Bozkurt B et al (2021) Universal definition and classification of heart failure: a report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure. J Card Fail 27(4):387–413

Article  Google Scholar 

Dunlay SM, Roger VL, Redfield MM (2017) Epidemiology of heart failure with preserved ejection fraction. Nat Rev Cardiol 14(10):591–602

Article  PubMed  Google Scholar 

Roger VL (2021) Epidemiology of heart failure: a contemporary perspective. Circ Res 128(10):1421–1434

Article  CAS  PubMed  Google Scholar 

Owan TE et al (2006) Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med 355(3):251–259

Article  CAS  PubMed  Google Scholar 

Obokata M et al (2017) Evidence supporting the existence of a distinct obese phenotype of heart failure with preserved ejection fraction. Circulation 136(1):6–19

Article  CAS  PubMed  PubMed Central  Google Scholar 

Teramoto K et al (2022) Epidemiology and clinical features of heart failure with preserved ejection fraction. Card Fail Rev 8:e27

Article  PubMed  PubMed Central  Google Scholar 

Shah SJ, Katz DH, Deo RC (2014) Phenotypic spectrum of heart failure with preserved ejection fraction. Heart Fail Clin 10(3):407–418

Article  PubMed  PubMed Central  Google Scholar 

Kitzman DW, Shah SJ (2016) The HFpEF obesity phenotype: the elephant in the room. J Am Coll Cardiol 68(2):200–203

Article  PubMed  Google Scholar 

Pandey A et al (2021) Exercise intolerance in older adults with heart failure with preserved ejection fraction: JACC state-of-the-art review. J Am Coll Cardiol 78(11):1166–1187

Article  PubMed  PubMed Central  Google Scholar 

Kitzman DW et al (2002) Pathophysiological characterization of isolated diastolic heart failure in comparison to systolic heart failure. JAMA 288(17):2144–2150

Article  PubMed  Google Scholar 

Borlaug BA et al (2006) Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction. Circulation 114(20):2138–2147

Article  PubMed  Google Scholar 

Maeder MT et al (2010) Hemodynamic basis of exercise limitation in patients with heart failure and normal ejection fraction. J Am Coll Cardiol 56(11):855–863

Article  PubMed  Google Scholar 

Nayor M et al (2020) Impaired exercise tolerance in heart failure with preserved ejection fraction: quantification of multiorgan system reserve capacity. JACC Heart Fail 8(8):605–617

Article  PubMed  PubMed Central  Google Scholar 

Mehra MR et al (2016) The 2016 International Society for Heart Lung Transplantation listing criteria for heart transplantation: a 10-year update. J Heart Lung Transplant 35(1):1–23

Article  PubMed  Google Scholar 

Mangla A et al (2013) Comparison of predictors of heart failure-related hospitalization or death in patients with versus without preserved left ventricular ejection fraction. Am J Cardiol 112(12):1907–1912

Article  PubMed  Google Scholar 

Shafiq A et al (2016) Prognostic value of cardiopulmonary exercise testing in heart failure with preserved ejection fraction. The Henry Ford HospITal CardioPulmonary EXercise Testing (FIT-CPX) project. Am Heart J 174:167–72

Article  PubMed  PubMed Central  Google Scholar 

Nadruz W Jr et al (2017) Prognostic value of cardiopulmonary exercise testing in heart failure with reduced, midrange, and preserved ejection fraction. J Am Heart Assoc 6(11):e006000

Article  PubMed  PubMed Central  Google Scholar 

Zhuang C et al (2021) The effect of exercise training and physiotherapy on diastolic function, exercise capacity and quality of life in patients with heart failure with preserved ejection fraction: a systematic review and meta-analysis. Kardiol Pol 79(10):1107–1115

Article  PubMed  Google Scholar 

Kitzman DW et al (2016) Effect of caloric restriction or aerobic exercise training on peak oxygen consumption and quality of life in obese older patients with heart failure with preserved ejection fraction: a randomized clinical trial. JAMA 315(1):36–46

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mattavelli I et al (2023) Beyond VO2: the complex cardiopulmonary exercise test. Eur J Prev Cardiol 30(Suppl 2):ii34-ii39

Kitzman DW et al (1991) Exercise intolerance in patients with heart failure and preserved left ventricular systolic function: failure of the Frank-Starling mechanism. J Am Coll Cardiol 17(5):1065–1072

Article  CAS  PubMed  Google Scholar 

Haykowsky MJ, Kitzman DW (2014) Exercise physiology in heart failure and preserved ejection fraction. Heart Fail Clin 10(3):445–452

Article  PubMed  PubMed Central  Google Scholar 

Flamm SD et al (1990) Redistribution of regional and organ blood volume and effect on cardiac function in relation to upright exercise intensity in healthy human subjects. Circulation 81(5):1550–1559

Article  CAS  PubMed  Google Scholar 

Miller JD et al (2005) Skeletal muscle pump versus respiratory muscle pump: modulation of venous return from the locomotor limb in humans. J Physiol 563(Pt 3):925–943

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rosenwinkel ET et al (2001) Exercise and autonomic function in health and cardiovascular disease. Cardiol Clin 19(3):369–387

Article  CAS  PubMed  Google Scholar 

Higginbotham MB et al (1986) Regulation of stroke volume during submaximal and maximal upright exercise in normal man. Circ Res 58(2):281–291

Article  CAS  PubMed  Google Scholar 

van Heerebeek L et al (2006) Myocardial structure and function differ in systolic and diastolic heart failure. Circulation 113(16):1966–1973

Article  PubMed  Google Scholar 

Zile MR, Brutsaert DL (2002) New concepts in diastolic dysfunction and diastolic heart failure: Part I: diagnosis, prognosis, and measurements of diastolic function. Circulation 105(11):1387–1393

Article  PubMed  Google Scholar 

Aurigemma GP, Gaasch WH (2004) Clinical practice. Diastolic heart failure. N Engl J Med 351(11):1097–105

Haykowsky MJ et al (2011) Determinants of exercise intolerance in elderly heart failure patients with preserved ejection fraction. J Am Coll Cardiol 58(3):265–274

Article  PubMed  PubMed Central  Google Scholar 

Borlaug BA et al (2011) Diastolic relaxation and compliance reserve during dynamic exercise in heart failure with preserved ejection fraction. Heart 97(12):964–969

Article  PubMed  Google Scholar 

Shibata S et al (2011) Congestive heart failure with preserved ejection fraction is associated with severely impaired dynamic Starling mechanism. J Appl Physiol 110(4):964–971

Article  PubMed  PubMed Central  Google Scholar 

Abudiab MM et al (2013) Cardiac output response to exercise in relation to metabolic demand in heart failure with preserved ejection fraction. Eur J Heart Fail 15(7):776–785

Article  PubMed  PubMed Central  Google Scholar 

Borlaug BA et al (2010) Exercise hemodynamics enhance diagnosis of early heart failure with preserved ejection fraction. Circ Heart Fail 3(5):588–595

Article  PubMed  PubMed Central  Google Scholar 

Borlaug BA (2014) Mechanisms of exercise intolerance in heart failure with preserved ejection fraction. Circ J 78(1):20–32