Adlam D, Alfonso F, Maas A, Vrints C, Writing C. European Society of Cardiology, acute cardiovascular care association, SCAD study group: a position paper on spontaneous coronary artery dissection. Eur Heart J. 2018;39(36):3353–68.
Article PubMed PubMed Central Google Scholar
Hayes SN, Kim ESH, Saw J, Adlam D, Arslanian-Engoren C, Economy KE, et al. Spontaneous coronary artery dissection: current state of the science: a scientific statement from the American Heart Association. Circulation. 2018;137(19):e523–57.
Article PubMed PubMed Central Google Scholar
Luong C, Starovoytov A, Heydari M, Sedlak T, Aymong E, Saw J. Clinical presentation of patients with spontaneous coronary artery dissection. Catheter Cardiovasc Interv. 2017;89(7):1149–54.
Saw J, Humphries K, Aymong E, Sedlak T, Prakash R, Starovoytov A, et al. Spontaneous coronary artery dissection: clinical outcomes and risk of recurrence. J Am Coll Cardiol. 2017;70(9):1148–58.
Poon K, Bell B, Raffel OC, Walters DL, Jang IK. Spontaneous coronary artery dissection: utility of intravascular ultrasound and optical coherence tomography during percutaneous coronary intervention. Circ Cardiovasc Interv. 2011;4(2):e5-7.
Vrints CJ. Spontaneous coronary artery dissection. Heart. 2010;96(10):801–8.
Saw J. Spontaneous coronary artery dissection. Can J Cardiol. 2013;29(9):1027–33.
Amrani-Midoun A, Adlam D, Bouatia-Naji N. Recent advances on the genetics of spontaneous coronary artery dissection. Circ Genom Precis Med. 2021;14(6):e003393.
Article PubMed CAS Google Scholar
Kim ESH, Saw J, Kadian-Dodov D, Wood M, Ganesh SK. FMD and SCAD: sex-biased arterial diseases with clinical and genetic pleiotropy. Circ Res. 2021;128(12):1958–72.
Article PubMed PubMed Central CAS Google Scholar
Gad MM, Mahmoud AN, Saad AM, Bazarbashi N, Ahuja KR, Karrthik AK, et al. Incidence, clinical presentation, and causes of 30-day readmission following hospitalization with spontaneous coronary artery dissection. JACC Cardiovasc Interv. 2020;13(8):921–32.
Clare R, Duan L, Phan D, Moore N, Jorgensen M, Ichiuji A, et al. Characteristics and clinical outcomes of patients with spontaneous coronary artery dissection. J Am Heart Assoc. 2019;8(10):e012570.
Article PubMed PubMed Central Google Scholar
Nakashima T, Noguchi T, Haruta S, Yamamoto Y, Oshima S, Nakao K, et al. Prognostic impact of spontaneous coronary artery dissection in young female patients with acute myocardial infarction: a report from the Angina Pectoris-Myocardial Infarction Multicenter Investigators in Japan. Int J Cardiol. 2016;207:341–8.
Faden MS, Bottega N, Benjamin A, Brown RN. A nationwide evaluation of spontaneous coronary artery dissection in pregnancy and the puerperium. Heart. 2016;102(24):1974–9.
Prasad M, Tweet MS, Hayes SN, Leng S, Liang JJ, Eleid MF, et al. Prevalence of extracoronary vascular abnormalities and fibromuscular dysplasia in patients with spontaneous coronary artery dissection. Am J Cardiol. 2015;115(12):1672–7.
Kadian-Dodov D, Gornik HL, Gu X, Froehlich J, Bacharach JM, Chi YW, et al. Dissection and aneurysm in patients with fibromuscular dysplasia: findings from the U.S. Registry for FMD. J Am Coll Cardiol. 2016;68(2):176–85.
Kok SN, Hayes SN, Cutrer FM, Raphael CE, Gulati R, Best PJM, et al. Prevalence and clinical factors of migraine in patients with spontaneous coronary artery dissection. J Am Heart Assoc. 2018;7(24):e010140.
Article PubMed PubMed Central Google Scholar
Gornik HL, Persu A, Adlam D, Aparicio LS, Azizi M, Boulanger M, et al. First International Consensus on the diagnosis and management of fibromuscular dysplasia. Vasc Med. 2019;24(2):164–89.
Shivapour DM, Erwin P, Kim E. Epidemiology of fibromuscular dysplasia: a review of the literature. Vasc Med. 2016;21(4):376–81.
Kim ESH. Spontaneous coronary-artery dissection. N Engl J Med. 2020;383(24):2358–70.
Article PubMed CAS Google Scholar
Saw J, Aymong E, Sedlak T, Buller CE, Starovoytov A, Ricci D, et al. Spontaneous coronary artery dissection: association with predisposing arteriopathies and precipitating stressors and cardiovascular outcomes. Circ Cardiovasc Interv. 2014;7(5):645–55.
• Verstraeten A, Perik M, Baranowska AA, Meester JAN, Van Den Heuvel L, Bastianen J, et al. Enrichment of rare variants in Loeys-Dietz syndrome genes in spontaneous coronary artery dissection but not in severe fibromuscular dysplasia. Circulation. 2020;142(10):1021–4. Identifies rare variants with large effect sizes in genes typically associated with syndromic and non-syndomic thoracic aortic disease.
Murad AM, Hill HL, Wang Y, Ghannam M, Yang ML, Pugh NL, et al. Spontaneous coronary artery dissection is infrequent in individuals with heritable thoracic aortic disease despite partially shared genetic susceptibility. Am J Med Genet A. 2022;188(5):1448–56.
Article PubMed PubMed Central CAS Google Scholar
• Carss KJ, Baranowska AA, Armisen J, Webb TR, Hamby SE, Premawardhana D, et al. Spontaneous coronary artery dissection: insights on rare genetic variation from genome sequencing. Circ Genom Precis Med. 2020;13(6):e003030. Evaluates variants that would meet clinical criteria for pathogenicity among individuals with SCAD.
Article PubMed PubMed Central CAS Google Scholar
Henkin S, Negrotto SM, Tweet MS, Kirmani S, Deyle DR, Gulati R, et al. Spontaneous coronary artery dissection and its association with heritable connective tissue disorders. Heart. 2016;102(11):876–81.
Kaadan MI, MacDonald C, Ponzini F, Duran J, Newell K, Pitler L, et al. Prospective cardiovascular genetics evaluation in spontaneous coronary artery dissection. Circ Genom Precis Med. 2018;11(4):e001933.
Article PubMed CAS Google Scholar
Turley TN, Theis JL, Sundsbak RS, Evans JM, O’Byrne MM, Gulati R, et al. Rare missense variants in TLN1 are associated with familial and sporadic spontaneous coronary artery dissection. Circ Genom Precis Med. 2019;12(4):e002437.
Article PubMed PubMed Central CAS Google Scholar
Monkley SJ, Kostourou V, Spence L, Petrich B, Coleman S, Ginsberg MH, et al. Endothelial cell talin1 is essential for embryonic angiogenesis. Dev Biol. 2011;349(2):494–502.
Article PubMed PubMed Central CAS Google Scholar
Sun Y, Chen Y, Li Y, Li Z, Li C, Yu T, et al. Association of TSR1 variants and spontaneous coronary artery dissection. J Am Coll Cardiol. 2019;74(2):167–76.
Article PubMed CAS Google Scholar
McCaughan UM, Jayachandran U, Shchepachev V, Chen ZA, Rappsilber J, Tollervey D, et al. Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases. Nat Commun. 2016;7:11789.
Article PubMed PubMed Central CAS Google Scholar
Georges A, Albuisson J, Berrandou T, Dupre D, Lorthioir A, D’Escamard V, et al. Rare loss-of-function mutations of PTGIR are enriched in fibromuscular dysplasia. Cardiovasc Res. 2021;117(4):1154–65.
Article PubMed CAS Google Scholar
•• Wang Y, Starovoytov A, Murad AM, Hunker KL, Brunham LR, Li JZ, et al. Burden of rare genetic variants in spontaneous coronary artery dissection with high-risk features. JAMA Cardiol. 2022;7(10):1045–55. Identifies higher percentage of rare, large effect variants among subset of individuals with SCAD with high-risk features (conmpared to all individuals with SCAD.
• Saw J, Yang ML, Trinder M, Tcheandjieu C, Xu C, Starovoytov A, et al. Chromosome 1q21.2 and additional loci influence risk of spontaneous coronary artery dissection and myocardial infarction. Nat Commun. 2020;11(1):4432. Identifies novel risk loci for SCAD through association analyses.
Tarr I, Hesselson S, Iismaa SE, Rath E, Monger S, Troup M, et al. Exploring the genetic architecture of spontaneous coronary artery dissection using whole-genome sequencing. Circ Genom Precis Med. 2022;15(4):e003527.
Article PubMed PubMed Central CAS Google Scholar
Adlam D, Olson TM, Combaret N, Kovacic JC, Iismaa SE, Al-Hussaini A, et al. Association of the PHACTR1/EDN1 genetic locus with spontaneous coronary artery dissection. J Am Coll Cardiol. 2019;73(1):58–66.
Article PubMed PubMed Central CAS Google Scholar
Kiando SR, Tucker NR, Castro-Vega LJ, Katz A, D’Escamard V, Treard C, et al. PHACTR1 is a genetic susceptibility locus for fibromuscular dysplasia supporting its complex genetic pattern of inheritance. PLoS Genet. 2016;12(10):e1006367.
Article PubMed PubMed Central Google Scholar
Freilinger T, Anttila V, de Vries B, Malik R, Kallela M, Terwindt GM, et al. Genome-wide association analysis identifies susceptibility loci for migraine without aura. Nat Genet. 2012;44(7):777–82.
Article PubMed PubMed Central CAS Google Scholar
Giri A, Hellwege JN, Keaton JM, Park J, Qiu C, Warren HR, et al. Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. Nat Genet. 2019;51(1):51–62.
Article PubMed CAS Google Scholar
Kichaev G, Bhatia G, Loh PR, Gazal S, Burch K, Freund MK, et al. Leveraging polygenic functional enrichment to improve GWAS power. Am J Hum Genet. 2019;104(1):65–75.
Article PubMed CAS Google Scholar
Debette S, Kamatani Y, Metso TM, Kloss M, Chauhan G, Engelter ST, et al. Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection. Nat Genet. 2015;47(1):78–83.
Comments (0)