Kollef MH, Shorr AF, Bassetti M, Timsit J-F, Micek ST, Michelson AP, et al. Timing of antibiotic therapy in the ICU. Crit Care. 2021;25:360.

Article  PubMed  PubMed Central  Google Scholar 

Patel IH, Chen S, Parsonnet M, Hackman MR, Brooks MA, Konikoff J, et al. Pharmacokinetics of ceftriaxone in humans. Antimicrob Agents Chemother. 1981;20:634–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eldougdoug MW, Youssef DM, El-Shal AS, Sharaf YA, Raparla S, Jasti BR, et al. Evaluation of ceftriaxone pharmacokinetics in hospitalized Egyptian pediatric patients. Eur J Pediatr. 2023;182:4407–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roberts JA, Lipman J. Pharmacokinetic issues for antibiotics in the critically ill patient. Crit Care Med. 2009;37:840–51 quiz 859.

Article  CAS  PubMed  Google Scholar 

Novy E, Martinière H, Roger C. The current status and future perspectives of beta-lactam therapeutic drug monitoring in critically ill patients. Antibiotics (Basel). 2023;12:681.

Article  CAS  PubMed  Google Scholar 

Ulldemolins M, Roberts JA, Rello J, Paterson DL, Lipman J. The effects of hypoalbuminaemia on optimizing antibacterial dosing in critically ill patients. Clin Pharmacokinet. 2011;50:99–110.

Article  CAS  PubMed  Google Scholar 

European Medicines Agency. Guideline on bioanalytical method validation. EMA/CHMP/EWP/192217/2009.

Research C for DE and. Bioanalytical Method Validation Guidance for Industry. FDA; 2020. Available from: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/bioanalytical-method-validation-guidance-industry. Accessed 18 Nov 2024

Comité de l’Antibiograme de la Société Française de Microbiologie. Société Française de Microbiologie. Available from: https://www.sfm-microbiologie.org/boutique/_comite-de-lantibiogramme-de-la-sfm-ca-sfm-v1-0-juin-2024/. Accessed 13 Nov 2024

Mouton JW, Brown DFJ, Apfalter P, Cantón R, Giske CG, Ivanova M, et al. The role of pharmacokinetics/pharmacodynamics in setting clinical MIC breakpoints: the EUCAST approach. Clin Microbiol Infect. 2012;18:E37-45.

Article  CAS  PubMed  Google Scholar 

Pressat-Laffouilhère T, Balayé P, Dahamna B, Lelong R, Billey K, Darmoni SJ, et al. Evaluation of Doc’EDS: a French semantic search tool to query health documents from a clinical data warehouse. BMC Med Inform Decis Mak. 2022;22:34.

Article  PubMed  PubMed Central  Google Scholar 

R Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing; 2023. Available from: https://www.R-project.org/.

RStudio Team. RStudio: Integrated Development Environment for R. Boston, MA: RStudio, PBC; 2023. Available from: https://posit.co/download/rstudio-desktop/.

Wickham H. ggplot2: Elegant Graphics for Data Analysis. Springer-Verlag New York; 2016. Available from: https://ggplot2.tidyverse.org.

Xiao N. ggsci: Scientific Journal and Sci-Fi Themed Color Palettes for “ggplot2”. 2024. Available from: https://CRAN.R-project.org/package=ggsci.

Kassambara A. ggpubr: “ggplot2” Based Publication Ready Plots [Internet]. 2023. Available from: https://CRAN.R-project.org/package=ggpubr.

Wickham H. Reshaping data with the reshape package. J Stat Softw. 2007;21:1–20.

Article  Google Scholar 

Wilke CO. cowplot: Streamlined Plot Theme and Plot Annotations for “ggplot2”. 2024. Available from: https://CRAN.R-project.org/package=cowplot.

Wickham H. forcats: Tools for Working with Categorical Variables (Factors). 2023. Available from: https://CRAN.R-project.org/package=forcats.

Wickham H, François R, Henry L, Müller K, Vaughan D. dplyr: A Grammar of Data Manipulation. 2023. Available from: https://CRAN.R-project.org/package=dplyr.

Gohel D, Skintzos P. flextable: Functions for Tabular Reporting. 2024. Available from: https://CRAN.R-project.org/package=flextable.

Auguie B. gridExtra: Miscellaneous Functions for “Grid” Graphics. 2017. Available from: https://CRAN.R-project.org/package=gridExtra.

Iannone R, Cheng J, Schloerke B, Hughes E, Lauer A, Seo J, et al. gt: Easily Create Presentation-Ready Display Tables. 2024. Available from: https://CRAN.R-project.org/package=gt.

Sjoberg DD, Whiting K, Curry M, Lavery JA, Larmarange J. Reproducible summary tables with the gtsummary package. R J. 2021;13:570–80.

Article  Google Scholar 

Gohel D, Moog S. officer: Manipulation of Microsoft Word and PowerPoint Documents. 2024. Available from: https://CRAN.R-project.org/package=officer.

Kassambara A. ggcorrplot: Visualization of a Correlation Matrix using “ggplot2”. 2023. Available from: https://CRAN.R-project.org/package=ggcorrplot.

Fay MP. Confidence intervals that match Fisher’s exact or Blaker’s exact tests. Biostatistics. 2010;11:373–4.

Article  PubMed  Google Scholar 

Kuznetsova A, Brockhoff PB, Christensen RHB. lmerTest package: tests in linear mixed effects models. J Stat Softw. 2017;82:1–26.

Article  Google Scholar 

Neuwirth E. RColorBrewer: ColorBrewer Palettes. 2022. Available from: https://CRAN.R-project.org/package=RColorBrewer.

Hothorn T, Bretz F, Westfall P. Simultaneous inference in general parametric models. Biom J. 2008;50:346–63.

Article  PubMed  Google Scholar 

Lode H, File TM, Mandell L, Ball P, Pypstra R, Thomas M, et al. Oral gemifloxacin versus sequential therapy with intravenous ceftriaxone/oral cefuroxime with or without a macrolide in the treatment of patients hospitalized with community-acquired pneumonia: a randomized, open-label, multicenter study of clinical efficacy and tolerability. Clin Ther. 2002;24:1915–36.

Article  CAS  PubMed  Google Scholar 

Serafino Wani RL, Filson SA, Chattaway MA, Godbole G. Invasive shigellosis in MSM. Int J STD AIDS. 2016;27:917–9.

Article  PubMed  Google Scholar 

Rambaud A, Gaborit BJ, Deschanvres C, Le Turnier P, Lecomte R, Asseray-Madani N, et al. Development and validation of a dosing nomogram for amoxicillin in infective endocarditis. J Antimicrob Chemother. 2020;75:2941–50.

Article  CAS  PubMed  Google Scholar 

Nathan BR, Scheld WM. The efficacy of trovafloxacin versus ceftriaxone in the treatment of experimental brain abscess/cerebritis in the rat. Life Sci. 2003;73:1773–82.

Article  CAS  PubMed  Google Scholar 

Marsot A. Population pharmacokinetic models of first choice beta-lactam antibiotics for severe infections treatment: What antibiotic regimen to prescribe in children? J Pharm Pharm Sci. 2020;23:470–85.

Article  CAS  PubMed  Google Scholar 

Perry TR, Schentag JJ. Clinical use of ceftriaxone: a pharmacokinetic-pharmacodynamic perspective on the impact of minimum inhibitory concentration and serum protein binding. Clin Pharmacokinet. 2001;40:685–94.

Article  CAS  PubMed  Google Scholar 

Simon N, Dussol B, Sampol E, Purgus R, Brunet P, Lacarelle B, et al. Population pharmacokinetics of ceftriaxone and pharmacodynamic considerations in haemodialysed patients. Clin Pharmacokinet. 2006;45:493–501.

Article  CAS  PubMed  Google Scholar 

Wang Y-K, Wu Y-E, Li X, Tian L-Y, Khan MW, Tang B-H, et al. Optimal dosing of ceftriaxone in infants based on a developmental population pharmacokinetic-pharmacodynamic analysis. Antimicrob Agents Chemother. 2020;64:e01412-e1420.

CAS  PubMed  PubMed Central  Google Scholar 

Blumer JL, Reed MD, Kaplan EL, Drusano GL. Explaining the poor bacteriologic eradication rate of single-dose ceftriaxone in group a streptococcal tonsillopharyngitis: a reverse engineering solution using pharmacodynamic modeling. Pediatrics. 2005;116:927–32.

Article  PubMed  Google Scholar 

Tsai D, Stewart P, Goud R, Gourley S, Hewagama S, Krishnaswamy S, et al. Total and unbound ceftriaxone pharmacokinetics in critically ill Australian Indigenous patients with severe sepsis. Int J Antimicrob Agents. 2016;48:748–52.

Article  CAS  PubMed  Google Scholar 

Meletiadis J, Turlej-Rogacka A, Lerner A, Adler A, Tacconelli E, Mouton JW, et al. Amplification of antimicrobial resistance in gut flora of patients treated with ceftriaxone. Antimicrob Agents Chemother. 2017;61:e00473-e517.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang Girdwood S, Dong M, Tang P, Stoneman E, Jones R, Yunger T, et al. Population pharmacokinetic modeling of total and free ceftriaxone in critically ill children and young adults and Monte Carlo simulations support twice daily dosing for target attainment. Antimicrob Agents Chemother. 2022;66:e0142721.

Article  PubMed  Google Scholar 

Meenks SD, le Noble JLML, Foudraine NA, de Vries F, Neef K, Janssen PKC. Population pharmacokinetics of unbound ceftriaxone in a critically ill population. Int J Clin Pharmacol Ther. 2022;60:373–83.

Article  PubMed  Google Scholar 

Cheng V, Abdul-Aziz MH, Burrows F, Buscher H, Cho Y-J, Corley A, et al. Population pharmacokinetics and dosing simulations of ceftriaxone in critically ill patients receiving extracorporeal membrane oxygenation (An ASAP ECMO study). Clin Pharmacokinet. 2022;61:847–56.

Article  CAS  PubMed  PubMed Central