Chronic venous insufficiency in heart failure: exploring a reciprocal influence on cardiovascular health

Krizanova O, Penesova A, Hokynkova A, Pokorna A, Samadian A, Babula P (2024) Chronic venous insufficiency and venous leg ulcers: aetiology, on the pathophysiology-based treatment. Int Wound J 21(2):e14405

Google Scholar 

Prochaska JH, Arnold N, Falcke A, Kopp S, Schulz A, Buch G et al (2021) Chronic venous insufficiency, cardiovascular disease, and mortality: a population study. Eur Heart J 42(40):4157–4165

PubMed  Google Scholar 

Eberhardt RT, Raffetto JD (2014) Chronic venous insufficiency. Circulation 130(4):333–346

PubMed  Google Scholar 

Fatih K, Levent F, As AK, Köksal F, Tatli AB, Vatansever F et al (2023) Does chronic venous insufficiency affect cardiac functions? A speckle tracking echocardiography study. Eur Res J 9(5):848–854

Google Scholar 

Abbas M, Yahya MM, Hamilton M, Mwipatayi BP, Sieunarine K (2005) Sonographic evaluation of chronic venous insufficiency in right heart failure. J Diagnostic Med Sonogr 21(3):238–242

Google Scholar 

Akay H, Yavas S, UĞUZ E, Şirlak M, Özçinar E, Yener A, et al. 2024 Risk factors for chronic venous insufficiency in nurses in Türkiye-NueVo TR. Turkish J Vasc Surg 33(1)

Hamburg NM. 2021 The legs are a pathway to the heart: connections between chronic venous insufficiency and cardiovascular disease.  European heart journal. Oxford University Press; 42: 4166–8

Perger E, Blaise S, Vermorel C, Boge GS, Pépin J, Redolfi S et al (2020) Subjects with venous insufficiency have high risk of obstructive sleep apnea in relationship to fluid shift. Sleep Med 72:135–137

PubMed  Google Scholar 

Pang PS, Levy P (2010) Pathophysiology of volume overload in acute heart failure syndromes. Congest Hear Fail 16:S1-6

Google Scholar 

Piazza G (2014) Varicose veins. Circulation 130(7):582–587

PubMed  Google Scholar 

Ortega MA, Fraile-Martínez O, García-Montero C, Álvarez-Mon MA, Chaowen C, Ruiz-Grande F et al (2021) Understanding chronic venous disease: a critical overview of its pathophysiology and medical management. J Clin Med 10(15):3239

PubMed  PubMed Central  Google Scholar 

Castro-Ferreira R, Cardoso R, Leite-Moreira A, Mansilha A (2018) The role of endothelial dysfunction and inflammation in chronic venous disease. Ann Vasc Surg 46:380–393

PubMed  Google Scholar 

Lurie F, Passman M, Meisner M, Dalsing M, Masuda E, Welch H et al (2020) The 2020 update of the CEAP classification system and reporting standards. J Vasc Surg Venous Lymphat Disord 8(3):342–352

PubMed  Google Scholar 

Ligi D, Croce L, Mannello F. 2018 Chronic venous disorders: the dangerous, the good, and the diverse. Vol. 19, International journal of molecular sciences. MDPI;  2544.

Ortega MA, Fraile-Martínez O, García-Montero C, Pekarek L, Alvarez-Mon MA, Guijarro LG et al (2021) Tissue remodelling and increased DNA damage in patients with incompetent valves in chronic venous insufficiency. J Cell Mol Med 25(16):7878–7889

CAS  PubMed  PubMed Central  Google Scholar 

Labropoulos N (2019) How does chronic venous disease progress from the first symptoms to the advanced stages? A review Adv Ther 36:13–19

PubMed  Google Scholar 

Woo KY, LeBlanc K, Livingston M (2015) Management of venous stasis ulcers in the older adult. Curr Geriatr Reports 4:229–236

Google Scholar 

Grudzińska E, Czuba ZP (2014) Immunological aspects of chronic venous disease pathogenesis. Cent Eur J Immunol 39(4):525–531

PubMed  PubMed Central  Google Scholar 

Dardi P, dos Reis Costa DEF, Assunção HCR, Rossoni LV.  2022 Venous endothelial function in cardiovascular disease. Biosci Rep 42(11):BSR20220285

Zhang J, Wu Z, Feng Q, Huang H, Ma Y (2022) Cardiac Doppler parameters and progress in clinical manifestation of primary lower extremity varicose veins: a prospective study in China. Front Surg 9:791598

PubMed  PubMed Central  Google Scholar 

Rusinovich Y, Rusinovich V (2020) Cardiac Doppler in patients with primary varicose veins of lower extremities. Phlebology 35(1):62–66

PubMed  Google Scholar 

Kolluri R, Bashir R, Matros T, Albers A, Fowler BC, Frederick A et al (2020) Prevalence and predictors of elevated central venous pressure and obstructive sleep apnea in patients with lower extremity chronic venous disease. J Vasc Surg Venous Lymphat Disord 8(5):775–782

PubMed  Google Scholar 

Colombo PC, Onat D, Harxhi A, Demmer RT, Hayashi Y, Jelic S et al (2014) Peripheral venous congestion causes inflammation, neurohormonal, and endothelial cell activation. Eur Heart J 35(7):448–454

CAS  PubMed  Google Scholar 

Molnár AÁ, Nádasy GL, Dörnyei G, Patai BB, Delfavero J, Fülöp GÁ et al (2021) The aging venous system: from varicosities to vascular cognitive impairment. Geroscience 43(6):2761–2784

PubMed  PubMed Central  Google Scholar 

Liberale L, Badimon L, Montecucco F, Lüscher TF, Libby P, Camici GG (2022) Inflammation, aging, and cardiovascular disease: JACC review topic of the week. J Am Coll Cardiol 79(8):837–847

CAS  PubMed  PubMed Central  Google Scholar 

Terentes-Printzios D, Vlachopoulos C, Xaplanteris P, Ioakeimidis N, Aznaouridis K, Baou K et al (2017) Cardiovascular risk factors accelerate progression of vascular aging in the general population: results from the CRAVE study (Cardiovascular Risk Factors Affecting Vascular Age). Hypertension 70(5):1057–1064

CAS  PubMed  Google Scholar 

Gwozdzinski L, Pieniazek A, Gwozdzinski K (2024) Factors influencing venous remodeling in the development of varicose veins of the lower limbs. Int J Mol Sci 25(3):1560

CAS  PubMed  PubMed Central  Google Scholar 

Harvey A, Montezano AC, Lopes RA, Rios F, Touyz RM (2016) Vascular fibrosis in aging and hypertension: molecular mechanisms and clinical implications. Can J Cardiol 32(5):659–668

PubMed  Google Scholar 

Dogdus M, Akhan O, Ozyasar M, Yilmaz A, Altintas MS (2018) Evaluation of arterial stiffness using pulse wave velocity and augmentation index in patients with chronic venous insufficiency. Int J Vasc Med 2018(1):5437678

PubMed  PubMed Central  Google Scholar 

Nogueira JFL, Teixeira-Viana FC, Barboza-Silva BL, Mendes-Pinto D, da Glória R-M (2023) Advanced levels of chronic venous insufficiency are related to an increased in arterial stiffness. Ann Vasc Surg 96:365–373

PubMed  Google Scholar 

Gianesini S, De Luca L, Feodor T, Taha W, Bozkurt K, Lurie F (2023) Cardiovascular insights for the appropriate management of chronic venous disease: a narrative review of implications for the use of venoactive drugs. Adv Ther 40(12):5137–5154

PubMed  PubMed Central  Google Scholar 

Strait JB, Lakatta EG (2012) Aging-associated cardiovascular changes and their relationship to heart failure. Heart Fail Clin 8(1):143–164

PubMed  PubMed Central  Google Scholar 

Hung MY, Hung MJ, Kuo LT, Wang CH, Cherng WJ (2001) Pulsation, systolic thrill and murmur in femoral veins secondary to severe tricuspid regurgitation. Cardiology 95(3):164–166

CAS  PubMed  Google Scholar 

Wolfson V, Tsikonova I, Keren D, Barmeir E, Yeshurun D, Naschitz JE (2000) Pulsatile venous insufficiency in severe tricuspid regurgitation: does pulsatility protect against complications of venous disease? Angiology 51(3):231–239

PubMed  Google Scholar 

Casian D, Gutsu E, Culiuc V (2009) Surgical treatment of severe chronic venous insufficiency caused by pulsatile varicose veins in a patient with tricuspid regurgitation. Phlebology 24(2):79–81

CAS  PubMed  Google Scholar 

Aldemir M, Emren SV, Balçık Ç, Onrat E, Gürsoy M (2018) Primary pulmonary arterial hypertension with preserved right ventricular function leads to lower extremity venous insufficiency. Vascular 26(2):183–188

PubMed  Google Scholar 

Rai DB (2013) The dynamic function of the atrial diastole of the heart and motion of venous valves in humans. Int J Angiol 22(01):37–44

PubMed  PubMed Central  Google Scholar 

Mäkivaara LA, Ahti TM, Luukkaala T, Hakama M, Laurikka JO (2009) The risk of congestive heart failure is increased in persons with varicose veins. Int Angiol 28(6):452

PubMed  Google Scholar 

Lee ML, Chou WY, Kao YW, Chen MC, Shia BC, Lee PS et al (2023) Varicose veins are associated with an increased risk of mitral valve regurgitation: a nationwide population-based cohort study. Int Angiol 42:352–361

PubMed  Google Scholar 

Guo P, Fang Q, Wang Y (2024) Associations between varicose veins and heart failure: a genetic correlation and mendelian randomization study. Medicine (Baltimore) 103(20):e38175

CAS  PubMed  Google Scholar 

Wu NC, Chen ZC, Feng IJ, Ho CH, Chiang CY, Wang JJ et al (2020) Severe varicose veins and the risk of mortality: a nationwide population-based cohort study. BMJ Open 10(6):e034245

PubMed  PubMed Central  Google Scholar 

Abohelwa M, Kopel J, Shurmur S, Ansari MM, Awasthi Y, Awasthi S (2023) The framingham study on cardiovascular disease risk and stress-defenses: a historical review. J Vasc Dis 2(1):122–164

Google Scholar 

Guo X, Zhang K, Sun Y, Dong R (2024) Causal association of chronic venous insufficiency and cardiovascular diseases: a univariable and multivariable Mendelian Randomization Study. Rev Cardiovasc Med 25(10):357

PubMed  PubMed Central  Google Scholar 

Labropoulos N, Patel PJ, Tiongson JE, Pryor L, Leon LR Jr, Tassiopoulos AK (2007) Patterns of venous reflux and obstruction in patients with skin damage due to chronic venous disease. Vasc Endovascular Surg 41(1):33–40

PubMed  Google Scholar 

Kahn SR. 2016 The post-thrombotic syndrome. Hematol 2014, Am Soc Hematol Educ Progr B. 2016(1):413–8.

Poyyamoli S, Mehta P, Cherian M, Anand RR, Patil SB, Kalva S et al (2021) May-Thurner syndrome Cardiovasc Diagn Ther 11(5):1104

PubMed 

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