Comparing plasma and skin imprint metabolic profiles in COVID-19 diagnosis and severity assessment

The RECOVERY Collaborative Group (2021) Dexamethasone in hospitalized patients with Covid-19. N Engl J Med 384

Panahi Y, Gorabi AM, Talaei S, Beiraghdar F, Akbarzadeh A, Tarhriz V, Mellatyar H (2023) An overview on the treatments and prevention against COVID-19. Virol J 20:23

Article  PubMed  PubMed Central  Google Scholar 

NIH (2021) COVID-19 rapid guideline: managing COVID-19. National Institute of Health and Care Excellence

Caterino M, Gelzo M, Sol S, Fedele R, Annunziata A, Calabrese C, Fiorentino G, D’Abbraccio M, Dell’Isola C, Fusco FM et al (2021) Dysregulation of lipid metabolism and pathological inflammation in patients with COVID-19. Sci Rep 11:1–10

Article  Google Scholar 

Shen B, Yi X, Sun Y, Bi X, Du J, Zhang C, Quan S, Zhang F, Sun R, Qian L et al (2020) Proteomic and metabolomic characterization of COVID-19 patient sera. Cell 182:59–72

Article  CAS  PubMed  PubMed Central  Google Scholar 

Delafiori J, Navarro LC, Siciliano RF, de Melo GC, Busanello ENB, Nicolau JC, Sales GM, de Oliveira AN, Val FFA, de Oliveira DN et al (2021) Covid-19 automated diagnosis and risk assessment through metabolomics and machine learning. Anal Chem 93:2471–2479

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grassin-Delyle S, Roquencourt C, Moine P, Saffroy G, Carn S, Heming N, Fleuriet J, Salvator H, Naline E, Couderc LJ et al (2021) Metabolomics of exhaled breath in critically ill COVID-19 patients: a pilot study. EBioMedicine 63:103154

Article  CAS  PubMed  Google Scholar 

Dos Santos C, Junior G, Pereira CM, Da Silva K, Fidalgo T, Valente AP (2020) Saliva NMR-Based Metabolomics in the War against COVID-19. Anal Chem 92:15688–15692

Article  Google Scholar 

Su Y, Chen D, Yuan D, Lausted C, Choi J, Dai CL, Voillet V, Duvvuri VR, Scherler K, Troisch P et al (2020) Multi-omics resolves a sharp disease-state shift between mild and moderate COVID-19. Cell 183:1479–1495

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu D, Shu T, Yang X, Song J-X, Zhang M, Yao C, Liu W, Huang M, Yu Y, Yang Q et al (2020) Plasma metabolomic and lipidomic alterations associated with COVID-19. Natl Sci Rev 7:1157–1168

Article  CAS  PubMed  PubMed Central  Google Scholar 

Song JW, Lam SM, Fan X, Cao WJ, Wang SY, Tian H, Chua GH, Zhang C, Meng FP, Xu Z et al (2020) Omics-driven systems interrogation of metabolic dysregulation in COVID-19 pathogenesis. Cell Metab 32:188–202

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barberis E, Amede E, Khoso S, Castello L, Sainaghi PP, Bellan M, Balbo PE, Patti G, Brustia D, Giordano M et al (2021) Metabolomics diagnosis of covid-19 from exhaled breath condensate. Metabolites 11:847

Article  CAS  PubMed  PubMed Central  Google Scholar 

Spick M, Lewis HM, Frampas CF, Longman K, Costa C, Stewart A, Dunn-Walters D, Greener D, Evetts G, Wilde MJ et al (2022) An integrated analysis and comparison of serum, saliva and sebum for COVID-19 metabolomics. Sci Rep 12:11867

Article  CAS  PubMed  PubMed Central  Google Scholar 

D’Alessandro A, Thomas T, Akpan IJ, Reisz JA, Cendali FI, Gamboni F, Nemkov T, Thangaraju K, Katneni U, Tanaka K et al (2021) Biological and clinical factors contributing to the metabolic heterogeneity of hospitalized patients with and without covid-19. Cells 10:2293

Article  PubMed  PubMed Central  Google Scholar 

Valdés A, Moreno LO, Rello SR, Orduña A, Bernardo D, Cifuentes A (2022) Metabolomics study of COVID-19 patients in four different clinical stages. Sci Rep 12:1650

Article  PubMed  PubMed Central  Google Scholar 

Bruzzone C, Bizkarguenaga M, Gil-Redondo R, Diercks T, Arana E, García de Vicuña A, Seco M, Bosch A, Palazón A, San Juan I et al (2020) SARS-CoV-2 infection dysregulates the metabolomic and lipidomic profiles of serum. iScience 23:101645

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meoni G, Ghini V, Maggi L, Vignoli A, Mazzoni A, Salvati L, Capone M, Vanni A, Tenori L, Fontanari P et al (2021) Metabolomic/lipidomic profiling of COVID-19 and individual response to tocilizumab. PLoS Pathog 17:e1009243

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghini V, Meoni G, Pelagatti L, Celli T, Veneziani F, Petrucci F, Vannucchi V, Bertini L, Luchinat C, Landini G et al (2022) Profiling metabolites and lipoproteins in COMETA, an Italian cohort of COVID-19 patients. PLoS Pathog 18:e1010443

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Silva IW, Nayek S, Singh V, Reddy J, Granger JK, Verbeck GF (2020) Paper spray mass spectrometry utilizing Teslin® substrate for rapid detection of lipid metabolite changes during COVID-19 infection. Analyst 145:5725–5732

Article  PubMed  Google Scholar 

Spick M, Longman K, Frampas C, Lewis H, Costa C, Walters DD, Stewart A, Wilde M, Greener D, Evetts G et al (2021) Changes to the sebum lipidome upon COVID-19 infection observed via rapid sampling from the skin. EClinicalMedicine 33:100786

Article  PubMed  PubMed Central  Google Scholar 

Piédrola I, Martínez S, Gradillas A, Villaseñor A, Alonso-Herranz V, Sánchez-Vera I, Escudero E, Martín-Antoniano IA, Varona JF, Ruiz A et al (2023) Deficiency in the production of antibodies to lipids correlates with increased lipid metabolism in severe COVID-19 patients. Front Immunol 14:1188786

Article  PubMed  PubMed Central  Google Scholar 

Hao Y, Zhang Z, Feng G, Chen M, Wan Q, Lin J, Wu L, Nie W, Chen S (2021) Distinct lipid metabolic dysregulation in asymptomatic COVID-19. iScience 24:102974

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schmelter F, Föh B, Mallagaray A, Rahmöller J, Ehlers M, Lehrian S, von Kopylow V, Künsting I, Lixenfeld AS, Martin E et al (2021) Metabolic and lipidomic markers differentiate COVID-19 from non-hospitalized and other intensive care patients. Front Mol Biosci 8:737039

Article  CAS  PubMed  PubMed Central  Google Scholar 

Castañé H, Iftimie S, Baiges-Gaya G, Rodríguez-Tomàs E, Jiménez-Franco A, López-Azcona AF, Garrido P, Castro A, Camps J, Joven J (2022) Machine learning and semi-targeted lipidomics identify distinct serum lipid signatures in hospitalized COVID-19-positive and COVID-19-negative patients. Metabolism 131:155197

Article  PubMed  PubMed Central  Google Scholar 

Barberis E, Timo S, Amede E, Vanella VV, Puricelli C, Cappellano G, Raineri D, Cittone MG, Rizzi E, Pedrinelli AR et al (2020) Large-scale plasma analysis revealed new mechanisms and molecules associated with the host response to sars-cov-2. Int J Mol Sci 21:8623

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stromberg S, Baxter BA, Dooley G, LaVergne SM, Gallichotte E, Dutt T, Tipton M, Berry K, Haberman J, Natter N et al (2022) Relationships between plasma fatty acids in adults with mild, moderate, or severe COVID-19 and the development of post-acute sequelae. Front Nutr 9:960409

Article  PubMed  PubMed Central  Google Scholar 

Byeon SK, Madugundu AK, Garapati K, Ramarajan MG, Saraswat M, Kumar-M P, Hughes T, Shah R, Patnaik MM, Chia N et al (2022) Development of a multiomics model for identification of predictive biomarkers for COVID-19 severity: a retrospective cohort study. Lancet Digit Health 4:E632–E645

Article  CAS  PubMed  PubMed Central  Google Scholar 

Géhin C, Tokarska J, Fowler SJ, Barran PE, Trivedi DK (2023) No skin off your back: the sampling and extraction of sebum for metabolomics. Metabolomics 19:21

Article  PubMed  PubMed Central  Google Scholar 

Xue X, Mi Z, Wang Z, Pang Z, Liu H, Zhang F (2021) High expression of ACE2 on keratinocytes reveals skin as a potential target for SARS-CoV-2. J Investig Dermatol 141:206–209

Article  CAS  PubMed  Google Scholar 

Garg S, Garg M, Prabhakar N, Malhotra P, Agarwal R (2020) Unraveling the mystery of Covid-19 cytokine storm: From skin to organ systems. Dermatol Ther 33:e13859

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guarneri C, Rullo EV, Pavone P, Berretta M, Ceccarelli M, Natale A, Nunnari G (2021) Silent COVID-19: what your skin can reveal. Lancet Infect Dis 21:24–25

Article  CAS  PubMed  Google Scholar 

Genovese G, Moltrasio C, Berti E, Marzano AV (2021) Skin manifestations associated with COVID-19: current knowledge and future perspectives. Dermatology 237:1–12

Article  CAS  PubMed  Google Scholar 

Lima EDO, de Macedo CS, Esteves CZ, de Oliveira DN, Pessolani MCV, Nery JADC, Sarno EN, Catharino RR (2015) Skin imprinting in silica plates: a potential diagnostic methodology for leprosy using high-resolution mass spectrometry. Anal Chem 87:3585–3592

Article  CAS  PubMed  Google Scholar 

Esteves CZ, de Aguilar Dias L, de Oliveira Lima E, de Oliveira DN, Rodrigues Melo CFO, Delafiori J, Souza Gomez CC, Ribeiro JD, Ribeiro AF, Levy CE et al (2018) Skin biomarkers for cystic fibrosis: a potential non-invasive approach for patient screening. Front Pediatr 5:290

Article  PubMed  PubMed Central  Google Scholar 

Pang Z, Zhou G, Ewald J, Chang L, Hacariz O, Basu N, Xia J (2022) Using MetaboAnalyst 5.0 for LC–HRMS spectra processing, multi-omics

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