Albaugh VL, Mukherjee K, Barbul A (2017) Proline precursors and collagen synthesis: biochemical challenges of nutrient supplementation and wound healing. J Nutr 147(11):2011–2017
Article PubMed PubMed Central CAS Google Scholar
Arnold PK, Finley LW (2023) Regulation and function of the mammalian tricarboxylic acid cycle. J Biol Chem 299(2):102838
Article PubMed CAS Google Scholar
Bacigalupa ZA, Rathmell WK (2021) Upcycling the TCA cycle—rewiring tumour-associated fibroblasts. Nat Metab 3(11):1439–1440
Article PubMed PubMed Central CAS Google Scholar
Bae J-E, Hwang S-M, Aryal YP, Kim T-Y, Sohn W-J, An S-Y, Kim J-Y, An C-H, Lee Y, Kim Y-G (2022) Effects of erythropoietin on osteoblast in the tooth extraction socket in mice periodontitis model. Front Physiol 13:987625
Article PubMed PubMed Central Google Scholar
Chen J, Long F (2015) mTORC1 signaling promotes osteoblast differentiation from preosteoblasts. PLoS ONE 10(6):e0130627
Article PubMed PubMed Central Google Scholar
D’Aniello C, Patriarca EJ, Phang JM, Minchiotti G (2020) Proline metabolism in tumor growth and metastatic progression. Front Oncol 10:776
Article PubMed PubMed Central Google Scholar
Eni-Aganga I, Lanaghan ZM, Balasubramaniam M, Dash C, Pandhare J (2021) PROLIDASE: a review from discovery to its role in health and disease. Front Mol Biosci 8:723003
Article PubMed PubMed Central CAS Google Scholar
Gelse K, Pöschl E, Aigner T (2003) Collagens–structure, function, and biosynthesis. Adv Drug Deliv Rev 55(12):1531–1546
Article PubMed CAS Google Scholar
Hudson DM, Garibov M, Dixon DR, Popowics T, Eyre DR (2017) Distinct post-translational features of type I collagen are conserved in mouse and human periodontal ligament. J Periodontal Res 52(6):1042–1049
Article PubMed PubMed Central CAS Google Scholar
Hwang S-M, Kim T-Y, Kim A, Kim Y-G, Park J-W, Lee J-M, Kim J-Y, Suh J-Y (2024) Resveratrol facilitates bone formation in high-glucose conditions. Front Physiol 15:1347756
Article PubMed PubMed Central Google Scholar
Kaku M, Yamauchi M (2014) Mechano-regulation of collagen biosynthesis in periodontal ligament. J Prosthodont Res 58(4):193–207
Article PubMed PubMed Central Google Scholar
Karna E, Szoka L, Huynh TYL, Palka JA (2020) Proline-dependent regulation of collagen metabolism. Cell Mol Life Sci 77:1911–1918
Article PubMed CAS Google Scholar
Kay EJ, Koulouras G, Zanivan S (2021) Regulation of extracellular matrix production in activated fibroblasts: roles of amino acid metabolism in collagen synthesis. Front Oncol 11:719922
Article PubMed PubMed Central CAS Google Scholar
Kim TY, Jung HG, Pokharel E, Kim JY, Ha JH, An SY, An CH, Sohn WJ, Jung JK, Aryal YP, Kim JY (2022) Gene profiling in dorso-ventral patterning of mouse tongue development. Genes Genomics 44(10):1181–1189
Article PubMed CAS Google Scholar
Kim TY, Kim A, Aryal YP, Sung S, Pokharel E, Neupane S, Choi SY, Ha JH, Jung JK, Yamamoto H (2024) Functional modulation of lysophosphatidic acid type 2 G-protein coupled receptor facilitates alveolar bone formation. J Cell Physiol 239(1):e31148
Martínez-Reyes I, Chandel NS (2020) Mitochondrial TCA cycle metabolites control physiology and disease. Nat Commun 11(1):102
Article PubMed PubMed Central Google Scholar
Naomi R, Ridzuan PM, Bahari H (2021) Current insights into collagen type I. Polymers (Basel) 13(16):2642
Article PubMed CAS Google Scholar
Palka J, Oscilowska I, Szoka L (2021) Collagen metabolism as a regulator of proline dehydrogenase/proline oxidase-dependent apoptosis/autophagy. Amino Acids 53(12):1917–1925
Article PubMed PubMed Central CAS Google Scholar
Patriarca EJ, Cermola F, D’Aniello C, Fico A, Guardiola O, De Cesare D, Minchiotti G (2021) The multifaceted roles of proline in cell behavior. Front Cell Dev Biol 9:728576
Article PubMed PubMed Central Google Scholar
Phang JM (2023) The regulatory mechanisms of proline and hydroxyproline metabolism: recent advances in perspective. Front Oncol 12:1118675
Article PubMed PubMed Central Google Scholar
Phang JM, Liu W, Zabirnyk O (2010) Proline metabolism and microenvironmental stress. Annu Rev Nutr 30(1):441–463
Article PubMed PubMed Central CAS Google Scholar
Ponzetti M, Rucci N (2021) Osteoblast differentiation and signaling: established concepts and emerging topics. Int J Mol Sci 22(13):6651
Article PubMed PubMed Central CAS Google Scholar
Selvaraj V, Sekaran S, Dhanasekaran A, Warrier S (2024) Type 1 collagen: synthesis, structure and key functions in bone mineralization. Differentiation 136:100757
Article PubMed CAS Google Scholar
Shen L, Yu Y, Karner CM (2022a) SLC38A2 provides proline and alanine to regulate postnatal bone mass accrual in mice. Front Physiol 13:992679
Article PubMed PubMed Central Google Scholar
Shen L, Yu Y, Zhou Y, Pruett-Miller SM, Zhang G-F, Karner CM (2022b) SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation. Elife 11:e76963
Article PubMed PubMed Central CAS Google Scholar
Szoka L, Karna E, Hlebowicz-Sarat K, Karaszewski J, Palka JA (2017) Exogenous proline stimulates type I collagen and HIF-1α expression and the process is attenuated by glutamine in human skin fibroblasts. Mol Cell Biochem 435:197–206
Article PubMed PubMed Central CAS Google Scholar
Titorencu I, Pruna V, Jinga VV, Simionescu M (2014) Osteoblast ontogeny and implications for bone pathology: an overview. Cell Tissue Res 355(1):23–33
Article PubMed CAS Google Scholar
Van Doren SR (2015) Matrix metalloproteinase interactions with collagen and elastin. Matrix Biol 44:224–231
Vettore LA, Westbrook RL, Tennant DA (2021) Proline metabolism and redox; maintaining a balance in health and disease. Amino Acids 53(12):1779–1788
Article PubMed PubMed Central CAS Google Scholar
Wada N, Tomokiyo A, Gronthos S, Bartold PM (2015) Immunomodulatory properties of PDLSC and relevance to periodontal regeneration. Current Oral Health Rep 2:245–251
Werner H (2023) The IGF1 signaling pathway: from basic concepts to therapeutic opportunities. Int J Mol Sci 24(19):14882
Comments (0)