mir-330-5p from mesenchymal stem cell-derived exosomes targets SETD7 to reduce inflammation in rats with cerebral ischemia-reperfusion injury

Abels ER, Breakefield XO (2016) Introduction to Extracellular vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake. Cell Mol Neurobiol 36(3):301–312

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ambrosini S, Montecucco F, Kolijn D, Pedicino D, Akhmedov A, Mohammed SA et al (2023) Methylation of the Hippo effector YAP by the methyltransferase SETD7 drives myocardial ischaemic injury: a translational study. Cardiovasc Res 118(17):3374–3385

Article  PubMed  Google Scholar 

Anrather J, Iadecola C (2016) Inflammation and stroke: an overview. Neurotherapeutics 13(4):661–670

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bai X, Zhang J, Yang H, Linghu K, Xu M (2023) SNHG3/miR-330-5p/HSD11B1 alleviates myocardial ischemia-reperfusion injury by regulating the ERK/p38 signaling pathway. Protein Pept Lett

Bansal A, Prathap R, Gupta S, Chaurasia A, Chaudhary P (2019) Role of microRNAs in stroke recovery. J Family Med Prim Care 8(6):1850–1854

Article  PubMed  PubMed Central  Google Scholar 

Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H (1986) Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17(3):472–476

Article  PubMed  CAS  Google Scholar 

Cheng C, Chen X, Wang Y, Cheng W, Zuo X, Tang W et al (2021) MSCsderived exosomes attenuate ischemia-reperfusion brain injury and inhibit microglia apoptosis might via exosomal miR-26a-5p mediated suppression of CDK6. Mol Med 27(1):67

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chiang C, Yang H, Zhu L, Chen C, Chen C, Zuo Y, Zheng D (2022) The Epigenetic Regulation of Nonhistone Proteins by SETD7: new targets in Cancer. Front Genet 13:918509

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dang Y, Ma X, Li Y, Hao Q, Xie Y, Zhang Q et al (2018) Inhibition of SETD7 protects cardiomyocytes against hypoxia/reoxygenation-induced injury through regulating Keap1/Nrf2 signaling. Biomed Pharmacother 106:842–849

Article  PubMed  CAS  Google Scholar 

Ding DC, Shyu WC, Lin SZ (2011) Mesenchymal stem cells. Cell Transpl 20(1):5–14

Article  Google Scholar 

Eltzschig HK, Eckle T (2011) Ischemia and reperfusion–from mechanism to translation. Nat Med 17(11):1391–1401

Article  PubMed  CAS  Google Scholar 

Fu J, Huang Y, Xian L (2022) LncRNA SNHG15 regulates hypoxic-ischemic brain injury via miR-153-3p/SETD7 axis. Histol Histopathol 37(11):1113–1125

PubMed  CAS  Google Scholar 

Hou D, Zhang L, Hu Y, Yang G, Yu D (2023) Bone marrow mesenchymal stem cell exosomal mir-345-3p ameliorates cerebral ischemia-reperfusion Injury by Targeting TRAF6. Curr Neurovasc Res 20(4):493–504

Article  PubMed  CAS  Google Scholar 

Huang M, Cheng G, Tan H, Qin R, Zou Y, Wang Y et al (2017) Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors. Exp Neurol 295:66–76

Article  PubMed  PubMed Central  CAS  Google Scholar 

Jurcau A, Simion A (2021) Neuroinflammation in cerebral ischemia and Ischemia/Reperfusion injuries: from pathophysiology to therapeutic strategies. Int J Mol Sci 23(1)

Kawabori M, Yenari MA (2015) Inflammatory responses in brain ischemia. Curr Med Chem 22(10):1258–1277

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kuang Y, Zheng X, Zhang L, Ai X, Venkataramani V, Kilic E, Hermann DM, Majid A, Bahr M, Doeppner TR (2020) Adipose-derived mesenchymal stem cells reduce autophagy in stroke mice by extracellular vesicle transfer of miR-25. J Extracell Vesicles 10(1):e12024

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lee RHC, Lee MHH, Wu CYC, Couto ESA, Possoit HE, Hsieh TH et al (2018) Cerebral ischemia and neuroregeneration. Neural Regen Res 13(3):373–385

Article  PubMed  PubMed Central  CAS  Google Scholar 

Li S, Li X, Xing X, Wang L (2020) Mir-597-5p inhibits cell growth and promotes cell apoptosis by targeting ELK1 in pancreatic cancer. Hum Cell 33(4):1165–1175

Article  PubMed  CAS  Google Scholar 

Li M, Tang H, Li Z, Tang W (2022a) Emerging treatment strategies for cerebral ischemia-reperfusion Injury. Neuroscience 507:112–124

Article  PubMed  CAS  Google Scholar 

Li X, Bi T, Yang S (2022b) Exosomal microRNA-150-5p from bone marrow mesenchymal stromal cells mitigates cerebral ischemia/reperfusion injury via targeting toll-like receptor 5. Bioengineered 13(2):3030–3043

Article  PubMed  Google Scholar 

Li S, Zhang L, Lin J, Su A, Liu X, Zhang J, Xian X, Hu Y, Li W, Sun S et al (2022c) LncRNA BIRF promotes brain ischemic tolerance Induced by cerebral ischemic preconditioning through upregulating GLT-1 via sponging miR-330-5p. Mol Neurobiol 59(7):3996–4014

Article  PubMed  PubMed Central  CAS  Google Scholar 

Li Y, Sun M, Wang X, Cao X, Li N, Pei D et al (2022d) Dental stem cell-derived extracellular vesicles transfer mir-330-5p to treat traumatic brain injury by regulating microglia polarization. Int J Oral Sci 14(1):44

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liu X, Zhang M, Liu H, Zhu R, He H, Zhou Y, Zhang Y, Li C, Liang D, Zeng Q et al (2021) Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia M1/M2 phenotypes. Exp Neurol 341:113700

Article  PubMed  CAS  Google Scholar 

Liu H, Xue Q, Cai H, Jiang X, Cao G, Chen T et al (2022) RUNX3-mediated circDYRK1A inhibits glutamine metabolism in gastric cancer by up-regulating microRNA-889-3p-dependent FBXO4. J Transl Med 20(1):120

Article  PubMed  PubMed Central  CAS  Google Scholar 

Naeli P, Winter T, Hackett AP, Alboushi L, Jafarnejad SM (2023) The intricate balance between microRNA-induced mRNA decay and translational repression. FEBS J 290(10):2508–2524

Article  PubMed  CAS  Google Scholar 

Naji A, Eitoku M, Favier B, Deschaseaux F, Rouas-Freiss N, Suganuma N (2019) Biological functions of mesenchymal stem cells and clinical implications. Cell Mol Life Sci 76(17):3323–3348

Article  PubMed  PubMed Central  CAS  Google Scholar 

Pan Q, Kuang X, Cai S, Wang X, Du D, Wang J et al (2020) Mir-132-3p priming enhances the effects of mesenchymal stromal cell-derived exosomes on ameliorating brain ischemic injury. Stem Cell Res Ther 11(1):260

Article  PubMed  PubMed Central  CAS  Google Scholar 

Pan X, Fan J, Peng F, Xiao L, Yang Z (2022) SET domain containing 7 promotes oxygen-glucose deprivation/reoxygenation-induced PC12 cell inflammation and oxidative stress by regulating Keap1/Nrf2/ARE and NF-kappaB pathways. Bioengineered 13(3):7253–7261

Article  PubMed  PubMed Central  CAS  Google Scholar 

Shin TH, Lee DY, Basith S, Manavalan B, Paik MJ, Rybinnik I et al (2020) Metabolome changes in cerebral ischemia. Cells 9(7)

Sun Y, Liu G, Zhang K, Cao Q, Liu T, Li J (2021) Mesenchymal stem cells-derived exosomes for drug delivery. Stem Cell Res Ther 12(1):561

Article  PubMed  PubMed Central  CAS  Google Scholar 

Tahamtan A, Teymoori-Rad M, Nakstad B, Salimi V (2018) Anti-inflammatory MicroRNAs and their potential for inflammatory diseases treatment. Front Immunol 9:1377

Article  PubMed 

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