Elagawany M, Schmitt M, Ghiaty A, El-Etrawy A, Ibrahim M, Bihel F, et al. Synthesis and antiproliferative effects of 5,6-disubstituted pyridazin-3(2H)-ones designed as conformationally constrained combretastatin A-4 analogues. Anti-Cancer Agents Med Chem. 2013;13:1133–40. https://doi.org/10.2174/1871520611313070018
Negi AS, Gautam Y, Alam S, Chanda D, Luqman S, Sarkar J, et al. Natural antitubulin agents: Importance of 3,4,5-trimethoxyphenyl fragment. Bioorg Med Chem. 2015;23:373–89. https://doi.org/10.1016/j.bmc.2014.12.027
Article CAS PubMed Google Scholar
Wen Z, Xu J, Wang Z, Qi H, Xu Q, Bai Z, et al. 3-(3,4,5-Trimethoxyphenylselenyl)-1 H -indoles and their selenoxides as combretastatin A-4 analogs: Microwave-assisted synthesis and biological evaluation. Eur J Med Chem. 2015;90:184–94. https://doi.org/10.1016/j.ejmech.2014.11.024
Article CAS PubMed Google Scholar
El-Subbagh HI, Hassan GS, El-Messery SM, Al-Rashood ST, Al-Omary FAM, Abulfadl YS, et al. Nonclassical antifolates, part 5. Benzodiazepine analogs as a new class of DHFR inhibitors: Synthesis, antitumor testing and molecular modeling study. Eur J Med Chem. 2014;74:234–45. https://doi.org/10.1016/j.ejmech.2014.01.004
Article CAS PubMed Google Scholar
Li X, Hilgers M, Cunningham M, Chen Z, Trzoss M, Zhang J, et al. Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines. Bioorg Med Chem Lett. 2011;21:5171–6. https://doi.org/10.1016/j.bmcl.2011.07.059
Article CAS PubMed Google Scholar
Chaudhary A, Sharma PP, Bhardwaj G, Jain V, Bharatam PV, Shrivastav B, et al. Synthesis, biological evaluation, and molecular modeling studies of novel heterocyclic compounds as anti-proliferative agents. Med Chem Res. 2013;22:5654–69. https://doi.org/10.1007/s00044-013-0556-x
Novoa A, Pellegrini-Moïse N, Bourg S, Thoret S, Dubois J, Aubert G, et al. Design, synthesis and antiproliferative activities of biarylolefins based on polyhydroxylated and carbohydrate scaffolds. Eur J Med Chem. 2011;46:3570–80. https://doi.org/10.1016/j.ejmech.2011.05.021
Article CAS PubMed Google Scholar
Jeong CH, Park HB, Jang WJ, Jung SH, Seo YH. Discovery of hybrid Hsp90 inhibitors and their anti-neoplastic effects against gefitinib-resistant non-small cell lung cancer (NSCLC). Bioorg Med Chem Lett. 2014;24:224–7. https://doi.org/10.1016/j.bmcl.2013.11.034
Article CAS PubMed Google Scholar
Li Y, Zhang LP, Dai F, Yan WJ, Wang HB, Tu ZS, et al. Hexamethoxylated monocarbonyl analogues of curcumin cause G2/M cell cycle arrest in NCI-H460 cells via michael acceptor-dependent redox intervention. J Agric Food Chem. 2015;63:7731–42. https://doi.org/10.1021/acs.jafc.5b02011
Article CAS PubMed Google Scholar
Ma LY, Zheng YC, Wang SQ, Wang B, Wang ZR, Pang LP, et al. Design, synthesis, and structure-activity relationship of novel lsd1 inhibitors based on pyrimidine-thiourea hybrids as potent, orally active antitumor agents. J Med Chem. 2015;58:1705–16. https://doi.org/10.1021/acs.jmedchem.5b00037
Article CAS PubMed Google Scholar
Mohedas AH, Wang Y, Sanvitale CE, Canning P, Choi S, Xing X, et al. Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J Med Chem. 2014;57:7900–15. https://doi.org/10.1021/jm501177w
Article CAS PubMed PubMed Central Google Scholar
Singh S, Prasad NR, Chufan EE, Patel BA, Wang YJ, Chen ZS, et al. Design and synthesis of human ABCB1 (P-glycoprotein) inhibitors by peptide coupling of diverse chemical scaffolds on carboxyl and amino termini of (S)-valine-derived thiazole amino acid. J Med Chem. 2014;57:4058–72. https://doi.org/10.1021/jm401966m
Article CAS PubMed PubMed Central Google Scholar
Bin JW, Wong ILK, Hu X, Yu ZX, Xing LF, Jiang T, et al. Structure-activity relationship study of permethyl ningalin B analogues as P-glycoprotein chemosensitizers. J Med Chem. 2013;56:9057–70. https://doi.org/10.1021/jm400930e
Article CAS PubMed Google Scholar
Silva T, Reis J, Teixeira J, Borges F. Alzheimer’s disease, enzyme targets and drug discovery struggles: From natural products to drug prototypes. Ageing Res Rev. 2014;15:116–45. https://doi.org/10.1016/j.arr.2014.03.008
Article CAS PubMed Google Scholar
Horbert R, Pinchuk B, Johannes E, Schlosser J, Schmidt D, Cappel D, et al. Optimization of potent dfg-in inhibitors of platelet derived growth factor receptorβ (PDGF-Rβ) guided by water thermodynamics. J Med Chem. 2015;58:170–82. https://doi.org/10.1021/jm500373x
Article CAS PubMed Google Scholar
Chavan HV, Bandgar BP, Adsul LK, Dhakane VD, Bhale PS, Thakare VN, et al. Design, synthesis, characterization and anti-inflammatory evaluation of novel pyrazole amalgamated flavones. Bioorg Med Chem Lett. 2013;23:1315–21. https://doi.org/10.1016/j.bmcl.2012.12.094
Article CAS PubMed Google Scholar
Sriram D, Ratan Bal T, Yogeeswari P. Aminopyimidinimo isatin analogues: design of novel non-nucleoside HIV-1 reverse transcriptase inhibitors with broadspectrum chemotherapeutic properties. J Pharm Pharm Sci. 2005;8:565–77.
Kovackova S, Chang L, Bekerman E, Neveu G, Barouch-Bentov R, Chaikuad A, et al. Selective inhibitors of cyclin G associated kinase (GAK) as anti-hepatitis C agents. J Med Chem. 2015;58:3393–410. https://doi.org/10.1021/jm501759m
Article CAS PubMed PubMed Central Google Scholar
Ponnala S, Kapadia N, Harding WW. Erratum: Identification of tris-(phenylalkyl)amines as new selective h5-HT2B receptor antagonists (Med Chem Comm (2015). MedChemComm.2015;6:732. https://doi.org/10.1039/c5md90005k. https://doi.org/10.1039/c4md00418c.
Salado IG, Redondo M, Bello ML, Perez C, Liachko NF, Kraemer BC, et al. Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis. J Med Chem. 2014;57:2755–72. https://doi.org/10.1021/jm500065f
Article CAS PubMed PubMed Central Google Scholar
Sashidhara KV, Modukuri RK, Singh S, Bhaskara Rao K, Aruna Teja G, Gupta S, et al. Design and synthesis of new series of coumarin-aminopyran derivatives possessing potential anti-depressant-like activity. Bioorg Med Chem Lett. 2015;25:337–41. https://doi.org/10.1016/j.bmcl.2014.11.036
Article CAS PubMed Google Scholar
Gaali S, Kirschner A, Cuboni S, Hartmann J, Kozany C, Balsevich G, et al. Selective inhibitors of the FK506-binding protein 51 by induced fit. Nat Chem Biol. 2015;11:33–37. https://doi.org/10.1038/nchembio.1699
Article CAS PubMed Google Scholar
Abdel-Aziz AAM, Eltahir KEH, Asiri YA. Synthesis, anti-inflammatory activity and COX-1/COX-2 inhibition of novel substituted cyclic imides. Part 1: Molecular docking study. Eur J Med Chem. 2011;46:1648–1655. https://doi.org/10.1016/j.ejmech.2011.02.013
Article CAS PubMed Google Scholar
Abdel-Aziz M, Beshr EA, Abdel-Rahman IM, Ozadali K, Tan OU, Aly OM. 1-(4-Methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-3- carboxamides: Synthesis, molecular modeling, evaluation of their anti-inflammatory activity and ulcerogenicity. Eur J Med Chem. 2014;77:155–65. https://doi.org/10.1016/j.ejmech.2014.03.001
Article CAS PubMed Google Scholar
Salum LB, Altei WF, Chiaradia LD, Cordeiro MNS, Canevarolo RR, Melo CPS, et al. Cytotoxic 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors. Eur J Med Chem. 2013;63:501–10. https://doi.org/10.1016/j.ejmech.2013.02.037
Article CAS PubMed PubMed Central Google Scholar
Assadieskandar A, Amini M, Ostad SN, Riazi GH, Cheraghi-Shavi T, Shafiei B, et al. Design, synthesis, cytotoxic evaluation and tubulin inhibitory activity of 4-aryl-5-(3,4,5-trimethoxyphenyl)-2-alkylthio-1H-imidazole derivatives. Bioorg Med Chem. 2013;21:2703–9. https://doi.org/10.1016/j.bmc.2013.03.011
Article CAS PubMed Google Scholar
Taldone T, Chiosis G. Purine-scaffold Hsp90 inhibitors. Curr Top Med Chem. 2009;9:1436–46. https://doi.org/10.2174/156802609789895737
Article CAS PubMed PubMed Central Google Scholar
Taldone T, Sun W, Chiosis G. Discovery and development of heat shock protein 90 inhibitors. Bioorg Med Chem. 2009;17:2225–35. https://doi.org/10.1016/j.bmc.2008.10.087
Article CAS PubMed Google Scholar
Zurlo M, Romagnoli R, Oliva P, Gasparello J, Finotti A, Gambari R. Synergistic effects of a combined treatment of glioblastoma U251 cells with An Anti-miR-10b-5p molecule and an anticancer agent based on 1-(3′,4′,5′-Trimethoxyphenyl)-2-Aryl-1H-Imidazole scaffold. Int J Mol Sci. 2022;23:5991 https://doi.org/10.3390/ijms23115991.
Article CAS PubMed PubMed Central Google Scholar
Gangjee A, Namjoshi OA, Raghavan S, Queener SF, Kisliuk RL, Cody V. Design, synthesis, and molecular modeling of novel pyrido[2,3-d]pyrimidine analogues as antifolates; Application of buchwald-hartwig aminations of heterocycles. J Med Chem. 2013;56:4422–41. https://doi.org/10.1021/jm400086g
Article CAS PubMed PubMed Central Google Scholar
Gigant B, Cormier A, Dorléans A, Ravelli RBG, Knossow M. Microtubule-destabilizing agents: Structural and mechanistic insights from the interaction of colchicine and vinblastine with tubulin. Top Curr Chem. 2009;286:259–78. https://doi.org/10.1007/128_2008_11
Article CAS PubMed Google Scholar
Nagai H, Kim YH. Cancer prevention from the perspective of global cancer burden patterns. J Thorac Dis. 2017;9:448–51. https://doi.org/10.21037/j
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