Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr, Lenfant C (2004) Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 109(3):433–438

Article  PubMed  Google Scholar 

Saljoughian M (2017) Cardiometabolic syndrome a global health issue. US Pharm 42(2):HS19–HS21

Google Scholar 

Cheng X, Ma T, Ouyang F, Zhang G, Bai Y (2022) Trends in the prevalence of cardiometabolic multimorbidity in the United States, 1999–2018. Int J Environ Res Public Health 19(8):4726

Article  PubMed  PubMed Central  Google Scholar 

Jadhav UM (2018) Cardio-metabolic disease in India—the up-coming tsunami. Ann Transl Med 6(15):295

Article  PubMed  PubMed Central  Google Scholar 

Prasad DS, Kabir Z, Dash AK, Das BC (2012) Prevalence and risk factors for metabolic syndrome in Asian Indians: a community study from urban Eastern India. J Cardiovasc Dis Res 3:204–211

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ogurtsova K, Guariguata L, Barengo NC, Ruiz PLD, Sacre JW, Karuranga S et al (2022) IDF diabetes Atlas: global estimates of undiagnosed diabetes in adults for 2021. Diabetes Res Clin Pract 183:109118

Article  PubMed  Google Scholar 

Ahirwar R, Mondal PR (2019) Prevalence of obesity in India: a systematic review. Diabetes Metab Syndr 13(1):318–321

Article  PubMed  Google Scholar 

Gupta R, Rao RS, Misra A, Sharma SK (2017) Recent trends in epidemiology of dyslipidemias in India. Indian Heart J 69(3):382–392

Article  PubMed  PubMed Central  Google Scholar 

Ramakrishnan S, Zachariah G, Gupta K, Rao JS, Mohanan PP, Venugopal K et al (2019) Prevalence of hypertension among Indian adults: results from the great India blood pressure survey. Indian Heart J 71(4):309–313

Article  PubMed  PubMed Central  Google Scholar 

Adair LS, Gordon-Larsen P, Du SF, Zhang B, Popkin BM (2014) The emergence of cardiometabolic disease risk in Chinese children and adults: consequences of changes in diet, physical activity and obesity. Obes Rev 15:49–59

Article  PubMed  PubMed Central  Google Scholar 

Jain J, Rao T, Desmukh P, Banait S (2015) Prevalence and correlates of metabolic syndrome in young population: a cross sectional study. J Diabetes Metab 6(503):2

Google Scholar 

Manjunath D, Uthappa CK, Kattula SR, Allam RR, Chava N, Oruganti G (2014) Metabolic syndrome among urban Indian young adults: prevalence and associated risk factors. Metab Syndr Relat Disord 12(7):381–389

Article  CAS  PubMed  Google Scholar 

Mezhal F, Oulhaj A, Abdulle A, AlJunaibi A, Alnaeemi A, Ahmad A et al (2023) High prevalence of cardiometabolic risk factors amongst young adults in the United Arab Emirates: the UAE Healthy Future Study. BMC Cardiovasc Disord 23(1):137

Article  PubMed  PubMed Central  Google Scholar 

Malik VS, Willett WC, Hu FB (2013) Global obesity: trends, risk factors and policy implications. Nat Rev Endocrinol 9(1):13–27

Article  PubMed  Google Scholar 

Mishra D, Naorem K, Saraswathy KN (2018) Angiotensin-converting enzyme gene insertion/deletion polymorphism and cardiometabolic risk factors: a study among Bhil tribal population from two environmental settings. Biochem Genet 56:295–314

Article  CAS  PubMed  Google Scholar 

Montes-de-Oca-García A, Perez-Bey A, Velázquez-Díaz D, Corral-Pérez J, Opazo-Díaz E, Rebollo-Ramos M et al (2021) Influence of ace gene I/D polymorphism on cardiometabolic risk, maximal fat oxidation, cardiorespiratory fitness, diet and physical activity in young adults. Int J Environ Health Res 18(7):3443

Article  Google Scholar 

Sayed-Tabatabaei FA, Oostra BA, Isaacs A, Van Duijn CM, Witteman JC (2006) ACE polymorphisms. Circ Res 98(9):1123–1133

Article  CAS  PubMed  Google Scholar 

Dhar S, Ray S, Dutta A, Sengupta B, Chakrabarti S (2012) Polymorphism of ACE gene as the genetic predisposition of coronary artery disease in Eastern India. Indian Heart J 64(6):576–581

Article  PubMed  PubMed Central  Google Scholar 

Behbodikhah J, Ahmed S, Elyasi A, Kasselman LJ, De Leon J, Glass AD, Reiss AB (2021) Apolipoprotein B and cardiovascular disease: biomarker and potential therapeutic target. Metabolites 11(10):690

Article  CAS  PubMed  PubMed Central  Google Scholar 

Contois JH, McConnell JP, Sethi AA, Csako G, Devaraj S, Hoefner DM, Warnick GR (2009) Apolipoprotein B and cardiovascular disease risk: position statement from the AACC Lipoproteins and Vascular Diseases Division Working Group on Best Practices. Clin Chem 55(3):407–419

Article  CAS  PubMed  Google Scholar 

Misra A, Chowbey P, Makkar BM, Vikram NK, Wasir JS, Chadha D et al (2009) Consensus statement for diagnosis of obesity, abdominal obesity and the metabolic syndrome for Asian Indians and recommendations for physical activity, medical and surgical management. J Assoc Physicians India 57:163–170

CAS  PubMed  Google Scholar 

Ashwell M, Gibson S (2016) Waist-to-height ratio as an indicator of ‘early health risk’: simpler and more predictive than using a ‘matrix’ based on BMI and waist circumference. BMJ Open 6(3):e010159

Article  PubMed  PubMed Central  Google Scholar 

Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ, Dennison Himmelfarb C et al (2018) 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension 71(6):1269–1324

Article  CAS  PubMed  Google Scholar 

Miller SA, Dykes DD, Polesky HF (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16(3):1215

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cho DS, Woo S, Kim S, Byrne CD, Kong JH, Sung KC (2012) Estimation of plasma apolipoprotein B concentration using routinely measured lipid biochemical tests in apparently healthy Asian adults. Cardiovasc Diabetol 11:1–6

Article  Google Scholar 

National Cholesterol Education Program (2001) ATP III guidelines at-a-glance quick desk reference. [Bethesda, Md.] [National Institutes of Health, National Heart, Lung, and Blood Institute]. https://www.nhlbi.nih.gov/files/docs/guidelines/atglance.pdf. Accessed 14 Jan 2023

World Health Organization (2006) Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia: report of a WHO/IDF consultation. World Health Organization, Geneva. https://apps.who.int/iris/bitstream/handle/10665/43588/9241594934_eng.pdf?sequence=1&isAllowed=y. Accessed 14 Jan 2023

Rigat B, Hubert C, Corvol P, Soubrier F (1992) PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1)(dipeptidyl carboxypeptidase 1). Nucleic acids Res 20(6):1433

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aryal N, Wasti SP (2016) The prevalence of metabolic syndrome in South Asia: a systematic review. Int J Diabetes Dev Ctries 36:255–262

Article  Google Scholar 

Misra A, Khurana L (2009) The metabolic syndrome in South Asians: epidemiology, determinants, and prevention. Metab Syndr Relat Disord 7(6):497–514

Article  PubMed  Google Scholar 

Misra A, Misra R, Wijesuriya M, Banerjee D (2007) The metabolic syndrome in South Asians: continuing escalation & possible solutions. Indian J Med Res 125(3):345–354

PubMed  Google Scholar 

Kumari N, Yadav A, Ahirwar R, Sagar SK, Mondal PR (2022) Angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism and its association with cardiovascular adversities—a systematic review. Human Gene 34:201117

Article  CAS  Google Scholar 

Xi B, Ruiter R, Chen J, Pan H, Wang Y, Mi J (2012) The ACE insertion/deletion polymorphism and its association with metabolic syndrome. Metab Clin Exp 61(6):891–897

Article  CAS  PubMed  Google Scholar 

Onat A, Can G, Çiçek G, Ayhan E, Doğan Y (2010) Predictive value of serum apolipoprotein B/LDL-cholesterol ratio in cardiometabolic risk: population-based cohort study. Clin Biochem 43(18):1381–1386

Article  CAS  PubMed  Google Scholar 

Relimpio F, Losada F, Pumar A, Mangas MA, Morales F, Astorga R (2002) Relationships of apolipoprotein B100 with the metabolic syndrome in Type 2 diabetes mellitus. Diabetes Res Clin Pract 57(3):199–220

Article  CAS  PubMed  Google Scholar 

Cantey EP, Wilkins JT (2018) Discordance between lipoprotein particle number and cholesterol content: an update. Curr Opin Endocrinol Diabetes Obes 25(2):130–136

Article  CAS  PubMed  Google Scholar