BRN3A, a transcription factor, regulates the expression of genes involved in biological processes shaping the HPV induced cervical cancer

Aksoy P, Gottschalk EY, Meneses PI (2017) HPV entry into cells. Mutat Res Rev Mutat Res 772:13–22. https://doi.org/10.1016/j.mrrev.2016.09.004

Article  CAS  PubMed  Google Scholar 

Balasubramaniam SD, Balakrishnan V, Oon CE, Kaur G (2019) Key molecular events in cervical cancer development. Medicina (Kaunas) 55:1–13. https://doi.org/10.3390/medicina55070384

Article  Google Scholar 

Bhagwat AS, Vakoc CR (2015) Targeting transcription factors in cancer. Trends Cancer 1:53–65. https://doi.org/10.1016/j.trecan.2015.07.001

Article  PubMed  PubMed Central  Google Scholar 

Bruni L, Albero G, Serrano B, Mena M, Gómez D, Muñoz J et al (2019) ICO/IARC Information Centre on HPV and Cancer (HPV Information Centre). In: Human papillomavirus and related diseases in India. Summary report 17

Budhram-Mahadeo V, Morris PJ, Smith MD, Midgley CA, Boxer LM, Latchman DS (1999) p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor. J Biol Chem 274:15237–15244. https://doi.org/10.1074/jbc.274.21.15237

Article  CAS  PubMed  Google Scholar 

Burd EM (2003) Human papillomavirus and cervical cancer. Clin Microbiol Rev 16:1–17. https://doi.org/10.1128/CMR.16.1.1-17.2003

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bushweller JH (2019) Targeting transcription factors in cancer—from undruggable to reality. Nat Rev Cancer 19:611–624. https://doi.org/10.1038/s41568-019-0196-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cantuti-Castelvetri L, Ojha R, Pedro LD, Djannatian M, Franz J, Kuivanen S et al (2020) Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Science 370:856–860. https://doi.org/10.1126/science.abd2985

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carey MF, Peterson CL, Smale ST (2009) Chromatin immunoprecipitation (ChIP). Cold Spring Harb Protoc 9:1–8. https://doi.org/10.1101/pdb.prot5279

Article  Google Scholar 

Cheon H, Borden EC, Stark GR (2014) Interferons and their stimulated genes in the tumor microenvironment. Semin Oncol 41:156–173. https://doi.org/10.1053/j.seminoncol.2014.02.002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chong T, Apt D, Gloss B, Isa M, Bernard HU (1991) The enhancer of human papillomavirus type 16: binding sites for the ubiquitous transcription factors oct-1, NFA, TEF-2, NF1, and AP-1 participate in epithelial cell-specific transcription. J Virol 65:5933–5943. https://doi.org/10.1128/JVI.65.11.5933-5943.1991

Article  CAS  PubMed  PubMed Central  Google Scholar 

Collum RG, Fisher PE, Datta M, Mellis S, Thiele C, Huebner K et al (1992) A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system. Nucleic Acids Res 20:4919–4925. https://doi.org/10.1093/nar/20.18.4919

Article  CAS  PubMed  PubMed Central  Google Scholar 

Daly JL, Simonetti B, Klein K, Chen KE, Williamson MK, Antón-Plágaro C et al (2020) Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science 370:861–865. https://doi.org/10.1126/science.abd3072

Article  CAS  PubMed  PubMed Central  Google Scholar 

D’Anna R, Le Buanec H, Bizzini B, Burny A, Giannouli C, Zagury JF, Gallo RC, Zagury D, D’Alessio P (2001) Human papillomavirus-16-E7 oncoprotein enhances the expression of adhesion molecules in cervical endothelial cells but not in human umbilical vein endothelial cells. J Hum Virol 4:85–95

CAS  PubMed  Google Scholar 

Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, Lempicki RA (2003) DAVID: database for annotation, visualization and integrated discovery. Genome Biol 4:3

Article  Google Scholar 

Dent CL, McIndoe GA, Latchman DS (1991) The constitutively expressed octamer binding protein OTF-1 and a novel octamer binding protein expressed specifically in cervical cells bind to an octamer-related sequence in the human papillomavirus 16 enhancer. Nucleic Acids Res 19:4531–4535. https://doi.org/10.1093/nar/19.16.4531

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dobo C, Oshima CT, De Oliveira LF, Gomes TS, Stávale JN, Arias V, Ribeiro DA, Focchi GR (2014) Cell-cycle analysis and apoptosis-associated proteins in cervical lesions of Brazilian women. Anticancer Res 34:2789–2796

PubMed  Google Scholar 

Dong J, Wang R, Ren G, Li X, Wang J, Sun Y, Liang J, Nie Y, Wu K, Feng B, Shang Y, Fan D (2017) HMGA2-FOXL2 axis regulates metastases and epithelial-to-mesenchymal transition of chemoresistant gastric cancer. Clin Cancer Res 23:3461–3473. https://doi.org/10.1158/1078-0432.CCR-16-2180

Article  CAS  PubMed  Google Scholar 

Dykes IM, Tempest L, Lee SI, Turner EE (2011) Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation. J Neurosci 31:9789–9799. https://doi.org/10.1523/JNEUROSCI.0901-11.2011

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fedtsova NG, Turner EE (1995) Brn-3.0 expression identifies early post-mitotic CNS neurons and sensory neural precursors. Mech Dev 53:291–304. https://doi.org/10.1016/0925-4773(95)00435-1

Article  CAS  PubMed  Google Scholar 

Fensterl V, Chattopadhyay S, Sen GC (2015) No love lost between viruses and interferons. Annu Rev Virol 2:549–572. https://doi.org/10.1146/annurev-virology-100114-055249

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferreira AR, Ramalho AC, Marques M, Ribeiro D (2020) The interplay between antiviral signaling and carcinogenesis in Human Papillomavirus infections. Cancers (Basel) 12:646. https://doi.org/10.3390/cancers12030646

Article  CAS  PubMed  Google Scholar 

Fitzmaurice C, Allen C, Barber RM, Barregard L, Bhutta ZA, Brenner H et al (2017) Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the global burden of disease study. JAMA Oncol 3:524–548. https://doi.org/10.1001/jamaoncol.2017.0098

Article  PubMed  Google Scholar 

Gao L, Ren R, Shen J, Hou J, Ning J, Feng Y, Wang M, Wu L, Sun Y, Wang H, Wang D, Cao J (2022) Values of OAS gene family in the expression signature, immune cell infiltration and prognosis of human bladder cancer. BMC Cancer 22(1):1016. https://doi.org/10.1186/s12885-022-10102-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gay RD, Dawson SJ, Murphy WJ, Russell SW, Latchman DS (1998) Activation of the iNOS gene promoter by Brn-3 POU family transcription factors is dependent upon the octamer motif in the promoter. Biochim Biophys Acta 1443:315–322. https://doi.org/10.1016/s0167-4781(98)00234-6

Article  CAS  PubMed  Google Scholar 

Gerrero MR, McEvilly RJ, Turner E, Lin CR, O’Connell S, Jenne KJ, Hobbs MV, Rosenfeld MG (1993) Brn-3.0: a POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs. Proc Natl Acad Sci USA 90:10841–10845. https://doi.org/10.1073/pnas.90.22.10841

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gómez-Herranz M, Nekulova M, Faktor J, Hernychova L, Kote S, Sinclair EH, Nenutil R, Vojtesek B, Ball KL, Hupp TR (2019) The effects of IFITM1 and IFITM3 gene deletion on IFNγ stimulated protein synthesis. Cell Signal 60:39–56. https://doi.org/10.1016/j.cellsig.2019.03.024

Article  CAS  PubMed  PubMed Central  Google Scholar 

González-Mariscal L, Lechuga S, Garay E (2007) Role of tight junctions in cell proliferation and cancer. Prog Histochem Cytochem 42:1–57. https://doi.org/10.1016/j.proghi.2007.01.001

Article  CAS  PubMed  Google Scholar 

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