Head-to-head comparison of [11C]methionine PET, [11C]choline PET, and 4-dimensional CT as second-line scans for detection of parathyroid adenomas in primary hyperparathyroidism

Yeh M, Ituarte P, Zhou H, Nishimoto S, Liu I, Harari A, Haigh P, Adams A. Incidence and prevalence of primary hyperparathyroidism in a racially mixed population. Clin Endocrinol Metab. 2013;98:1122–9.

Article  CAS  Google Scholar 

Yeh MW, Zhou H, Adams AL, Ituarte PH, Li N, Liu IL, Haigh PI. The relationship of parathyroidectomy and bisphosphonates with fracture risk in primary hyperparathyroidism: an observational study. Ann Intern Med. 2016;164:715–23.

Article  PubMed  Google Scholar 

Mollerup CL, Vestergaard P, Frøkjaer VG, Mosekilde L, Christiansen P, Blichert-Toft M. Risk of renal stone events in primary hyperparathyroidism before and after parathyroid surgery: controlled retrospective follow up study. BMJ. 2002;325:807.

Article  PubMed  PubMed Central  Google Scholar 

Pasieka JL, Parsons L, Jones J. The long-term benefit of parathyroidectomy in primary hyperparathyroidism: a 10-year prospective surgical outcome study. Surgery. 2009;146:1006–13.

Article  PubMed  Google Scholar 

Ruda J, Hollenbeak C, Stack B. A systematic review of the diagnosis and treatment of primary hyperparathyroidism from 1995 to 2003. Otolaryngol Head Neck Surg. 2005;132:359–72.

Article  PubMed  Google Scholar 

Singh Ospina NM, Rodriguez-Gutierrez R, Maraka S, Espinosa de Ycaza AE, Jasim S, Castaneda-Guarderas A, Gionfriddo MR, Al Nofal A, Brito JP, Erwin P, Richards M, Wermers R, Montori VM. Outcomes of parathyroidectomy in patients with primary hyperparathyroidism: a systematic review and meta-analysis. World J Surg. 2016;40:2359–77.

Article  PubMed  Google Scholar 

Jinih M, O’Connell E, O’Leary DP, Liew A, Redmond HP. Focused versus bilateral parathyroid exploration for primary hyperparathyroidism: a systematic review and meta-analysis. Ann Surg Oncol. 2017;24:1924–34.

Article  PubMed  Google Scholar 

Bergenfelz AO, Hellman P, Harrison B, Sitges-Serra A, Dralle H, European Society of Endocrine Surgeons. Positional statement of the European Society of Endocrine Surgeons (ESES) on modern techniques in pHPT surgery. Langenbecks Arch Surg. 2009;394:761–4.

Article  PubMed  Google Scholar 

Wilhelm S, Wang T, Ruan D, Lee J, Asa S, Duh Q, Doherty G, Herrera M, Pasieka J, Perrier N, Silverberg S, Solórzano C, Sturgeon C, Tublin M, Udelsman R, Carty S. The American Association of Endocrine Surgeons Guidelines for Definitive Management of Primary Hyperparathyroidism. JAMA Surg. 2016;151:959–68.

Article  PubMed  Google Scholar 

Petranović Ovčariček P, Giovanella L, Carrió Gasset I, Hindié E, Huellner MW, Luster M, Piccardo A, Weber T, Talbot JN, Verburg FA. The EANM practice guidelines for parathyroid imaging. Eur J Nucl Med Mol Imaging. 2021. https://doi.org/10.1007/s00259-021-05334-y.

Article  PubMed  PubMed Central  Google Scholar 

Patel C, Salahudeen H, Lansdown M, Scarsbrook A. Clinical utility of ultrasound and 99mTc sestamibi SPECT/CT for preoperative localization of parathyroid adenoma in patients with primary hyperparathyroidism. Clin Radiol. 2010;65:278–87.

Article  CAS  PubMed  Google Scholar 

Akbaba G, Berker D, Isik S, Aydin Y, Ciliz D, Peksoy I, Ozuguz U, Tutuncu Y, Guler S. A comparative study of pre-operative imaging methods in patients with primary hyperparathyroidism: ultrasonography, 99mTc sestamibi, single photon emission computed tomography, and magnetic resonance imaging. J Endocrinol Investig. 2012;35:359–64.

CAS  Google Scholar 

Cheung K, Wang TS, Farrokhyar F, Roman SA, Sosa JA. A meta-analysis of preoperative localization techniques for patients with primary hyperparathyroidism. Ann Surg Oncol. 2012;19:577–83.

Article  PubMed  Google Scholar 

Caldarella C, Treglia G, Isgrò M, Giordano A. Diagnostic performance of positron emission tomography using 11C-methionine in patients with suspected parathyroid adenoma: a meta-analysis. Endocrine. 2013;43:78–83.

Article  CAS  PubMed  Google Scholar 

Kim S, Lee S, Jeong S, Pak K, Kim K. Diagnostic performance of F-18 fluorocholine PET/CT for parathyroid localization in hyperparathyroidism: a systematic review and meta-analysis. Horm Cancer. 2018;9:440–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Orevi M, Freedman N, Mishani E, Bocher M, Jacobson O, Krausz Y. Localization of parathyroid adenoma by 11C-choline PET/CT: preliminary results. Clin Nucl Med. 2014;39:1033–8.

Article  PubMed  Google Scholar 

Rodgers SE, Hunter GJ, Hamberg LM, Schellingerhout D, Doherty DB, Ayers GD, Shapiro SE, Edeiken BS, Truong MT, Evans DB, Lee JE, Perrier ND. Improved preoperative planning for directed parathyroidectomy with 4-dimensional computed tomography. Surgery. 2006;140:932–41.

Article  PubMed  Google Scholar 

Lundstroem AK, Trolle W, Soerensen CH, Myschetzky PS. Preoperative localization of hyperfunctioning parathyroid glands with 4D-CT. Eur Arch Otorhinolaryngol. 2016;273:1253–9.

Article  PubMed  Google Scholar 

Noltes M, Coester A, van der Horst-Schrivers A, Dorgelo B, Jansen L, Noordzij W, Lemstra C, Brouwers A, Kruijff S. Localization of parathyroid adenomas using 11C-methionine pet after prior inconclusive imaging. Langenbecks Arch Surg. 2017;402:1109–17.

Article  PubMed  PubMed Central  Google Scholar 

Yuan L, Liu J, Kan Y, Yang J, Wang X. The diagnostic value of 11C-methionine PET in hyperparathyroidism with negative 99mTc-MIBISPECT: a meta-analysis. Acta Radiol. 2017;58:558–64.

Article  PubMed  Google Scholar 

Mathey C, Keyzer C, Blocklet D, Van Simaeys G, Trotta N, Lacroix S, Corvilain B, Goldman S, Moreno-Reyes R. (18)F-Fluorocholine PET/CT is more sensitive than (11)C-methionine PET/CT for the localization of hyperfunctioning parathyroid tissue in primary hyperparathyroidism. J Nucl Med. 2022. https://doi.org/10.2967/jnumed.121.262395.

Article  PubMed  Google Scholar 

Treglia G, Piccardo A, Imperiale A, Strobel K, Kaufmann P, Prior J, Giovanella L. Diagnostic performance of choline PET for detection of hyperfunctioning parathyroid glands in hyperparathyroidism: a systematic review and meta-analysis. Eur J Nucl Med Mol Imaging. 2019;46:751–65.

Article  CAS  PubMed  Google Scholar 

Evangelista L, Ravelli I, Magnani F, Iacobone M, Giraudo C, Camozzi V, Spimpolo A, Cecchin D. (18)F-choline PET/CT and PET/MRI in primary and recurrent hyperparathyroidism: a systematic review of the literature. Ann Nucl Med. 2020;34:601–19.

Article  PubMed  PubMed Central  Google Scholar 

Ismail A, Christensen JW, Krakauer M, Søndergaard SB, Zerahn B, Nygaard B, Bennedbæk FN, Kristensen B, Jensen LT. (11)C-Choline PET/CT vs. (99m)Tc-MIBI/(123) iodide subtraction SPECT/CT for preoperative detection of abnormal parathyroid glands in primary hyperparathyroidism: a prospective, single-centre clinical trial in 60 patients. Diagnostics (Basel). 2020;10:975. https://doi.org/10.3390/diagnostics10110975.

Article  CAS  PubMed  Google Scholar 

Noltes ME, Kruijff S, Jansen L, Westerlaan HE, Zandee WT, Dierckx RAJO, Brouwers AH. A retrospective analysis of the diagnostic performance of (11)C-choline PET/CT for detection of hyperfunctioning parathyroid glands after prior negative or discordant imaging in primary hyperparathyroidism. EJNMMI Res. 2021;11:32–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tian Y, Tanny S, Einsiedel P, Lichtenstein M, Stella D, Phal P, Miller J. Four-dimensional computed tomography: clinical impact for patients with primary hyperparathyroidism. Ann Surg Oncol. 2018;25:117–21.

Article  PubMed  Google Scholar 

Yeh R, Tay Y, Tabacco G, Dercle L, Kuo J, Bandeira L, McManus C, Leung D, Lee J, Bilezikian J. Diagnostic performance of 4D CT and sestamibi SPECT/CT in localizing parathyroid adenomas in primary hyperparathyroidism. Radiology. 2019;291:469–76.

Article  PubMed  Google Scholar 

Noltes ME, Brands S, Dierckx RAJO, Jager PL, Kelder W, Brouwers AH, Francken AB, Kruijff S. Non-adherence to consensus guidelines on preoperative imaging in surgery for primary hyperparathyroidism. Laryngoscope Investig Otolaryngol. 2020;5:1247–53.

Article  PubMed  PubMed Central  Google Scholar 

Bilezikian JP, Khan AA, Silverberg SJ, Fuleihan GE, Marcocci C, Minisola S, Perrier N, Sitges-Serra A, Thakker RV, Guyatt G, Mannstadt M, Potts JT, Clarke BL, Brandi ML, International Workshop on Primary Hyperparathyroidism. Evaluation and management of primary hyperparathyroidism: summary statement and guidelines from the Fifth International Workshop. J Bone Miner Res 2022. https://doi.org/10.1002/jbmr.4677.

Bollerslev J, Rejnmark L, Zahn A, Heck A, Appelman-Dijkstra NM, Cardoso L, Hannan FM, Cetani F, Sikjær T, Formenti AM, Björnsdottir S, Schalin-Jantti C, Belaya Z, Gibb FW, Lapauw B, Amrein K, Wicke C, Grasemann C, Krebs M, Ryhänen EM, Makay O, Minisola S, Gaujoux S, Bertocchio JP, Hassan-Smith ZK, Linglart A, Winter EM, Kollmann M, Zmierczak HG, Tsourdi E, Pilz S, Siggelkow H, Gittoes NJ, Marcocci C, Kamenicky P. PARAT Working Group Collaborators. European Expert Consensus on Practical Management of Specific Aspects of Parathyroid Disorders in Adults and in Pregnancy: Recommendations of the ESE Educational Program of Parathyroid Disorders Eur J Endocrinol. 2021;186(2):33–63. https://doi.org/10.1530/EJE-21-1044.

Connor RJ. Sample size for testing differences in proportions for the paired-sample design. Biometrics. 1987;43:207–11.

Article  CAS  PubMed  Google Scholar 

Newcombe RG. Interval estimation for the difference between independent proportions: comparison of eleven methods. Stat Med. 1998;17:873–90.

Article  CAS  PubMed  Google Scholar 

Chun IK, Cheon GJ, Paeng JC, Kang KW, Chung JK, Lee DS. Detection and characterization of parathyroid adenoma/hyperplasia for preoperative localization: comparison between (11)C-methionine PET/CT and (99m)Tc-sestamibi scintigraphy. Nucl Med Mol Imaging. 2013;47:166–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Beheshti M, Hehenwarter L, Paymani Z, Rendl G, Imamovic L, Rettenbacher R, Tsybrovskyy O, Langsteger W, Pirich C. (18)F-Fluorocholine PET/CT in the assessment of primary hyperparathyroidism compared with (99m)Tc-MIBI or (99m)Tc-tetrofosmin SPECT/CT: a prospective dual-centre study in 100 patients. Eur J Nucl Med Mol Imaging. 2018;45:1762–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Piccardo A, Bottoni G, Boccalatte LA, Camponovo C, Musumeci M, Bacigalupo L, Collaud C, Ugolini M, Fiz F, Trimboli P. Head-to-head comparison among (18)F-choline PET/CT, 4D contrast-enhanced CT, and (18)F-choline PET/4D contrast-enhanced CT in the detection of hyperfunctioning parathyroid glands: a systematic review and meta-analysis. Endocrine. 2021;74:404–12.

Article  CAS  PubMed  Google Scholar 

Ferrari C, Santo G, Mammucci P, Pisani AR, Sardaro A, Rubini G. Diagnostic value of choline PET in the preoperative localization of hyperfunctioning parathyroid gland(s): a comprehensive overview. Biomedicines. 2021;9:231. https://doi.org/10.3390/biomedicines9030231.

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