Plant cross-fertilization for production of dual-specific antibodies targeting both Ebola virus–like particles and HER2 protein in F1 plants

Chabrol E, Stojko J, Nicolas A, Botzanowski T, Fould B, Antoine M, Cianferani S, Ferry G, Boutin JA (2020) VHH characterization. Recombinant VHHs: production, characterization and affinity. Anal Biochem 589:113491

Article  PubMed  CAS  Google Scholar 

Eroglu Z, Tagawa T, Somlo G (2014) Human epidermal growth factor receptor family-targeted therapies in the treatment of HER2-overexpressing breast cancer. Oncologist 19:135–150

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hurvitz SA, Hegg R, Chung WP, Im SA, Jacot W, Ganju V, Chiu JWY, Xu B, Hamilton E, Madhusudan S et al (2023) Trastuzumab deruxtecan versus trastuzumab emtansine in patients with HER2-positive metastatic breast cancer: updated results from DESTINY-Breast03, a randomised, open-label, phase 3 trial. Lancet 401:105–117

Article  PubMed  CAS  Google Scholar 

Jamal A, Lee J-H, Lee K-J, Oh D-B, Kim D-S, Lee K-K, Choo Y-K, Hwang K-A, Ko K (2013) Chimerism of multiple monoclonal antibodies expressed in a single plant. Hortic Environ Biotechnol 53:544–551

Jin C, Kang YJ, Park SR, Oh YJ, Ko K (2023) Production, expression, and function of dual-specific monoclonal antibodies in a single plant. Planta 259:15

Article  PubMed  Google Scholar 

Kang YJ, Kim DS, Kim S, Seo YJ, Ko K (2023) Plant-derived PAP proteins fused to immunoglobulin A and M fc domains induce anti-prostate cancer immune response in mice. BMB Rep 56:392–397

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kim D-S, Lee S-H, Ko K (2015) Expression and function of plant-derived recombinant multiple monoclonal antibodies for the recognition of human colorectal cancer cells. Plant Biotechnol Rep 9:361–368

Article  Google Scholar 

Lai CC, Weng TC, Tseng YF, Chiang JR, Lee MS, Hu AY (2019) Evaluation of novel disposable bioreactors on pandemic influenza virus production. PLoS ONE 14:e0220803

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lee JH, Ko K (2017) Production of recombinant anti-cancer vaccines in plants. Biomol Ther (Seoul) 25:345–353

Article  PubMed  CAS  Google Scholar 

Lee Y, Park J, Kim Y, Hwang H, Jin C, Oh Y, Kang Y, Lee D, Song M, Lee Y et al (2024) Transient plant expression of recombinant rabies virus glycoprotein: a strategy for vaccine production. Hortic Sci Technol 42:264–278

CAS  Google Scholar 

Lim S, Chung HJ, Oh YJ, Hinterdorfer P, Myung SC, Seo YJ, Ko K (2024) Modification of Fc-fusion protein structures to enhance efficacy of cancer vaccine in plant expression system. Plant Biotechnol J. https://doi.org/10.1111/pbi.14552

Article  PubMed  Google Scholar 

Lim S, Kim DS, Ko K (2020) Expression of a large single-chain 13F6 antibody with binding activity against ebola virus-like particles in a plant system. Int J Mol Sci 21:7007

Article  PubMed  PubMed Central  CAS  Google Scholar 

Malik S, Kishore S, Nag S, Dhasmana A, Preetam S, Mitra O, Leon-Figueroa DA, Mohanty A, Chattu VK, Assefi M et al (2023) Ebola Virus Disease vaccines. Development, Current Perspectives and Challenges. Vaccines (Basel) 11

Moussavou G, Ko K, Lee JH, Choo YK (2015) Production of monoclonal antibodies in plants for cancer immunotherapy. Biomed Res Int 2015, 306164

Article  PubMed  PubMed Central  Google Scholar 

Nessa MU, Rahman MA, Kabir Y (2020) Plant-produced monoclonal antibody as immunotherapy for cancer. Biomed Res Int 2020, 3038564

Article  Google Scholar 

Oh S, Kim K, Kang YJ, Hwang H, Kim Y, Hinterdorfer P, Kim MK, Ko K, Lee YK, Kim DS et al (2023) Co-transient expression of PSA-Fc and PAP-Fc fusion protein in plant as prostate cancer vaccine candidates and immune responses in mice. Plant Cell Rep 42:1203–1215

Article  PubMed  CAS  Google Scholar 

Park C, Kim K, Kim Y, Zhu R, Hain L, Seferovic H, Kim MH, Woo HJ, Hwang H, Lee SH et al (2024) Plant-derived anti-human epidermal growth factor receptor 2 antibody suppresses trastuzumab-resistant breast cancer with enhanced nanoscale binding. ACS Nano 18:16126–16140

Article  PubMed  PubMed Central  CAS  Google Scholar 

Park SR, Lee JH, Kim K, Kim TM, Lee SH, Choo YK, Kim KS, Ko K (2020) Expression and in vitro function of anti-breast cancer llama-based single domain antibody VHH expressed in tobacco plants. Int J Mol Sci 21:1354

Article  PubMed  PubMed Central  CAS  Google Scholar 

Tremblay R, Wang D, Jevnikar AM, Ma S (2010) Tobacco, a highly efficient green bioreactor for production of therapeutic proteins. Biotechnol Adv 28:214–221

Article  PubMed  CAS  Google Scholar 

Zagorskaya AA, Deineko EV (2021) Plant-expression systems: a new stage in production of Biopharmaceutical preparations. Russ J Plant Physiol 68:17–30

Article  CAS  Google Scholar 

Zeitlin L, Pettitt J, Scully C, Bohorova N, Kim D, Pauly M, Hiatt A, Ngo L, Steinkellner H, Whaley KJ et al (2011) Enhanced potency of a fucose-free monoclonal antibody being developed as an Ebola virus immunoprotectant. Proc Natl Acad Sci U S A 108:20690–20694

Article  PubMed  PubMed Central  CAS  Google Scholar 

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