Andersen M, Nagaev I, Meyer MK, Nagaeva O, Wikberg J, Mincheva-Nilsson L, Andersen GN (2017) Melanocortin 2, 3 and 4 receptor gene expressions are downregulated in CD 8 + T cytotoxic lymphocytes and CD 19 + B lymphocytes in rheumatoid arthritis responding to TNF‐α inhibition. Scand J Immunol 86:31–39
Article CAS PubMed Google Scholar
Auriemma M, Brzoska T, Klenner L, Kupas V, Goerge T, Voskort M, Zhao Z, Sparwasser T, Luger TA, Loser K (2012) α-MSH-stimulated tolerogenic dendritic cells induce functional regulatory T cells and ameliorate ongoing skin inflammation. J Invest Dermatology 132:1814–1824
Baek H, Ye M, Kang G-H, Lee C, Lee G, Choi DB, Jung J, Kim H, Lee S, Kim JS (2016) Neuroprotective effects of CD4 + CD25 + Foxp3 + regulatory T cells in a 3xTg-AD Alzheimer’s Disease model. Oncotarget 7:69347
Article PubMed PubMed Central Google Scholar
Banks WA, Gray AM, Erickson MA, Salameh TS, Damodarasamy M, Sheibani N, Meabon JS, Wing EE, Morofuji Y, Cook DG (2015) Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit. J Neuroinflamm 12:1–15
Bhatia D, Grozdanov V, Ruf WP, Kassubek J, Ludolph AC, Weishaupt JH, Danzer KM (2021) T-cell dysregulation is associated with Disease severity in Parkinson’s Disease. J Neuroinflamm 18:1–10
Block ML, Zecca L, Hong J-S (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 8:57–69
Article CAS PubMed Google Scholar
Blum-Degena D, Müller T, Kuhn W, Gerlach M, Przuntek H, Riederer P (1995) Interleukin-1β and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer’s and de novo Parkinson’s Disease patients. Neurosci Lett 202:17–20
Brochard V, Combadière B, Prigent A, Laouar Y, Perrin A, Beray-Berthat V, Bonduelle O, Alvarez-Fischer D, Callebert J, Launay J-M (2008) Infiltration of CD4 + lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson Disease. The Journal of clinical investigation 119.
Cai W, Feng D, Schwarzschild MA, Mclean PJ, Chen X (2018) Bimolecular fluorescence complementation of alpha-synuclein demonstrates its oligomerization with dopaminergic phenotype in mice. EBioMedicine 29:13–22
Article PubMed PubMed Central Google Scholar
Cai W, Srivastava P, Feng D, Lin Y, Vanderburg CR, Xu Y, Mclean P, Frosch MP, Fisher DE, Schwarzschild MA (2022) Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson’s Disease. Mol Neurodegeneration 17:1–21
Catania A, Gatti S, Colombo G, Lipton JM (2004) Targeting melanocortin receptors as a novel strategy to control inflammation. Pharmacol Rev 56:1–29
Article CAS PubMed Google Scholar
Chauhan A, Al Mamun A, Spiegel G, Harris N, Zhu L, Mccullough LD (2018) Splenectomy protects aged mice from injury after experimental Stroke. Neurobiol Aging 61:102–111
Chen J-F, Steyn S, Staal R, Petzer JP, Xu K, Van Der Schyf CJ, Castagnoli K, Sonsalla PK, Castagnoli N, Schwarzschild MA (2002) 8-(3-Chlorostyryl) caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonism. J Biol Chem 277:36040–36044
Article CAS PubMed Google Scholar
Chen X, Lan X, Roche I, Liu R, Geiger JD (2008) Caffeine protects against MPTP-induced blood‐brain barrier dysfunction in mouse striatum. J Neurochem 107:1147–1157
Article CAS PubMed PubMed Central Google Scholar
Chen X, Burdett TC, Desjardins CA, Logan R, Cipriani S, Xu Y, Schwarzschild MA (2013) Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegeneration. Proc Natl Acad Sci 110:300–305
Article CAS PubMed Google Scholar
Chen X, Chen H, Cai W, Maguire M, Ya B, Zuo F, Logan R, Li H, Robinson K, Vanderburg CR (2017a) The melanoma-linked redhead MC1R influences dopaminergic neuron survival. Ann Neurol 81:395–406
Article CAS PubMed PubMed Central Google Scholar
Chen X, Feng D, Schwarzschild MA, Gao X (2017b) Red hair, MC1R variants, and risk for Parkinson’s disease–a meta-analysis. Ann Clin Transl Neurol 4:212–216
Article CAS PubMed PubMed Central Google Scholar
Chung DW, Yoo K-Y, Hwang IK, Kim DW, Chung JY, Lee CH, Choi JH, Choi SY, Youn HY, Lee IS (2010) Systemic administration of lipopolysaccharide induces cyclooxygenase-2 immunoreactivity in endothelium and increases microglia in the mouse hippocampus. Cell Mol Neurobiol 30:531–541
Article CAS PubMed Google Scholar
Ciccocioppo F, Lanuti P, Pierdomenico L, Simeone P, Bologna G, Ercolino E, Buttari F, Fantozzi R, Thomas A, Onofrj M (2019) The characterization of regulatory T-cell profiles in Alzheimer’s Disease and multiple sclerosis. Sci Rep 9:8788
Article PubMed PubMed Central Google Scholar
Danikowski K, Jayaraman S, Prabhakar B (2017) Regulatory T cells in multiple sclerosis and myasthenia gravis. J Neuroinflamm 14:1–16
Dimant H, Kalia SK, Kalia LV, Zhu LN, Kibuuka L, Ebrahimi-Fakhari D, Mcfarland NR, Fan Z, Hyman BT, Mclean PJ (2013) Direct detection of alpha synuclein oligomers in vivo. Acta Neuropathol Commun 1:1–10
Fu S, Luo X, Wu X, Zhang T, Gu L, Wang Y, Gao M, Cheng Y, Xie Z (2020) Activation of the melanocortin-1 receptor by NDP-MSH attenuates oxidative stress and neuronal apoptosis through PI3K/Akt/Nrf2 pathway after intracerebral hemorrhage in mice. Oxidative medicine and cellular longevity 2020
Galiano-Landeira J, Torra A, Vila M, Bove J (2020) CD8 T cell nigral infiltration precedes synucleinopathy in early stages of Parkinson’s Disease. Brain 143:3717–3733
García-Domínguez I, Veselá K, García-Revilla J, Carrillo-Jiménez A, Roca-Ceballos MA, Santiago M, De Pablos RM, Venero JL (2018) Peripheral inflammation enhances microglia response and nigral dopaminergic cell death in an in vivo MPTP model of Parkinson’s Disease. Front Cell Neurosci 12:398
Article PubMed PubMed Central Google Scholar
Gatti S, Lonati C, Acerbi F, Sordi A, Leonardi P, Carlin A, Gaini SM, Catania A (2012) Protective action of NDP-MSH in experimental subarachnoid Hemorrhage. Exp Neurol 234:230–238
Article CAS PubMed Google Scholar
Gendelman HE, Appel SH (2011) Neuroprotective activities of regulatory T cells. Trends Mol Med 17:687
Article PubMed PubMed Central Google Scholar
Giuliani D, Bitto A, Galantucci M, Zaffe D, Ottani A, Irrera N, Neri L, Cavallini GM, Altavilla D, Botticelli AR (2014) Melanocortins protect against progression of Alzheimer’s Disease in triple-transgenic mice by targeting multiple pathophysiological pathways. Neurobiol Aging 35:537–547
Article CAS PubMed Google Scholar
Gray MT, Woulfe JM (2015) Striatal blood–brain barrier permeability in Parkinson’s Disease. J Cereb Blood Flow Metabolism 35:747–750
Grozdanov V, Bliederhaeuser C, Ruf WP, Roth V, Fundel-Clemens K, Zondler L, Brenner D, Martin-Villalba A, Hengerer B, Kassubek J (2014) Inflammatory dysregulation of blood monocytes in Parkinson’s Disease patients. Acta Neuropathol 128:651–663
Article CAS PubMed PubMed Central Google Scholar
Grozdanov V, Bousset L, Hoffmeister M, Bliederhaeuser C, Meier C, Madiona K, Pieri L, Kiechle M, Mclean PJ, Kassubek J (2019) Increased immune activation by pathologic α-synuclein in parkinson’s Disease. Ann Neurol 86:593–606
Article CAS PubMed Google Scholar
Guida S, Guida G, Goding CR (2022) MC1R functions, expression, and implications for targeted therapy. J Invest Dermatology 142:293–302e1
Harms AS, Thome AD, Yan Z, Schonhoff AM, Williams GP, Li X, Liu Y, Qin H, Benveniste EN, Standaert DG (2018) Peripheral monocyte entry is required for alpha-synuclein induced inflammation and neurodegeneration in a model of Parkinson Disease. Exp Neurol 300:179–187
Article CAS PubMed Google Scholar
Haskell-Luevano C, Holder JR, Monck EK, Bauzo RM (2001) Characterization of melanocortin NDP-MSH agonist peptide fragments at the mouse central and peripheral melanocortin receptors. J Med Chem 44:2247–2252
Article CAS PubMed Google Scholar
Henry CJ, Huang Y, Wynne AM, Godbout JP (2009) Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines. Brain Behav Immun 23:309–317
Article CAS PubMed Google Scholar
Huang Y, Liu Z, Cao B-B, Qiu Y-H, Peng Y-P (2020) Treg cells attenuate neuroinflammation and protect neurons in a mouse model of Parkinson’s Disease. J Neuroimmune Pharmacol 15:224–237
Jackson-Lewis V, Przedborski S (2007) Protocol for the MPTP mouse model of Parkinson’s Disease. Nat Protoc 2:141–151
Article CAS PubMed Google Scholar
Jurga AM, Paleczna M, Kuter KZ (2020) Overview of general and discriminating markers of differential microglia phenotypes. Front Cell Neurosci 14:198
Article PubMed PubMed Central Google Scholar
Kadiri JJ, Tadayon S, Thapa K, Suominen A, Hollmén M, Rinne P (2021) Melanocortin 1 receptor Deficiency in hematopoietic cells promotes the expansion of inflammatory leukocytes in atherosclerotic mice. Front Immunol 12:774013
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