Jafari Z, Kolb BE, Mohajerani MH (2019) Age-related hearing loss and tinnitus, dementia risk, and auditory amplification outcomes. Ageing Res Rev 56:100963. https://doi.org/10.1016/j.arr.2019.100963
Le TN, Straatman LV, Lea J, Westerberg B (2017) Current insights in noise-induced hearing loss: a literature review of the underlying mechanism, pathophysiology, asymmetry, and management options. J Otolaryngol Head Neck Surg 46(1):41. https://doi.org/10.1186/s40463-017-0219-x
Article PubMed PubMed Central Google Scholar
Maas IL, Brüggemann P, Requena T, Bulla J, Edvall NK, Hjelmborg JVB, Szczepek AJ, Canlon B, Mazurek B, Lopez-Escamez JA, Cederroth CR (2017) Genetic susceptibility to bilateral tinnitus in a Swedish twin cohort. Genet Med 19(9):1007–1012. https://doi.org/10.1038/gim.2017.4
Article CAS PubMed PubMed Central Google Scholar
Bogo R, Farah A, Karlsson KK, Pedersen NL, Svartengren M, Skjönsberg A (2017) Prevalence, incidence proportion, and heritability for tinnitus: a longitudinal twin study. Ear Hear 38(3):292–300. https://doi.org/10.1097/AUD.0000000000000397
Cederroth CR, PirouziFard M, Trpchevska N, Idrizbegovic E, Canlon B, Sundquist J, Sundquist K, Zöller B (2019) Association of genetic vs environmental factors in Swedish adoptees with clinically significant tinnitus. JAMA Otolaryngol Head Neck Surg 145(3):222–229. https://doi.org/10.1001/jamaoto.2018.3852
Article PubMed PubMed Central Google Scholar
Trpchevska N, Bulla J, Prada Hellberg M, Edvall NK, Lazar A, Mehraei G, Uhlen I, Schlee W, Canlon B, Gallus S, Lopez-Escamez JA, Cederroth CR (2020) Sex-dependent aggregation of tinnitus in Swedish families. J Clin Med 9(12):3812. https://doi.org/10.3390/jcm9123812
Article PubMed PubMed Central Google Scholar
Amanat S, Gallego-Martinez A, Lopez-Escamez JA (2021) Genetic inheritance and its contribution to tinnitus. Curr Top Behav Neurosci 51:29–47. https://doi.org/10.1007/7854_2020_155
Article CAS PubMed Google Scholar
Amanat S, Gallego-Martinez A, Sollini J, Perez-Carpena P, Espinosa-Sanchez JM, Aran I, Soto-Varela A, Batuecas-Caletrio A, Canlon B, May P, Caderroth CR, Lopez-Escamez JA (2021) Burden of rare variants in synaptic genes in patients with severe tinnitus: an exome based extreme phenotype study. EBioMedicine 66:103309. https://doi.org/10.1016/j.ebiom.2021.103309
Article CAS PubMed PubMed Central Google Scholar
Bhatt IS, Wilson N, Dias R, Torkamani A (2022) A genome-wide association study of tinnitus reveals shared genetic links to neuropsychiatric disorders. Sci Rep 12(1):22511. https://doi.org/10.1038/s41598-022-26413-6
Article ADS CAS PubMed PubMed Central Google Scholar
Boussaty EC, Friedman RA, Clifford RE (2022) Hearing loss and tinnitus: association studies for complex-hearing disorders in mouse and man. Hum Genet 141(3–4):981–990. https://doi.org/10.1007/s00439-021-02317-9
Article CAS PubMed Google Scholar
Clifford RE, Maihofer AX, Stein MB, Ryan AF, Nievergelt CM (2020) Novel risk loci in tinnitus and causal inference with neuropsychiatric disorders among adults of European ancestry. JAMA Otolaryngol Head Neck Surg 146(11):1015–1025. https://doi.org/10.1001/jamaoto.2020.2920
Article PubMed PubMed Central Google Scholar
Lopez-Escamez JA, Bibas T, Cima RF, Van de Heyning P, Knipper M, Mazurek B, Szczepek AJ, Cederroth CR (2016) Genetics of tinnitus: an emerging area for molecular diagnosis and drug development. Front Neurosci 10:377. https://doi.org/10.3389/fnins.2016.00377
Article PubMed PubMed Central Google Scholar
Sullivan PF, Geschwind DH (2019) Defining the genetic, genomic, cellular, and diagnostic architectures of psychiatric disorders. Cell 177(1):162–183. https://doi.org/10.1016/j.cell.2019.01.015
Article CAS PubMed PubMed Central Google Scholar
Visscher PM, Yengo L, Cox NJ, Wray NR (2021) Discovery and implications of polygenicity of common diseases. Science 373(6562):1468–1473. https://doi.org/10.1126/science.abi8206
Article ADS CAS PubMed PubMed Central Google Scholar
De Ridder D, Schlee W, Vanneste S, Londero A, Weisz N, Kleinjung T et al (2021) Tinnitus and tinnitus disorder: theoretical and operational definitions (an international multidisciplinary proposal). Prog Brain Res 260:1–25. https://doi.org/10.1016/bs.pbr.2020.12.002
Cederroth CR, Lugo A, Edvall NK, Lazar A, Lopez-Escamez JA, Bulla J et al (2020) Association between hyperacusis and tinnitus. J Clin Med 9(8):2412. https://doi.org/10.3390/jcm9082412
Article PubMed PubMed Central Google Scholar
Henton A, Tzounopoulos T (2021) What’s the buzz? The neuroscience and the treatment of tinnitus. Physiol Rev 101(4):1609–1632. https://doi.org/10.1152/physrev.00029.2020
Article CAS PubMed PubMed Central Google Scholar
Langguth B, Elgoyhen AB, Cederroth CR (2019) Therapeutic approaches to the treatment of tinnitus. Annu Rev Pharmacol Toxicol 59:291–313. https://doi.org/10.1146/annurev-pharmtox-010818-021556
Article CAS PubMed Google Scholar
Langguth B, Kreuzer PM, Kleinjung T, De Ridder D (2013) Tinnitus: causes and clinical management. Lancet Neurol 12(9):920–930. https://doi.org/10.1016/s1474-4422(13)70160-1
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71
Article PubMed PubMed Central Google Scholar
Higgins J, Morgan R, Rooney A, Taylor K, Thayer K, Silva R et al (2022) Risk of bias in non-randomized studies of -exposure (ROBINS-E). Retrieved from https://www.riskofbias.info/welcome/robins-e-tool
Choi JS, Yu AJ, Voelker CCJ, Doherty JK, Oghalai JS, Fisher LM (2020) Prevalence of tinnitus and associated factors among Asian Americans: results from a national sample. Laryngoscope 130(12):E933-e940. https://doi.org/10.1002/lary.28535
House L, Bishop CE, Spankovich C, Su D, Valle K, Schweinfurth J (2018) Tinnitus and its risk factors in African Americans: the Jackson Heart Study. Laryngoscope 128(7):1668–1675. https://doi.org/10.1002/lary.26964
Ramage-Morin PL, Banks R, Pineault D, Atrach M (2019) Tinnitus in Canada. Health Rep 30(3):3–11. https://doi.org/10.25318/82-003-x201900300001-eng
Dziendziel B, Skarżyński PH, Rajchel JJ, Gos E, Skarżyński H (2019) Prevalence and severity of tinnitus in Polish otosclerosis patients qualified for stapes surgery. Eur Arch Otorhinolaryngol 276(6):1585–1590. https://doi.org/10.1007/s00405-019-05317-8
Article PubMed PubMed Central Google Scholar
Lima AF, Moreira FC, Costa IE, Azevedo C, Mar F, Dias L (2022) Tinnitus and otosclerosis: an exploratory study about the prevalence, features and impact in daily life. Int Arch Otorhinolaryngol 26(3):e390–e395. https://doi.org/10.1055/s-0041-1739967
Humphriss R, Hall AJ, Baguley DM (2016) Prevalence and characteristics of spontaneous tinnitus in 11-year-old children. Int J Audiol 55(3):142–148. https://doi.org/10.3109/14992027.2015.1120890
Oosterloo BC, Croll PH, Baatenburg de Jong RJ, Ikram MK, Goedegebure A (2021) Prevalence of tinnitus in an aging population and its relation to age and hearing loss. Otolaryngol Head Neck Surg 164(4):859–868. https://doi.org/10.1177/0194599820957296
Hackenberg B, Döge J, O’Brien K, Bohnert A, Lackner KJ, Beutel ME et al (2023) Tinnitus and its relation to depression, anxiety, and stress—a population-based cohort study. J Clin Med 12(3):1169. https://doi.org/10.3390/jcm12031169
Article PubMed PubMed Central Google Scholar
Hackenberg B, O’Brien K, Döge J, Lackner KJ, Beutel ME, Münzel T et al (2023) Tinnitus prevalence in the adult population—results from the Gutenberg Health Study. Medicina (Lithuania) 59(3):620. https://doi.org/10.3390/medicina59030620
Nemholt S, Schmidt JH, Wedderkopp N, Baguley DM (2019) A cross-sectional study of the prevalence and factors associated with tinnitus and/or hyperacusis in children. Ear Hear 41(2):344–355. https://doi.org/10.1097/AUD.0000000000000759
Choi JE, Ahn J, Park HW, Baek SY, Kim S, Moon IJ (2017) Prevalence of minimal hearing loss in South Korea. PLoS ONE 12(2):e0171635. https://doi.org/10.1371/journal.pone.0171635
Article CAS PubMed PubMed Central Google Scholar
Park KH, Lee SH, Koo JW, Park HY, Lee KY, Choi YS et al (2014) Prevalence and associated factors of tinnitus: data from the Korean National Health and Nutrition Examination Survey 2009–2011. J Epidemiol 24(5):417–426. https://doi.org/10.2188/jea.je20140024
Article PubMed PubMed Central Google Scholar
Park RJ, Moon JD (2014) Prevalence and risk factors of tinnitus: the Korean National Health and Nutrition Examination Survey 2010–2011, a cross-sectional study. Clin Otolaryngol 39(2):89–94. https://doi.org/10.1111/coa.12232
Comments (0)