Shore-Lesserson L, Baker RA, Ferraris VA, et al. The Society of Thoracic Surgeons, The Society of Cardiovascular Anesthesiologists, and The American Society of ExtraCorporeal Technology: clinical practice guidelines-anticoagulation during cardiopulmonary bypass. Ann Thorac Surg 2018; 105: 650–62. https://doi.org/10.1016/j.athoracsur.2017.09.061
Lax M, Pesonen E, Hiippala S, Schramko A, Lassila R, Raivio P. Heparin dose and point-of-care measurements of hemostasis in cardiac surgery-results of a randomized controlled trial. J Cardiothorac Vasc Anesth 2020; 34: 2362–8. https://doi.org/10.1053/j.jvca.2019.12.050
Article CAS PubMed Google Scholar
Paparella D, Yau TM, Young E. Cardiopulmonary bypass induced inflammation: pathophysiology and treatment. An update. Eur J Cardiothorac Surg 2002; 21: 232–44. https://doi.org/10.1016/s1010-7940(01)01099-5
Article CAS PubMed Google Scholar
Besser MW, Klein AA. The coagulopathy of cardiopulmonary bypass. Crit Rev Clin Lab Sci 2010; 47: 197–212. https://doi.org/10.3109/10408363.2010.549291
Falter F, MacDonald S, Matthews C, Kemna E, Cañameres J, Besser M. Evaluation of point-of-care ACT coagulometers and anti-Xa activity during cardiopulmonary bypass. J Cardiothorac Vasc Anesth 2020; 34: 2921–7. https://doi.org/10.1053/j.jvca.2020.06.027
Article CAS PubMed Google Scholar
Miles LF, Coulson TG, Galhardo C, Falter F. Pump priming practices and anticoagulation in cardiac surgery: results from the global cardiopulmonary bypass survey. Anesth Analg 2017; 125: 1871–7. https://doi.org/10.1213/ane.0000000000002052
Despotis GJ, Joist JH, Hogue CW Jr, et al. More effective suppression of hemostatic system activation in patients undergoing cardiac surgery by heparin dosing based on heparin blood concentrations rather than ACT. Thromb Haemost 1996; 76: 902–8.
Article CAS PubMed Google Scholar
Okita Y, Takamoto S, Ando M, et al. Coagulation and fibrinolysis system in aortic surgery under deep hypothermic circulatory arrest with aprotinin: the importance of adequate heparinization. Circulation 1997; 96: 376–81.
Hirsh J, Anand SS, Halperin JL, Fuster V, American Heart Association. AHA scientific statement: guide to anticoagulant therapy: heparin: a statement for healthcare professionals from the American Heart Association. Arterioscler Thromb Vasc Biol 2001; 21: E9. https://doi.org/10.1161/hq0701.093520
Miles LF, Burt C, Arrowsmith J, et al. Optimal protamine dosing after cardiopulmonary bypass: the PRODOSE adaptive randomised controlled trial. PLoS Med 2021; 18: e1003658. https://doi.org/10.1371/journal.pmed.1003658
Article CAS PubMed PubMed Central Google Scholar
Whitehead AL, Julious SA, Cooper CL, Campbell MJ. Estimating the sample size for a pilot randomised trial to minimise the overall trial sample size for the external pilot and main trial for a continuous outcome variable. Stat Methods Med Res 2016; 25: 1057–73. https://doi.org/10.1177/0962280215588241
Boisclair MD, Lane DA, Philippou H, Sheikh S, Hunt B. Thrombin production, inactivation and expression during open heart surgery measured by assays for activation fragments including a new ELISA for prothrombin fragment F1 + 2. Thromb Haemost 1993; 70: 253–8.
Article CAS PubMed Google Scholar
Brister SJ, Ofosu FA, Buchanan MR. Thrombin generation during cardiac surgery: is heparin the ideal anticoagulant? Thromb Haemost 1993; 70: 259–62.
Article CAS PubMed Google Scholar
Apte G, Börke J, Rothe H, Liefeith K, Nguyen TH. Modulation of platelet-surface activation: current state and future perspectives. ACS Appl Bio Mater 2020; 3: 5574–89. https://doi.org/10.1021/acsabm.0c00822
Article CAS PubMed Google Scholar
Koster A, Yeter R, Buz S, et al. Assessment of hemostatic activation during cardiopulmonary bypass for coronary artery bypass grafting with bivalirudin: results of a pilot study. J Thorac Cardiovasc Surg 2005; 129: 1391–4. https://doi.org/10.1016/j.jtcvs.2004.09.016
Lander H, Zammert M, FitzGerald D. Anticoagulation management during cross-clamping and bypass. Best Pract Res Clin Anaesthesiol 2016; 30: 359–70. https://doi.org/10.1016/j.bpa.2016.07.002
Article CAS PubMed Google Scholar
Garvin S, Fitzgerald D, Muehlschlegel JD, et al. Heparin dose response is independent of preoperative antithrombin activity in patients undergoing coronary artery bypass graft surgery using low heparin concentrations. Anesth Analg 2010; 111: 856–61. https://doi.org/10.1213/ane.0b013e3181ce1ffa
Article CAS PubMed PubMed Central Google Scholar
Shuhaibar MN, Hargrove M, Millat MH, O'Donnell A, Aherne T. How much heparin do we really need to go on pump? A rethink of current practices. Eur J Cardiothorac Surg 2004; 26: 947–50. https://doi.org/10.1016/j.ejcts.2004.07.009
Article CAS PubMed Google Scholar
Bull BS, Korpman RA, Huse WM, Briggs BD. Heparin therapy during extracorporeal circulation. I. Problems inherent in existing heparin protocols. J Thorac Cardiovasc Surg 1975; 69: 674–84.
Palmer K, Ridgway T, Al-Rawi O, Poullis M. Heparin therapy during extracorporeal circulation: deriving an optimal activated clotting time during cardiopulmonary bypass for isolated coronary artery bypass grafting. J Extra Corpor Technol 2012; 44: 145–50.
Article PubMed PubMed Central Google Scholar
Delavenne X, Ollier E, Chollet S, et al. Pharmacokinetic/pharmacodynamic model for unfractionated heparin dosing during cardiopulmonary bypass. Br J Anaesth 2017; 118: 705–12. https://doi.org/10.1093/bja/aex044
Article CAS PubMed Google Scholar
Sniecinski RM, Chandler WL. Activation of the hemostatic system during cardiopulmonary bypass. Anesth Analg 2011; 113: 1319–33. https://doi.org/10.1213/ane.0b013e3182354b7e
Chandler WL, Velan T. Plasmin generation and D-dimer formation during cardiopulmonary bypass. Blood Coagul Fibrinolysis 2004; 15: 583–91. https://doi.org/10.1097/00001721-200410000-00009
Article CAS PubMed Google Scholar
Nossel HL, Ti M, Kaplan KL, Spanondis K, Soland T, Butler VP Jr. The generation of fibrinopeptide A in clinical blood samples: evidence for thrombin activity. J Clin Invest 1976; 58: 1136–44. https://doi.org/10.1172/jci108566
Article CAS PubMed PubMed Central Google Scholar
Davies GC, Sobel M, Salzman EW. Elevated plasma fibrinopeptide A and thromboxane B2 levels during cardiopulmonary bypass. Circulation 1980; 61: 808–14. https://doi.org/10.1161/01.cir.61.4.808
Article CAS PubMed Google Scholar
Muedra V, Bonanad S, Gómez M, Villalonga V, Sánchez F, Llopis JE. Relationships between antithrombin activity, anticoagulant efficacy of heparin therapy and perioperative variables in patients undergoing cardiac surgery requiring cardiopulmonary bypass. Perfusion 2011; 26: 487–95. https://doi.org/10.1177/0267659111412999
Article CAS PubMed Google Scholar
Chandler WL, Velan T. Estimating the rate of thrombin and fibrin generation in vivo during cardiopulmonary bypass. Blood 2003; 101: 4355–62. https://doi.org/10.1182/blood-2002-08-2400
Article CAS PubMed Google Scholar
Sato H, Yamamoto K, Kakinuma A, Nakata Y, Sawamura S. Accelerated activation of the coagulation pathway during cardiopulmonary bypass in aortic replacement surgery: a prospective observational study. J Cardiothorac Surg 2015; 10: 84. https://doi.org/10.1186/s13019-015-0295-9
Article PubMed PubMed Central Google Scholar
Riedel T, Suttnar J, Brynda E, Houska M, Medved L, Dyr JE. Fibrinopeptides A and B release in the process of surface fibrin formation. Blood 2011; 117: 1700–6. https://doi.org/10.1182/blood-2010-08-300301
Article CAS PubMed PubMed Central Google Scholar
Rimpo K, Tanaka A, Ukai M, Ishikawa Y, Hirabayashi M, Shoyama T. Thrombin-antithrombin complex measurement using a point-of-care testing device for diagnosis of disseminated intravascular coagulation in dogs. PLoS One 2018; 13: e0205511. https://doi.org/10.1371/journal.pone.0205511
Article CAS PubMed PubMed Central Google Scholar
Ruhl H, Berens C, Winterhagen A, Müller J, Oldenburg J, Potzsch B. Label-free kinetic studies of hemostasis-related biomarkers including D-dimer using autologous serum transfusion. PLoS One 2015; 10: e0145012. https://doi.org/10.1371/journal.pone.0145012
Article CAS PubMed PubMed Central Google Scholar
Eisenberg PR, Lucore C, Kaufman L, Sobel BE, Jaffe AS, Rich S. Fibrinopeptide A levels indicative of pulmonary vascular thrombosis in patients with primary pulmonary hypertension. Circulation 1990; 82: 841–7. https://doi.org/10.1161/01.cir.82.3.841
Article CAS PubMed Google Scholar
Ainle FN, Preston RJ, Jenkins PV, et al. Protamine sulfate down-regulates thrombin generation by inhibiting factor V activation. Blood 2009; 114: 1658–65. https://doi.org/10.1182/blood-2009-05-222109
Meesters MI, Veerhoek D, de Jong JR, Boer C. A Pharmacokinetic model for protamine dosing after cardiopulmonary bypass. J Cardiothorac Vasc Anesth 2016; 30: 1190–5. https://doi.org/10.1053/j.jvca.2016.04.021
Article CAS PubMed Google Scholar
Goedhart AL, Gerritse BM, Rettig TC, et al. A 0.6-protamine/heparin ratio in cardiac surgery is associated with decreased transfusion of blood products. Interact Cardiovasc Thorac Surg 2020; 31: 391–7.
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