Acute expression of human APOBEC3B in mice results in RNA editing and lethality

Rayon-Estrada V, Papavasiliou FN, Harjanto D. RNA Editing Dynamically Rewrites the Cancer Code. Trends Cancer. 2015;1:211–2.

Article  PubMed  PubMed Central  Google Scholar 

Baysal BE, Sharma S, Hashemikhabir S, Janga SC. RNA Editing in Pathogenesis of Cancer. Cancer Res. 2017;77:3733–9.

Article  CAS  PubMed  Google Scholar 

Kung CP, Maggi LB, Weber JD. The Role of RNA Editing in Cancer Development and Metabolic Disorders. Front Endocrinol. 2018;9:762.

Article  Google Scholar 

Kurkowiak M, Arcimowicz Ł, Chruściel E, Urban-Wójciuk Z, Papak I, Keegan L, et al. The effects of RNA editing in cancer tissue at different stages in carcinogenesis. Rna Biol. 2021;18:1524–39.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lerner T, Papavasiliou FN, Pecori R. RNA Editors, Cofactors, and mRNA Targets: An Overview of the C-to-U RNA Editing Machinery and Its Implication in Human Disease. Genes-basel. 2018;10:13.

Article  PubMed  PubMed Central  Google Scholar 

Powell LM, Wallis SC, Pease RJ, Edwards YH, Knott TJ, Scott J. A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine. Cell. 1987;50:831–40.

Article  CAS  PubMed  Google Scholar 

Powell-Braxton L, Véniant M, Latvala RD, Hirano KI, Won WB, Ross J, et al. A mouse model of human familial hypercholesterolemia: Markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat chow diet. Nat Med. 1998;4:934–8.

Article  CAS  PubMed  Google Scholar 

Xie Y, Luo J, Kennedy S, Davidson NO. Conditional Intestinal Lipotoxicity in Apobec-1 -/- Mttp-IKO Mice. J Biol Chem. 2007;282:33043–51.

Article  CAS  PubMed  Google Scholar 

Cappione AJ, French BL, Skuse GR. A potential role for NF1 mRNA editing in the pathogenesis of NF1 tumors. Am J Hum Genet. 1997;60:305–12.

CAS  PubMed  PubMed Central  Google Scholar 

Mukhopadhyay D, Anant S, Lee RM, Kennedy S, Viskochil D, Davidson NO. C→U Editing of Neurofibromatosis 1 mRNA Occurs in Tumors That Express Both the Type II Transcript and apobec-1, the Catalytic Subunit of the Apolipoprotein B mRNA–Editing Enzyme. Am J Hum Genetics. 2002;70:38–50.

Article  CAS  Google Scholar 

Yamanaka S, Poksay KS, Arnold KS, Innerarity TL. A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme. Gene Dev. 1997;11:321–33.

Article  CAS  PubMed  Google Scholar 

Alqassim EY, Sharma S, Khan ANMNH, Emmons TR, Gomez EC, Alahmari A, et al. RNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage polarization. Commun Biology. 2021;4:102.

Article  CAS  Google Scholar 

Peng X, Xu X, Wang Y, Hawke DH, Yu S, Han L, et al. A-to-I RNA Editing Contributes to Proteomic Diversity in Cancer. Cancer Cell. 2018;33:817-828.e7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gassner FJ, Zaborsky N, Buchumenski I, Levanon EY, Gatterbauer M, Schubert M, et al. RNA editing contributes to epitranscriptome diversity in chronic lymphocytic leukemia. Leukemia. 2021;35:1053–63.

Article  CAS  PubMed  Google Scholar 

Teng B, Burant CF, Davidson NO. Molecular Cloning of an Apolipoprotein B Messenger RNA Editing Protein. Science. 1993;260:1816–9.

Article  CAS  PubMed  Google Scholar 

Yamanaka S, Balestra ME, Ferrell LD, Fan J, Arnold KS, Taylor S, et al. Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals. Proc Nat Acad Sci. 1995;92:8483 LP – 8487.

Article  Google Scholar 

Sharma S, Patnaik SK, Taggart RT, Kannisto ED, Enriquez SM, Gollnick P, et al. APOBEC3A cytidine deaminase induces RNA editing in monocytes and macrophages. Nat Commun. 2015;6:6881.

Article  CAS  PubMed  Google Scholar 

Jalili P, Bowen D, Langenbucher A, Park S, Aguirre K, Corcoran RB, et al. Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots. Nat Commun. 2020;11:2971.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sharma S, Wang J, Alqassim E, Portwood S, Gomez EC, Maguire O, et al. Mitochondrial hypoxic stress induces widespread RNA editing by APOBEC3G in natural killer cells. Genome Biol. 2019;20:37.

Article  PubMed  PubMed Central  Google Scholar 

Saraconi G, Severi F, Sala C, Mattiuz G, Conticello SG. The RNA editing enzyme APOBEC1 induces somatic mutations and a compatible mutational signature is present in esophageal adenocarcinomas. Genome Biol. 2014;15:417.

Article  PubMed  PubMed Central  Google Scholar 

Harris RS, Petersen-Mahrt SK, Neuberger MS. RNA Editing Enzyme APOBEC1 and Some of Its Homologs Can Act as DNA Mutators. Mol Cell. 2002;10:1247–53.

Article  CAS  PubMed  Google Scholar 

Petersen-Mahrt SK, Neuberger MS. In Vitro Deamination of Cytosine to Uracil in Single-stranded DNA by Apolipoprotein B Editing Complex Catalytic Subunit 1 (APOBEC1)*. J Biol Chem. 2003;278:19583–6.

Article  CAS  PubMed  Google Scholar 

Barka A, Berríos KN, Bailer P, Schutsky EK, Wang T, Kohli RM. The Base-Editing Enzyme APOBEC3A Catalyzes Cytosine Deamination in RNA with Low Proficiency and High Selectivity. Acs Chem Biol. 2022;17:629–36.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feng Y, Seija N, Noia JMD, Martin A. AID in Antibody Diversification: There and Back Again. Trends Immunol. 2020;41:586–600.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burns MB, Lackey L, Carpenter MA, Rathore A, Land AM, Leonard B, et al. APOBEC3B is an enzymatic source of mutation in breast cancer. Nature. 2013;494:366–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Swanton C, McGranahan N, Starrett GJ, Harris RS. APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity. Cancer Discov. 2015;5:704–12.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiao X, Yang H, Arutiunian V, Fang Y, Besse G, Morimoto C, et al. Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation. Nucleic Acids Res. 2017;45:gkx564.

Article  Google Scholar 

Bransteitter R, Pham P, Scharff MD, Goodman MF. Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc National Acad Sci. 2003;100:4102–7.

Article  CAS  Google Scholar 

McCann JL, Cristini A, Law EK, Lee SY, Tellier M, Carpenter MA, et al. APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer. Nat Genet. 2023;55:1721–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Petljak M, Green AM, Maciejowski J, Weitzman MD. Addressing the benefits of inhibiting APOBEC3-dependent mutagenesis in cancer. Nat Genet. 2022;54:1599–608.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roberts SA, Lawrence MS, Klimczak LJ, Grimm SA, Fargo D, Stojanov P, et al. An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers. Nature Genetics. 2013;45:970–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio SAJR, Behjati S, Biankin AV, et al. Signatures of mutational processes in human cancer. Nature. 2013;500:415–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burns MB, Temiz NA, Harris RS. Evidence for APOBEC3B mutagenesis in multiple human cancers. Nat Genet. 2013;45:977–83.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alexandrov LB, Kim J, Haradhvala NJ, Huang MN, Ng AWT, Wu Y, et al. The repertoire of mutational signatures in human cancer. Nature. 2020;578:94–101.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jarvis MC, Carpenter MA, Temiz NA, Brown MR, Richards KA, Argyris PP, et al. Mutational impact of APOBEC3B and APOBEC3A in a human cell line. Biorxiv. 2022;26:489523.

Google Scholar 

Landry S, Narvaiza I, Linfesty DC, Weitzman MD. APOBEC3A can activate the DNA damage response and cause cell-cycle arrest. Embo Rep. 2011;12:444–50.

Article  CAS  PubMed  PubMed Central  G

Comments (0)

No login
gif