Agrawal P, Nair MS (2022) An insight into the pharmacological and analytical potential of Andrographolide. Fundam Clin Pharmacol 36(4):586–600. https://doi.org/10.1111/fcp.12757
Article PubMed CAS Google Scholar
Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124(4):783–801. https://doi.org/10.1016/j.cell.2006.02.015
Article PubMed CAS Google Scholar
Barochia A, Solomon S, Cui X, Natanson C, Eichacker PQ (2011) Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies. Expert Opin Drug Metab Toxicol 7(4):479–494. https://doi.org/10.1517/17425255.2011.558190
Article PubMed PubMed Central CAS Google Scholar
Bruno K, Woller SA, Miller YI, Yaksh TL, Wallace M, Beaton G, Chakravarthy K (2018) Targeting toll-like receptor-4 (TLR4)-an emerging therapeutic target for persistent pain states. Pain 159(10):1908–1915. https://doi.org/10.1097/j.pain.0000000000001306
Article PubMed PubMed Central CAS Google Scholar
Burgos RA, Alarcon P, Quiroga J, Manosalva C, Hancke J (2020) Andrographolide, an anti-inflammatory Multitarget drug: all roads lead to Cellular Metabolism. Molecules 26(1). https://doi.org/10.3390/molecules26010005
Chang S, Li X, Zheng Y, Shi H, Zhang D, Jing B, Chen Z, Qian G, Zhao G (2022) Kaempferol exerts a neuroprotective effect to reduce neuropathic pain through TLR4/NF-kB signaling pathway. Phytother Res 36(4):1678–1691. https://doi.org/10.1002/ptr.7396
Article PubMed PubMed Central CAS Google Scholar
Chen G, Zhang YQ, Qadri YJ, Serhan CN, Ji RR (2018) Microglia in Pain: detrimental and protective roles in Pathogenesis and Resolution of Pain. Neuron 100(6):1292–1311. https://doi.org/10.1016/j.neuron.2018.11.009
Article PubMed PubMed Central CAS Google Scholar
Chen Y, Zhou Y, Li XC, Ma X, Mi WL, Chu YX, Wang YQ, Mao-Ying QL (2022) Neuronal GRK2 regulates microglial activation and contributes to electroacupuncture analgesia on inflammatory pain in mice. Biol Res 55(1):5. https://doi.org/10.1186/s40659-022-00374-6
Article PubMed PubMed Central CAS Google Scholar
Clark AK, Staniland AA, Marchand F, Kaan TK, Mcmahon SB, Malcangio M (2010) P2X7-dependent release of interleukin-1beta and nociception in the spinal cord following lipopolysaccharide. J Neurosci 30(2):573–582. https://doi.org/10.1523/JNEUROSCI.3295-09.2010
Article PubMed PubMed Central CAS Google Scholar
Gereau RT, Sluka KA, Maixner W, Savage SR, Price TJ, Murinson BB, Sullivan MD, Fillingim RB (2014) A pain research agenda for the 21st century. J Pain 15(12):1203–1214. https://doi.org/10.1016/j.jpain.2014.09.004
Article PubMed PubMed Central Google Scholar
Guan Z, Hellman J, Schumacher M (2016) Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. F1000Res. 510.12688/f1000research.8710.1
Article PubMed PubMed Central Google Scholar
Guo W, Sun Y, Liu W, Wu X, Guo L, Cai P, Wu X, Wu X, Shen Y, Shu Y, Gu Y, Xu Q (2014) Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer. Autophagy 10(6):972–985. https://doi.org/10.4161/auto.28374
Article PubMed PubMed Central CAS Google Scholar
Gupta S, Mishra KP, Singh SB, Ganju L (2018) Inhibitory effects of andrographolide on activated macrophages and adjuvant-induced arthritis. Inflammopharmacology 26(2):447–456. https://doi.org/10.1007/s10787-017-0375-7
Article PubMed CAS Google Scholar
Hartung JE, Eskew O, Wong T, Tchivileva IE, Oladosu FA, O’Buckley SC, Nackley AG (2015) Nuclear factor-kappa B regulates pain and COMT expression in a rodent model of inflammation. Brain Behav Immun 50:196–202. https://doi.org/10.1016/j.bbi.2015.07.014
Article PubMed PubMed Central CAS Google Scholar
Hernangomez M, Klusakova I, Joukal M, Hradilova-Svizenska I, Guaza C, Dubovy P (2016) CD200R1 agonist attenuates glial activation, inflammatory reactions, and hypersensitivity immediately after its intrathecal application in a rat neuropathic pain model. J Neuroinflamm 13:43. https://doi.org/10.1186/s12974-016-0508-8
Hess A, Axmann R, Rech J, Finzel S, Heindl C, Kreitz S, Sergeeva M, Saake M, Garcia M, Kollias G, Straub RH, Sporns O, Doerfler A, Brune K, Schett G (2011) Blockade of TNF-alpha rapidly inhibits pain responses in the central nervous system. Proc. Natl. Acad. Sci. U. S. A. 108(9), 3731-6. https://doi.org/10.1073/pnas.1011774108
Inoue K (2006) The function of microglia through purinergic receptors: neuropathic pain and cytokine release. Pharmacol Ther 109(1–2) 210 – 26. https://doi.org/10.1016/j.pharmthera.2005.07.001
Inoue K, Tsuda M (2018) Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential. Nat Rev Neurosci 19(3):138–152. https://doi.org/10.1038/nrn.2018.2
Article PubMed CAS Google Scholar
Ishan M, Chen G, Yu W, Wang Z, Giovannini M, Cao X, Liu HX (2021) Deletion of Nf2 in neural crest-derived tongue mesenchyme alters tongue shape and size, Hippo signalling and cell proliferation in a region- and stage-specific manner. Cell Prolif 54(12):e13144. https://doi.org/10.1111/cpr.13144
Article PubMed PubMed Central CAS Google Scholar
Ji A, Xu J (2021) Neuropathic Pain: Biomolecular Intervention and imaging via Targeting Microglia activation. Biomolecules 11(9). https://doi.org/10.3390/biom11091343
Ji RR, Berta T, Nedergaard M (2013) Glia and pain: is chronic pain a gliopathy? Pain 154(1):S10–S28. https://doi.org/10.1016/j.pain.2013.06.022
Article PubMed PubMed Central Google Scholar
Ji RR, Xu ZZ, Gao YJ (2014) Emerging targets in neuroinflammation-driven chronic pain. Nat Rev Drug Discov 13(7):533–548. https://doi.org/10.1038/nrd4334
Article PubMed PubMed Central CAS Google Scholar
Ji RR, Nackley A, Huh Y, Terrando N, Maixner W (2018) Neuroinflammation and Central Sensitization in chronic and widespread Pain. Anesthesiology 129(2):343–366. https://doi.org/10.1097/ALN.0000000000002130
Karin M, Lin A (2002) NF-kappaB at the crossroads of life and death. Nat Immunol 3(3):221–227. https://doi.org/10.1038/ni0302-221
Article PubMed CAS Google Scholar
Kawasaki Y, Zhang L, Cheng JK, Ji RR (2008) Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and Tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord. J Neurosci 28(20):5189–5194. https://doi.org/10.1523/JNEUROSCI.3338-07.2008
Article PubMed PubMed Central CAS Google Scholar
Lawrence T (2009) The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harbor Perspect Biol 1(6):a001651. https://doi.org/10.1101/cshperspect.a001651
Li Q, Verma IM (2002) NF-kappaB regulation in the immune system. Nat Rev Immunol 2(10):725–734. https://doi.org/10.1038/nri910
Article PubMed CAS Google Scholar
Li CX, Li HG, Zhang H, Cheng RH, Li M, Liang JY, Gu Y, Ling B, Yao ZR, Yu H (2016) Andrographolide suppresses thymic stromal lymphopoietin in phorbol myristate acetate/calcium ionophore A23187-activated mast cells and 2,4-dinitrofluorobenzene-induced atopic dermatitis-like mice model. Drug Des Devel Ther 10:781–791. https://doi.org/10.2147/DDDT.S94056
Article PubMed PubMed Central Google Scholar
Lu J, Ma Y, Wu J, Huang H, Wang X, Chen Z, Chen J, He H, Huang C (2019) A review for the neuroprotective effects of andrographolide in the central nervous system. Biomed Pharmacother 117:109078. https://doi.org/10.1016/j.biopha.2019.109078
Article PubMed CAS Google Scholar
Lu Y, Cao DL, Ma LJ, Gao YJ (2022) TRAF6 contributes to CFA-Induced spinal microglial activation and Chronic Inflammatory Pain in mice. Cell Mol Neurobiol 42(5):1543–1555. https://doi.org/10.1007/s10571-021-01045-y
Article PubMed CAS Google Scholar
Lynch ME, Watson CP (2006) The pharmacotherapy of chronic pain: a review. Pain Res Manag 11(1):11–38. https://doi.org/10.1155/2006/642568
Article PubMed PubMed Central Google Scholar
Medzhitov R (2001) Toll-like receptors and innate immunity. Nat Rev Immunol 1(2):135–145. https://doi.org/10.1038/35100529
Article PubMed CAS Google Scholar
Mills S, Nicolson KP, Smith BH (2019) Chronic pain: a review of its epidemiology and associated factors in population-based studies. Br J Anaesth 123(2):e273–e283. https://doi.org/10.1016/j.bja.2019.03.023
Article PubMed PubMed Central Google Scholar
Monnet E, Lapeyre G, Poelgeest EV, Jacqmin P, Graaf K, Reijers J, Moerland M, Burggraaf J, Min C (2017) Evidence of NI-0101 pharmacological activity, an anti-TLR4 antibody, in a randomized phase I dose escalation study in healthy volunteers receiving LPS. Clin Pharmacol Ther 101(2):200–208. https://doi.org/10.1002/cpt.522
Article PubMed CAS Google Scholar
Park J, Kim YT (2020) Erythronium Japonicum alleviates Inflammatory Pain by inhibiting MAPK activation and by suppressing NF-kappaB activation via ERK/Nrf2/HO-1 signaling pathway. Antioxidants 9(7). https://doi.org/10.3390/antiox9070626
Ren K, Torres R (2009) Role of interleukin-1beta during pain and inflammation. Brain Res Rev 60(1):57–64. https://doi.org/10.1016/j.brainresrev.2008.12.020
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