Zadoorian A, Du X, Yang H. Lipid droplet biogenesis and functions in health and disease. Nat Rev Endocrinol. 2023;19:443–59.
Article CAS PubMed Google Scholar
Olzmann JA, Carvalho P. Dynamics and functions of lipid droplets. Nat Rev Mol Cell Biol. 2019;20:137–55.
Article CAS PubMed PubMed Central Google Scholar
Monson EA, Trenerry AM, Laws JL, Mackenzie JM, Helbig KJ. Lipid droplets and lipid mediators in viral infection and immunity. FEMS Microbiol Rev. 2021;45:fuaa066.
Article CAS PubMed PubMed Central Google Scholar
Awadh AA. The role of cytosolic lipid droplets in hepatitis C virus replication, assembly, and release. Biomed Res Int. 2023;2023:5156601.
Article PubMed PubMed Central Google Scholar
Roingeard P, Melo RC. Lipid droplet hijacking by intracellular pathogens. Cell Microbiol. 2017;19:e12688.
Bosch M, Sanchez-Alvarez M, Fajardo A, Kapetanovic R, Steiner B, Dutra F, et al. Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense. Science. 2020;370:eaay8085.
Article CAS PubMed Google Scholar
Kiarely Souza E, Pereira-Dutra FS, Rajao MA, Ferraro-Moreira F, Goltara-Gomes TC, Cunha-Fernandes T, et al. Lipid droplet accumulation occurs early following Salmonella infection and contributes to intracellular bacterial survival and replication. Mol Microbiol. 2022;117:293–306.
Article CAS PubMed Google Scholar
Hu S, Zhao X, Li R, Hu C, Wu H, Li J, et al. Activating transcription factor 3, glucolipid metabolism, and metabolic diseases. J Mol Cell Biol. 2023;14:mjac067.
Herker E, Vieyres G, Beller M, Krahmer N, Bohnert M. Lipid droplet contact sites in health and disease. Trends Cell Biol. 2021;31:345–58.
Article CAS PubMed Google Scholar
Puza S, Caesar S, Poojari C, Jung M, Seemann R, Hub JS, et al. Lipid droplets embedded in a model cell membrane create a phospholipid diffusion barrier. Small. 2022;18:e2106524.
Prevost C, Sharp ME, Kory N, Lin Q, Voth GA, Farese RV Jr., et al. Mechanism and determinants of amphipathic helix-containing protein targeting to lipid droplets. Dev Cell. 2018;44:73–86.e4.
Article CAS PubMed PubMed Central Google Scholar
den Brok MH, Raaijmakers TK, Collado-Camps E, Adema GJ. Lipid droplets as immune modulators in myeloid cells. Trends Immunol. 2018;39:380–92.
Ventura AE, Pokorna S, Huhn N, Santos TCB, Prieto M, Futerman AH, et al. Cell lipid droplet heterogeneity and altered biophysical properties induced by cell stress and metabolic imbalance. Biochim Biophys Acta Mol Cell Biol Lipids. 2023;1868:159347.
Article CAS PubMed Google Scholar
Tratwal J, Falgayrac G, During A, Bertheaume N, Bataclan C, Tavakol DN, et al. Raman microspectroscopy reveals unsaturation heterogeneity at the lipid droplet level and validates an in vitro model of bone marrow adipocyte subtypes. Front Endocrinol. 2022;13:1001210.
Hugenroth M, Bohnert M. Come a little bit closer! Lipid droplet-ER contact sites are getting crowded. Biochim Biophys Acta Mol Cell Res. 2020;1867:118603.
Article CAS PubMed Google Scholar
Wang S, Yang M, Li P, Sit J, Wong A, Rodrigues K, et al. High-fat diet-induced DeSUMOylation of E4BP4 promotes lipid droplet biogenesis and liver steatosis in mice. Diabetes. 2023;72:348–61.
Article CAS PubMed Google Scholar
Xin H, Huang R, Zhou M, Chen J, Zhang J, Zhou T, et al. Daytime-restricted feeding enhances running endurance without prior exercise in mice. Nat Metab. 2023;5:1236–51.
Article CAS PubMed Google Scholar
Jung HS, Shimizu-Albergine M, Shen X, Kramer F, Shao D, Vivekanandan-Giri A, et al. TNF-alpha induces acyl-CoA synthetase 3 to promote lipid droplet formation in human endothelial cells. J Lipid Res. 2020;61:33–44.
Article CAS PubMed Google Scholar
Jeon YG, Kim YY, Lee G, Kim JB. Physiological and pathological roles of lipogenesis. Nat Metab. 2023;5:735–59.
Article CAS PubMed Google Scholar
Jackson CL. Lipid droplet biogenesis. Curr Opin Cell Biol. 2019;59:88–96.
Article CAS PubMed Google Scholar
Romanauska A, Kohler A. The inner nuclear membrane is a metabolically active territory that generates nuclear lipid droplets. Cell. 2018;174:700–15.e18.
Article CAS PubMed PubMed Central Google Scholar
Liao Y, Tham DKL, Liang FX, Chang J, Wei Y, Sudhir PR, et al. Mitochondrial lipid droplet formation as a detoxification mechanism to sequester and degrade excessive urothelial membranes. Mol Biol Cell. 2019;30:2969–84.
Article CAS PubMed PubMed Central Google Scholar
Tirinato L, Pagliari F, Limongi T, Marini M, Falqui A, Seco J, et al. An overview of lipid droplets in cancer and cancer stem cells. Stem Cells Int. 2017;2017:1656053.
Article CAS PubMed PubMed Central Google Scholar
Valm AM, Cohen S, Legant WR, Melunis J, Hershberg U, Wait E, et al. Applying systems-level spectral imaging and analysis to reveal the organelle interactome. Nature. 2017;546:162–7.
Article CAS PubMed PubMed Central Google Scholar
Kitada M, Koya D. Autophagy in metabolic disease and ageing. Nat Rev Endocrinol. 2021;17:647–61.
Eyme KM, Sammarco A, Jha R, Mnatsakanyan H, Pechdimaljian C, Carvalho L, et al. Targeting de novo lipid synthesis induces lipotoxicity and impairs DNA damage repair in glioblastoma mouse models. Sci Transl Med. 2023;15:eabq6288.
Article CAS PubMed PubMed Central Google Scholar
Henne WM, Reese ML, Goodman JM. The assembly of lipid droplets and their roles in challenged cells. EMBO J. 2019;38:e101816.
Article PubMed PubMed Central Google Scholar
Akbar Gharehbagh S, Tolouei Azar J, Razi M. ROS and metabolomics-mediated autophagy in rat’s testicular tissue alter after exercise training; evidence for exercise intensity and outcomes. Life Sci. 2021;277:119585.
Article CAS PubMed Google Scholar
Ioannou MS, Jackson J, Sheu SH, Chang CL, Weigel AV, Liu H, et al. Neuron-astrocyte metabolic coupling protects against activity-induced fatty acid toxicity. Cell. 2019;177:1522–35.e14.
Article CAS PubMed Google Scholar
Luo J, Yang H, Song BL. Mechanisms and regulation of cholesterol homeostasis. Nat Rev Mol Cell Biol. 2020;21:225–45.
Article CAS PubMed Google Scholar
Povero D, Chen Y, Johnson SM, McMahon CE, Pan M, Bao H, et al. HILPDA promotes NASH-driven HCC development by restraining intracellular fatty acid flux in hypoxia. J Hepatol. 2023;79:378–93.
Article CAS PubMed Google Scholar
Cheng X, Geng F, Pan M, Wu X, Zhong Y, Wang C, et al. Targeting DGAT1 ameliorates glioblastoma by increasing fat catabolism and oxidative stress. Cell Metab. 2020;32:229–42.e8.
Article CAS PubMed PubMed Central Google Scholar
Nguyen TB, Louie SM, Daniele JR, Tran Q, Dillin A, Zoncu R, et al. DGAT1-dependent lipid droplet biogenesis protects mitochondrial function during starvation-induced autophagy. Dev Cell. 2017;42:9–21.e5.
Article CAS PubMed PubMed Central Google Scholar
Klecker T, Braun RJ, Westermann B. Lipid droplets guard mitochondria during autophagy. Dev Cell. 2017;42:1–2.
Article CAS PubMed Google Scholar
Robichaud S, Fairman G, Vijithakumar V, Mak E, Cook DP, Pelletier AR, et al. Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells. Autophagy. 2021;17:3671–89.
Article CAS PubMed PubMed Central Google Scholar
Petan T, Jarc E, Jusovic M. Lipid droplets in cancer: guardians of fat in a stressful world. Molecules. 2018;23:1941.
Article PubMed PubMed Central Google Scholar
Bombarda-Rocha V, Silva D, Badr-Eddine A, Nogueira P, Goncalves J, Fresco P. Challenges in pharmacological intervention in perilipins (PLINs) to modulate lipid droplet dynamics in obesity and cancer. Cancers. 2023;15:4013.
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