Cardiac Regeneration in Adult Zebrafish: A Review of Signaling and Metabolic Coordination

Lam NT, Sadek HA. Neonatal heart regeneration: Comprehensive Literature Review. Circulation. 2018;138:412–23.

Article  PubMed  PubMed Central  Google Scholar 

Di Cesare M, Perel P, Taylor S, Kabudula C, Bixby H, Gaziano TA, et al. The heart of the World. Glob Heart. 2024;19:11.

Article  PubMed  PubMed Central  Google Scholar 

Price EL, Vieira JM, Riley PR. Model organisms at the heart of regeneration. Dis Model Mech [Internet]. 2019;12. Available from: https://doi.org/10.1242/dmm.040691

Behal RH, Buxton DB, Robertson JG, Olson MS. Regulation of the pyruvate dehydrogenase multienzyme complex. Annu Rev Nutr. 1993;13:497–520.

Article  CAS  PubMed  Google Scholar 

Khyeam S, Lee S, Huang GN, Genetic. Epigenetic, and post-transcriptional basis of divergent tissue regenerative capacities among vertebrates. Adv Genet [Internet]. 2021;2. Available from: https://doi.org/10.1002/ggn2.10042

Cutie S, Huang GN. Vertebrate cardiac regeneration: evolutionary and developmental perspectives. Cell Regen. 2021;10:6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Poss KD, Wilson LG, Keating MT. Heart regeneration in zebrafish. Science. 2002;298:2188–90.

Article  CAS  PubMed  Google Scholar 

Costa A, Cushman S, Haubner BJ, Derda AA, Thum T, Bär C. Neonatal injury models: integral tools to decipher the molecular basis of cardiac regeneration. Basic Res Cardiol. 2022;117:26.

Article  PubMed  PubMed Central  Google Scholar 

Porrello ER, Mahmoud AI, Simpson E, Hill JA, Richardson JA, Olson EN, et al. Transient regenerative potential of the neonatal mouse heart. Science. 2011;331:1078–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang H, Paulsen MJ, Hironaka CE, Shin HS, Farry JM, Thakore AD et al. Natural heart regeneration in a neonatal rat myocardial infarction model. Cells [Internet]. 2020;9. Available from: https://doi.org/10.3390/cells9010229

Ali SR, Hippenmeyer S, Saadat LV, Luo L, Weissman IL, Ardehali R. Existing cardiomyocytes generate cardiomyocytes at a low rate after birth in mice. Proc Natl Acad Sci U S A. 2014;111:8850–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haubner BJ, Schneider J, Schweigmann U, Schuetz T, Dichtl W, Velik-Salchner C, et al. Functional recovery of a human neonatal heart after severe myocardial infarction. Circ Res. 2016;118:216–21.

Article  CAS  PubMed  Google Scholar 

Bergmann O, Bhardwaj RD, Bernard S, Zdunek S, Barnabé-Heider F, Walsh S, et al. Evidence for cardiomyocyte renewal in humans. Science. 2009;324:98–102.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Senyo SE, Steinhauser ML, Pizzimenti CL, Yang VK, Cai L, Wang M, et al. Mammalian heart renewal by pre-existing cardiomyocytes. Nature. 2013;493:433–6.

Article  CAS  PubMed  Google Scholar 

Raya A, Koth CM, Büscher D, Kawakami Y, Itoh T, Raya RM, et al. Activation of notch signaling pathway precedes heart regeneration in zebrafish. Proc Natl Acad Sci U S A. 2003;100(Suppl 1):11889–95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kikuchi K, Holdway JE, Werdich AA, Anderson RM, Fang Y, Egnaczyk GF, et al. Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes. Nature. 2010;464:601–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao L, Borikova AL, Ben-Yair R, Guner-Ataman B, MacRae CA, Lee RT, et al. Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration. Proc Natl Acad Sci U S A. 2014;111:1403–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Poss KD. Getting to the heart of regeneration in zebrafish. Semin Cell Dev Biol. 2007;18:36–45.

Article  CAS  PubMed  Google Scholar 

Zhang L, Jaswal JS, Ussher JR, Sankaralingam S, Wagg C, Zaugg M, et al. Cardiac insulin-resistance and decreased mitochondrial energy production precede the development of systolic heart failure after pressure-overload hypertrophy. Circ Heart Fail. 2013;6:1039–48.

Article  CAS  PubMed  Google Scholar 

Lepilina A, Coon AN, Kikuchi K, Holdway JE, Roberts RW, Burns CG, et al. A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. Cell. 2006;127:607–19.

Article  CAS  PubMed  Google Scholar 

Gandoy-Fieiras N, Gonzalez-Juanatey JR, Eiras S. Myocardium metabolism in physiological and pathophysiological states: implications of epicardial adipose tissue and potential therapeutic targets. Int J Mol Sci [Internet]. 2020;21. Available from: https://doi.org/10.3390/ijms21072641

Sakamoto T, Kelly DP. Cardiac maturation. J Mol Cell Cardiol. 2024;187:38–50.

Article  CAS  PubMed  Google Scholar 

Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, et al. The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell. 2014;157:565–79.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lalowski MM, Björk S, Finckenberg P, Soliymani R, Tarkia M, Calza G, et al. Characterizing the key metabolic pathways of the neonatal mouse heart using a quantitative combinatorial Omics Approach. Front Physiol. 2018;9:365.

Article  PubMed  PubMed Central  Google Scholar 

Cardoso AC, Lam NT, Savla JJ, Nakada Y, Pereira AHM, Elnwasany A, et al. Mitochondrial substrate utilization regulates Cardiomyocyte Cell cycle progression. Nat Metab. 2020;2:167–78.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yester JW, Kühn B. Mechanisms of Cardiomyocyte Proliferation and differentiation in Development and Regeneration. Curr Cardiol Rep. 2017;19:13.

Article  PubMed  PubMed Central  Google Scholar 

Nakada Y, Canseco DC, Thet S, Abdisalaam S, Asaithamby A, Santos CX, et al. Hypoxia induces heart regeneration in adult mice. Nature. 2017;541:222–7.

Article  CAS  PubMed  Google Scholar 

Canseco DC, Kimura W, Garg S, Mukherjee S, Bhattacharya S, Abdisalaam S, et al. Human ventricular unloading induces cardiomyocyte proliferation. J Am Coll Cardiol. 2015;65:892–900.

Article  PubMed  PubMed Central  Google Scholar 

Ausoni S, Sartore S. From fish to amphibians to mammals: in search of novel strategies to optimize cardiac regeneration. J Cell Biol. 2009;184:357–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bely AE. Evolutionary loss of animal regeneration: pattern and process. Integr Comp Biol. 2010;50:515–27.

Article  PubMed  Google Scholar 

Dunoyer LA, Seifert AW, Van Cleve J. Evolutionary bedfellows: reconstructing the ancestral state of autotomy and regeneration. J Exp Zool B Mol Dev Evol. 2021;336:94–115.

Article  PubMed  Google Scholar 

Vivien CJ, Hudson JE, Porrello ER. Evolution, comparative biology and ontogeny of vertebrate heart regeneration. NPJ Regen Med. 2016;1:16012.

Article  PubMed  PubMed Central  Google Scholar 

Jaźwińska A, Sallin P. Regeneration versus scarring in vertebrate appendages and heart. J Pathol. 2016;238:233–46.

Article  PubMed  Google Scholar 

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