Chen Y, Harris S, Rogers Y, Ahmad T, Asselbergs FW (2022) Nudging within learning health systems: next generation decision support to improve cardiovascular care. Eur Heart J 43(13):1296-1306A. https://doi.org/10.1093/EURHEARTJ/EHAC030

Article  PubMed  PubMed Central  Google Scholar 

Kao DP, Trinkley KE, Lin CT (2020) Heart failure management innovation enabled by electronic health records. JACC Heart Fail 8(3):223–233. https://doi.org/10.1016/j.jchf.2019.09.008

Article  PubMed  PubMed Central  Google Scholar 

Fuery MA, Kadhim B, Samsky MD et al (2023) Electronic health record embedded strategies for improving care of patients with heart failure. Curr Heart Fail Rep 20(4):280–286. https://doi.org/10.1007/s11897-023-00614-0

Article  PubMed  Google Scholar 

Heidenreich PA, Bozkurt B, Aguilar D et al (2022) 2022 AHA/ACC/HFSA guideline for the management of heart failure: executive summary: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol 79(17):1757–1780. https://doi.org/10.1016/J.JACC.2021.12.011

Article  PubMed  Google Scholar 

Kittleson MM, Breathett K, Ziaeian B, et al. 2024 Update to the 2020 ACC/AHA clinical performance and quality measures for adults with heart failure: a report of the American Heart Association/American College of Cardiology Joint Committee on Performance Measures. Circ Cardiovasc Qual Outcomes. Published online August 8, 2024. https://doi.org/10.1161/HCQ.0000000000000132

Greene SJ, Ayodele I, Pierce JB, et al. Eligibility and projected benefits of rapid initiation of quadruple therapy for newly diagnosed heart failure. JACC Heart Fail. 2024;12(8). https://doi.org/10.1016/J.JCHF.2024.03.001

Tang AB, Brownell NK, Roberts JS et al (2024) Interventions for optimization of guideline-directed medical therapy: a systematic review. JAMA Cardiol 9(4):397–404. https://doi.org/10.1001/JAMACARDIO.2023.5627

Article  PubMed  Google Scholar 

Jalloh MB, Averbuch T, Kulkarni P et al (2023) Bridging treatment implementation gaps in patients with heart failure: JACC Focus Seminar. J Am Coll Cardiol 82(6):544. https://doi.org/10.1016/J.JACC.2023.05.050

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahmad T, Desai NR, Yamamoto Y et al (2022) Alerting clinicians to 1-year mortality risk in patients hospitalized with heart failure: the REVEAL-HF randomized clinical trial. JAMA Cardiol 7(9):905–912. https://doi.org/10.1001/JAMACARDIO.2022.2496

Article  PubMed  PubMed Central  Google Scholar 

Rahimi K, Bennett D, Conrad N et al (2014) Risk prediction in patients with heart failure: a systematic review and analysis. JACC Heart Fail 2(5):440–446. https://doi.org/10.1016/J.JCHF.2014.04.008

Article  PubMed  Google Scholar 

Lee DS, Lee JS, Schull MJ et al (2019) Prospective validation of the emergency heart failure mortality risk grade for acute heart failure. Circulation 139(9):1146–1156. https://doi.org/10.1161/CIRCULATIONAHA.118.035509

Article  PubMed  Google Scholar 

Ghazi L, Yamamoto Y, Riello RJ et al (2022) Electronic alerts to improve heart failure therapy in outpatient practice: a cluster randomized trial. J Am Coll Cardiol 79(22):2203–2213. https://doi.org/10.1016/j.jacc.2022.03.338

Article  CAS  PubMed  Google Scholar 

Ghazi L, Desai NR, Simonov M et al (2022) Rationale and design of a cluster-randomized pragmatic trial aimed at improving use of guideline directed medical therapy in outpatients with heart failure: PRagmatic trial of messaging to providers about treatment of heart failure (PROMPT-HF). Am Heart J 244:107–115. https://doi.org/10.1016/j.ahj.2021.11.010

Article  PubMed  Google Scholar 

Ghazi L, O’Connor K, Yamamoto Y et al (2023) Pragmatic trial of messaging to providers about treatment of acute heart failure: the PROMPT-AHF trial. Am Heart J 257:111–119. https://doi.org/10.1016/J.AHJ.2022.12.002

Article  PubMed  Google Scholar 

Ghazi L, Yamamoto Y, Fuery M et al (2023) Electronic health record alerts for management of heart failure with reduced ejection fraction in hospitalized patients: the PROMPT-AHF trial. Eur Heart J 44(40):4233–4242. https://doi.org/10.1093/EURHEARTJ/EHAD512

Article  CAS  PubMed  Google Scholar 

Mukhopadhyay A, Reynolds HR, Xia Y et al (2023) Design and pilot implementation for the BETTER CARE-HF trial: a pragmatic cluster-randomized controlled trial comparing two targeted approaches to ambulatory clinical decision support for cardiologists. Am Heart J 258:38–48. https://doi.org/10.1016/j.ahj.2022.12.016

Article  PubMed  PubMed Central  Google Scholar 

Mukhopadhyay A, Reynolds HR, Phillips LM et al (2023) Cluster-randomized trial comparing ambulatory decision support tools to improve heart failure care. J Am Coll Cardiol 81(14):1303–1316. https://doi.org/10.1016/j.jacc.2023.02.005

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mukhopadhyay A, Reynolds HR, King WC et al (2024) Impact of visit volume on the effectiveness of electronic tools to improve heart failure care. JACC Heart Fail 12(4):665–674. https://doi.org/10.1016/J.JCHF.2023.11.002

Article  CAS  PubMed  Google Scholar 

Clark KAA, Victoria-Castro AM, Ghazi L et al (2024) Rationale, design, and patient characteristics of a cluster-randomized pragmatic trial to improve mineralocorticoid antagonist use. JACC Heart Fail 12(2):322–332. https://doi.org/10.1016/J.JCHF.2023.08.025

Article  CAS  PubMed  Google Scholar 

Sax DR, Mark DG, Rana JS et al (2024) Pilot trial of an electronic decision support to improve care for emergency department patients with acute heart failure. ESC Heart Fail Published online. https://doi.org/10.1002/EHF2.14989

Article  Google Scholar 

Venechuk GE, Khazanie P, Page RL et al (2020) An Electronically delivered, Patient-activation tool for Intensification of medications for Chronic Heart Failure with reduced ejection fraction: rationale and design of the EPIC-HF trial. Am Heart J 229:144–155. https://doi.org/10.1016/j.ahj.2020.08.013

Article  PubMed  Google Scholar 

Allen LA, Venechuk G, McIlvennan CK et al (2021) An Electronically Delivered Patient-Activation Tool for Intensification of Medications for Chronic Heart Failure With Reduced Ejection Fraction: The EPIC-HF Trial. Circulation 143(5):427–437. https://doi.org/10.1161/CIRCULATIONAHA.120.051863

Article  PubMed  Google Scholar 

Thompson J, Matlock D, McIlvennan C et al (2025) Rationale And Design Of The Implementation And Interaction Of Clinician And Patient-facing Tools Aiming To Intensify Neurohormonal Medicines For Heart Failure With Reduced Ejection Fraction (I-I-CAPTAIN-HF) Trial: novel delivery science to overcome therapeutic inertia. J Card Fail 31(1):238. https://doi.org/10.1016/J.CARDFAIL.2024.10.147

Article  Google Scholar 

Waddell KJ, Shah PD, Adusumalli S, Patel MS (2020) Using behavioral economics and technology to improve outcomes in cardio-oncology. JACC CardioOncol 2(1):84–96. https://doi.org/10.1016/J.JACCAO.2020.02.006

Article  PubMed  PubMed Central  Google Scholar 

Patel MS, Volpp KG, Asch DA (2018) Nudge units to improve the delivery of health care. N Engl J Med 378(3):214–216. https://doi.org/10.1056/NEJMP1712984

Article  PubMed  PubMed Central  Google Scholar 

Chaparro JD, Hussain C, Lee JA, Hehmeyer J, Nguyen M, Hoffman J (2020) Reducing interruptive alert burden using quality improvement methodology. Appl Clin Inform 11(1):46–58. https://doi.org/10.1055/S-0039-3402757

Article  PubMed  PubMed Central  Google Scholar 

McGreevey JD, Mallozzi CP, Perkins RM, Shelov E, Schreiber R (2020) Reducing alert burden in electronic health records: state of the art recommendations from four health systems. Appl Clin Inform 11(1):1. https://doi.org/10.1055/S-0039-3402715

Article  PubMed  PubMed Central  Google Scholar 

Khalifa M, Zabani I (2016) Improving utilization of clinical decision support systems by reducing alert fatigue: strategies and recommendations. Stud Health Technol Inform 226:51–54. https://doi.org/10.3233/978-1-61499-664-4-51

Article  PubMed  Google Scholar 

Sutton RT, Pincock D, Baumgart DC, Sadowski DC, Fedorak RN, Kroeker KI. An overview of clinical decision support systems: benefits, risks, and strategies for success. npj Digital Medicine 2020 3:1. 2020;3(1):1–10. https://doi.org/10.1038/s41746-020-0221-y

Page N, Baysari MT, Westbrook JI (2017) A systematic review of the effectiveness of interruptive medication prescribing alerts in hospital CPOE systems to change prescriber behavior and improve patient safety. Int J Med Inform 105:22–30. https://doi.org/10.1016/j.ijmedinf.2017.05.011

Article  CAS  PubMed  Google Scholar 

Kabachinski J (2013) A look at clinical decision support systems. Biomed Instrum Technol 47(5):432–434. https://doi.org/10.2345/0899-8205-47.5.432

Article