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Comment on Ziegler K, Ahles A, Dueck A, Esfandyari D, Pichler P, Weber K, Kotschi S, Bartelt A, Sinicina I, Graw M, Leonhardt H, Weckbach L, Massberg S, Schifferer M, Simons M, Hoeher L, Luo J, Erturk A, Schiattarella G, Sassi Y, Misgeld T, and Engelhardt S, Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease. Science, 2023. 381(6655): p. 285–290. https://doi.org/10.1126/science.abn6366.