The Role of MicroRNA in the Development of Type 2 Diabetes Mellitus

Klinicheskie rekomendatsii. Sakharnyi diabet 2 tipa u v-zroslykh (Clinical Recommendations. Type 2 Diabetes Mellitus in Adults), Obshchestvennaya Organizatsiya “Rossiiskaya Assotsiatsiya Endokrinologov,” 2022.

Kurkin, D.V., Morkovin, E.I., Bakulin, D.A., Gorbunova, Yu.V., Strygin, A.V., Robertus, A.I., Makarenko, I.E., Saparova, V.B., Drai, R.V., and Petrov, V.I., Modern concepts of the pathogenesis of type 2 diabetes mellitus, Vestn. Volgogr. Gos. Med. Univ., 2022, vol. 19, pp. 34–49. https://doi.org/10.19163/1994-9480-2022-19-4-34-49

Article  Google Scholar 

Dedov, I.I., Shestakova, M.V., Vikulova, O.K., Zheleznyakova, A.V., Isakov, M.A., Serkov, A.A., and Mokrysheva, N.G., Dynamics of epidemiological indicators of diabetes mellitus in the Russian Federation for the period 2017−2021, in Sbornik tezisov IX (XXVIII) Natsional’nyi diabetologicheskii kongress s mezhdunarodnym uchastiem “Sakharnyi diabet i ozhirenie–neinfektsionnye mezhdistsiplinarnye pandemii XXI veka” (Proceedings of 9th (28th) National Diabetes Congress with International Participation “Diabetes Mellitus and Obesity—Non-Infectious Interdisciplinary Pandemics of the 21st Century”), 2022, p. 63. https://doi.org/10.14341/Conf05-08.09.22-61

Ushanova, F.O., Izmailova, M.Ya., and Plakhotnyaya, V.M., Difficulties in differential diagnosis of type 2 diabetes mellitus in clinical practice, Russ. Med. Zh., 2020, vol. 12, pp. 14–16.

Google Scholar 

Tonyan, Z.N., Nasykhova, Y.A., Mikhailova, A.A., and Glotov, A.S., MicroRNAs as potential biomarkers of type 2 diabetes mellitus, Russ. J. Genet., 2021, vol. 57, no. 7, pp. 764–777. https://doi.org/10.1134/S1022795421060107

Article  CAS  Google Scholar 

Ho, P.T.B., Clark, I.M., and Le, L.T.T., MicroRNA-based diagnosis and therapy, Int. J. Mol. Sci., 2022, vol. 23, p. 7167. https://doi.org/10.3390/ijms23137167

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu, C., Wang, D., Feng, Y., Feng, L., and Li, Z., miR-720 regulates insulin secretion by targeting Rab35, Biomed. Res. Int., 2021, vol. 2021, p. 6662612. https://doi.org/10.1155/2021/6662612

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghaffari, M., Razi, S., Zalpoor, H., Nabi-Afjadi, M., Mohebichamkhorami, F., and Zali, H., Association of microRNA-146a with type 1 and 2 diabetes and their related complications, J. Diabetes Res., 2023, vol. 2023, p. 2587104. https://doi.org/10.1155/2023/2587104

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jankauskas, S.S., Gambardella, J., Sardu, C., Lombardi, A., and Santulli, G., Functional role of miR-155 in the pathogenesis of diabetes mellitus and its complications, Non-Coding RNA, 2021, vol. 7, p. 39. https://doi.org/10.3390/ncrna7030039

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sadeghzadeh, S., Dehghani Ashkezari, M., Seifa-ti, S.M., Vahidi Mehrjardi, M.Y., Dehghan Tezerjani, M., Sadeghzadeh, S., Ladan, S.A.B., Circulating miR-15a and miR-222 as potential biomarkers of type 2 diabetes, Diabetes, Metab. Syndr. Obes.: Targets Ther., 2020, vol. 13, pp. 3461–3469. https://doi.org/10.2147/dmso.s263883

Article  CAS  Google Scholar 

Tonyan, Z.N., Barbitoff, Y.A., Nasykhova, Y.A., Danilova, M.M., Kozyulina, P.Y., Mikhailova, A.A., Bulgakova, O.L., Vlasova, M.E., Golovkin, N.V., and Glotov, A.S., Plasma microRNA profiling in type 2 diabetes mellitus: A pilot study, Int. J. Mol. Sci., 2023, vol. 24, p. 17406. https://doi.org/10.3390/ijms242417406

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baroukh, N.N. and Van Obberghen, E., Function of microRNA-375 and microRNA-124a in pancreas and brain, FEBS J., 2009, vol. 276, pp. 6509–6521. https://doi.org/10.1111/j.1742-4658.2009.07353.x

Article  CAS  PubMed  Google Scholar 

Wysham, C. and Shubrook, J., Beta-cell failure in type 2 diabetes: Mechanisms, markers, and clinical implications, Postgrad. Med., 2020, vol. 132, pp. 676–686. https://doi.org/10.1080/00325481.2020.1771047

Article  CAS  PubMed  Google Scholar 

Poy, M.N., Eliasson, L., Krutzfeldt, J., Kuwajima, S., Ma, X., Macdonald, P.E., Pfeffer, S., Tuschl, T., Rajewsky, N., Rorsman, P., and Stoffel, M., A pancreatic islet-specific microRNA regulates insulin secretion, Nature, 2004, vol. 432, pp. 226–230. https://doi.org/10.1038/nature03076

Article  CAS  PubMed  Google Scholar 

Cooper, M.E., Vranes, D., Youssef, S., Stacker, S.A., Cox, A.J., Rizkalla, B., Casley, D.J., Bach, L.A., Kelly, D.J., and Gilbert, R.E., Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes, Diabetes, 1999, vol. 48, pp. 2229–2239. https://doi.org/10.2337/diabetes.48.11.2229

Article  CAS  PubMed  Google Scholar 

Meng, S., Cao, J.T., Zhang, B., Zhou, Q., Shen, C.X., and Wang, C.Q., Downregulation of microRNA-126 in endothelial progenitor cells from diabetes patients, impairs their functional properties, via target gene Spred-1, J. Mol. Cell. Cardiol., 2012, vol. 53, pp. 64–72. https://doi.org/10.1016/j.yjmcc.2012.04.003

Article  CAS  PubMed  Google Scholar 

Gallagher, I.J., Scheele, C., Keller, P., Nielsen, A.R., Remenyi, J., Fischer, C.P., Roder, K., Babraj, J., Wahlestedt, C., Hutvagner, G., Pedersen, B.K., and Timmons, J.A., Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes, Genome Med., 2010, vol. 2, p. 9. https://doi.org/10.1186/gm130

Article  CAS  PubMed  PubMed Central  Google Scholar 

Al-Kafaji, G., Al-Mahroos, G., Abdulla Al-Muhtaresh, H., Sabry, M.A., Abdul Razzak, R., and Salem, A.H., Circulating endothelium-enriched microRNA-126 as a potential biomarker for coronary artery disease in type 2 diabetes mellitus patients, Biomarkers, 2017, vol. 22, pp. 268–278. https://doi.org/10.1080/1354750X.2016

Article  CAS  PubMed  Google Scholar 

Ebrahimi, F., Gopalan, V., Smith, R.A., and Lam, A.K., miR-126 in human cancers: Clinical roles and current perspectives, Exp. Mol. Pathol., 2014, vol. 96, pp. 98–107. https://doi.org/10.1016/j.yexmp.2013.12.004

Article  CAS  PubMed  Google Scholar 

Lovis, P., Roggli, E., Laybutt, D.R., Gattesco, S., Yang, J.Y., Widmann, C., Abderrahmani, A., and Regazzi, R., Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction, Diabetes, 2008, vol. 57, pp. 2728–2736. https://doi.org/10.2337/db07-1252

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu, H., Du, X., Xu, J., Zhang, Y., Tian, Y., Liu, G., Wang, X., Ma, M., Du, W., Liu, Y., Dai, L., Huang, W., Tong, N., Wei, Y., and Fu, X., Pancreatic β cell microRNA-26a alleviates type 2 diabetes by improving peripheral insulin sensitivity and preserving β cell function, PLoS Biol., 2020, vol. 18, p. e3000603. https://doi.org/10.1371/journal.pbio.3000603

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zeinali, F., Aghaei Zarch, S.M., Jahan-Mihan, A., Kalantar, S.M., Vahidi Mehrjardi, M.Y., Fallahzadeh, H., Hosseinzadeh, M., Rahmanian, M., and Mozaffari-Khosravi, H., Circulating microRNA-122, microRNA-126-3p and microRNA-146a are associated with inflammation in patients with prediabetes and type 2 diabetes mellitus: A case control study, PLoS One, 2021, vol. 16, p. e0251697. https://doi.org/10.1371/journal.pone.0251697

Article  CAS  PubMed  PubMed Central  Google Scholar 

Agbu, P. and Carthew, R.W., MicroRNA-mediated regulation of glucose and lipid metabolism, Nat. Rev. Mol. Cell Biol., 2021, vol. 22, pp. 425–438. https://doi.org/10.1038/s41580-021-00354-w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu, X., Li, Y., Man, B., and Li, D., Assessing micro-RNA-375 levels in type 2 diabetes mellitus (T2DM) patients and their first-degree relatives with T2DM, Diabetes, Metab. Syndr. Obes.: Targets Ther., 2021, vol. 14, pp. 1445–1451. https://doi.org/10.2147/DMSO.S298735

Article  Google Scholar 

Shen, Y., Xu, H., Pan, X., Wu, W., Wang, H., Yan, L., Zhang, M., Liu, X., Xia, S., and Shao, Q., miR-34a and miR-125b are upregulated in peripheral blood mononuclear cells from patients with type 2 diabetes mellitus, Exp. Ther. Med., 2017, vol. 14, pp. 5589–5596. https://doi.org/10.3892/etm.2017.5254

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li, Z., Peng, B., Chen, S., Li, J., Hu, K., Liao, L., Xie, Q., Yao, M., Liang, L., Tomlinson, S., Yuan, G., and He, S., Transcriptome sequencing and metabolome analysis reveal the metabolic reprogramming of partial hepatectomy and extended hepatectomy, BMC Genomics, 2023, vol. 24, p. 532. https://doi.org/10.1186/s12864-023-09647-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kruglova, N.A. and Filatov, A.V., RNA sequencing (RNA-SEQ) method in immunological studies, Immunologiya, 2017, vol. 38, pp. 112–117. https://doi.org/10.18821/0206-4952-2017-38-2-112-117

Article  Google Scholar 

Gareev, I.F. and Beylerli, O.A., Circulating microR-NAs as biomarkers: What are perspectives?, Profil. Med., 2018, vol. 21, pp. 142–150. https://doi.org/10.17116/profmed201821061142

Article  Google Scholar

Comments (0)

No login
gif