Selective cyclooxygenase-2 (COX-2) inhibitors and breast cancer risk. Breast 20:66–70. https://doi.org/10.1016/j.breast.2010.07.004

Article  PubMed  Google Scholar 

Avgoustakis K (2004) Pegylated poly(lactide) and poly(lactide-co-glycolide) nanoparticles: preparation, properties and possible applications in drug delivery. Curr Drug Deliv 1:321–333. https://doi.org/10.2174/1567201043334605

Article  CAS  PubMed  Google Scholar 

Azevedo MF, Faucz FR, Bimpaki E, Horvath A, Levy I, de Alexandre RB, Ahmad F, Manganiello V, Stratakis CA (2014) Clinical and molecular genetics of the phosphodiesterases (PDEs). Endocr Rev 35:195–233. https://doi.org/10.1210/er.2013-1053

Article  CAS  PubMed  Google Scholar 

Baer AN, Costello PB, Green FA (1991) In vivo activation of an omega-6 oxygenase in human skin. Biochem Biophys Res Commun 180:98–104. https://doi.org/10.1016/s0006-291x(05)81260-4

Article  CAS  PubMed  Google Scholar 

Bahrami B, Hojjat-Farsangi M, Mohammadi H, Anvari E, Ghalamfarsa G, Yousefi M, Jadidi-Niaragh F (2017) Nanoparticles and targeted drug delivery in cancer therapy. Immunol Lett 190:64–83. https://doi.org/10.1016/j.imlet.2017.07.015

Article  CAS  PubMed  Google Scholar 

Balasubramanian S, Girija AR, Nagaoka Y, Iwai S, Suzuki M, Kizhikkilot V, Yoshida Y, Maekawa T, Nair SD (2014) Curcumin and 5-fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia. Int J Nanomed 9:437–459. https://doi.org/10.2147/IJN.S49882

Article  CAS  Google Scholar 

Barnard ME, Poole EM, Curhan GC, Eliassen AH, Rosner BA, Terry KL, Tworoger SS (2018) Association of analgesic use with risk of ovarian cancer in the nurses’ health studies. JAMA Oncol 4:1675–1682. https://doi.org/10.1001/jamaoncol.2018.4149

Article  PubMed  PubMed Central  Google Scholar 

Benelli R, Barboro P, Costa D, Astigiano S, Barbieri O, Capaia M, Poggi A, Ferrari N (2019) Multifocal signal modulation therapy by celecoxib: a strategy for managing castration-resistant prostate cancer. Int J Mol Sci. https://doi.org/10.3390/ijms20236091

Article  PubMed  PubMed Central  Google Scholar 

Berger J, Moller DE (2002) The mechanisms of action of PPARs. Annu Rev Med 53:409–435. https://doi.org/10.1146/annurev.med.53.082901.104018

Article  CAS  PubMed  Google Scholar 

Bertrand N, Wu J, Xu X, Kamaly N, Farokhzad OC (2014) Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. Adv Drug Deliv Rev 66:2–25. https://doi.org/10.1016/j.addr.2013.11.009

Article  CAS  PubMed  Google Scholar 

Betancourt T, Byrne JD, Sunaryo N, Crowder SW, Kadapakkam M, Patel S, Casciato S, Brannon-Peppas L (2009) PEGylation strategies for active targeting of PLA/PLGA nanoparticles. J Biomed Mater Res A 91:263–276. https://doi.org/10.1002/jbm.a.32247

Article  CAS  PubMed  Google Scholar 

Bhattacharya S, Prajapati BG, Singh S (2023) A critical review on the dissemination of PH and stimuli-responsive polymeric nanoparticular systems to improve drug delivery in cancer therapy. Crit Rev Oncol Hematol 185:103961. https://doi.org/10.1016/j.critrevonc.2023.103961

Article  PubMed  Google Scholar 

Bjorkman DJ (1999) Current status of nonsteroidal anti-inflammatory drug (NSAID) use in the United States: risk factors and frequency of complications. Am J Med 107(6):3–8. https://doi.org/10.1016/s0002-9343(99)00362-9

Article  Google Scholar 

Bleijs M, van de Wetering M, Clevers H, Drost J (2019) Xenograft and organoid model systems in cancer research. EMBO J. https://doi.org/10.15252/embj.2019101654

Article  PubMed  PubMed Central  Google Scholar 

Bonnesen K, Schmidt M (2021) Recategorization of non-aspirin nonsteroidal anti-inflammatory drugs according to clinical relevance: abandoning the traditional nsaid terminology. Can J Cardiol 37:1705–1707. https://doi.org/10.1016/j.cjca.2021.06.014

Article  PubMed  Google Scholar 

Comments (0)

No login
gif